Could a sugar pill replace insulin shots for tiny preemies?
NCT ID NCT05687500
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests whether an oral liquid form of glibenclamide can safely control high blood sugar in very premature infants (born before 32 weeks, weighing under 1.5 kg). The goal is to see if it can replace insulin injections. The trial involves 35 babies and monitors blood sugar control over 72 hours, watching for side effects like severe low blood sugar.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
glibenclamide (oral suspension)
What this could lead to
If successful, this could offer a simpler, oral alternative to insulin for managing high blood sugar in premature babies.
What could go wrong
This is a small, early-phase trial with only 35 infants. The drug may not control blood sugar well enough, or could cause dangerously low blood sugar.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hopital Necker - Enfants malades
Paris, 75015, France