Assistance Publique - Hôpitaux De Paris

This study tests whether a reduced dose of the clot-dissolving drug alteplase, given alongside standard blood thinners, can improve outcomes for people with intermediate-high-risk pulmonary embolism (a serious blood clot in the lungs). About 800 adults with confirmed acute pulmon…

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This phase 3 trial looks at whether people with severe sarcoidosis who are in remission should stop or continue taking infliximab. 32 adults who have been on infliximab for at least 6 months and are stable on low-dose steroids will be randomly assigned to stop or continue the dru…

This phase 2 trial tests whether giving two immunotherapy drugs (durvalumab and tremelimumab) before and after a standard ablation procedure can help prevent liver cancer from returning. Thirty adults with early-stage liver cancer will receive one infusion of the drug combination…

This study tests whether giving nifedipine, a drug that relaxes the uterus, for 48 hours can improve health outcomes for babies when a pregnant person's water breaks too early (between 22 and 34 weeks). About 857 participants will receive either nifedipine or a placebo. The goal …

This study tests whether an oral liquid form of glibenclamide can safely control high blood sugar in very premature infants (born before 32 weeks, weighing under 1.5 kg). The goal is to see if it can replace insulin injections. The trial involves 35 babies and monitors blood suga…

This study tests whether adding evolocumab (Repatha) to standard care helps people who recently had a heart attack reach very low LDL cholesterol levels and avoid death or unplanned heart-related hospital stays. About 2,166 participants with STEMI or NSTEMI will be randomly assig…

This study was designed to see if adding hydroxychloroquine to standard treatment (aspirin and heparin) could help women with antiphospholipid syndrome have a healthy full-term pregnancy. It planned to enroll pregnant women before 14 weeks of gestation. However, the trial was wit…

This was a planned Phase 2 trial to test two immunotherapy drugs—monalizumab and MEDI5752—in people with metastatic cancers that have a specific genetic feature called MSI/dMMR. The study was withdrawn before enrolling any participants, so no data or results are available. The go…

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This early study tests a device that keeps donor hearts alive outside the body for longer periods before transplant. The goal is to see if hearts preserved this way work well within 15 days after surgery. Twenty adults with severe heart failure who cannot get a standard transplan…

This study tests a minimally invasive procedure called radiofrequency to treat thyroid cancer that has spread to lymph nodes in the neck. It involves 14 adults who have already had surgery and radioactive iodine therapy. The goal is to see if the heat-based treatment can shrink o…

This study tests whether regular email communication between gout patients and their doctors can help lower uric acid levels more effectively than standard care. 204 adults with confirmed gout will either follow usual care or use a secure messaging system to adjust their medicati…

This study tests whether the targeted drug lenvatinib, given before and after a standard tumor-burning procedure (ablation), can help prevent liver cancer from returning in patients with aggressive tumors. About 32 adults with high-risk features (like high AFP levels or infiltrat…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis, a chronic bowel disease. About 150 adults with active or steroid-dependent disease will receive either real fecal transplants or a sham procedure. The goal is to see i…

This study tests whether myo-inositol, an oral dietary supplement, can help pregnant women with gestational diabetes control their blood sugar without needing insulin shots. About 1,080 women with newly diagnosed gestational diabetes will receive either myo-inositol or a placebo …

This study compares nicotine e-cigarettes, nicotine-free e-cigarettes, and the medication varenicline to see which works best for helping people quit smoking. About 650 adult smokers who want to quit will take part. The main goal is to see who can stay away from regular cigarette…

This study tests whether metformin, a drug used for type 2 diabetes, can slow the buildup of calcium in leg arteries of people with type 1 diabetes. 230 adults will take either metformin or a placebo for two years. The goal is to see if metformin reduces artery hardening, which c…

This study planned to test whether a direct injection of potassium chloride could help people whose hearts had stopped and were not responding to standard shocks. The trial was withdrawn before any patients were enrolled, so no results are available.

This study tests whether a drug called mepolizumab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) reach remission better than standard treatments. About 100 adults with active EGPA will receive either mepolizumab or usual care, and…

This study was designed to test whether the drug eculizumab could treat early, symptom-free antibody-mediated rejection in kidney transplant recipients. The goal was to prevent long-term damage and chronic rejection. However, the trial was withdrawn before enrolling any participa…

This study aimed to look back at children with Lipin-1 deficiency who were given hydroxychloroquine to prevent severe muscle breakdown and pain. The condition causes repeated, dangerous episodes of muscle damage. Researchers planned to check safety and effectiveness by measuring …

This French study looks at 2,044 children and teens with acute lymphoblastic leukemia (ALL) to find the best way to give the drug pegaspargase. Some patients get one large dose, while others get two smaller doses. The goal is to see which schedule works better and causes fewer si…

This study tests whether irbesartan, a blood pressure medication, can reduce the risk of major heart problems and kidney disease in people who had acute kidney injury while in the intensive care unit (ICU). About 500 adults aged 18-75 will take either irbesartan or a placebo for …

This study was designed to see if a special MRI technique (BOLD) could measure how well fetal lungs work in babies with diaphragmatic hernia or abdominal wall defects. Researchers planned to scan the lungs while the mother breathed normal air and then oxygen, looking for changes …

This study looks at whether women with immune-mediated inflammatory diseases (like lupus or Sjögren's syndrome) can use a vaginal self-sampling kit to check for high-risk HPV, the virus that can cause cervical cancer. Researchers will track 300 women aged 30-65 to see how many ha…

This study aimed to see if a surgical procedure called scleral buckling could prevent retinal detachment in people with Stickler syndrome, a genetic condition that raises the risk of vision loss. The plan was to treat one eye in patients aged 5 to 35 who had already lost vision i…

This study was designed to see if treating a common stomach bacteria (H. pylori) along with using a stomach acid drug could prevent ulcers caused by low-dose aspirin. It planned to enroll adults with heart or artery disease who needed long-term aspirin therapy. However, the study…

This trial tests whether training general practitioners to better manage persistent symptoms after COVID-19 can improve patients' quality of life. Adults with at least two long COVID symptoms (like fatigue, breathlessness, or brain fog) lasting over two months will be enrolled. T…

This study tests whether telling smokers their estimated 'pulmonary age' (how old their lungs act) helps them quit. About 100 smokers aged 25+ will be randomly assigned to get their pulmonary age or not. Success is measured by a breath test at 6 months. The goal is to see if this…

This study looks at whether a ketogenic diet (high-fat, low-carb) is practical and safe for people with early-stage Alzheimer's disease over one year. The diet may provide an alternative energy source for the brain and reduce inflammation. Researchers will track diet adherence, b…

This study aimed to see if an educational game called Yapouni could help children aged 3 to 16 use their CPAP or NIV breathing machines more consistently. The game was designed to motivate children by linking machine use to a hot air balloon's flight. However, the study was withd…

This study aimed to see if using a connected toothbrush (Ara® KOLIBREE) for one month before alveolar bone graft surgery could improve oral hygiene in children aged 5 to 12 with cleft lip and palate. The trial was withdrawn before enrolling any participants, so no results are ava…

This study tests if anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease or who have had a kidney transplant. Gout causes sudden, severe joint pain. Standard treatments can be risky for these patients. The study measures pain …

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study aims to find genetic and metabolic markers that explain why some people develop diabetes, high blood pressure, or bone loss from glucocorticoids while others do not. Researchers will analyze blood and urine samples from up to 600 participants, including those with exce…

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to help them better understand and respond to their child's signals. The goal is to improve joint attention, a key skill for social communication. Twenty-seven families will be ran…

This study planned to see if faster testing and treatment for hepatitis C could be given to inmates right when they enter prison. The goal was to start medication sooner to reduce the spread of the virus. However, the study was withdrawn and no one took part.

This study is collecting blood samples and health information from 1,613 HIV patients to learn more about the infection and how to improve care. Researchers will track heart and brain health, as well as other medical conditions. The goal is to use this knowledge to make HIV treat…

This study looks at whether the standard blood test given to pregnant women to screen for fetal conditions can also detect signs of cancer in the mother. Researchers will analyze DNA from 300 pregnant women with known or newly diagnosed cancer to identify specific chromosomal pat…

This study tests a remote monitoring wristband (Bora Care) to see if it can detect early signs of worsening COPD. 64 people with COPD who have had recent flare-ups are being followed. The goal is to see if the device can alert patients and doctors before a serious attack happens.

This study was designed to see if a test using acetylcholine could predict whether people with congenital heart disease and high blood pressure in the lungs would develop worsening high blood pressure after surgery to close a heart shunt. The test would have measured how well the…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study aimed to look at bone health in young women aged 16 to 25 who took a specific type of birth control pill (macro-progestins) for at least six months. Researchers planned to review medical records and run blood and urine tests to see if these pills affected bone density.…

This study looked at nursing mothers who had a breast abscess drained using ultrasound guidance. The goal was to understand why abscesses happen and whether women can safely continue breastfeeding after treatment. However, the study was withdrawn before enrolling any participants…

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…

This study was designed to observe brain wave (EEG) changes in adults with chronic neuropathic pain during ketamine treatment. Researchers hoped to find patterns that could predict which patients benefit most. However, the study was withdrawn before enrolling any participants, so…

This study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…

This study follows 69 people infected with HTLV-1, some of whom have developed a rare blood cancer called adult T-cell leukemia/lymphoma. Researchers will track survival rates over 2 and 5 years, along with viral levels and genetic markers. The goal is to better understand how th…

This study follows 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how many survive. They will also check for antibiotic resi…

This study aimed to find out if video recordings of pre-surgery interviews could reveal behavioral signs of anxiety in day-surgery patients. Researchers planned to compare these signs with patients' own reports of anxiety. However, the study was withdrawn before enrolling any par…

This study aimed to create and test a new questionnaire to better measure how lumbar spinal stenosis limits daily activities. It planned to enroll adults aged 50 and older with the condition, who would fill out several online surveys. However, the study was withdrawn before any p…

This study was designed to learn how the protein calprotectin might change blood stem cells in people with severe COVID-19 or certain blood cancers. Researchers planned to compare cells from patients and healthy donors in the lab. However, the study was withdrawn before any parti…

This study was designed to investigate whether new skin lesions on fingers or toes were linked to COVID-19. It planned to test adults with these lesions for the virus using PCR and antibody tests. However, the study was withdrawn before enrolling any participants, so no results a…

This study aimed to measure two proteins, ACE2 and TMPRSS2, in tonsils and adenoids of children and adults. These proteins help the COVID-19 virus enter cells. The goal was to understand where the virus might enter the body. However, the study was withdrawn before any participant…

This study aimed to see how common delirium is in children in the pediatric intensive care unit (PICU) by using a French version of a screening tool called the Cornell Assessment of Pediatric Delirium (CAPD). The plan was to check each child twice a day during their stay. However…

This study was designed to observe how well medications like antidepressants and anti-androgens work over time for men with paraphilia who have committed sex offenses, and what side effects occur. It planned to follow participants for three years, but was withdrawn before enrolli…

This study aimed to see if a simple breathing test (Müller maneuver) could predict which patients on ventilators would develop fluid in their lungs during a weaning trial. The test measures changes in heart output to assess fluid status. The study was withdrawn before enrolling a…

This study follows 25 people with limb-girdle muscular dystrophy type 2A (LGMD2A), a rare genetic disease that causes progressive muscle weakness. Researchers will measure how muscle strength changes over time and how it affects quality of life. The goal is to better understand t…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study collects blood and urine samples from 500 people with rare brain vessel diseases, such as CADASIL and moya-moya. Researchers aim to find biomarkers that could improve care or identify new treatment targets. Participants are already part of an existing rare disease coho…

This study is collecting blood samples from 550 adults with different types of pulmonary hypertension to measure two proteins, Activin-A and FSTL3. Researchers want to see if these proteins can predict who will need a lung transplant or die within two years. The goal is to find a…

This study aimed to see if a web-based fracture liaison service (e-FLS) could help more older adults start osteoporosis treatment after a fracture compared to standard in-person services. It planned to include men and women over 60 in France who had a low-trauma fracture. However…

This study follows 73 young women with breast cancer to see if certain genes make them more likely to lose fertility after chemotherapy. Researchers measure ovarian reserve (egg supply) before and up to 5 years after treatment. The goal is to better predict who might face fertili…

This study was designed to track heart muscle changes in people with Duchenne muscular dystrophy using two cardiac MRIs taken two years apart, along with blood tests for heart failure markers. It planned to enroll participants aged 6 and older with a confirmed genetic diagnosis. …

This study tests a new care protocol (EXPRIM) for extremely preterm infants born between 22 and 26 weeks. The protocol involves early counseling, standardized steroid use, and team-based decisions. Researchers will compare survival without severe health problems in 2377 babies ac…

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study looks at whether analyzing CT scans with a computer technique called radiomics can predict which patients with advanced pancreatic cancer will not respond to chemotherapy. Researchers will study 400 patients and track survival over time. The goal is to find early signs…

This study planned to observe different surgical approaches for children with cataracts, focusing on implant types and surgery timing. It was withdrawn before enrolling any participants, so no information was collected. The goal was to understand which strategies work best for yo…

This study tests a new 3D imaging method to measure how much air the lungs can hold in people with suspected diaphragm weakness. About 100 adults will have two quick 3D scans while holding their breath. The goal is to see if this technique gives reliable results compared to stand…

This study looks at whether using a connected scale that measures body composition (not just weight) can improve the physical and mental quality of life for people with chronic diseases. About 90 adults will take part in a 6-week physical activity rehab program. Half will use the…

This study was designed to compare certain immune cells (called ILC2) in the lungs of children with severe asthma versus children without asthma. The goal was to see if these cells are higher in asthmatic children and if they relate to other markers of airway inflammation. Howeve…

This study aimed to learn how video calls affect education sessions for people with chronic diseases and their caregivers. It planned to interview patients, parents, and healthcare workers about their experiences. However, the study was withdrawn before enrolling any participants…

This study planned to train 400 hospital workers each year using realistic emergency drills for children. Researchers wanted to see if the training boosted staff confidence, teamwork, and reduced stress. However, the study was withdrawn before enrolling any participants, so no re…

This study planned to create artificial intelligence tools that could diagnose kidney transplant rejection using urine tests instead of invasive biopsies. Researchers wanted to combine urine markers with standard medical data to make diagnosis safer and easier. However, the study…

This study was planned to learn how certain rare genetic mutations disrupt protein production and cause severe diseases affecting the lungs, liver, brain, and digestion. Researchers would have used cells from patients to measure protein levels and stress responses. However, the s…

This study aimed to translate and validate a French version of the COMQ-12 questionnaire, which measures quality of life in children with chronic otitis media (ongoing ear infections). Researchers planned to have children aged 7 to 15 with and without ear infections fill out the …

This study follows 35 infants with spinal muscular atrophy (SMA) who are receiving gene therapy or other advanced treatments. Researchers use small wearable motion sensors to measure how well the babies move their arms and legs over two years. The goal is to create a more precise…

This study follows 362 children with severe asthma to identify different types of the disease and what makes it worse. Researchers will track their health from childhood into adulthood to see how asthma changes over time. The goal is to find risk factors and improve treatment str…

This study follows 50 adults with tophaceous gout who are starting or adjusting urate-lowering therapy. Researchers use a special CT scan (Dual-Energy CT) to measure how much the uric acid crystals in tophi shrink after 6 and 12 months of treatment. They also check whether bone e…

This study planned to see if a cheap thermal camera that attaches to a smartphone could help doctors figure out how deep a child's second-degree burn is. Deep burns often need skin grafts, but it can take over a week to tell. The idea was that deeper, cooler areas would show up o…