Assistance Publique - Hôpitaux De Paris

This study is testing whether a blood pressure medication (an ARB called irbesartan) can help prevent future heart problems in people who survived a stay in the intensive care unit (ICU) and had acute kidney injury. About 508 participants will be randomly assigned to take either …

This study is testing whether adding a specific peptide called cpFT to the liquid where eggs and embryos grow during IVF (ICSI procedure) can increase the chance of having a live baby. It involves 366 couples where the woman is under 37 years old. Participants are randomly assign…

This trial is testing a new machine that keeps donor hearts alive and healthy outside the body for much longer than currently possible. The goal is to safely transport hearts from distant locations, like the French Caribbean islands, to patients in France who have no other chance…

This study aimed to test if a direct injection of potassium chloride could help restart the heart in adults experiencing a specific type of out-of-hospital cardiac arrest where the heart is in a chaotic rhythm (ventricular fibrillation) that doesn't respond to three standard elec…

This study aimed to see if an online follow-up system could work as well as in-person clinic visits to help prevent more broken bones. It planned to compare the two methods for getting osteoporosis treatment to people over 60 who recently had a low-trauma fracture. The goal was t…

This study is testing if following up with patients by email helps doctors better control gout. The goal is to see if regular email check-ins help adjust medication doses to reach a target level in the blood, which can dissolve the crystals that cause gout pain. It compares this …

This study is testing a new, standardized way of caring for women at risk of extremely early birth and their babies. It aims to improve the babies' chances of surviving without severe long-term disabilities like cerebral palsy or blindness. The trial involves over 2,300 participa…

This study is testing whether using radiofrequency (heat energy) can safely shrink or eliminate thyroid cancer that has spread to lymph nodes in the neck. It involves a small group of 14 patients who have already had standard surgery and radioactive iodine treatment. Doctors use …

This study aimed to see if a drug called eculizumab could stop a hidden type of kidney transplant rejection from causing permanent damage. It planned to treat sensitized patients who showed early signs of this rejection on a biopsy but had stable kidney function. The goal was to …

This study is testing whether a dietary supplement called myo-inositol can help women with pregnancy-related diabetes (gestational diabetes) better control their blood sugar. Over 1,000 pregnant women diagnosed with this condition will take either the supplement or a placebo pill…

This study is testing if adding a cancer drug called lenvatinib can improve outcomes for people with a hard-to-treat form of early-stage liver cancer. Patients receive the drug for a short time before and after a procedure that burns or freezes their tumor. The goal is to see if …

This study aimed to follow men with paraphilia who had committed a sex offense, tracking them for three years to see how well their medications worked over time and what side effects they experienced. It planned to compare two common types of drugs (SSRI antidepressants and anti-…

This study is testing if metformin, a common diabetes medication, can slow the buildup of calcium in leg arteries (hardening) in people with long-term type 1 diabetes. Over two years, 230 participants will take either metformin or a placebo pill, and researchers will use leg CT s…

This study aims to find out if nicotine e-cigarettes are a good tool to help people quit smoking. It directly compares them against nicotine-free e-cigarettes and a leading prescription quit-smoking medication called varenicline. The trial involves 650 adult smokers who are motiv…

This large French study aims to find the best way to give a key drug called pegaspargase to children and teenagers with acute lymphoblastic leukemia (ALL). The drug works by starving the leukemia cells. Researchers are comparing two different dosing schedules to see which one is …

This study compares a newer drug, mepolizumab, against standard steroid-based treatment for people with eosinophilic granulomatosis with polyangiitis (EGPA), a rare autoimmune disease. It aims to see if the new approach can better control disease flares and allow patients to use …

This study aimed to compare two ways to prevent stomach damage in people who need to take low-dose aspirin long-term for heart conditions. Researchers wanted to see if eliminating a common stomach bacteria (H. pylori) worked better than using a stomach-protecting medication (pant…

This study aimed to see if using a connected, smart toothbrush could help children with cleft lip and palate clean their teeth better before a major bone graft surgery. Good oral hygiene before this surgery is critical because poor cleaning can lead to serious complications like …

This study is testing if adding a cholesterol-lowering injection called evolocumab to standard care is better at reaching very low cholesterol goals after a heart attack. It involves over 2,100 patients in Europe who have had a serious heart attack and received a stent. The main …

This study is testing whether transferring healthy gut bacteria from a donor (a fecal microbiota transplant) can help people with ulcerative colitis. It will involve 150 adults with active colitis who are also taking steroid medication. Researchers want to see if this procedure c…

This study aimed to review the safety and effectiveness of hydroxychloroquine for children with a rare, severe genetic disease called Lipin-1 deficiency. The disease causes painful, life-threatening muscle breakdown episodes. Researchers looked back at medical records of children…

This study investigates whether routine prenatal blood tests, which screen for fetal genetic conditions, can also detect early-stage cancer in pregnant women. Researchers will analyze blood samples from 300 pregnant women with cancer to identify specific genetic patterns that sig…

This study is testing if a quick, automated eye scan can predict which patients in the intensive care unit (ICU) on breathing machines are at high risk for developing delirium, a serious state of confusion. Researchers will measure the pupils of 213 patients to see if specific ch…

This study is testing whether a simple, at-home vaginal swab can reliably detect HPV, the virus that causes cervical cancer, in women with chronic immune system diseases. It aims to see if this easier method can help these higher-risk women get screened more regularly. The study …

This study aimed to create artificial intelligence (AI) tools to diagnose and predict rejection in kidney transplant patients without invasive biopsies. It planned to analyze years of patient data, including urine test results and standard health information, to train the AI mode…

This study is testing a new, non-invasive 3D scanning method to measure how well a person's diaphragm muscle works during breathing. It involves taking two quick 3D pictures of a person's chest and abdomen while they hold their breath. The goal is to see if this scan is as accura…

This study aimed to test if a simple thermal camera attached to a smartphone could help doctors quickly figure out how deep a child's burn is. It planned to measure temperature differences between burned and healthy skin in children under 18 with second-degree burns. The goal was…

This study is testing if using a smart scale that measures body composition (like muscle and fat) helps people with chronic diseases feel better during a 6-week exercise program. 90 participants are split into two groups: one uses the smart scale, and the other receives standard …

This study aimed to see if a special educational game could help children and their parents better manage a challenging nighttime breathing therapy. The game, called Yapouni, used a hot air balloon that flew higher the longer a child used their CPAP or NIV machine, hoping to impr…

This study aims to find a better way to treat sudden gout attacks in people with advanced kidney disease or kidney transplants. It compares two medications—anakinra and prednisone—to see which one reduces pain faster and with fewer side effects. The trial involves about 200 hospi…

This study is exploring whether group therapy sessions involving multiple families can help teenagers with severe school refusal. It involves 74 teens in France who have been out of school for weeks due to anxiety. Researchers will measure changes in anxiety, school attendance, a…

This study aims to understand how painful lumps caused by gout change when patients take standard uric acid-lowering medication. Researchers will use a special type of CT scan to closely measure the size of these lumps in the hands and feet of 50 patients over one year. The goal …

This study aimed to translate an English tool for detecting delirium into French and test how well it works in a pediatric intensive care unit (PICU). The goal was to see how often delirium occurs in critically ill children and whether nurses and staff could easily use the new Fr…

This study aimed to understand how severe COVID-19 disrupts the body's ability to make new blood cells, a process called emergency hematopoiesis. Researchers planned to compare blood cell samples from three groups: patients with severe COVID-19, patients with certain chronic bloo…

This study aims to improve our understanding of HIV as a long-term condition. Researchers are observing over 1,600 adults with HIV to collect health information and blood samples. The goal is to learn about complications from the virus and its treatments over many years, which ma…

This study aimed to see if a patient's body language and behavior during a pre-surgery interview could reveal their anxiety levels. Researchers planned to video record these interviews with adults having day surgery and look for patterns. The goal was to find a more objective way…

This study aimed to learn how a specific type of birth control pill (macro-progestin) might affect bone health in young women aged 16-25. It planned to do this by observing and measuring bone health markers in patients already taking this medication. The study was purely observat…

This study aimed to learn about remote health education sessions delivered by video. Researchers planned to interview both the healthcare providers who teach these sessions and the patients or caregivers who receive them. The goal was to understand how this remote approach works …

This study aimed to understand how specific genetic mutations cause rare and severe diseases that affect multiple organs in children, including the lungs, liver, and brain. Researchers planned to study skin cells from patients in a lab to see how these mutations disrupt the cell'…

This study follows patients infected with HTLV-1 virus to understand their long-term survival. It tracks two groups: those who develop a serious blood cancer (ATL) and those who don't. Researchers will collect detailed medical information over time to learn how the disease progre…

This study aims to better understand severe childhood asthma by following a group of children over time. Researchers will collect health information and biological samples to identify what factors make asthma severe and how it affects kids as they grow into adults. The goal is to…

This study aimed to understand the role of specific immune cells in children with severe asthma. Researchers planned to compare samples from children with severe asthma to those without asthma to see if these cells were more common and linked to asthma symptoms. The goal was to g…

This study is creating a collection of biological samples from 500 patients with rare diseases affecting the blood vessels in the brain and eyes. The goal is to store these samples for future research to discover new markers that can predict how the disease will progress or to fi…

This study aims to learn more about patients who get very sick with pneumonia caused by Mycoplasma or Chlamydia bacteria and need hospital intensive care. Researchers will observe 100 adult patients to understand their characteristics, how they are treated, and what their outcome…

This study aims to understand why some young women treated for breast cancer experience more severe fertility loss after chemotherapy than others. Researchers will follow 73 young women to see if specific genetic markers, linked to the age of natural menopause, can predict who is…

This study is testing a new way to analyze standard CT or MRI scans, called radiomics, to see if it can predict early on which patients with advanced pancreatic cancer will not respond to first-line chemotherapy. It involves looking back at the scans and records of 400 patients w…

This study aimed to see if a simple breathing test, called the Müller maneuver, could predict which patients on ventilators would develop dangerous fluid in their lungs when trying to breathe on their own. Researchers planned to measure heart function before and after the test in…

This study aims to find out if two specific proteins in the blood, called Activin-A and FSTL3, can help doctors predict how patients with pulmonary hypertension will fare over time. It will follow 550 adults with different types of this serious lung and heart condition. The goal …

This study aimed to collect information on how doctors perform cataract surgery on children to understand which techniques work best. It planned to track children aged 0-17 years who had the surgery at a specific hospital in Paris. The goal was to compare different surgical appro…

This study aimed to investigate whether skin lesions appearing on adults' fingers and toes were directly linked to COVID-19 infection. Researchers planned to collect blood samples and small skin biopsies from participants to test for the virus and understand how these lesions for…

This study aims to understand how limb-girdle muscular dystrophy type 2A (LGMD2A) progresses over two years. Researchers will closely monitor 25 patients to measure changes in their muscle strength, movement abilities, and quality of life. The goal is to gather detailed informati…

This study aimed to gather information about pregnancy in women with rare autoimmune diseases like lupus and rheumatoid arthritis. Researchers planned to follow these pregnancies to understand complications and how medications affect both mother and baby. The goal was to use this…

This study aimed to create and test a new questionnaire specifically designed to measure how lumbar spinal stenosis limits people's daily activities. Researchers planned to develop the questionnaire by interviewing patients and then testing it in a larger group. The study was wit…

This study aimed to understand how the virus that causes COVID-19 might infect the tonsils and adenoids. Researchers planned to measure two key proteins (ACE2 and TMPRSS2) in tissue samples removed from children and adults during routine surgeries. The goal was to see if differen…

This study aimed to test whether MRI scans could provide better information about how the placenta works during pregnancy, especially when a baby isn't growing properly. Researchers planned to compare MRI measurements of blood flow and structure in placentas from high-risk and lo…

This study, which was withdrawn before starting, aimed to understand how realistic, on-site emergency simulation training affects hospital staff. It planned to train 400 doctors, nurses, and aides per year at a children's hospital using fake emergency scenarios in real hospital r…

This study aims to understand why some women develop long-term chronic headaches after receiving a 'blood patch' treatment for a spinal headache caused by an epidural during childbirth. Researchers will follow 98 women for six months, collecting details about their initial headac…

This study aimed to learn more about breast abscesses, which are painful infections that can occur during breastfeeding. Researchers planned to look at women who had their abscess treated with a needle guided by ultrasound. The goal was to understand what causes these infections,…

This study is testing a new way to measure movement in babies with spinal muscular atrophy (SMA) who are receiving new gene or drug therapies. Researchers will use small, wearable motion sensors on the babies' arms and legs to get a more detailed picture of their motor function. …

This study aimed to learn how common chronic pain is in teenagers with juvenile idiopathic arthritis, especially when their disease is not very active. Researchers planned to survey teens aged 12-17 to measure their pain levels and see how it impacts their daily life, sleep, mood…

This study aimed to see if a special type of MRI scan, which measures oxygen levels in the blood, could be used on fetuses with certain birth defects (like a hole in the diaphragm or abdominal wall) to predict how well their lungs will work after birth. The goal was to gather inf…

This study aimed to translate and test a French version of a quality of life questionnaire for children with chronic ear infections. The goal was to create a tool to help doctors better track symptoms and treatment effectiveness over time. The study was withdrawn before any parti…

This study aimed to understand how Duchenne muscular dystrophy affects the heart over two years. Researchers planned to use detailed heart MRI scans and blood tests to track changes in heart muscle and function in boys and men with DMD. The study was withdrawn before any particip…