Assistance Publique - Hôpitaux De Paris

This study tested whether a 14-day course of doxycycline pills works as well as the standard penicillin shot for curing early syphilis. About 200 adults with early-stage syphilis took part. The goal is to offer a reliable oral option, especially when penicillin is in short supply…

This study tested a two-step vaccine approach in 70 adults who had their spleen removed. Participants received one shot of a conjugate vaccine followed by a second shot of a polysaccharide vaccine two months later. The goal was to see if this combination triggers a strong immune …

This study tested whether starting ECMO (a heart-lung bypass machine) right at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. Researchers enrolled 65 adults with refractory cardiac arr…

This trial investigates whether giving two different pneumonia vaccines—one followed by another a year later—boosts immune protection more than a single vaccine alone in adults who have had their spleen removed. People without a spleen are at higher risk for serious pneumococcal …

This trial investigates whether cardiac resynchronization therapy (CRT) — a special type of pacing — can improve how far people can walk in six minutes. It includes adults with congenital heart disease where the right ventricle pumps blood to the body (systemic right ventricle). …

This trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…

This study tested whether using non-invasive blood biomarkers to guide when to perform a biopsy is as safe as doing routine biopsies at set times in kidney transplant recipients. 342 patients were randomly assigned to either a biomarker-guided group or a routine biopsy group. The…

This early-phase trial tested whether injecting special immune-building cells (HTLPs) could help children with severe combined immunodeficiency (SCID) rebuild their immune system faster after a partially matched stem cell transplant. Only 4 children took part. The goal was to see…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested whether triggering the sperm's acrosome reaction (a natural process that releases enzymes to help fertilize an egg) before doing ICSI (a type of IVF) could improve pregnancy outcomes. Researchers enrolled 111 couples undergoing their first ICSI cycle with at lea…

This study tested whether the drug rituximab, given with steroids, works better than steroids alone for people with a rare disease called microscopic polyangiitis that inflames small blood vessels. Only 8 patients took part, and the goal was to see if the combination could preven…

This study tested a drug called bosentan in 16 adults with scleroderma who had a serious kidney complication called scleroderma renal crisis. The goal was to see if bosentan could help protect kidney function and improve survival over 6 months to a year. The drug works by blockin…

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study tracked over 4,200 immunocompromised patients who received monoclonal antibodies to prevent or treat severe COVID-19. Researchers measured how many were hospitalized or died from the virus. The goal was to see if these antibody treatments help protect people whose immu…

This study tested whether people with rheumatoid arthritis, psoriatic arthritis, or spine arthritis could safely switch from receiving infliximab through an IV infusion at a clinic to giving themselves a simple shot under the skin at home. 22 adults who were already stable on IV …

This Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…

This Phase 3 trial tested whether lanreotide, a drug that blocks certain growth hormones, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Participants received ei…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study tested whether taking a probiotic called VSL#3, alongside standard treatment, can reduce disease activity in children with juvenile idiopathic arthritis (JIA). Fifty-one children aged 1 to 7 with specific types of JIA took either the probiotic or a placebo. Researchers…

This study tested a new ovarian stimulation protocol for IVF that aims to keep estrogen levels more natural while still producing many eggs. 129 women with good IVF prognosis participated. The goal was to see if this approach leads to more live births compared to the standard met…

This study tested whether a short course of the steroid prednisone could improve sperm quality in men with infertility caused by inflammation. Researchers measured markers of oxidative stress and sperm health six months after treatment. The trial involved 200 men and compared pre…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested a drug called alemtuzumab (Campath) as a first treatment for children with hemophagocytic lymphohistiocytosis (HLH), a rare and life-threatening immune disorder. The goal was to see if it could help children survive until they could receive a stem cell transplan…

This study tested whether denosumab, a drug given as a shot every 6 months, can improve bone density in people with osteoporosis caused by systemic mastocytosis. 24 adults with the condition took part. The goal was to see if the drug strengthens bones and prevents fractures bette…

This study tested two ways of using liquid nutrition to prevent Crohn's disease from flaring up again in children aged 6 to 18. One group got all their calories from a special liquid diet for one week out of every four (cyclic), while the other group got 25% of their calories fro…

This study tested whether a serious computer game called DIVE helps children aged 10-17 with newly diagnosed type 1 diabetes learn about their disease. 78 kids played the game twice a week for at least an hour, covering topics like diet and treatment. Researchers measured their k…

This study tested a new ovarian stimulation protocol using degarelix (a drug typically used for prostate cancer) to help breast cancer patients preserve their fertility before chemotherapy. The goal was to keep estrogen levels low while still collecting enough eggs for freezing. …

This study looked at two different ways to manage blood sugar in pregnant women with MODY2 diabetes, a genetic condition that affects insulin release. The goal was to see if using ultrasound to guide insulin treatment could prevent the baby from growing too large. 46 women took p…

This study tested whether sending supportive text messages to teenagers with poorly controlled type 1 diabetes could help lower their blood sugar levels. 92 teens aged 12-21 with high HbA1c levels participated. The approach used mobile phone reminders to encourage better diabetes…

This study tested whether an early, computer-guided dosing strategy for vancomycin helps children with MRSA infections reach the right drug levels faster than the usual approach. 100 children aged 1 month to 16 years took part. The goal was to improve treatment effectiveness whil…

This study looked at how well the drug Ivacaftor works and how safe it is for people with cystic fibrosis who have a specific genetic change (G551D mutation) in everyday life, not just in a controlled trial. Researchers followed 57 French patients aged 6 and older for one year af…

This study tested an experimental drug called METAZYM (a lab-made enzyme) in one child with late infantile metachromatic leukodystrophy (MLD) who had already received a stem cell transplant. The goal was to see if the enzyme could improve nerve function and reduce harmful buildup…

This study tested a personalized way to dose the blood thinner enoxaparin in 50 children after kidney transplant. The goal was to prevent dangerous blood clots in the new kidney while avoiding excessive bleeding. Doctors used a computer model (Bayesian approach) to adjust doses b…

This study looked at 62 children with juvenile idiopathic arthritis whose disease was inactive. Researchers tested whether slowly reducing and then stopping their biologic medication was as safe and effective as staying on the full dose for 24 weeks. The goal was to see if taperi…

This trial tested a gene therapy for X-linked severe combined immunodeficiency (SCID-X1), a life-threatening condition where boys are born without a working immune system. Five boys who had no matching bone marrow donor received a single infusion of their own blood stem cells tha…

This study looked at 84 hospitalized adults with severe COVID-19 who received the drug remdesivir. Researchers analyzed their recovery over 15 days to see how the drug affected their clinical course. The goal was to understand if remdesivir helps improve outcomes in severe cases.

This Phase 2 trial tested a high dose (10 mg/kg/day) of the antifungal drug liposomal amphotericin B (Ambisome) in 40 people with zygomycosis, a rare but serious fungal infection. The goal was to see if the high dose could effectively control the infection after 4 weeks of treatm…

This study tested the drug allopurinol in 8 children and adults with adenylosuccinate lyase deficiency (ADSL), a rare genetic disorder that can cause autism, seizures, and developmental delays. Researchers measured changes in thinking, daily skills, and seizure control over 12 mo…

This study tested a new way to treat children aged 6 to 18 who have a dead nerve in an immature tooth. The new method uses a material called MTA to help the tooth form a hard barrier, compared to the standard treatment with calcium hydroxide. The goal was to see which method work…

This early-phase study tested a gene therapy for sickle cell disease in 6 patients aged 12-20. Doctors took the patients' own blood stem cells, added a working gene to help produce healthy red blood cells, and infused them back after chemotherapy. The goal was to see if the treat…

This study tested whether a drug that blocks TNF-alpha, a protein involved in inflammation and scar formation, can reduce sciatica pain in people who developed spinal scar tissue after back surgery. 38 adults with persistent pain after discectomy received either the drug or a pla…

This study tested a surgical technique called osteodistraction to improve breathing in 14 children with faciocraniosynostosis, a condition where skull bones fuse too early. The surgery uses devices to gradually separate and reshape the skull and face. The main goal was to see if …

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study tested whether a drug called bortezomib, given with steroids, plasma exchange, and immunoglobulins, can treat chronic antibody-mediated rejection in kidney transplant recipients. The trial included 60 adults who had a kidney transplant and developed donor-specific anti…

This study tested a simple technique called controlled cord traction (gently pulling the umbilical cord) to see if it reduces the risk of postpartum hemorrhage (heavy bleeding after birth). Over 4,300 women having a vaginal delivery were randomly assigned to either receive this t…

This trial compared two approaches for twin-to-twin transfusion syndrome (TTTS) stage 1: immediate laser surgery versus careful observation. 179 pregnant women with TTTS stage 1 and favorable conditions took part. The goal was to see which strategy leads to better survival and br…

This study tested whether turning off the labor drug oxytocin once a woman reaches 6 cm dilation (active labor) could lower the chance of newborn complications. Over 2,400 women with a single, full-term baby in head-down position took part. The goal was to see if this simple chan…

This phase 3 trial tested whether giving only PCV chemotherapy, instead of chemotherapy plus radiotherapy, could protect thinking abilities in people with a specific brain tumor (1p/19q codeleted anaplastic glioma). 280 newly diagnosed adults were randomly assigned to receive eit…

This completed study tested a technique called continuous anterior chest compression (CACC) in 20 adults with moderate to severe acute respiratory distress syndrome (ARDS). The goal was to see if manually pressing on the chest could improve how air and blood move through the lung…

This phase 3 trial tested whether giving two anti-seizure drugs together (levetiracetam plus clonazepam) works better than clonazepam alone for stopping prolonged seizures in the ambulance or at home. 203 adults with generalized tonic-clonic status epilepticus took part. The main…

This study tested whether the drug rituximab can help people with a rare disease called eosinophilic granulomatosis with polyangiitis (EGPA) achieve remission better than standard treatments. 107 adults with active EGPA were randomly assigned to receive either rituximab or conven…

This study tested what happens when patients with rheumatoid arthritis, Crohn's disease, or eye inflammation switch from the original drug Remicade to its lower-cost biosimilar Inflectra. Over 260 adults who had been on Remicade for at least 4 months were switched. The main goal …

This trial tested whether a less invasive ultrasound-guided drainage procedure works as well as laparoscopic surgery for treating tubo-ovarian abscess. 208 women with uncomplicated abscess were randomly assigned to one of the two procedures, both combined with antibiotics. The ma…

This study tested whether giving a higher dose of oxytocin (a drug that strengthens contractions) could lower the rate of C-sections in obese women having their first baby. Over 400 women took part, receiving either a standard or a higher dose during labour. The goal was to see i…

This study tested the drug ITACITINIB in 35 adults with a mild form of a rare immune disease called HLH. The goal was to see if the drug could control the disease by improving symptoms within 15 days. The trial is now complete, and results will show how well the drug works for th…

This study tested whether giving small amounts of milk under the tongue (sublingual immunotherapy) could help children with cow milk allergy tolerate more milk. Fifty-one children aged 5 and older with confirmed IgE-mediated cow milk allergy participated. Over 12 months, research…

This study tested whether topiramate, a drug usually used for seizures, can help severely obese children and teenagers lose weight. 18 participants aged 9 to 17 took either topiramate or a placebo for 9 months. The main goal was to see if the drug could lower their Body Mass Inde…

This study followed 852 cystic fibrosis patients aged 12 and older who started taking Orkambi outside of a clinical trial. Researchers tracked how many stopped treatment, why, and measured lung function and nutrition over one year. The goal was to see how the drug performs in rea…

This study tested whether a medicine called isosorbide mononitrate, given to help soften the cervix, could reduce the need for C-sections in first-time mothers whose pregnancies went past 41 weeks. Over 1,400 women took part. The goal was to see if this outpatient treatment could…

This study compared two antibiotics, cloxacillin and cefazolin, in 315 adults with a serious bloodstream infection caused by methicillin-susceptible Staphylococcus aureus (MSSA). The goal was to see if cefazolin works as well as cloxacillin, the standard treatment, while potentia…

This study tested whether using a special antiseptic dressing on ECMO tubes can reduce serious infections in critically ill patients. About 270 adults on ECMO for heart or lung failure were randomly assigned to get either the special dressing or a standard one. The goal was to se…

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested whether giving strong, early treatment to people with severe sepsis or septic shock right in the ambulance could lower the number of deaths. The treatment included early antibiotics and fluids to support blood pressure. The study involved 398 adults and measured…

This study tested whether rosuvastatin, a common cholesterol-lowering drug, could reduce early signs of artery hardening in 121 people with ANCA-associated vasculitis. Participants were in remission and received either rosuvastatin or a placebo for up to 2 years. The goal was to …

This phase 3 study tested whether high doses of erythropoietin, a hormone that boosts red blood cell production, could improve survival and brain development in full-term newborns who suffered oxygen deprivation at birth. All 120 babies also received standard cooling therapy. The…

This study tested whether giving a stronger pneumococcal vaccine schedule (either two doses close together or a single larger dose) followed by a standard booster could improve immune protection in 96 adults with ANCA-associated vasculitis who are also receiving rituximab therapy…

This study tested whether rituximab, a drug used for certain cancers and autoimmune diseases, can reduce joint pain and swelling in people with systemic sclerosis (scleroderma). Twenty-two adults with active arthritis took rituximab or a placebo, plus standard care. Researchers c…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested whether sodium phenylbutyrate, a drug already used for other conditions, can reduce a marker of kidney injury in people with proteinuric kidney disease. 26 participants took the drug for 14 days. The goal was to see a 50% drop in a urine marker called Lcn2, whic…

This study tested if the antibiotic temocillin works as well as a stronger antibiotic (carbapenem) for treating urinary tract infections caused by resistant bacteria. 29 hospitalized adults took part. The goal was to see if both treatments could clear the infection and symptoms. …

This study tested whether using technology for remote check-ins helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part. The main goal was to see if their body mass index (BMI) improved after 15 months.

This early-stage study tested a new gene therapy in 2 HIV-positive people with high-risk lymphoma. The therapy involved taking their own stem cells and immune cells, adding a gene to block HIV, and giving them back after chemotherapy. The main goal was to see if the procedure was…

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study tested whether giving oxygen at home during the night could prevent severe pain episodes and other complications in pregnant women with sickle cell disease. 178 pregnant women took part, using an oxygen device for 4 hours each night. The goal was to see if this simple …

This study tested whether rituximab (given as an infusion every 6 months) is better than azathioprine (daily pills) at keeping eosinophilic granulomatosis with polyangiitis (EGPA) in remission. 98 adults with newly diagnosed or relapsing EGPA who had already achieved remission to…

This study tested whether miglustat, a drug that blocks certain sugar processing, can improve salt movement in the noses of adults with cystic fibrosis who have the F508del gene mutation. Sixteen participants took miglustat for two weeks and a placebo for two weeks, with a washou…

This study tested whether giving methionine (an amino acid) by mouth or feeding tube is safe and tolerable for children with a severe, inherited lung disease called pulmonary alveolar proteinosis. The disease is caused by a faulty MARS gene that prevents cells from using methioni…

This study tested whether using small titanium screws (miniscrews) as anchors works better than using other teeth for support during orthodontic treatment. 99 patients aged 12 to 50 who needed two upper premolars extracted took part. The main goal was to see how well the extracti…

This study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…

This study tested whether rituximab, a targeted antibody therapy, is better than azathioprine, a standard immune-suppressing drug, at preventing relapses in people with ANCA-associated vasculitis. 117 patients who had achieved remission were randomly assigned to receive either ri…

This study looked at whether giving rituximab for 46 months instead of the usual 18 months can better prevent relapses of ANCA-associated vasculitis, a rare autoimmune disease that causes blood vessel inflammation. 97 patients who were already in remission after initial rituximab…

This study tested whether adding early steroids or SGLT2 inhibitors to standard blood pressure medication can better protect kidney function in people with IgA nephropathy who have severe kidney damage. 62 adults with active disease were randomly assigned to receive either the co…

This phase 3 trial tested whether high doses of epoetin alpha, a drug that boosts red blood cells and may protect the brain, could improve recovery in 500 comatose adults who survived a cardiac arrest. Half received the drug plus standard care, half got standard care alone. The m…

This small pilot study looked at whether the drug pirfenidone is safe and effective for people with a specific type of lung scarring (pulmonary fibrosis) linked to MPO antibodies or vasculitis. Seven adults took the drug for a year, and researchers measured changes in lung functi…

This small pilot study tested whether famotidine, a widely used heartburn drug, can reduce a blood marker linked to painful crises in children with sickle cell disease. Thirty children took the medicine for 29 days. The goal was to see if the drug lowers P-selectin levels, which …

This completed trial tested a personalized program of physical activity, nutrition guidance, and education for 128 adults with Prader-Willi syndrome. Participants followed the program during a 5-week hospital stay, with the goal of stabilizing or reducing their body mass index (B…

This study tested three biologic drugs—adalimumab, anakinra, and tocilizumab—in 112 people with severe, treatment-resistant uveitis, an inflammatory eye disease that can cause blindness. Participants received one of the drugs for 16 weeks. The goal was to see which drug best redu…

This study tested whether adding azathioprine to standard corticosteroid treatment helps people with certain types of vasculitis (blood vessel inflammation) achieve remission and avoid relapses. 114 newly diagnosed patients without poor prognosis factors took part. The goal was t…

This study tested whether a combination of the chemotherapy drug cyclophosphamide and the steroid prednisone could help people with scleroderma-related lung disease. Forty adults whose lung function had worsened in the past year received either the drug combo or a placebo plus pr…

This study tested a procedure called radiofrequency ablation (using heat to remove abnormal cells) in 125 people with Barrett's esophagus and low-grade dysplasia. Participants were randomly assigned to receive the ablation or regular endoscopic monitoring. The goal was to see if …

This study tested a daily injection called teduglutide (Revestive) in 25 children aged 2 to 18 with short bowel syndrome who rely on IV nutrition. The goal was to see if the drug helps their intestines absorb more nutrients, so they can reduce or stop IV feedings. Researchers mea…

This study tested whether somatostatin is better than octreotide at preventing pancreatic fistulas—a common and serious leak after pancreatic surgery. Researchers enrolled 655 adults undergoing pancreatic surgery and gave one of the two drugs for about a week. The goal was to see…

This study tested whether measuring a blood marker called procalcitonin (PCT) could help doctors decide when to stop antibiotics in newborns with late-onset sepsis. Over 500 newborns were included, and the goal was to reduce antibiotic use by 30% without increasing infection recu…

This early trial tested whether low doses of interleukin-2 (IL-2) could boost regulatory T cells in women who had at least five unexplained miscarriages. The goal was to see if this immune-calming approach could eventually prevent the body from rejecting a pregnancy. Only 18 wome…

This study tested whether a specially trained nurse (Advanced Practice Nurse) could help people with high blood pressure get it under control. Over 480 adults with essential hypertension received either usual care or an extra nurse visit that included health education, medication…

This study tested two ways to give pneumococcal vaccines to people with lupus, a disease where the immune system attacks the body. One group got a prime-boost strategy (two different vaccines six months apart), while the other got the standard single vaccine. The goal was to see …

This study tested a device called NEMOST, a growing rod implanted in the spine, along with physiotherapy, in 20 children aged 5 to 15 with progressive scoliosis. The goal was to see if it could keep the spine straight as the child grows and avoid the need for more surgeries. The …

This study tested a surgery performed before birth to repair a spinal defect called myelomeningocele, a severe form of spina bifida. The goal was to see if fixing the spine in the womb could reduce brain problems and nerve damage after birth. 38 pregnant women carrying fetuses wi…

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could reduce new cases of diabetes, heart disease, cancer, or death. Over 500 patients took part for two years, but…

This study tested a new liquid version of the diabetes drug glibenclamide in 10 children with neonatal diabetes. The goal was to see if the liquid form is easier to take and as safe as the standard pills. Children first took the pill form for one month, then switched to the liqui…

This phase 3 trial tests whether nintedanib, a drug already used for lung scarring, can slow the decline in lung function in lung transplant recipients who develop bronchiolitis obliterans syndrome (BOS), a form of chronic rejection. 58 participants received either nintedanib or …

This study tested a new, less invasive surgical technique to repair spina bifida before birth. Seven pregnant women carrying babies with the condition underwent a fetoscopic procedure using small incisions and a camera. The goal was to see if the surgery was feasible and safe for…

This small study tested ustekinumab, a drug that calms the immune system, in 16 adults with Behçet disease. The goal was to see if it could reduce mouth ulcers and eye inflammation. The trial is complete, but because it's early and small, we don't yet know if the drug will become…

This study tested the drug adalimumab against a placebo in 34 children with juvenile arthritis and active eye inflammation (uveitis) that wasn't controlled by steroid drops or methotrexate. The goal was to see if adalimumab could reduce eye inflammation after two months. After th…

This study tested whether a special type of dialysis (high-permeability hemodialysis) could help people in shock after being revived from cardiac arrest. The idea was to filter out inflammatory substances from the blood to improve blood pressure and reduce the need for strong med…

This study tested whether giving the antiviral drug valacyclovir to pregnant women with a CMV-infected fetus could reduce the chance of the baby being born with serious symptoms. 41 pregnant women took high doses of valacyclovir daily for up to 23 weeks. The goal was to see if th…

This study looked at men with advanced prostate cancer that no longer responds to hormone therapy. When the standard dose of abiraterone stopped working, some patients received a double dose to see if it could stabilize the disease. The goal was to find out if this approach is sa…

This large study tested whether the diabetes pill glyburide works as well as insulin shots for treating gestational diabetes in 914 pregnant women. The goal was to see if glyburide could prevent newborn complications like high birth weight, low blood sugar, and jaundice. If effec…

This study tested whether placing a balloon in the uterus early (within 15 minutes) helps control heavy bleeding after vaginal birth better than waiting 30 minutes. It included 405 women who had persistent bleeding after standard medication. The goal was to see if early balloon u…

This completed study looked at whether a nurse-led program of self-assessment and self-management, plus standardized screening for other health problems, helps people with axial spondyloarthritis. Over 500 adults took part. The goal was to see if this approach improves how patien…

This study tested a new way to treat low-risk prostate cancer using a microwave probe inserted through the rectum. The goal was to see if it could safely destroy the main tumor while protecting nearby tissues. Eleven patients were treated, and the researchers checked for complete…

This small pilot study tested whether drugs normally used for HIV could help children with Aicardi-Goutières syndrome (AGS), a rare genetic disorder that causes severe brain inflammation. The trial gave 11 children a combination of three reverse transcriptase inhibitors to see if…

This study tested two ways of giving rituximab to people with ANCA-associated vasculitis, a rare disease where the immune system attacks blood vessels. All 166 participants were in remission and received rituximab either on a fixed schedule or only when certain blood markers (ANC…

This study compares hysteroscopy (using a tiny camera) to standard curettage (scraping) for removing leftover tissue after an incomplete miscarriage. It involved 577 women under 45 who wanted to get pregnant again. The main goal was to see which procedure leads to more successful…

This phase 3 trial tested whether removing the kidney (nephrectomy) before taking the drug sunitinib helps people with metastatic kidney cancer live longer compared to taking sunitinib alone. 452 patients were randomly assigned to either surgery plus sunitinib or sunitinib only. …

This study tested whether the drug baclofen, typically used for muscle spasms, can help people with alcoholism reduce their drinking. Over 300 adults who wanted to cut back or quit took either baclofen or a placebo for a year. The main goal was to see if more people on baclofen a…

This study tested whether giving patients special immune cells (T cells) that target CMV or adenovirus could control these infections after a stem cell transplant. Sixteen children and adults received one or two doses of these cells. The goal was to reduce virus levels in the blo…

This study tested a new rapid bedside device (qLabs®FIB) that measures a key blood clotting protein called fibrinogen in women with severe bleeding after childbirth. The goal was to see if the quick test gives results as accurate as the standard lab test, which takes longer. 70 w…

This study tested a new blood test to diagnose Down syndrome (trisomy 21) in pregnant women without the risks of invasive procedures like amniocentesis. Researchers collected blood samples from 150 pregnant women at high risk and analyzed fetal cells. The goal is to provide a saf…

This study tested a new rapid test (InSPIRe kit) that uses a simple vaginal swab to detect bacteria and infection markers in pregnant women. The goal is to quickly identify women who might pass harmful bacteria to their babies during birth, so doctors can prevent newborn infectio…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study looked at whether newborns who fail their hearing screening can be diagnosed with congenital CMV infection and have a full hearing test before they turn one month old. Researchers tested 235 babies to see how quickly they could get results. The goal is to improve early…

This study tested a new imaging technique called Full Field Optical Coherence Tomography (FFOCT) to see if it can detect prostate cancer in biopsy samples as well as standard microscope analysis. Researchers compared FFOCT results to the usual pathology exam in 91 men with elevat…

This study tested whether a special MRI technique called ASL-MRI can measure blood flow in the brains of children with autism. The goal was to see if this could be used as a non-invasive diagnostic tool, similar to PET scans but without radiation. Researchers studied 115 children…

This study tested whether a blood test measuring the sFlt-1/PlGF ratio can help doctors decide the best care for pregnant people with suspected preeclampsia before 35 weeks. 84 participants were randomly assigned to have their care guided by the test or usual care. The goal was t…

This study tested whether saliva samples can detect the COVID-19 virus as well as the standard nose swab test. Over 5,000 people provided both nose swabs and saliva samples, which were compared using different detection methods. The goal was to see if a simpler, less invasive spi…

This study compared two imaging methods—ultra-low-dose CT and lung MRI—for assessing lung damage in adults with cystic fibrosis. Researchers wanted to see if MRI could provide similar information to standard CT but without radiation. The study involved 185 participants and used t…

This study looked at whether the Montreal Cognitive Assessment (MoCA), a short test, can accurately screen for thinking and memory problems in adults with sickle cell disease. Researchers compared MoCA results to a full set of standard cognitive tests in 65 adults. The goal is to…

This study looked at CT scans from over 10,000 people to see if they can help diagnose COVID-19 more accurately. Researchers compared CT results with standard PCR tests and also used AI to predict which patients might need a ventilator. The goal is to make diagnosis faster and he…

This study tested a new blood test that looks at fetal DNA in the mother's blood to detect Down syndrome (trisomy 21) as early as the first trimester. Researchers enrolled 976 pregnant women at high risk and compared the blood test results to standard invasive methods. The goal w…

This study tested whether a CT scan can accurately diagnose inhaled foreign bodies in children aged 6 months to 16 years, potentially avoiding the need for a more invasive endoscopy. Researchers compared CT scan results with endoscopy findings in 311 children suspected of having …

This study looked at 339 emergency room patients with suspected pneumonia to see if a chest CT scan could improve diagnosis. The goal was to find out if the CT scan changed the doctor's initial diagnosis, and if it led to changes in antibiotic treatment or hospital admission deci…

This study looked at whether a standard glucose tolerance test (drinking a sugary solution) can reliably diagnose acromegaly, a condition caused by too much growth hormone. Researchers tested 109 people, some with acromegaly and some without, giving them two glucose tests and one…

This study tested three new methods to diagnose bloodstream infections from central venous catheters in critically ill children, without removing the catheter. Researchers compared these methods to standard techniques in 148 children. The goal was to see if these tests could accu…

This study looked at whether a simple blood test measuring tiny molecules called microRNAs can spot rejection in heart transplant patients. Researchers tested 461 patients and compared the blood test results with standard heart biopsies. If the blood test works well, it could off…

This study tested whether using an MRI to guide prostate biopsies could detect cancer as well as the standard 12-sample systematic biopsy. Researchers enrolled 108 men aged 45-75 with elevated PSA levels and suspicious MRI findings. They compared the cancer detection rates of 3 t…

This study explored whether prostate cancer cells can be detected in blood samples instead of using a needle biopsy. Researchers collected blood from 127 men with suspected prostate cancer and used a special filter to isolate tumor cells. The goal was to see if this non-invasive …

This study tested whether a noninvasive device called FibroScan can accurately measure liver scarring (fibrosis) in children, potentially replacing the need for a liver biopsy. Researchers compared FibroScan results with biopsy results in 264 children aged 6 months to 18 years wi…

This study tested a new DNA test called the MycoGenie kit to see how well it can diagnose invasive aspergillosis, a serious fungal infection, in 350 blood cancer patients. The test looks for the fungus's DNA in blood samples and can also detect drug resistance. The goal is to fin…

This study tested a new, non-invasive tool that measures skin conductance to detect small nerve fiber damage in children undergoing chemotherapy. Nerve damage is a common and serious side effect of cancer treatment, but current tests are often painful or not suitable for children…

This study tested whether special ultrasound scans can detect kidney damage in people who have received a kidney transplant. 141 transplant recipients had ultrasound imaging at 15 days, 3 months, and 12 months after surgery. The goal was to see if these scans could measure kidney…

This study tested whether a fast diagnostic test (FilmArray) plus expert antibiotic advice improves care for patients who develop pneumonia in the hospital. 116 adults with hospital-acquired pneumonia were randomly assigned to get either standard care with expert advice or the sa…

This study compared a simple blood test (noninvasive prenatal testing, or NIPT) with the standard invasive procedure (amniocentesis or chorionic villus sampling) for detecting Down syndrome in over 2,100 pregnant women at high risk. The goal was to see if NIPT could reduce miscar…

This study looked at whether a panel of blood biomarkers can quickly identify stroke patients who have a large vessel occlusion (a major blockage) and would benefit from a specialized clot-removal procedure. Researchers enrolled nearly 3,900 adults with stroke symptoms and tested…

This study looked at whether measuring certain proteins in the blood (amyloid peptides) can help diagnose Alzheimer's disease or predict its progression. Over 1,000 older adults with mild cognitive impairment or Alzheimer's were followed for two years. Researchers compared blood …

This study tested whether lung ultrasound can accurately confirm that a breathing tube is in the right place in children. 79 intubated children received both an ultrasound and a chest X-ray. The goal was to see if ultrasound could replace X-ray, avoiding radiation exposure. Resul…

This study tested a new MRI technique that can take pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 had both a standard CT scan and this new MRI. The goal was to see if the MRI could produce clear images of the lungs, potentia…

This study tested whether functional MRI can detect differences in oxygen flow in the placenta and fetus between healthy pregnancies and those with intrauterine growth restriction (IUGR). Pregnant women breathed pure oxygen while MRI scans measured the BOLD effect, a signal chang…

This study looked at whether adding a CT venography scan (imaging of the pelvis and legs) to the standard chest CT can find more blood clots in women who recently gave birth and are suspected of having a pulmonary embolism. 125 women participated. The goal was to see if the combi…

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

This study tested the H1N1 flu vaccine in 439 people with cystic fibrosis to see if it prevents the flu and is safe. Participants included adults, children, pregnant women, and lung transplant recipients. Researchers measured immune response and tracked flu symptoms, using antivi…

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

This study tested whether hydroxychloroquine or azithromycin could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. 122 participants took one of the drugs or a placebo for 40 days. The study found no significant difference in infection rates…

This study looked at whether testing people for COVID-19 just before a large indoor concert could keep the event from causing new infections. Over 6,600 healthy adults aged 18-45 either attended the concert after a negative test or stayed home. The goal was to see if the concert …

This study looked at whether giving antibiotics early to trauma patients on breathing machines can prevent ventilator-associated pneumonia. Researchers analyzed data from 2,143 adults admitted to intensive care after severe trauma. The goal was to see if early antibiotics reduce …

This study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in elderly patients after leg fracture surgery. Delirium affects up to 40% of older adults after major surgery and can lead to longer hospital stays and loss of independ…

This pilot study tests whether playing a recording of a mother's voice and heartbeat can improve well-being in preterm newborns during their hospital stay. The study uses a special device called Calinange that records and plays back these sounds at a safe volume. Researchers will…

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study looked at whether multi-family therapy (therapy with several families together) can help teenagers who refuse to go to school because of anxiety. 74 teens aged 12-18 who had been out of school for at least 2 weeks took part. The researchers measured anxiety and school …

This study tests a therapy called Interaction Guidance Therapy (IGT) for mothers with post-traumatic stress disorder (PTSD) after a traumatic pregnancy or childbirth. The therapy uses video feedback to help mothers become more sensitive to their baby's cues. Researchers will comp…

This study tested whether a personalized home respiratory rehabilitation program is feasible for people with systemic sclerosis (scleroderma) who have early lung disease. Fifteen participants completed a 3-month program with one supervised session followed by home exercises. The …

This study tested whether applying a Xylocaine (numbing) compress before a trigger finger injection reduces pain during the procedure. 60 adults with trigger finger took part in a double-blind trial where neither they nor the doctor knew who got the numbing compress. The main goa…

This study tested a non-invasive brain stimulation technique called TMS in 20 young adults with autism. The goal was to see if stimulating a specific brain area could improve how they look at faces and interact socially. Participants received 10 daily sessions, and researchers me…

This study tested whether inhaling tranexamic acid or terlipressin can quickly stop mild to severe coughing up blood (hemoptysis) without needing invasive procedures. 315 adults were randomly assigned to receive one of the two drugs or a placebo via nebulizer for 3 days. The goal…

This study tested whether breathing high-flow oxygen for 15 minutes can stop dystonic or plegic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. 24 participants used oxygen or a placebo (med…

This study looked at whether a therapeutic education program can improve quality of life for children aged 8 to 12 with IgE-mediated food allergies, as well as their families. 46 children and their families took part. The program focused on teaching them how to manage allergies a…

This study tested whether a low dose of interleukin-2 (IL-2), a protein that helps regulate the immune system, could improve depressive symptoms in people with bipolar disorder. Fourteen participants already on mood stabilizers received the treatment. The goal was to see if it in…

This study tested whether warming the IV fluids given during a scheduled C-section helps prevent hypothermia (low body temperature) and shivering afterward. Seventy-five healthy women having planned C-sections under spinal anesthesia were randomly assigned to receive either warme…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested whether using a near-infrared light to see veins under the skin helps nurses draw blood or start an IV on the first try in children with hard-to-see veins. It included 163 newborns and children up to age 18 in hospitals. The goal was to see if the light reduces …

This study tested whether having a therapy dog present during dental visits could reduce anxiety and improve cooperation in autistic children aged 6 to 17. Fifty children received two sessions with a dog and one without. The goal was to see if the dog's presence made later visits…

This study tested whether a technique called ischemic preconditioning, which is used to protect organs during transplants, could reduce fat tissue damage after breast reconstruction surgery. 18 women who had breast reconstruction using their own belly fat were included. The appro…

This study tested whether a personalized rehabilitation program could improve quality of life for people with systemic sclerosis, a disease that causes skin and joint stiffness. 220 adults with the condition were randomly assigned to either the rehab program or usual care. The pr…

This study tested whether a 6-week personalized day-hospital program could improve quality of life for 80 people with persistent long COVID symptoms like fatigue, shortness of breath, and brain fog. The program included group education, tailored exercise, and cognitive behavioral…

This study tested whether sitting cross-legged (like on the floor) helps place an epidural catheter more successfully on the first try compared to the usual sitting position on the edge of the bed. Researchers studied 457 women in labor at one hospital in France. The goal is to s…

This study tested a web-based program called Diapason for family caregivers of people with Alzheimer's disease. The program provides information, relaxation techniques, and a forum to connect with other caregivers. Researchers measured stress levels in 49 caregivers over 6 months…

This study tested whether hypnosis can lower pain and anxiety during an ultrasound-guided liver biopsy. 70 adults were randomly assigned to receive either hypnosis or standard care during the procedure. Researchers measured pain and anxiety levels to see if hypnosis made the expe…

This study tested whether resveratrol, a natural substance found in grapes and red wine, can reduce pain in people with knee osteoarthritis. 142 adults with painful knee arthritis took either resveratrol or a placebo pill daily for three months. The main goal was to measure chang…

This study tested whether cannabidiol (CBD) can reduce severe itching in 10 children with a rare genetic skin condition called epidermolysis bullosa. The children took CBD syrup three times a day for a month. Researchers measured itch, pain, sleep, and quality of life before and …

This study tested whether adding a drug called droperidol to two standard anti-nausea medicines (ondansetron and dexamethasone) could better prevent vomiting after surgery in children at high risk. A total of 322 children aged 3 to 18 years took part. The main goal was to see if …

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study tested whether a safe, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) could reduce fatigue in people with multiple sclerosis (MS). Ten adults with MS-related fatigue used a home-based tDCS device. The goal was to see if i…

This study tested whether a 7-day course of prednisone, started in the emergency department, can lower inflammation (measured by C-reactive protein) in patients with acute heart failure. Only 3 people took part, and the main goal was to see how CRP levels changed. The researchers…

This study tested a device called ANI that measures pain during surgery in children having scoliosis correction. The goal was to see if using this monitor to guide pain medicine during surgery would lower the amount of morphine needed in the first 24 hours after surgery. The stud…

This study tested a short program of education and rehabilitation for people with subacute or chronic low back pain who are not severely disabled. The goal was to see if the program reduces activity limitations and changes risk factors. 100 participants took part in the program a…

This study tested whether using heat or cold packs during childbirth can lessen perineal pain after delivery. 115 women having their first vaginal birth took part. Researchers measured pain levels and healing. The goal was to find a simple, drug-free way to improve comfort after …

This study tested whether sophrology, a relaxation method, could help people with cystic fibrosis who have chronic pain. Thirteen patients received sophrology sessions at home in addition to their usual care. The goal was to see if this approach could reduce pain intensity and th…

This study tested whether 14 months of specialized medical care and monitoring of electromagnetic exposures could help people who report severe sensitivity to electromagnetic fields. Seventy-nine participants wore a dosimeter for a week and tracked their symptoms. The goal was to…

This study tested whether mangafodipir, an MRI contrast agent with antioxidant properties, could reduce nerve damage caused by oxaliplatin chemotherapy. Researchers enrolled 23 cancer patients who already had moderate nerve problems from oxaliplatin but needed to continue treatme…

This study tested a special ureteral stent with a magnetic end in 67 children with urinary tract problems or kidney transplants. The goal was to see if the stent could be removed without general anesthesia, using a magnetic catheter instead. The approach aims to make the removal …

This study tested whether a jaw-widening surgery (surgically assisted maxillary expansion) could improve quality of life in 9 adults with obstructive sleep apnea. Participants completed sleep questionnaires before surgery and again 3 months and 1 year after. The goal was to see i…

This study looked at 304 children aged 2 to 17 with broken arm or leg bones who came to the emergency room in severe pain. Researchers wanted to see if giving paracetamol (Tylenol) or ibuprofen (Advil) along with morphine worked better than morphine alone. They measured pain leve…

This small pilot study tested whether therapeutic gardening (horticulture) could reduce pain-related brain activity in 16 adults with chronic low back pain. Participants tried both gardening and handiwork sessions, and researchers used MRI scans to measure changes in a brain regi…

This study tested a virtual reality device to see if it could reduce pain in adults with chronic low back pain that didn't respond to medication. 122 participants used the VR system, which creates a 3D environment with changing colors. The main goal was to measure pain levels aft…

This study tested whether a numbing cream (ropivacaine) can reduce severe pain during bath and dressing changes in children and young adults with epidermolysis bullosa, a rare genetic skin condition. Ten participants applied the cream before dressing changes and reported their pa…

This study tested whether listening to music through headphones during cataract surgery could reduce anxiety and prevent high blood pressure. Over 300 patients took part, with some listening to music and others wearing silent headphones. The goal was to see if a simple, non-drug …

This study tested whether adding a sedative (midazolam) to standard morphine painkiller helps children with arm fractures feel less pain. Sixty children aged 5 to 16 were split into two groups: one got morphine plus midazolam, the other got morphine plus a placebo. Researchers me…

This pilot study tested whether lithium can improve social communication in children with autism spectrum disorder who also have a SHANK3 gene mutation (Phelan-McDermid syndrome). 22 children took either lithium or a placebo for 12 weeks. Researchers measured changes in social re…

This study tested whether giving a steroid (cortancyl) along with an antihistamine (levocetirizine) is better than the antihistamine alone for treating sudden hives in the emergency department. 137 adults with acute urticaria (with or without mild angioedema) were enrolled. The m…

This study tested a device that gently stimulates a nerve in the ear to reduce pain and inflammation in people with a severe form of hand osteoarthritis. 148 participants used either the active device or a sham (fake) device daily for 12 weeks. The goal was to see if the real dev…

This study tested whether a low dose of IL-2 (a protein that helps regulate the immune system) could reduce nasal symptoms in people with birch pollen allergy. Twenty-four adults with a history of seasonal allergies received either the drug or a placebo over several months. The g…

This study tested whether repetitive transcranial magnetic stimulation (rTMS) can reduce certain core symptoms of schizophrenia, called first rank symptoms. Thirty-one patients received either real rTMS or a sham (fake) treatment over 10 sessions in 5 days. The goal was to see if…

This study tested whether a 20-minute virtual reality session with hypnosis suggestions could reduce pain and anxiety in children with sickle cell disease during a painful crisis. Twelve children aged 6 and older used a VR headset while listening to calming narratives designed fo…

This study looked at whether injecting botulinum toxin A (like Botox) into a groin muscle could ease chronic pain in athletes with athletic pubalgia, a stubborn sports injury. Twenty athletes who had not gotten better with other treatments received one injection. Researchers trac…

This study tested whether wearing a weighted brace on the unaffected ankle for three months helps people who have had a stroke walk farther. Forty-two participants who had a stroke more than three months ago but less than five years ago took part. Half wore a weighted brace (2-4 …

This study tested whether a self-hypnosis smartphone app called Hypnotidoo could improve attention and reduce anxiety in children aged 7 to 12 with ADHD who were already taking methylphenidate. The app offers short, screenless audio sessions with stories and breathing exercises. …

This study tested whether a steroid injection directly into the spinal disc could reduce pain in people with chronic lower back pain and disc inflammation (Modic I). 137 participants received either the steroid or a placebo. The steroid helped lower pain at 1 month, but the effec…

This study tested a psycho-educational program designed to help family caregivers whose parents live in nursing homes. The program included group training and support to address feelings of anxiety, guilt, and loneliness. Researchers measured changes in anxiety and depression sco…

This study looked at whether telling patients they don't need to fast before cataract surgery could lower their anxiety. 126 adults having their first cataract surgery under topical anesthesia were surveyed. The goal was to see if a non-fasting recommendation could make the exper…

This study looked at whether art and movement workshops could help 8 children with unexplained chronic pain who had been bullied at school. The workshops combined dance-like movement and creating a street-art mural. Researchers measured self-esteem and pain before and after the p…

This study tested whether a social robot called PARO could help prevent pain during nursing care for elderly people with moderate to severe dementia. Ten participants living in nursing homes were given sessions with the PARO robot during care. The goal was to see if the robot cou…

This pilot study tested whether a short, 1.5-day program of education and exercise is feasible for people with subacute or chronic low back pain who haven't improved with first-line treatments. 23 working adults participated, and the study measured how acceptable they found the p…

This study looked at whether taking oral corticosteroids (prednisone) for 5 days can help people with COPD who are having a flare-up. The trial involved 189 adults aged 40 and older who were treated in general practice. Researchers tracked treatment failure, including emergency v…

This study looked at 55 adults with severe frozen shoulder (pain and stiffness for at least 3 months) who had not improved with standard treatments. They received one to three injections of steroid and numbing medicine into the shoulder joint, followed by intensive physiotherapy.…

This study tested whether having a mother lie on her side in a specific position (asymmetrical lateral decubitus) during labor could help turn a baby that is facing the wrong way (occipitoposterior position). 326 women were randomly assigned to either this position or usual care.…

This study looked at whether placing a cervical dilator (a small rod that expands) before medication can shorten labor during a second-trimester termination of pregnancy. Researchers compared 355 women who either got the dilator plus standard medication or medication alone. The m…

This study looked at whether 6 weeks of osteopathic treatment (gentle hands-on manipulation) could reduce pain in people with fibromyalgia. 101 adults with long-term fibromyalgia took part, comparing real osteopathy sessions to fake ones. The main goal was to track pain levels we…

This study tested whether a standardized osteopathic manipulation treatment works better than a placebo (light touch) for people with sub-acute or chronic non-specific low back pain. 400 adults aged 18-65 received 6 sessions over 12 weeks. The main goal was to see if the real tre…

This study tested whether a single ultrasound-guided injection of Botox into the thumb joint, combined with a splint, can reduce pain in people with base-of-thumb osteoarthritis. Sixty adults with moderate to severe pain received either Botox or a saline placebo injection. The ma…

This study tested whether a 2-week program of group education sessions and exercises before total knee replacement helps people recover function more quickly after surgery. 262 adults with knee osteoarthritis took part. The program included 4 education sessions and 4 exercise ses…

This study follows thousands of pregnant women in France who had or likely had COVID-19 during pregnancy or shortly after giving birth. Researchers track health problems in both mothers and newborns up to 12 weeks after delivery, using medical records and questionnaires about men…

This study looks at how the epilepsy drug levetiracetam is processed in pregnant women and how much reaches the baby. Researchers will collect blood and saliva samples throughout pregnancy and at delivery, plus cord blood and amniotic fluid. The goal is to create a model that cou…

This study looked at 45 people with patellofemoral pain syndrome (pain around the kneecap) to see if different types of the condition have unique movement problems. Participants had X-rays and walking tests to measure how their knees move. The goal was to better understand the co…

This study tests whether a device called Mostcare can predict if children need more fluids after surgery. Researchers will compare its readings with ultrasound measurements in 100 children aged 0-10 who are on breathing machines. The goal is to see if the device can help doctors …

This study explores whether analyzing the chemicals in exhaled breath can detect early changes in children with cystic fibrosis who start taking a medication called Kaftrio. Researchers will collect breath samples from 50 children under 12 before and after they begin treatment, l…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study tested whether infections might be linked to increased nuchal translucency, a marker seen on early pregnancy ultrasounds. Researchers used advanced genetic sequencing to look for viruses, bacteria, or parasites in placental tissue from 78 pregnant women. The goal was t…

This study measured the activity of an enzyme called glucocerebrosidase in 236 people with and without Lewy body dementia. The goal was to see if lower enzyme activity could help identify patients who might benefit from treatments already used for Gaucher disease. The study did n…

This completed study reviewed medical records of 203 adults hospitalized with Haemophilus influenzae pneumonia across 13 hospitals. Researchers aimed to find factors linked to early relapse (within 90 days) and severe outcomes like intensive care or death. By analyzing patient da…

This completed study involved 105 adults with PICC lines to see how well they understood and followed a therapeutic education program. The program used webinars and questionnaires to teach patients how to care for their lines and reduce risks. The goal was to help patients take a…

This pilot study looked at whether measuring arm speed in 3D can help track recovery in people with shoulder pain (subacromial pain syndrome). Thirteen adults had their shoulder movement measured before and after a standard 4-session rehab program. The goal was to see if these sp…

This completed study looked at scalp ringworm, a common fungal infection in children, across 11 French centers in 2023. Researchers collected 701 fungal samples to identify the species and test their sensitivity to common antifungal drugs. The goal was to understand which fungi c…

This study tested an artificial intelligence system that helps doctors decide when to give fluids during high-risk abdominal surgery. The goal was to see if using this smart system could reduce serious complications like kidney injury, infections, or heart problems within 30 days…

This study looked at 98 women who had a blood patch to treat severe headaches caused by an accidental spinal fluid leak during labor. Researchers wanted to see if certain factors during the blood patch procedure were linked to headaches that last 1 to 6 months. The goal is to bet…

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This completed study examined 127 melanoma patients to understand how the IL4I1 enzyme influences disease progression and resistance to treatments like immunotherapy and targeted therapy. Researchers analyzed blood and tumor tissue samples before and after treatment. The goal was…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study tested whether ultrasound measurements of the heart and blood vessels can predict which mechanically ventilated children will benefit from extra fluids. Only about half of children with shock respond to fluids, and too much fluid can be harmful. The researchers used a …

This study looked at 60 teens ages 12 to 18 to see if those with Avoidant and Restrictive Food Intake Disorder (ARFID) had more feeding problems before age 4 compared to healthy teens. Researchers used questionnaires to check early feeding history, growth, and sensory sensitiviti…

This study tested whether giving oxygen through a nasal tube (high-flow nasal oxygen) is better than a facemask for keeping oxygen levels up in children under 11 during anesthesia. 44 children having surgery took part. The goal was to see if the nasal method prevents oxygen drops…

This completed study collected blood and urine samples from 240 people with ciliopathies—rare genetic disorders that often lead to kidney failure. Researchers analyzed these samples to find biological markers that could predict how the disease will progress. The goal is to develo…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study looked at children aged 0-18 who had mild, delayed allergic reactions to beta-lactam antibiotics (like amoxicillin). Researchers compared short (1-4 days) and long (5-8 days) oral drug challenge tests to see if longer testing increased the growth of antibiotic-resistan…

This completed study looked at 54 children with severe asthma to better understand the different biological features (endotypes) of the disease. Researchers collected blood, saliva, and nasal samples, along with lung samples from bronchoscopies, to analyze immune cells, metabolis…

This study looked at whether specialized training for nurses on how to care for children with a rare, severe skin condition called epidermolysis bullosa (EB) can reduce their stress and anxiety. The study involved 19 nurses and nursing assistants at a hospital in France. Research…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This completed study tested whether phenelzine, a drug used for depression, could change how immune cells behave in people with COVID-19. Researchers took blood samples from 51 patients and exposed the cells to phenelzine in the lab. The goal was to see if the drug could reduce o…

This study looked at whether giving healthy volunteers a small amount of their own stored blood (200 ml) causes detectable changes in blood cells and particles. Researchers analyzed blood samples before and after transfusion to find markers that could reveal this type of doping i…

This study tested a smartphone app called Predigraft that helps kidney transplant patients and their doctors monitor the health of the new kidney from home. The app predicts how long the kidney might last and lets patients send in test results and vital signs. The goal was to see…

This study looked at how blood clots in people with liver cirrhosis, a condition that can cause bleeding problems. Researchers used a special machine called T-TAS to measure clotting in blood samples from 60 patients. They also tested whether tiny particles that act like platelet…

This completed study looked at levels of a specific antibody (IgG4) to cow's milk and egg in 135 children, both with and without allergies. Researchers wanted to see if these levels could help tell which children have outgrown their allergy. The study involved a single blood draw…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This study looked at why girls with Rett syndrome often develop weak bones (osteoporosis) at a very young age. Researchers checked bone density, looked at medical history, and measured certain proteins in the blood. The goal was to find risk factors and understand the biological …

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids. The goal was to see how often women later had a baby and what pregnancy complications occurred. The researchers reviewed medical records from one hospital in France to gat…

This completed study looked at why some pregnant women in France choose not to join randomized clinical trials about pregnancy and childbirth. Researchers surveyed 526 women to find out what factors — like age, education, or how the study was explained — might influence their dec…

This study looked at how families are told their child has craniosynostosis, a condition where skull bones fuse too early. Researchers interviewed and surveyed 574 parents and children to understand the emotional impact and improve the diagnosis process. The goal is to make the a…

This completed study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers collected blood samples and performed metabolic tests to identify genetic defects. The goal was to better understand these genetic forms of diabetes and possibl…

This study looked at 145 people who had an allergic or non-allergic reaction during surgery. Researchers wanted to find out which signs, like skin changes or heart rate, could tell the difference between a true allergy and a non-allergic reaction. The goal is to help doctors trea…

This study looked at 20 children with a rare lung condition called pulmonary alveolar proteinosis (PAP) caused by changes in the MARS gene. Researchers wanted to understand if the lung cleaning cells (macrophages) are not working properly. They grew these cells in a lab from bloo…

This study looked at how the cells lining blood vessels (endothelial cells) might be involved in stroke-like episodes in people with Congenital Disorders of Glycosylation (CDG). Researchers took blood samples from 6 CDG patients and grew their endothelial cells in the lab to test…

This study looked at how often blood clots form soon after placing a central venous catheter (a special IV line) in children in the pediatric intensive care unit. Researchers used ultrasound to scan for clots 1 to 13 days after placement. The goal was to better understand the tim…

This study looked at whether a non-invasive breathing test called the lung clearance index (LCI) can detect early lung disease in young children with cystic fibrosis. Researchers tested 53 children aged 3 to 6 years and compared the results with CT scans and other lung function t…

This study tested whether a special thermal camera could automatically detect breathing distress in patients on breathing machines. The camera measures heart rate, breathing rate, and facial expressions to spot signs of suffocation without needing a nurse to watch constantly. The…

This study looked back at 224 patients with tubulointerstitial nephritis (TIN), a common cause of kidney failure. Researchers reviewed kidney biopsies to better understand the causes, treatments, and long-term outcomes of the disease. The goal is to improve how doctors diagnose a…

This study tested whether 3D ultrasound can accurately measure kidney and tumor volumes compared to standard CT or MRI scans. 53 adults with chronic kidney disease or kidney tumors participated. Researchers compared 3D ultrasound measurements to those from contrast-enhanced CT or…

This completed study examined blood samples from 65 children aged 0 to 18 who were taking common HIV medications. The goal was to create computer models that show how these drugs behave in children, helping doctors adjust doses for each child's age, weight, and other factors. The…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study looked at 47 people with a rare condition called idiopathic CD4 lymphocytopenia, where the body has too few CD4 immune cells. Researchers collected blood samples and genetic data to understand what causes the condition and how it affects patients. The goal was to impro…

This study looked at whether the measles vaccine virus can be found in the breast milk of new mothers who received the MMR vaccine shortly after giving birth. Fourteen breastfeeding women with no immunity to measles or rubella provided milk samples over two weeks. The goal was to…

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This study looked at the emotional and psychological experiences of 12 children aged 10 to 16 who were born without one ear (ear aplasia) and chose to have reconstructive surgery. Researchers used interviews and tests to understand how the children think and feel, and how surgery…

This study followed 72 children who were diagnosed before birth with a missing or abnormal corpus callosum, the bundle of nerves connecting the brain's two halves. Researchers tested their thinking, movement, and behavior at age 3 to understand how they develop. The goal was to g…

This study looked at how the drug letermovir passes from a pregnant woman to her fetus during the second trimester. Seven women who were already scheduled to end their pregnancy for other reasons took part. The goal was to measure drug levels in fetal blood and amniotic fluid to …

This study looked at what factors make intensive care and pediatric nurses feel more or less overloaded at work. Researchers surveyed 484 nurses using a standard workload scale that measures mental demands, physical effort, time pressure, and frustration. The goal is to identify …

This completed study looked at 57 people with CURRARINO syndrome, a rare condition that can include a tumor near the tailbone. Researchers used yearly MRI scans and blood tests to track tumor growth and understand genetic links. The goal was to find out who is most at risk and wh…

This study followed 80 people with newly diagnosed Cushing's disease for three years to see how the disease affects the heart, bones, metabolism, and quality of life. Researchers used blood tests, heart scans, bone density tests, and questionnaires to track complications before a…

This study tested a simple bedside test—a 15-second pause in breathing—to see if it could predict whether infants in shock would benefit from more fluids. Ten infants under 2 years old on ventilators in intensive care were included. Researchers measured heart function before, dur…

This study looked at whether using frozen embryos instead of fresh ones in IVF leads to more live births. 237 women took part, and researchers compared pregnancy rates and baby health. The goal was to see if freezing embryos helps the womb lining work better.

This completed study followed 530 working-age adults (18–70) who were hospitalized for COVID-19. Researchers measured disability using WHO checklists at 12 and 36 months after hospitalization. The goal was to understand how severe COVID-19 affects people's ability to function and…

This study looked at how doctors, nurses, and physiotherapists in community health teams were affected by the COVID-19 pandemic. Researchers interviewed 62 healthcare workers about their work and personal challenges. The goal was to understand their experiences and identify what …

This study looked at immune cells from 138 people with Wegener's granulomatosis, a rare disease causing inflammation of blood vessels. Researchers measured levels of a protein called DAP12 in different immune cells to understand how the disease works. No new treatment was tested;…

This completed study looked at 289 children to understand what factors increase the risk of serious complications from pharyngitis (sore throat), such as abscesses or severe neck infections. Researchers compared children hospitalized for these complications with those who had pha…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This study looked at how the lungs move chloride, sodium, and bicarbonate in 42 patients with idiopathic bronchiectasis (widened airways of unknown cause). Researchers measured electrical signals in the airway lining during bronchoscopy and took nasal and bronchial samples. The g…

This completed study looked at 41 children with intestinal epithelial dysplasia (also called tufting enteropathy), a rare gut condition. Researchers collected blood and skin samples to find the genes and mutations responsible for the disease. The goal was to better understand the…

This study followed 179 children aged 4 to 16 who were born from twin pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). Researchers checked their heart function, blood pressure, kidney health, and blood sugar control to see if the condition during pregnancy cau…

This study looked at how physical therapy and rehabilitation departments function by interviewing 63 people, including doctors, nurses, and patients. The goal was to find ways to improve communication and patient care. No new treatments or drugs were tested—just gathering ideas t…

This study checks if men who had a treated urethritis infection still have signs of long-term inflammation and cell damage in their genital tract. Researchers measured a protein called elastase and markers of oxidative stress in semen 6 and 12 months after treatment. They compare…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This study tested whether having a clinical pharmacist review medications for cancer patients before they start treatment could prevent drug-related problems. Researchers observed 440 adults with solid tumors who were about to receive chemotherapy, immunotherapy, or oral targeted…

This study examined how people with mild or no COVID-19 symptoms respond to the virus. Researchers measured immune markers in the blood of 57 adults who tested positive. The goal was to understand why some people clear the virus quickly while others develop severe illness.

This completed study looked at how fourth-year medical students learn to build better relationships with patients. Over 400 students took part in training that included lectures, role play, simulated consultations, and Balint group discussions. Researchers interviewed students an…

This study tested whether a special MRI technique can measure lung stiffness in people with scleroderma, a disease that often causes lung scarring. Researchers enrolled 24 adults and compared MRI results to standard lung function tests. The goal was to see if MRI could offer a sa…

This study examined 33 preterm babies born before 30 weeks to mothers with preeclampsia. Researchers measured certain proteins in the mother's blood, umbilical cord blood, and amniotic fluid to see if they were linked to a lung condition called bronchopulmonary dysplasia (BPD). T…

This study looked at whether showing patients a short video, along with the usual oral and written information, helps them better understand upcoming medical exams for infectious diseases. 97 adults hospitalized in a French hospital took part. Researchers measured how well patien…

This study collected blood samples from 236 pregnant women with and without preeclampsia. The goal was to test a new approach that filters out a protein called sFlt-1 from the blood, which may help restore normal blood vessel function. The research is a first step toward a possib…

This study aimed to create a standard set of items, called an ICF core set, to describe the health and functioning of people with systemic sclerosis (scleroderma). Researchers gathered input from 100 patients and experts to identify the most important aspects of the disease. The …

This study looked at over 2,100 people with listeriosis, a serious foodborne infection that can cause blood infections, brain infections, and pregnancy complications. Researchers collected data to find out which clinical, biological, and genetic factors make someone more likely t…

This completed study looked at 60 babies who had heart surgery for a condition called transposition of the great vessels before 6 months of age. Researchers used a special questionnaire to check for sensory integration disorders one week after surgery, and again at one month and …

This study looked at 166 people with unexplained bleeding to find out how many have problems with tiny granules inside their platelets. These granules help blood clot. The researchers measured granule number, content, and release, and checked if these defects were linked to bleed…

This study looked at whether functional MRI (fMRI) can help doctors diagnose Auditory Processing Disorder (APD) in children aged 7 to 18. APD makes it hard for kids to understand sounds even though their ears work normally. Researchers compared brain scans of children with APD, c…

This completed study looked at how common depression and anxiety are in teenagers with cystic fibrosis and their parents. Researchers used questionnaires during routine clinic visits to screen for symptoms. The goal was to better understand mental health needs in this group.

This study looked at 423 adults on breathing machines in intensive care units (ICUs). Half were physically restrained only if severely agitated, while the other half were restrained routinely. Researchers measured how many days patients were free of delirium (confusion) over the …

This study followed 100 patients who had infectious endocarditis, a serious heart infection, to see how brain lesions found on MRI scans change over time. Researchers compared initial MRI results with follow-up scans and tested thinking and memory skills. The goal was to understa…

This completed study looked for genetic causes of Chiari type I malformation, a condition where part of the brain pushes into the spinal canal. Researchers took blood samples from 40 people with the condition and their relatives to analyze their DNA. The goal was to find specific…

This study followed 60 heart transplant patients for one year to see if levels of a harmless virus called TTV in the blood are linked to infections or organ rejection. Researchers took monthly blood samples alongside routine care. The goal is to find a new way to monitor transpla…

This study looked at how the pressure used in mechanical ventilators affects the right side of the heart in people with acute respiratory distress syndrome (ARDS). Researchers measured lung pressure and heart function in 50 adults and children. The goal was to find out if high lu…

This study aimed to create new mathematical models to better predict which patients with severe liver disease are at highest risk of dying while waiting for a liver transplant. Researchers analyzed data from 501 adults on the French national transplant waiting list. The goal is t…

This study tested whether a French translation of the SN-5 questionnaire, which measures quality of life in children with chronic rhinosinusitis, works as well as the original English version. Researchers asked 89 children (ages 2–12) and their parents to fill out the questionnai…

This study looked at how patients with advanced cancer respond to being offered a conversation about their future care preferences. Researchers invited 71 patients to discuss their wishes and tracked who took part. The goal was to learn more about what helps patients feel ready t…

This study looked at the types of fungi living on the head and neck skin of 30 adults with eczema (atopic dermatitis) compared to healthy volunteers. The goal was to understand if differences in the fungal community are linked to eczema in these areas. Researchers used advanced l…

This study tested French versions of three hearing and quality-of-life questionnaires (PEACH, SSQ-C, SSQ-P) in 101 children and teens aged 1 to 17. The goal was to see if these tools are reliable and accurate for measuring hearing performance and quality of life in French-speakin…

This study tested whether teaching emergency department staff about when IVs are truly needed could cut down on unnecessary placements. Over 500 patients took part, and researchers compared IV use before and after the training. The goal was to reduce complications, save time, and…

This completed study measured levels of two substances (IGF-I and IGFBP-3) in the blood of 693 older adults: some with Alzheimer's disease, some with mild cognitive impairment, and some with normal memory. The goal was to see if these levels differ between groups and relate to th…

This study looked at how much taxi drivers are exposed to tiny air pollution particles (ultrafine particles and black carbon) inside their cabs during a workday. Researchers measured the air in the taxi and tested drivers' breathing before and after their shift. The goal was to s…

This study looked at 29 newborns to see if exposure to a class of HIV drugs called anti-integrases (like raltegravir) in the womb affects their immune system at birth. Researchers compared these babies to those exposed to other HIV medications. The goal was to check the diversity…

This study followed 708 adults with early inflammatory back pain for up to 5 years. Researchers collected data to better understand how the disease progresses, what predicts joint damage, and how to improve diagnosis. The goal was to gather knowledge, not to test a new treatment.

This study used MRI scans to measure blood flow in the placenta of 135 women undergoing pregnancy termination for fetal reasons between 16 and 32 weeks. The goal was to create a set of normal reference ranges for placental perfusion, which could help doctors identify when the pla…

This study looks back at 84 cases of sacrococcygeal teratoma, a rare tumor in fetuses and infants. Researchers want to find factors that predict how the tumor will behave, whether it will come back, and what long-term effects it may have. The goal is to give parents clearer infor…

This study looked at pregnant women at high risk for placenta accreta, a serious condition where the placenta grows too deeply into the womb. Researchers wanted to find out which factors, such as how the condition is diagnosed and managed, affect the mother's health. Over 600 wom…

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study looked at why children with hereditary epidermolysis bullosa (a rare condition causing fragile skin and painful blisters) often do not take prescribed opioid painkillers before baths and bandage changes. Researchers interviewed 10 children and their parents to understa…

This study looked at 99 women with primary immune deficiency to learn more about their pregnancies and birth outcomes. Researchers tracked infections during pregnancy and after birth, as well as how well contraception worked. The goal is to help doctors give better advice to wome…

This completed study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers took blood samples from 57 children to measure drug levels and understand how the body processes it. The goal was to find the best dose for…

This study followed 40 children who needed ECMO (a heart-lung machine) to understand brain complications and their development one year later. Researchers used brain scans and developmental tests to identify risk factors. The goal is to improve care and outcomes for critically il…

This study measured normal nasalance scores in 131 French-speaking children aged 8 to 10 using a non-invasive device called a Nasometer. The goal is to create reference values that help doctors diagnose velopharyngeal dysfunction, a common issue in children with cleft palate, wit…

This study looked at 20 infants with severe bronchiolitis (a serious lung infection) to compare two types of breathing support: CPAP and NiPPV. The goal was to see which method reduces the effort of breathing more effectively. Researchers measured breathing effort using a special…

This study looked at whether a test using cells from the nose can predict if the drug Orkambi® will improve lung function in people with cystic fibrosis. Researchers collected nasal cells from 91 participants before they started Orkambi® and measured how well the drug fixed the c…

This completed study looked at 830 two-year-olds in France to see if drinking toddler milk formula helps prevent iron deficiency, a common problem that can affect brain development. Researchers checked iron levels in blood and asked parents about diet and background. The goal is …

This study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…

This completed study looked at 55 adults with acute respiratory failure to understand how their breathing, diaphragm, and lung ventilation relate to the need for a breathing tube. Researchers used ultrasound and electrical imaging to measure diaphragm movement and lung function. …

This study looked at whether heart rate variability and pupil reflexes can objectively measure anxiety before surgery. Researchers monitored 71 day-case surgery patients using a finger sensor and a portable pupilometer before, during, and after a small needle insertion. The goal …

This study looked at 127 pregnant women who received a steroid called betamethasone to help prevent lung problems in their premature babies. Researchers measured how much of the drug reached the baby and whether it reduced the risk or severity of hyaline membrane disease, a serio…

This study looked at how the antifungal medicine caspofungin is processed in the bodies of adults with serious burns. The goal was to find the best dose, since burns can change how drugs work. Only 2 people took part, so the results are very limited.

This study tested whether a special training program for 4th-year medical students could help them maintain or improve their empathy and emotional intelligence. Over 400 students took part in lectures, group discussions, role-plays, and exams with actors. Researchers measured cha…

This study looked at how often children with a rare adrenal gland problem (congenital adrenal insufficiency) experience dangerously low blood sugar. Even with standard treatment, these children may have low blood sugar without obvious symptoms. Researchers monitored 9 children ag…

This completed study involved 15 people with severe haemophilia B who were already taking eftrenonacog-alfa, a clotting factor medicine. Researchers compared different lab tests to see which ones best measure factor IX activity in real-life conditions. The goal was to improve mon…

This study looked for gene changes that might make children more prone to severe tooth decay. Researchers compared 390 young people with many cavities to cavity-free adults. They checked for mutations in genes that affect enamel, the hard outer layer of teeth. The goal is to unde…

This study tested whether an online decision support tool helps young women (18-40) with breast cancer make more informed choices about preserving their fertility before starting cancer treatment. 186 participants either received standard oral information alone or used the online…

This study looked at specific immune cells in the esophagus of children with eosinophilic esophagitis (EoE) compared to healthy children. Researchers counted these cells and also studied the microbiome. The goal was to better understand the disease, not to test a treatment. 35 ch…

This study looked at whether two common pain relievers, ibuprofen and ketoprofen, enter breastmilk in significant amounts. Researchers measured drug levels in milk from 35 breastfeeding women who had been taking one of these medicines for more than 24 hours. The goal was to help …

This study tested whether calling patients a few days before surgery with a checklist could lower the number of last-minute cancellations. Over 4,000 adults and children scheduled for day surgery took part. The goal was to see if this simple step helps hospitals run more smoothly…

This study looked at immune cells (T cells, NK cells, and macrophages) inside melanoma tumors from 217 patients. The goal was to understand how these cells affect the body's ability to fight the cancer and how chemotherapy might change them. It was an observational study, not a t…

This study looked at 70 patients who had a stem cell transplant for blood cancer. Researchers measured levels of complement proteins in the blood to see if they are linked to graft-versus-host disease, a common and serious side effect. The goal is to better understand how inflamm…

This study examined blood clotting in 57 people with Congenital Disorder of Glycosylation (CDG), a rare genetic condition. Researchers used a special test called the thrombin generation assay to see if the body's clotting system stays balanced despite having low levels of both cl…

This study tested a personalized way to reduce steroid doses in 72 lupus patients. Doctors used blood tests and regular check-ups over 3 months to safely lower prednisone. The goal was to find the best tapering schedule for each person, minimizing side effects while controlling t…

This study looked at 400 couples to understand how diet, lifestyle habits like smoking and exercise, and genetics influence fertility. Researchers compared fertile and infertile couples to find nutritional factors that may help or hinder conception. No treatment was given; the go…

This completed study looked at over 2,500 people with Parkinson's disease who were admitted to the hospital through the emergency room. Researchers wanted to find the main reasons for these hospital stays and compare them to people of the same age without Parkinson's. The goal wa…

This study follows up on 52 children, now aged 7 to 13, who were born very prematurely and received either hydrocortisone or a placebo in the PREMILOC trial. Researchers are measuring their blood pressure, pulse wave velocity, and other heart-related markers to see if the steroid…

This study looked at 45 pregnant women having planned C-sections to see if a simple finger sensor (measuring perfusion index) could predict dangerous drops in blood pressure after spinal anesthesia. The goal was to find an easy, non-invasive way to identify high-risk patients so …

This study reviewed 575 adults admitted to intensive care for a severe kidney infection called acute obstructive pyelonephritis. Researchers aimed to identify factors that lead to poor outcomes such as death or lasting kidney damage. The goal is to better understand which patient…

This completed study collected information from nearly 1,000 children who had both cancer and developmental abnormalities like birth defects or growth issues. The goal was to find new genetic syndromes that make children more likely to develop cancer. Researchers analyzed blood a…

This study examined anxiety, depression, fatigue, and quality of life in 20 adults with Behçet's disease using questionnaires. Researchers aimed to understand the psychological symptoms that often accompany this rare inflammatory condition. The study was observational and did not…

This completed study looked at 574 hospitalized adults with end-stage liver disease to see if alcoholic patients had the same chance of getting on the national liver transplant waiting list as non-alcoholic patients. The goal was to find out if non-medical reasons limit access fo…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This study tested a simple method to see if giving extra fluids would help patients on breathing machines who are in shock. Doctors used a short increase in breathing machine pressure (PEEP test) to predict fluid needs. The goal was to avoid unnecessary fluids. The study involved…

This study checked how common smell and taste problems are in 51 people with cardiac amyloidosis, a rare disease where abnormal proteins build up in the heart. Researchers used a simple smell test called Sniffin' Sticks to measure these senses. The goal was to see if these issues…

This completed study used donated placentas from 369 pregnant women to understand how the HIV drug tenofovir moves from mother to baby. Researchers used a special lab model that mimics the third trimester of pregnancy. The goal was to see if certain proteins or drug interactions …

This completed study looked at 150 children with severe to profound hearing loss to find how many have a specific genetic form called DFNB9. Researchers collected medical and genetic data from routine care. The goal was to better understand this condition and pave the way for fut…

This study looked at cells from the membranes that surround a baby during pregnancy, often called the 'water bag.' The goal was to find molecules these cells release that might signal the start of labor too early. Researchers collected tissues and blood from 24 women with healthy…

This study used a special MRI technique called diffusion tensor imaging to look at the spinal cord in 40 people with cervical spondylosis (neck arthritis). The goal was to see if spinal cord structure relates to symptoms like muscle weakness or numbness. Participants underwent im…

This study tested a new method called continuous anterior chest compression (CACC) to help people with severe lung injury (ARDS) breathe better. Twenty adults on ventilators were studied to see if pressing on the chest improved lung function compared to lying on the stomach. The …

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study analyzed data from 168 patients with a rare type of digestive neuroendocrine tumor (well-differentiated grade 3). Researchers compared survival and response rates in patients who received platinum-based chemotherapy versus those who received non-platinum chemotherapy. …

This study looked at how closely 227 adults with precapillary pulmonary hypertension follow their prescribed diuretic (water pill) regimen. Researchers used questionnaires and pharmacy records to measure adherence and identify reasons for missed doses. The goal is to understand n…

This study tested a more accurate method to measure kidney function in 90 critically ill ICU patients whose kidneys were working overtime. The standard creatinine clearance test can be misleading in these patients, so researchers compared it with the iohexol plasma clearance tech…

This study measured how often iron builds up in the heart muscle of people who receive many blood transfusions. Researchers used MRI scans to check heart iron levels in 110 patients with thalassemia, sickle cell disease, or myelodysplasia. The goal was to understand how common th…

This study looked at whether certain gene variations (ABCB1) make it harder for the brain to clear a protein called amyloid beta, which is linked to Alzheimer's disease. Researchers compared 510 people with and without Alzheimer's to see if these gene changes are more common in t…

This study followed 912 men and women over 60 in France who were hospitalized for severe osteoporotic fractures. Researchers tracked how many had another severe fracture within 2 and 5 years, and how many died during that time. The goal was to better understand the long-term risk…

This completed study tested a new 3D MRI technique to map cranial nerves in 7 children aged 1 to 5 with head and neck tumors or birth defects. The goal was to create detailed models that help surgeons avoid damaging important nerves during operations. The research focused on deve…

This study looked at how two different COVID-19 booster vaccines affect immune cells in the lymph nodes. Researchers used a needle to take samples from the lymph nodes of 12 adults who had already received at least three doses of an mRNA COVID-19 vaccine. The goal was to understa…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study looked at how attention and daydreaming influence obsessive thoughts in people with Obsessive Compulsive Disorder (OCD). Researchers compared 80 participants—some with OCD and some without—to see if obsessions change depending on how much the mind wanders. The goal was…

This study looks at whether low vitamin D levels in early pregnancy are linked to breathing problems in children ages 5 to 6. Researchers measured airway resistance in 142 children whose mothers had vitamin D levels checked during the first trimester. The goal is to understand if…

This study looked at the DNA of Staphylococcus epidermidis bacteria from 320 patients to find genetic markers that separate harmless strains from those that cause serious infections. The goal is to help doctors decide when antibiotics are truly needed. No new treatment was tested…

This study observed 5000 cataract surgery patients to see if using a special handpiece (Active Sentry) makes the procedure safer. The handpiece helps control pressure inside the eye during surgery, which may reduce the amount of energy needed and lower the risk of complications. …

This study looked at whether measuring pancreatic polypeptide levels after a meal can help doctors tell the difference between type 1 diabetes and type 3c diabetes (caused by pancreas damage). Thirty-six adults with either type 1 or type 3c diabetes gave blood and stool samples. …

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at whether changing how prescriptions are written (like using words instead of numbers) helps people over 75 make fewer errors when organizing their daily pills. 64 hospitalized older adults with mild or no memory problems were asked to fill pillboxes using diff…

This study looked back at medical records of 980 children who had surgery to fix a hole in their eardrum. The goal was to see how often the eardrum healed closed and how well hearing improved after the operation. Researchers checked results 9 to 18 months after surgery.

This study looked at nearly 6,000 ICU patients with severe kidney injury to see if a scoring tool called UNDERSCORE can predict when dialysis can be safely stopped. The goal was to avoid restarting dialysis or early death within 7 days. Researchers used existing hospital data to …

This study tested over 1,000 children and their parents for COVID-19 antibodies to find out how many had been infected. Researchers also checked for active virus in nose, saliva, and stool samples. The goal was to better understand infection rates and immune responses in families…

This study measured how often teenagers develop chronic kidney disease after having heart surgery as young children. Researchers collected blood and urine samples from 120 teens aged 10 to 15 during their regular heart check-ups. The goal was to find out how common kidney damage …

This study looked at whether a simple urine test could predict scarring in kidney transplants, instead of using a needle biopsy. Researchers measured certain genetic markers in urine cells from 300 kidney transplant recipients over the first year after transplant. The goal was to…

This study tested a new parent questionnaire called ORALQUEST to assess feeding and eating disorders in children aged 9 months to 6 years. Researchers included 338 children with chronic conditions like heart defects or autism, as well as those with picky eating. The goal was to s…

This study followed 512 children born to parents with type 1 diabetes to see if early immune system changes and other factors could predict who might develop the disease. Researchers looked at blood markers, gut bacteria, and family environment. The goal was to better understand …

This study aimed to find substances in vaginal fluid that could help doctors predict which pregnant women will go into labor early. Researchers studied 238 women, including those with signs of preterm labor and healthy pregnant women. The goal was to develop a simple test to impr…

This completed study surveyed 257 adults with sickle cell disease to understand how they use painkillers at home, including opioids and cannabis. Researchers wanted to find out how common opioid addiction is in this group. Patients answered a one-time questionnaire at three speci…

This study observed 120 children with asthma, aged 3 to 11, using smart inhalers to track how and when they used emergency medication at home. Parents also answered questions via a mobile app about symptoms and treatment effectiveness. The goal was to gather real-world data to cr…

This study looked at 119 children who had platinum-based chemotherapy for certain cancers. Researchers wanted to find out if certain genes make some kids more likely to develop hearing loss from the treatment. By analyzing DNA from saliva samples, they hope to identify high-risk …

This study looked at 225 adults with a rare, inherited form of kidney disease to find the genetic causes. Participants had chronic kidney failure and often had a family history of gout. Researchers tested for known gene mutations and searched for new ones in families without a cl…

This study looked at how cystinosis affects muscles, breathing, and swallowing in 20 teenagers and adults. Researchers measured motor function, strength, and walking ability over time. The goal was to better understand the disease's impact on the body, not to test a new treatment…

This study examined different programs aimed at improving how antibiotics are prescribed in French hospitals. Researchers looked at 27 hospitals to map existing strategies, measure how well doctors follow advice, and compare costs versus effectiveness. The goal is to find the mos…

This study looked at 57 people who had a stem cell transplant for blood cancer. Researchers wanted to see if certain immune cells (iNKT cells) could help predict the risk of graft-versus-host disease (GVHD), a serious side effect. They measured these cells in the blood and the tr…

This study looks at whether a simple 6-minute walk test can help predict how long cystic fibrosis patients will survive without needing a lung transplant. Researchers followed 291 adults with advanced cystic fibrosis, measuring how far they walked and their oxygen levels. The goa…

This study looked at why people with Lowe syndrome, a rare genetic disorder, may have unusual bleeding. Researchers took blood samples from 30 patients to test how well their platelets work. The goal was to confirm and understand any platelet problems that could cause bleeding ev…

This completed study looked at 126 children with juvenile idiopathic arthritis to find the best dose of the drug etanercept. Researchers measured drug levels in the blood and checked how well the disease was controlled. The goal is to help doctors give each child the right amount…

This study looked at whether a special type of scan (PET/CT) can help doctors see if treatment for a serious fungal lung infection is working earlier than usual. It involved 51 adults with blood cancer and invasive pulmonary aspergillosis. The goal was to see if the scan results …

This study looked at whether offering counselling to family members right after a loved one's sudden death helps their mental health. Over 600 relatives were offered support by the emergency medical team. Researchers then checked for signs of depression, anxiety, and post-traumat…

This study followed 150 people with a confirmed genetic form of nephronophthisis, a rare kidney disease, to see how it progresses over the long term. Researchers tracked both kidney function and damage to other organs. The goal was to better understand the disease's natural histo…

This study looked at whether immune cell responses can serve as a simpler way to measure how many insulin-producing beta cells remain in people with type 1 diabetes. Researchers followed 156 participants over 30 months, using meal tests and blood/urine samples. The goal was to fi…

This study looked at the DNA of 73 children with a rare birth defect called isolated congenital diaphragmatic hernia (CDH), where a hole in the diaphragm allows organs to move into the chest. Researchers wanted to find new genetic changes that might cause the condition. They used…

This study followed 133 people with PPNAD (a rare adrenal gland disorder) or Carney Complex (a related genetic condition) for three years. The goal was to better understand the symptoms and genetic causes of these diseases, not to test a new treatment. Participants had yearly che…

This study used powerful MRI scans to track how a rare genetic disease called metachromatic leukodystrophy (MLD) damages the brain's white matter in young children. Researchers studied 29 children aged 1 to 6 years with MLD, along with a control group, to better understand how th…

This completed study examined whether healthy skin near a melanoma tumor contains hidden cancer stem cells that might predict the disease's return. Researchers analyzed tissue from 226 people with early-stage melanoma to see if these cells are linked to 5-year survival. The goal …

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study looked at nearly 9,000 women giving birth to twins to figure out which delivery method is safest for both babies. Researchers tracked serious health problems in the second twin after birth. The goal is to help doctors choose the best way to deliver twins and reduce ris…

This study tested a new self-administered questionnaire called DYSLIM to measure shortness of breath and its impact on daily life in people with chronic respiratory diseases like COPD, cystic fibrosis, and pulmonary hypertension. Researchers enrolled 199 participants to check if …

This study looked at whether giving a small, fast fluid injection (mini-bolus) can help predict if a child with septic shock will benefit from more fluids. It included 11 children on breathing machines in intensive care. The goal was to find a simple way to guide fluid treatment …

This study looked at how many children of hospital workers had antibodies against the virus that causes COVID-19. Researchers tested blood and saliva samples from 563 family members to see if a parent's infection status affected the child's risk. The goal was to better understand…

This study reviewed medical records of 70 children under 18 who received clot-busting drugs or mechanical clot removal for a stroke. Researchers measured how quickly treatment was given and looked for side effects like bleeding. The goal is to better understand the safety and tim…

This study tested how well the flu vaccine works and if it's safe for people with inflammatory bowel disease (IBD). Researchers compared 228 adults with IBD who were either taking immunosuppressive drugs or not. The goal was to see if the vaccine triggers a strong immune response…

This study looked at 60 patients who were resuscitated after a cardiac arrest but remained unconscious. Researchers took blood samples at the hospital and on days 1 and 3 to analyze the activity of all genes (the transcriptome). The goal was to see if these gene patterns could pr…

This study looked at 146 children taking common steroids (prednisone, prednisolone, methylprednisolone, hydrocortisone) to understand why their bodies process these drugs so differently. By analyzing blood samples and genetic factors, researchers hope to find clues that could lea…

This study interviewed 25 health professionals who treat teens and young adults with long-lasting muscle or bone pain that is not caused by cancer. The goal was to learn how these experts figure out what is causing the pain, since there is no standard test. The results will help …

This study created a registry to collect medical information from 868 people with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to gather data on these conditions, not to test a new treatment. Participants were adults diagnosed with APS …

This study looked at the gut bacteria and bile acids of 80 people — half with coronary artery disease and half healthy. Researchers wanted to see if differences in these gut factors might be linked to heart disease. The goal is to better understand how the gut influences heart he…

This study looked at how often kidney hypodysplasia (a condition where one or both kidneys are small and underdeveloped) runs in families. Researchers collected DNA from 342 children aged 3 months to 18 years to try to find genes that may cause the condition. The goal was to bett…

This study compared four non-invasive methods—FibroTest, Fibroscan, ShearWave Elastography, and Magnetic Resonance Elastography—to measure liver fibrosis in 56 children with cystic fibrosis aged 6-18. The goal was to see which test best detects early liver damage, helping doctors…

This study aimed to find risk factors for osteoporosis in people with cystic fibrosis. Researchers took blood samples to study monocytes, which can turn into osteoclasts—cells that break down bone. They also tested how CFTR modulators affect these bone cells. The study included 2…

This study looked at how well patients and their doctors understood each other after an emergency room visit. Researchers compared the answers from patients and doctors on a questionnaire to see if they agreed. Over 1,800 adults from 14 hospitals took part. The goal was to find g…

This study tested whether giving parents a simple information leaflet about fever before their child's emergency room visit improves their knowledge of how to handle a fever. 220 parents of children aged 3 months to 15 years with a fever took part. The leaflet was based on offici…

This study looked at whether explaining the risks of chemotherapy more honestly to patients with incurable lung cancer could reduce the number who receive chemo in their last month of life. Researchers randomly assigned 123 patients to either standard information or a more detail…

This study tested whether it is possible to run diabetes education workshops for inmates at Paris' La Santé prison. 22 men with type 1 or type 2 diabetes took part in group classes covering diet, foot care, and medication. The main goal was simply to see if prisoners would attend…

This study looked at protein patterns in tumor samples from 44 children with a rare cancer called rhabdoid tumor. Researchers used advanced techniques to see how tumors differ from each other. The goal was to find new targets for future treatments. The study is complete and did n…

This study looked at over 8,800 infants under 2 years old who came to the emergency room with a minor head injury. Researchers wanted to see if a special checklist (the PELICAN rule) could help doctors decide when a CT scan is truly needed. The goal is to avoid unnecessary radiat…

This study looked at how the steroid medication prednisone is processed by the body and what side effects it causes. Researchers followed 114 adults taking prednisone for at least 3 months. They measured drug levels in the blood and tracked side effects like bone loss and infecti…

This completed study looked at 204 adults with hemophagocytic syndrome, a rare immune condition. Researchers aimed to identify biological markers and refine diagnosis criteria, which are currently based on children's genetics. The goal is to better understand the disease's causes…

This study talked to 27 children (ages 6 and up) who have a parent with cystic fibrosis. Through interviews and small group discussions led by a psychologist, researchers aimed to understand their feelings, worries, and needs. The goal is to use this information to create better …

This study tested whether sending three text message reminders to adults over 50 who had a low-trauma fracture would encourage them to get a bone density test. The goal was to improve screening for osteoporosis, a condition that weakens bones. Researchers enrolled 97 patients fro…

This completed study looked at 753 children with epilepsy to better understand how their bodies process antiepileptic drugs. Researchers measured drug levels in the blood and considered factors like age, weight, and other medications. The goal is to create models that help doctor…

This study followed 436 pregnant women whose babies were found to have a lung malformation on ultrasound. The goal was to identify signs during pregnancy that could predict whether the baby would have breathing difficulties right after birth. By better understanding these rare co…

This study looked at the experiences of family members who care for someone with systemic sclerosis (scleroderma), a rare and serious disease. Researchers surveyed 50 caregivers to understand their physical, mental, and social challenges. The goal is to use this information to cr…

This study looked at 175 premature babies to see if high iron levels in their blood during the first month of life are linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured iron-related markers and tracked which babies developed ROP. The …

This study looked at whether the seasonal flu vaccine works as well in people with sarcoidosis as it does in healthy people. Researchers gave the flu shot to 190 adults with sarcoidosis and compared their immune response to a group of healthy volunteers. The goal was to see if th…

This study looks at why some adults with cystic fibrosis are more physically active than others, focusing on factors outside the lungs like nutrition, diabetes, bone health, and mood. Eighty stable adults will wear an activity monitor for a week and complete questionnaires. The g…

This study tested a technique called ischemic preconditioning (IPC) in 81 adults having major liver surgery. Before the main operation, surgeons briefly stopped blood flow to the liver to see if it would reduce liver injury. The goal was to lower liver enzyme levels after surgery…

This study looked at 206 very premature babies (born before 32 weeks) to see how early nutrition affects their brain development. Researchers measured the amount of mother's milk, breastfeeding duration, and intake of healthy fats and iron during hospital stays. The goal was to f…

This completed French study looked at over 3,000 women whose labor was started artificially (induced). Researchers compared different methods like breaking the water, using hormones, or a balloon catheter. They tracked how often each method was used, how it affected the mother an…

This study looks at how the quality of life changes over time for young women with MRKH syndrome, a condition where the uterus and upper vagina are underdeveloped. Researchers followed 25 women who took part in an earlier study, asking them to fill out questionnaires about their …

This study looked at whether low vitamin D levels in the first trimester of pregnancy are linked to developing preeclampsia later on. Researchers measured vitamin D in over 3,000 pregnant women in France. The goal was to understand how common vitamin D deficiency is and if it rel…

This study examined 170 men from couples struggling with infertility to see if metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and abnormal cholesterol—is linked to poor sperm quality. Researchers measured sperm count and other sperm feature…

This study looked at what cystic fibrosis (CF) patients and their spouses think and feel about becoming parents. Researchers held small group discussions and one-on-one interviews led by a psychologist to gather their views. The goal was to identify common themes and needs, so be…

This study looked at tumor samples from 15 children with rhabdoid tumors to understand why some parts of the tumor resist treatment. By analyzing individual cells, researchers aimed to identify different cell types within each tumor and find potential new targets for therapy. The…

This study followed 19 teens and young adults with cystic fibrosis to see how starting the drug ORKAMBI changed their anxiety, depression, quality of life, and how well they stuck to their treatments. Researchers compared those taking ORKAMBI to a similar group not on the drug. T…

This study involved 39 adults and children with autoinflammatory diseases like FMF and Still's disease. Researchers conducted interviews to understand how these conditions affect quality of life. The goal was to create a tool that doctors can use to better assess and address pati…

This completed study looked at how levels of C-reactive protein (CRP), a marker of inflammation, change in 35 patients having emergency angioplasty for a heart attack. Researchers took blood samples before the procedure and at several time points up to 30 days after. The goal was…

This study involved 160 elite French athletes from athletics, rugby 7, and bobsleigh. Researchers measured how each athlete runs and the properties of their muscles to create personalized training programs. The goal was to reduce lower-limb muscle injuries while maintaining top s…

This pilot study looked at how hemodialysis changes the electrical properties of skin and muscle in 18 adults on chronic dialysis. Researchers measured these changes to better understand fluid shifts during treatment. The goal was to gather knowledge, not to test a new treatment.

This study looked at two important eye measurements—angle kappa and angle alpha—in 70 healthy adults. Researchers used eye exams and imaging to see how these angles relate to each other. The goal is to help eye doctors better plan surgeries like cataract or laser correction.

This study looked at 25 people with FOXP1 syndrome, a rare genetic condition, to better understand their psychiatric symptoms. Researchers used interviews and questionnaires with families to assess hyperactivity, attention, anxiety, autism traits, and more. The goal is to improve…

This completed study reviewed medical records of 152 infants with solid tumors in the chest, belly, or pelvis that were found before or shortly after birth. Researchers wanted to see how well prenatal imaging (like ultrasound or MRI) matched the final diagnosis after birth. The g…

This study tested whether a questionnaire called the Rheumatoid Arthritis Impact of Disease (RAID) could help doctors make better decisions during virtual consultations. 70 patients with rheumatoid arthritis participated. The goal was to see if using this tool reduced the need fo…

This study tested a new evaluation plan for parents learning to manage their child's home parenteral nutrition. Eleven parents completed questionnaires after the education program to see if the evaluation was useful. The goal is to improve the training program for future families…

This completed study looked at why some pregnant women chose not to take part in a larger trial on early screening for pre-eclampsia, a serious pregnancy condition. Researchers surveyed 472 women to find factors linked to refusal and to understand their reasons for saying yes or …

This study looked at 422 pregnant women who had a fever during labor to better understand if the fever was caused by an infection or other factors like medication or labor itself. Researchers collected detailed information on infections in mothers and newborns. The goal was to im…

This completed study looked at whether smoking or using nicotine products changes the risk of catching COVID-19. Researchers surveyed over 600 healthcare workers who had been tested for the virus. The goal was to see if there is a connection between tobacco or nicotine use and te…

This study looked at how the COVID-19 pandemic and related measures like lockdowns and mask-wearing affected severe Group A Strep infections in children in Paris. Researchers reviewed medical records of 269 children under 18 admitted to a Paris hospital between 2018 and 2023. The…

This study followed 14 people who called a crisis hotline after terror attacks in Paris, London, Barcelona, and Strasbourg. Researchers asked them to rate how their symptoms changed over time. The goal was to understand what kind of help they needed.

This study looked back at 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and a possible COVID-19 infection. The goal was to describe their symptoms, lab results, and heart function, and to figure out whether the virus directly damages the he…

This observational study followed 6 children with scoliosis who had spinal surgery with pelvic fixation. The goal was to see how their walking changed 6 months after surgery. Researchers measured walking quality, a walking test, and a questionnaire about daily activities.

This study looked at 72 adults with high blood pressure to see if the concentration of their urine is linked to stiffness in their arteries. Researchers measured urine concentration, blood pressure, and arterial stiffness during a one-day hospital visit. The goal was to better un…

This completed study measured normal tryptase levels in 402 children aged 0-18 to help doctors better diagnose mast cell disorders like mastocytosis and MCAS. Researchers used leftover blood from routine tests in children undergoing surgery. Knowing these normal ranges could redu…

This study tested whether M-mode ultrasound can accurately show where an epidural catheter is placed in women during labor. Researchers enrolled 100 women and used ultrasound to look for a specific sign when pain medicine was injected. The goal is to reduce the 27-32% failure rat…

This study tested whether daily washes with a medicated wipe (2% chlorhexidine) reduce skin bacteria more than regular mild soap in children staying in intensive care. Researchers took skin samples from 34 children before and after washing to measure germ levels. The goal was to …

This study looked at how trouble regulating body temperature affects sleep in people with hypohidrotic ectodermal dysplasia (HED), a condition that limits sweating. Researchers compared sleep quality, skin temperature, and melatonin levels in 22 HED patients and healthy volunteer…

This study reviewed medical records of 50 children on breathing machines to see if inhaled sedatives (halogenated gases) could reduce the need for other sedative drugs. The goal was to see if these gases help lower doses of medications like midazolam and morphine. The study is co…

This study tested a social robot named ARI in a day hospital for elderly patients. The robot welcomed people, reminded them about hygiene, and helped them prepare for medical visits. Researchers asked 115 participants—patients, family caregivers, and nurses—how acceptable and eas…

This study looked at whether patients getting ready for surgery can effectively preoxygenate themselves by holding the oxygen mask. 110 adults scheduled for surgery under general anesthesia took part. The main goal was to see how many could reach a high oxygen level within 3 minu…

This study looks at whether a listeria infection around the time of birth can lead to long-term thinking or behavior problems in children. Researchers will compare 53 children who had the infection with a control group using standard tests. The goal is to understand the role of t…

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…

This study looked at how certain immune cells, called neutrophils, behave in people with granulomatosis with polyangiitis (GPA), a rare blood vessel inflammation disease. Researchers collected blood samples from 93 participants, including patients with GPA and other related condi…

This completed study involved 307 children with asthma, their parents, and doctors. Participants ranked goals for asthma treatment, like preventing attacks or making medication easier to take. The aim was to gather preferences to guide future algorithm-based management tools.

This study looked at whether a breathing device called CPAP can reduce the effort of breathing and improve heart function in children with heart failure. Thirty children aged 8 months to 17 years were monitored during short periods of CPAP and normal breathing. The goal was to un…

This completed study looked at how endometriosis might affect egg quality in 16 women undergoing fertility treatment. Researchers analyzed the fluid around the eggs and cells from the egg's support cells to find any unique patterns. The goal was to see if these patterns could pre…

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…

This study looked at 46 obese men aged 18 to 50 who were scheduled for weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy). Researchers measured changes in sperm quality and other fertility-related factors before and after surgery. The goal was to understand if l…

This study followed 35 men with spinal cord injuries over 18 months to see how their sperm quality changes and what factors might cause problems. Researchers measured sperm health, inflammation, and infections from ejaculates collected every 6 months. The goal is to find ways to …

This study tested a French version of a questionnaire that measures dizziness symptoms in children aged 7 to 17. Researchers asked 85 kids with and without balance issues to fill out the survey twice, two weeks apart. The goal was to see if the translated questionnaire is reliabl…

This study looked at two ways of giving fluids during major liver surgery: a restrictive approach that limits fluids, and an individualized approach guided by a computer system. The goal was to see which method leads to less blood loss, fewer complications, and better recovery. 9…

This study used ultrasound to measure how the spine stiffens over time in children with neuromuscular scoliosis who had a new type of fusionless surgery. The researchers followed 36 participants, including those who had the surgery, those with the condition but no surgery, and he…

This study measured the hearing quality of life of 130 children aged 2 to 10 with hearing aids or cochlear implants. Parents filled out a questionnaire called PEACH to rate how well their child hears in quiet and noisy everyday situations. The goal was to understand how different…

This study looked at 90 adults with Marfan syndrome to compare spinal symptoms and daily limitations between those who have dural ectasia (a widening of the spinal sac) and those who do not. Researchers used questionnaires to measure pain, activity limits, and quality of life. Th…

This study looked at 76 healthy adults to understand how eye dominance (which eye your brain prefers), the angle lambda (a measure of eye alignment), and fixation disparity (how the eyes focus together) are related. Researchers used simple eye exams and photographs to measure the…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a machine called ECMO (which pumps and oxygenates blood). Researchers measured how well the heart was pumping at 28 days and 90 days after the arrest. The goal was to understand if…

This study looked at how teenagers with anorexia nervosa feel about taking antidepressants. Researchers interviewed 15 adolescents aged 12 to 25 who had been prescribed an SSRI antidepressant. The goal was to understand their personal experiences, including both positive and nega…

This completed study looked at 100 people who reported a suspected chemical submission (being secretly given drugs). Researchers performed detailed toxicology tests on blood and urine samples to find out which substances were present. The goal was to confirm how many cases involv…

This pilot study tested whether a combination of two drugs (G-CSF and plerixafor) could safely collect enough stem cells from the blood of children with Fanconi anemia for future gene therapy. Only 4 patients took part, and the main goal was to see if the cell collection process …

This study examined 22 deaf infants under 10 months old to find factors linked to early signs of neurodevelopmental disorders like autism. Researchers filmed psychiatric consultations and used a special scoring system to assess the babies' interaction and movement skills. By comp…

This study looked at whether waiting exactly three minutes after giving the muscle relaxant atracurium leads to better conditions for placing a breathing tube in obese women having gynecological surgery. One hundred adult female patients took part. Researchers rated intubation ba…

This study looked at 50 adults having thyroid or parathyroid surgery to see how quickly the muscle relaxant rocuronium wears off. Doctors need the drug to be gone so they can monitor a nerve that controls the voice box during surgery. The goal was to find the best timing for givi…

This study looked at whether an exercise test can be used to monitor patients with a rare hereditary disease that causes severe muscle breakdown (rhabdomyolysis). Researchers measured heart function and oxygen use during exercise in 27 patients. The goal was to find a reliable wa…

This study looked back at medical records of 91 children who had a malignant bone tumor removed from their leg and then had the bone rebuilt using one of three techniques: induced membrane, vascularized fibula, or vascularized fibula plus a bone graft. The goal was to compare how…

This study followed 50 children who received cochlear implants, measuring their brain's electrical responses to sounds and comparing them with speech and language test results over three years. The goal was to see if certain brain wave patterns could predict how well a child deve…

This study looked at how common migraines are in infertile women and how they change during IVF treatment. Researchers gave 137 women a simple questionnaire to track headaches and medical history. The goal was to understand if the hormone changes from IVF can trigger or worsen mi…

This study interviewed 28 patients with rare diseases at Necker Hospital in Paris to learn how their oral health affects their quality of life. Participants, aged 6 and older, talked with a doctor for 30 to 60 minutes about their experiences and access to dental care. The goal is…

This study looked at how brain blood flow and oxygen levels change when doctors treat critically ill children for shock or very low blood pressure. Researchers used a special light-based device (NIRS) and ultrasound to monitor 27 children in the intensive care unit. The goal was …

This study looks at how certain immune cells, called antigen-presenting cells, behave in people with sepsis—a life-threatening response to infection. Researchers collected blood samples from 119 participants, including sepsis patients, other ICU patients, and healthy volunteers. …

This study looks at how growth hormone treatment affects the quality of life of children with short stature once they reach their final adult height. Researchers are giving questionnaires to 36 young people who were treated with growth hormone and comparing their answers to ones …

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…

This study looked at whether epidural or spinal anesthesia during childbirth leads to more infections in women with primary immunodeficiencies (weak immune systems). Researchers tracked 30 women from a national registry for 28 days after delivery to see if they developed serious …

This completed study followed 85 COVID-19 survivors who needed a breathing machine in the ICU. Researchers tracked their physical, thinking, and emotional recovery from the hospital until they returned home. They compared walking patterns to healthy people to understand the chall…

This completed study looked at how the pigment layer of the eye works in 30 people with neurofibromatosis type 1. Researchers used special eye tests to measure electrical signals from the pigment layer and compared them to images of the back of the eye. The goal was to confirm ea…

This completed study analyzed data from 249 adults with blood cancers like lymphoma and leukemia who received immunotherapy. The goal was to find markers—such as patient history or lab results—that could predict who will respond well and who might have severe side effects. By ide…

This study looked at 21 children, teens, and young adults who had surgery for Moyamoya disease, a rare brain vessel condition. Researchers used questionnaires to measure anxiety, depression, attachment, and quality of life in patients and their parents. The goal was to understand…

This study looked back at 72 children treated for Wilms tumor (a kidney cancer) that had spread into the vena cava, the large vein carrying blood to the heart. Researchers reviewed medical records from 1999 to 2019 to understand how surgery was managed and what complications occu…

This study tested whether a passive leg raising test, done before spinal anesthesia, can predict low blood pressure in women having planned C-sections. Researchers measured heart function with ultrasound before and after raising the legs. They then tracked blood pressure drops an…

This study looked at whether teenagers with restrictive eating disorders, like anorexia or ARFID, have different sensory processing compared to healthy teens. Researchers used questionnaires to measure sensory sensitivity and also screened for autism and anxiety. The goal was to …

This study looked at blood neutrophils (a type of immune cell) in 47 adults with cystic fibrosis. Researchers compared these cells between patients and healthy donors, and also examined how chronic infection, CFTR modulator drugs, and lung flare-ups affect neutrophil behavior. Th…

This study looked at the quality of supportive and palliative care for infants under one year old with spinal muscular atrophy (SMA) type 1, a severe genetic muscle disease. Researchers followed 39 infants and asked families to keep a diary about care. One year after the child's …

This study gave 20 men with enlarged prostates a single dose of the antibiotic ertapenem before their scheduled prostate surgery. Researchers then measured how much of the drug actually reached the prostate tissue. The goal was to see if a pre-surgery dose could provide enough an…

This study looked at whether a simple stool test could help predict serious gut inflammation in premature babies. Researchers collected stool samples from 122 preterm infants born at 33 weeks or less, testing for a protein called calprotectin. The goal was to see if this test, co…

This study looked at whether a special type of PET scan can help doctors diagnose and treat a rare fungal infection of the liver and spleen in people with blood cancer or those who had a stem cell transplant. The infection often appears after severe neutropenia (low white blood c…

This study looked for genetic causes of a rare lung condition called congenital cystic adenomatoid malformation (CCAM). Researchers analyzed blood and tissue samples from 45 children under 8 who had surgery for this condition. The goal was to find abnormal genes or proteins that …

This completed study used a non-invasive brain stimulation technique called rTMS to investigate how a specific brain area (the superior temporal sulcus) influences social perception in people with autism and healthy controls. Researchers measured changes in eye-gaze patterns and …

This study tested whether a special brain MRI could predict which unborn babies with poor growth (intrauterine growth restriction) will have health problems after birth. Researchers scanned 82 fetuses before 32 weeks of pregnancy and compared the results to their health at delive…

This study followed 58 babies with sickle cell disease from 3 months to 2 years old to find early clues that might predict a life-threatening spleen complication called acute splenic sequestration. Researchers took blood samples and used special scans to measure spleen size and f…

This study follows 355 teenagers who were born very prematurely (26–32 weeks) in 1997 in France. Researchers measure their lung function and breathing symptoms to see how preterm birth affects respiratory health later in life. It is an observational study, meaning no treatment is…

This study looked at 558 people with congenital hypothyroidism, a rare thyroid condition found in newborns. Researchers examined their genes, medical images, and health records to find links between genetic changes and the type or severity of the disease. The goal is to improve e…

This study enrolled 349 people with myelodysplastic syndromes (MDS) to see how certain gene mutations affect survival. Researchers collected blood samples at diagnosis and tracked patients over time. The goal was to understand which mutations are linked to better or worse outcome…

This early-phase study tested whether a single injection of plerixafor could safely and effectively mobilize stem cells in 3 adults with severe sickle cell disease who lacked a matched sibling donor. The goal was to see if enough stem cells could be collected for a possible futur…

This study looked at two ways of managing the pushing stage of labor in first-time mothers with epidurals. One group was encouraged to push only twice per contraction (moderate), while the other pushed three times (intensive). The goal was to see if moderate pushing leads to bett…

This study looked at whether an ultrasound measurement of the lower uterine segment can predict the risk of uterine rupture in pregnant women who have had a previous C-section. Over 2,900 women were enrolled to see if using this measurement alongside a decision rule could reduce …

This study looked at 66 postmenopausal women with osteoporosis who were either taking alendronate (a common bone-strengthening drug) or not. Researchers measured how well the jawbone healed after a tooth extraction using X-rays taken right after, then at 30 and 90 days. The goal …

This study looked at 254 newborns with congenital cytomegalovirus (CMV) infection to find early signs that predict hearing loss or other brain-related problems at age 1. Researchers used clinical exams, brain scans, and lab tests to build a scoring system. The goal is to help doc…

This completed trial looked at whether a center focused on standard care for rheumatoid arthritis (RA) can improve how patients manage their disease. Nearly 1,000 adults with stable RA took part. The study tested two things: a nurse visit to check for and treat common RA-related …

This study followed over 1,400 pregnant women with endometriosis to see how the disease affects pregnancy outcomes like preterm birth. Researchers compared different types of endometriosis to understand which pose higher risks. The goal is to improve pregnancy monitoring and care…

This study examined 151 mothers and their newborns to understand why some babies get a severe infection from a specific strain of Group B Strep (GBS). Researchers tested samples from the mother's vagina, breast milk, and the baby's mouth and stool. They hope to find how gut bacte…

This completed study looked at how group B streptococcus (GBS) bacteria colonize the digestive tract of newborns. Researchers followed nearly 950 mothers and their babies, taking samples from the mother and umbilical cord at birth. The goal was to see if a specific, more dangerou…

This completed study looked at 138 women with Rokitansky syndrome, a condition where the vagina and uterus are underdeveloped. Researchers compared quality of life and sexual health in women who had surgery versus those who used vaginal dilation. The goal was to see which approac…