Assistance Publique - Hôpitaux De Paris

This study tested whether the drug adalimumab could reduce eye inflammation in children with juvenile arthritis whose eye problems weren't helped by standard steroid drops and methotrexate. For the first two months, some children received adalimumab while others received a placeb…

This study tested whether the drug nintedanib could slow the decline of lung function in transplant patients who develop chronic rejection. Fifty-eight lung transplant recipients with early-stage rejection were randomly assigned to receive either nintedanib or a placebo pill for …

This study tested whether sending text message reminders could help patients get important follow-up care after breaking a bone. Researchers enrolled 97 adults over 50 who came to the emergency room with a low-trauma fracture. One group received standard advice, while another got…

This study tested an artificial intelligence (AI) system designed to help eye doctors predict whether a patient's diabetic retinopathy will get worse. Researchers followed over 3,000 diabetic patients for about 2 years, collecting retinal scans and medical data to train and valid…

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants filled out sleep and quality-of-life questionnaires before surgery and again 3 months and 1 year after. …

This study tested a low dose of interleukin-2 (IL-2) in 14 people with bipolar disorder who were currently depressed. The goal was to see if the treatment could increase certain immune cells (Tregs) and improve mood. Participants continued their usual mood stabilizers or antidepr…

This study tested whether adding a third anti-nausea drug (droperidol) to the standard two-drug combination works better at preventing vomiting after surgery in children. Researchers enrolled 322 children aged 3-18 who were at high risk for post-surgery vomiting. They compared th…

This study tested whether a drug called ILT-101 (low-dose IL-2) could reduce allergy symptoms in people sensitive to birch pollen. The drug aims to boost the body's natural 'peacekeeper' immune cells to calm down the allergic reaction. Twenty-four adults with confirmed birch poll…

This study looked for special molecules in vaginal fluid that could help doctors predict which pregnant women will deliver early. Researchers studied 238 women, including those with preterm labor and healthy pregnant women. The goal is to find a simple test to catch preterm birth…

This study looked at how often low blood sugar (hypoglycemia) happens in children aged 6 months to 6 years with congenital adrenal insufficiency, a condition where the body doesn't make enough cortisol. Even with standard treatment, these children may still be at risk. Researcher…

This study tested specially engineered versions of a natural immune protein (IL-2) in blood samples from 67 people with autoimmune or inflammatory diseases like lupus, multiple sclerosis, and rheumatoid arthritis. The goal was to see if these modified proteins could selectively a…

This study compared two different methods for measuring kidney function in critically ill ICU patients whose kidneys work unusually fast. Researchers tested 90 ICU patients to see if a newer test using a special dye (iohexol) gives more accurate results than the standard creatini…