Assistance Publique - Hôpitaux De Paris

This trial tested a refined gene therapy to cure boys born with a severe, life-threatening immune deficiency called SCID-X1. For infants without a suitable bone marrow donor, doctors collected their own blood stem cells, inserted a corrected gene in the lab, and returned the cell…

This early-stage study tested a one-time gene therapy for people with severe sickle cell disease. Doctors collected a patient's own blood stem cells, used a modified virus to insert a healthy gene into them in the lab, and then gave the corrected cells back to the patient. The go…

This study aimed to see how well the H1N1 flu vaccine protected people with cystic fibrosis, a serious lung condition. Researchers followed about 1,000 patients, including children and pregnant women, during the 2009-2010 flu season. They checked if the vaccine prevented the flu,…

This study tested how well flu vaccines work in people with autoimmune diseases like lupus or rheumatoid arthritis, many of whom take medications that weaken their immune systems. Researchers gave 234 participants both seasonal and H1N1 flu vaccines and measured their immune resp…

This study checked if the annual flu vaccine works well and is safe for adults with Crohn's disease or ulcerative colitis, especially those taking medications that weaken the immune system. Researchers compared the body's immune response to the vaccine in 228 patients who were ei…

This study tested if babies with a rare, permanent form of diabetes caused by specific genetic mutations could safely switch from daily insulin injections to an oral pill called glibenclamide. It involved 19 infants and young children to see if the pill could control their blood …

This study aimed to help doctors better manage steroid treatment for people with lupus. Researchers followed 72 patients for three months to see if measuring steroid levels in their blood could predict how well the drug worked and what side effects they had. The goal was to find …

This study compared two methods for moving teeth during orthodontic treatment after premolar extractions. Researchers tested whether using tiny temporary screws (MINISCREW) placed in the jawbone works better than using other teeth for anchorage when closing extraction spaces. The…

This study tested whether the cholesterol-lowering drug rosuvastatin (Crestor) could reduce hidden artery plaque and prevent heart attacks or strokes in people with ANCA-associated vasculitis, a rare autoimmune disease. The trial involved 121 adult patients whose vasculitis was i…

This study followed 852 cystic fibrosis patients in France for one year to see how well the Orkambi drug combination works in everyday treatment. Researchers tracked whether patients continued taking the medication, monitored side effects, and measured lung function and overall h…

This study tested whether a drug called rituximab is better than standard therapy at getting a rare inflammatory blood vessel disease (EGPA) into remission and keeping it there. It involved 107 adults with newly diagnosed or flaring EGPA, who were randomly assigned to receive eit…

This study tested a surgery performed on fetuses still in the womb to repair a severe spinal cord defect called myelomeningocele (a type of spina bifida). The goal was to see if fixing the defect before 26 weeks of pregnancy could reduce brain complications and lead to better lon…

This study tested an experimental enzyme replacement therapy for a child with late infantile MLD, a rare and severe brain disease. The child had previously received a stem cell transplant but still needed additional treatment. Researchers gave intravenous enzyme infusions every o…

This study tested a new way to decide how long to give antibiotics to newborns with a serious blood infection called late-onset sepsis. Researchers wanted to see if using a blood marker called procalcitonin could safely shorten the antibiotic course compared to standard doctor-gu…

This study tested if a brief, controlled interruption of blood flow to the liver before major surgery could protect the organ from damage. It involved 81 adults undergoing surgery to remove large liver tumors. Researchers compared outcomes between patients who received this 'prec…

This study tested whether adding the drug bortezomib to standard treatments could help control chronic rejection in kidney transplant patients. The trial involved 60 people whose bodies were attacking their transplanted kidneys with harmful antibodies. Researchers aimed to see if…

This study tested whether a drug called allopurinol could help people with a rare genetic condition called adenylosuccinate lyase deficiency (ADSL). The condition causes intellectual disability, autism, and epilepsy. Eight children and adults took the drug for a year to see if it…

This study tested two different long-term treatment plans for patients with a serious autoimmune disease called ANCA-associated vasculitis, who were already in remission. The goal was to see which plan was better at preventing the disease from flaring up again. One plan gave ritu…

This study compared two approaches for managing Barrett's esophagus with low-grade dysplasia, a pre-cancerous condition. One group received a heat-based procedure (radiofrequency ablation) to destroy the abnormal cells, while the other group was closely monitored with regular che…

This study tested whether taking a low dose of aspirin twice a day is better than once a day at preventing future heart attacks, strokes, or other serious heart problems in people with diabetes or obesity who recently had a heart attack or chest pain. Researchers enrolled over 2,…

This study tested whether children with juvenile idiopathic arthritis (JIA) whose disease was well-controlled could safely have their biologic medication slowly reduced and stopped. Researchers compared children who gradually reduced their medication to those who kept taking the …

This study tested if adding a 7-day course of the steroid prednisone to standard emergency care could help patients hospitalized with sudden, severe heart failure. Researchers wanted to see if reducing body-wide inflammation, measured by a blood protein called CRP, could lead to …

This study tested a new fertility treatment method for women undergoing IVF. The goal was to see if creating a more natural hormone environment during egg stimulation could lead to better pregnancy and live birth rates compared to the standard method. The study involved 129 women…

This large study tested whether a vaginal medication (isosorbide mononitrate) could help prepare the cervix for labor in first-time mothers whose pregnancies went past 41 weeks. The goal was to see if this approach could reduce the need for cesarean sections. Over 1,400 women par…

This study tested whether a 5-day course of oral steroids helps people with COPD during sudden worsening of symptoms (flare-ups). Researchers compared steroids to placebo in 189 outpatients to see if the treatment reduced emergency visits and hospitalizations over 8 weeks. The go…

This study tested whether starting aggressive treatment for severe sepsis immediately in ambulances could save lives. Emergency medical teams gave antibiotics and fluids to stabilize blood pressure right away, rather than waiting until patients reached the hospital. The goal was …

This study looked at switching patients with rheumatoid arthritis, spondyloarthritis, or psoriatic arthritis from receiving their infliximab medication through an intravenous (IV) infusion at a clinic to giving themselves a subcutaneous (SC) injection at home. The main goal was t…

This study tested whether three HIV medications could help children with Aicardi-Goutières syndrome (AGS), a rare genetic disorder that causes severe brain inflammation. Eleven children received the medications for one year to see if they could reduce the harmful overactive immun…

This completed Phase 3 trial tested whether adding intravenous cyclophosphamide to standard prednisone treatment could better stabilize or improve lung function in people with scleroderma-related lung scarring. The study involved 40 adults whose lung function had recently worsene…

This small study tested whether a drug called pirfenidone could safely slow the progression of lung scarring (pulmonary fibrosis) in patients who also have a specific immune system marker or related blood vessel inflammation. The trial involved 7 adults with this specific conditi…

This study tested if a technique used in organ transplants could improve outcomes for breast reconstruction surgery. In 18 women who had a mastectomy for breast cancer, surgeons briefly interrupted and restored blood flow to the abdominal tissue flap before using it for reconstru…

This large, completed trial tested a new treatment order for adults with a rare, aggressive brain tumor. It compared starting with chemotherapy alone versus the standard approach of radiation followed by chemo. The main goal was to see if delaying radiation could better protect p…

This study tested whether treating inflammation in the male reproductive system could improve sperm health and fertility. Researchers enrolled 200 men with infertility and signs of inflammation in their semen. They compared a common anti-inflammatory steroid (prednisone) against …

This study tested whether using a mobile app for remote follow-up could help obese teenagers lose more weight than traditional in-person clinic visits. After an initial intensive program, 91 teens were randomly assigned to either continue with quarterly clinic visits or use a spe…

This study tested if taking an oral antibiotic (doxycycline) for two weeks works as well as the standard single penicillin injection for curing early syphilis. It involved 200 adults with early-stage syphilis and aimed to provide a proven alternative treatment, especially importa…

This small, early-stage study tested whether doctors could safely collect enough stem cells from the blood of children with Fanconi anemia. The goal was to see if these cells could then be used in a future gene therapy treatment. Researchers used two drugs to move stem cells from…

This study tested whether a drug called sodium phenylbutyrate could reduce levels of a specific harmful protein (NGAL/Lcn2) in the urine of people with chronic kidney disease and high protein loss. The goal was to see if reducing this protein could help slow the progression of ki…

This study compared two surgical procedures for treating incomplete miscarriage to see which leads to better future pregnancy rates. 577 women under 45 who wanted future pregnancies were randomly assigned to receive either the standard curettage procedure or a newer hysteroscopy …

This study tested whether sending daily text message reminders could help teenagers with poorly controlled type 1 diabetes improve their blood sugar management. Researchers enrolled 92 adolescents and randomly assigned some to receive standard care plus text message support for 6…

This study looked back at medical records to compare three different surgical techniques used to rebuild leg bones in children after removing cancerous bone tumors. Researchers analyzed about 90 patients treated between 1986 and 2017 to see which technique led to better bone heal…

This study tested a modified surgical technique for children with a rare condition where skull bones fuse too early, which often causes severe sleep apnea. The goal was to see if using more and improved devices during surgery could better open their airways and improve breathing …

This study tested if giving two seizure-stopping drugs together works better than one alone for adults experiencing a dangerous, prolonged seizure before they reach the hospital. It involved 203 patients and was designed to find a safer, more effective emergency treatment that pa…

This study tested whether giving rituximab (a medication that calms the immune system) for a longer time could better prevent relapses in people with ANCA-associated vasculitis—a serious autoimmune disease that causes blood vessel inflammation. The trial involved 97 patients who …

This study aimed to find the best non-invasive breathing support for infants hospitalized with severe viral bronchiolitis. It directly compared two common methods—CPAP and NiPPV—to see which one more effectively reduced the infant's breathing effort. The goal was to gather eviden…

This study tested whether lithium, a medication, could improve social communication difficulties in children with a specific genetic condition called Phelan-McDermid syndrome, which causes autism. Twenty-two children received either lithium or a placebo for 12 weeks to see if it …

This study tested whether giving patients the amino acid methionine by mouth or feeding tube was safe and could help control a severe, rare genetic lung disease. The disease, which has no cure, causes lung damage and other serious health problems. Researchers tried this approach …

This study compared two methods for adjusting the antibiotic vancomycin in children with serious MRSA infections. Researchers tested whether using a computer model to guide early dose changes could help children reach the right drug level in their blood faster than the usual meth…

This study tested if having a woman lie on her side in a specific tilted position helps turn a baby that is facing the wrong way during labor. It involved 326 women in labor whose babies were in a 'posterior' position (facing the mother's front). Researchers compared outcomes for…

This small, early-stage study tested whether a drug called ustekinumab could help control symptoms of Behçet disease, a rare inflammatory condition. It involved 16 adults with active disease, specifically targeting painful mouth sores or serious eye inflammation. The goal was to …

This study tested if a less invasive procedure works as well as surgery for treating a tubo-ovarian abscess, a painful pelvic infection. Researchers compared ultrasound-guided needle drainage through the vagina to laparoscopic surgery. Both procedures were done along with antibio…

This study aimed to find the best dose of the drug etanercept for children with juvenile idiopathic arthritis (JIA). Researchers measured drug levels in the blood of 126 children already taking the medication to see if adjusting the dose based on these levels could improve treatm…

This study tested whether a high dose of the antifungal medicine Ambisome could effectively treat zygomycosis, a rare but serious fungal infection. The trial involved 40 patients with confirmed infections and measured how well they responded to treatment over four weeks. Research…

This study tested whether adding a high dose of the drug erythropoietin to standard cooling therapy could improve outcomes for full-term newborns who suffered a lack of oxygen at birth (birth asphyxia). The goal was to see if the drug helped more babies survive without long-term …

This study followed 57 French cystic fibrosis patients with a specific genetic mutation (G551D) who took the drug Ivacaftor for at least one year. Researchers wanted to see if the drug remained effective and safe in everyday use after it was officially approved. They tracked lung…

This study compared two intravenous antibiotics for treating serious urinary tract infections caused by drug-resistant bacteria. It tested whether temocillin works as well as carbapenems, which are currently used but can contribute to antibiotic resistance. The trial involved 29 …

This study aimed to find out if patients with kidney cancer that has spread (metastasized) live longer by having their kidney removed first, followed by the drug sunitinib, compared to just taking the drug alone. It involved 452 adults with a specific type of advanced kidney canc…

This study tested whether a specialized clinic visit could help people with rheumatoid arthritis. It checked if a nurse reviewing other health risks (like heart disease or infections) and teaching patients to track their own arthritis activity led to better care. About 970 stable…

This trial tested whether the drug adalimumab could reduce painful eye inflammation (uveitis) in children with juvenile arthritis. The study involved 34 children whose eye inflammation did not improve with standard steroid drops and methotrexate. For the first two months, half re…

This study tested whether adding the drug baricitinib to standard steroid treatment works better for children newly diagnosed with juvenile dermatomyositis, a rare and serious autoimmune disease that causes muscle weakness and skin rashes. Sixteen children aged 3-18 participated …

This study tested whether giving the antiviral drug valacyclovir to pregnant women could help their unborn babies who were already infected with cytomegalovirus (CMV). CMV is a leading infectious cause of lifelong neurological disabilities in newborns. Researchers gave the drug t…

This study looked at whether having a pharmacist review a patient's medications before starting cancer treatment could prevent harmful drug interactions. Researchers followed 440 adult cancer patients starting chemotherapy, immunotherapy, or oral targeted therapy. The goal was to…

This study tested whether a medication called baclofen could help people with alcohol problems reduce their drinking or stop completely. Over 300 participants were randomly assigned to take either baclofen or a placebo pill for one year. Researchers compared how many people in ea…

This study tested the safety of a new gene therapy for people living with HIV who also have a high-risk type of lymphoma (a blood cancer). Researchers collected a patient's own blood cells, modified them with a gene designed to resist HIV, and then gave them back after a stem cel…

This study tested a drug called Revestive® in children with short bowel syndrome, a condition where the gut can't absorb enough nutrients. The goal was to see if the drug could help the intestine absorb more food from eating, reduce diarrhea, and decrease or even stop the need fo…

This study tested whether using just an antihistamine pill works as well as the usual combination of an antihistamine plus a steroid pill for treating sudden, severe hives (acute urticaria) in the emergency room. Researchers wanted to see if avoiding steroids could reduce side ef…

This study tested whether a non-invasive brain stimulation technique (rTMS) could help reduce specific, severe symptoms of schizophrenia, like hearing voices or feeling controlled by outside forces. Researchers gave 31 patients with these symptoms magnetic stimulation targeted at…

This study tested whether the drug nintedanib could slow the decline in lung function for people who developed a serious complication called bronchiolitis obliterans syndrome (BOS) after a lung transplant. In this Phase 3 trial, 58 transplant recipients with early to moderate BOS…

This study tested whether giving children with cow milk allergy tiny, controlled amounts of milk placed under the tongue (sublingual immunotherapy) could help their bodies become less reactive to milk over time. It involved 51 children over 5 years old who had confirmed milk alle…

This study tested whether a drug called itacitinib could help adults with a non-severe form of hemophagocytic lymphohistiocytosis (HLH), a rare and serious condition where the immune system becomes dangerously overactive. The goal was to see if itacitinib could control the diseas…

This study tested a special spinal rod called NEMOST, combined with physical therapy, to treat children with worsening scoliosis. The goal was to correct the spinal curve while allowing the child to grow, without needing repeated surgeries every 6-12 months. Researchers followed …

This study tested whether an oral medication (glyburide) works as well as insulin injections for managing diabetes that develops during pregnancy. Researchers enrolled 914 pregnant women whose blood sugar wasn't controlled by diet alone. The trial compared whether the pill was as…

This study tested a new, less invasive way to perform surgery on babies in the womb to repair spina bifida. Instead of a large cut in the mother's womb, doctors used two small scopes to operate. The goal was to see if this method was possible and if it could reduce risks for the …

This study tested a new cell therapy for patients who develop dangerous viral infections after a stem cell transplant and don't respond to standard antiviral drugs. Doctors collected special immune cells (T cells) from the patient's original stem cell donor, grew cells that could…

This study looked at whether patients could safely switch from the brand-name drug Remicade to a very similar, lower-cost version called Inflectra. It involved 262 patients at a Paris hospital who were already using Remicade for conditions like rheumatoid arthritis or Crohn's dis…

This study tested a new computer-guided method to find the right dose of a blood thinner (enoxaparin) for children who just received a kidney transplant. The goal was to prevent dangerous blood clots in the new kidney without increasing the risk of serious bleeding. Researchers c…

This study aimed to see if a high dose of vitamin D could better protect kidney transplant patients from serious health problems like new diabetes, heart disease, cancer, and death, compared to a standard lower dose. It involved over 500 patients who were 1-4 years past their tra…

This study compared two different approaches to pushing during the final stage of labor. Researchers wanted to see if a more moderate pushing method (pushing less frequently with no time limit) is safer for babies and mothers than the standard intensive method (pushing more frequ…

This large study tested a new surgical handpiece designed to make cataract removal safer. Researchers followed 5,000 patients undergoing routine cataract surgery to see if the new tool reduced the energy needed during the procedure and lowered complication rates. The goal was to …

This study tested if a nurse-led program could help people with axial spondyloarthritis (a chronic inflammatory back disease) better manage their condition. Over 500 patients were split into groups to either receive a systematic check for other health problems (comorbidities) or …

This large Phase 3 trial tested whether giving a high dose of a drug called erythropoietin (epoetin alpha) soon after a cardiac arrest could help protect the brain and improve recovery. The study involved 500 comatose survivors who received either the standard treatment alone or …

This study tested whether one drug (somatostatin) works better than another (octreotide) at preventing serious leaks after pancreas surgery. Researchers enrolled 655 patients who were having pancreas surgery to directly compare these two medications. The goal was to find which dr…

This study tested whether adding the medication Topiramate to standard obesity treatment helps reduce body mass index (BMI) more than standard treatment alone in severely obese children and teens. The 9-month trial compared Topiramate against a placebo in participants aged 9-17. …

This study directly compared three biologic medications (adalimumab, anakinra, and tocilizumab) for treating severe uveitis that doesn't respond to standard treatments. Researchers enrolled 112 adults with this serious eye inflammation that can lead to blindness. The trial aimed …

This study tested whether a blood pressure/heart rate medication called nebivolol could prevent heart muscle weakness in boys with Duchenne muscular dystrophy. It involved 51 boys aged 10-15 who still had good heart function. Participants were randomly assigned to receive either …

This study tested whether giving pregnant women with sickle cell disease extra oxygen at home could prevent serious pain episodes and other complications for both mother and baby. It was a large, completed Phase 3 trial involving 178 women across France. Researchers compared stan…

This study compared two ways of managing fluids given to patients during major liver surgery. Researchers tested a standard restrictive method against a newer, personalized approach guided by a computer system. They wanted to see which method better controlled blood loss and redu…

This study compared two treatments for women with painful uterine fibroids who want to have children. It looked at whether surgical removal of fibroids or a less invasive procedure called uterine artery embolization leads to better pregnancy outcomes. Researchers followed 9 women…

This study aimed to find which patient characteristics or MRI scan features could predict who would respond best to a specific treatment for severe frozen shoulder. The treatment involved stretching the shoulder joint capsule with fluid and then doing intensive physical therapy. …

This study compared two approaches for treating sudden bleeding inside the eye. Researchers tested whether performing surgery immediately (early vitrectomy) was better than monitoring with ultrasound and performing surgery later if needed. The goal was to see if early surgery cou…

This study tested whether giving higher doses of the labor-inducing drug oxytocin could help obese first-time mothers have vaginal births instead of C-sections. Researchers compared standard and double-dose oxytocin in 443 women during spontaneous or induced labor. The goal was t…

This study aimed to find out if the antibiotic cefazolin works as well as the standard drug cloxacillin for treating a dangerous bloodstream infection called MSSA bacteremia. It involved 315 adults with this infection. Researchers wanted to see if cefazolin could be a safer and m…

This study tested a new, smarter balloon device for a fetal surgery called FETO, which is used to help babies with a severe birth defect called congenital diaphragmatic hernia (CDH). The new 'Smart-TO' balloon is designed to be deflated using an MRI machine's magnetic field, maki…

This study tested whether doubling the dose of the prostate cancer drug abiraterone acetate could help control the disease in patients whose cancer was progressing despite standard treatment. Researchers enrolled 94 men with advanced prostate cancer that had spread and stopped re…

This study tested a new method to help patients with severe lung failure (ARDS) breathe better while on a ventilator. Researchers compared a chest strap that gently compresses the front of the chest to the standard treatment of lying patients face-down. The goal was to see if the…

This study aimed to find the most accurate laboratory method for measuring clotting factor levels in patients with severe Hemophilia B who were taking a specific medication called eftrenonacog-alfa. Researchers compared four different blood tests in 15 patients to see which one g…

This study tested whether a special high-permeability dialysis filter could help patients in shock after their heart was restarted. The filter was designed to remove harmful inflammatory substances from the blood. Researchers compared adding this treatment to standard care to see…

This study tested a new, targeted procedure using microwaves to destroy the main tumor in men with low-risk prostate cancer. The goal was to see if this approach was precise and safe enough to treat the cancer while causing fewer side effects like urinary and sexual problems comp…

This study tested whether adding the drug azathioprine to standard steroid treatment works better than steroids alone for adults newly diagnosed with certain rare autoimmune diseases (microscopic polyangiitis, polyarteritis nodosa, or eosinophilic granulomatosis with polyangiitis…

This study tested whether adding steroid therapy to standard kidney-protecting medications works better for IgA nephropathy patients with severe kidney damage seen on biopsy. Researchers compared two treatment approaches over two years in 62 adults with this autoimmune kidney dis…

This small, early-stage study tested the safety and effectiveness of a single injection of a drug called plerixafor. The goal was to see if it could safely move stem cells from the bone marrow into the bloodstream of adults with severe sickle cell disease, so those cells could be…

This study looked back at the medical records of 980 children who had surgery to repair a hole in their ear drum. The goal was to understand what factors, like a child's age or other health conditions, lead to a successful surgery where the eardrum stays closed and hearing improv…

This study tested whether sending text message reminders could help patients get important follow-up care after breaking a bone. Researchers enrolled 97 adults over 50 who came to the emergency room with a low-trauma fracture. One group received standard advice, while another got…

This study tested a new liquid version of a diabetes medicine for babies and children with a rare, genetic form of the disease. The goal was to see if this liquid is easier for young children to take and is as safe and effective as the current pill form. It involved 10 children w…

This trial aimed to find the best approach for early-stage twin-twin transfusion syndrome (TTTS), a serious condition where twins share a placenta unevenly. It compared immediate laser surgery to careful weekly monitoring, with surgery only if the condition worsened. The goal was…

This study tested whether a drug called miglustat could help fix the faulty protein that causes cystic fibrosis in adults with a specific genetic type of the disease. Sixteen participants received either miglustat or a placebo in a crossover design. Researchers measured changes i…

This study tested whether the drug rituximab is better than the standard drug azathioprine at keeping a rare autoimmune disease called EGPA in remission. It involved 98 adults whose disease had recently been brought under control. The goal was to see which drug helped patients st…

This study looked at whether adding support from specially trained Advanced Practice Nurses (APNs) to regular doctor visits helps people with high blood pressure control it better. Researchers compared 483 patients who received this extra nurse support to those who got usual care…

This study explored whether diabetes education programs could work for prisoners at the Paris La Santé jail. Researchers offered 22 male prisoners with diabetes four educational workshops about their condition, food, exercise, and foot care. The main goal was to see if such a pro…

This study tested a new 5-week hospital program designed to help adults with Prader-Willi syndrome, a rare genetic disorder that causes constant hunger and leads to severe obesity. The program combined tailored physical activity, nutrition guidance, and education workshops. Resea…

This study tested whether using wrist restraints only when absolutely necessary, rather than as a standard practice, could help reduce the duration of delirium (a serious state of confusion) in intensive care unit (ICU) patients on breathing machines. 423 adult patients expected …

This study tested whether the drug rituximab is better than the standard drug azathioprine at keeping two severe autoimmune diseases (Wegener's granulomatosis and microscopic polyangiitis) in remission. It involved 117 adults whose disease was under control after initial treatmen…

This study tested whether famotidine, a safe and widely used heartburn medication, could help children with sickle cell disease. Researchers gave the drug to 30 children for 29 days to see if it reduced a specific marker of blood vessel inflammation linked to painful blockages. T…

This study aimed to find the best way to manage pregnancy for women with MODY2, a rare genetic form of diabetes. It compared two care strategies: starting insulin treatment early in pregnancy versus starting it only if ultrasound scans showed the baby was growing too large. The g…

This study tested whether using a special balloon device earlier in treatment helps control severe, life-threatening bleeding after a vaginal birth. It compared using the balloon at the same time as a second medication versus waiting to see if the medication alone worked first. T…

This study aimed to see if a simple bedside test could help predict a common and serious side effect of spinal anesthesia for cesarean sections. Researchers tested 64 pregnant women scheduled for C-sections by raising their legs before surgery to check their body's fluid status. …

This study tested whether a special type of MRI brain scan could predict which babies growing too slowly in the womb would have serious health problems after birth. Researchers compared scan results from 82 pregnancies where the baby was very small. They looked for differences be…

This study compared two approaches for prostate biopsies to see which better detects cancer. Researchers tested whether 3 targeted biopsies guided by MRI imaging could be as effective as the standard 12 systematic ultrasound-guided biopsies. The study involved 108 men with elevat…

This study tested whether a simple, non-invasive finger sensor could predict which pregnant women are most likely to experience a dangerous drop in blood pressure after receiving spinal anesthesia for a scheduled cesarean section. Researchers monitored 45 women using the sensor a…

This study tested whether using an ultrasound to measure the thickness of a C-section scar could help doctors and patients decide the safest way to give birth. For women who have had a previous C-section, the study compared using this ultrasound measurement to guide delivery deci…

This study tested whether a non-invasive urine test could predict dangerous scarring in transplanted kidneys. Researchers followed 300 kidney transplant patients for a year, analyzing genetic markers in their urine. The goal was to see if this test could accurately identify patie…

This study aimed to find better ways to diagnose auditory processing disorder (APD), a condition where children have trouble understanding sounds even with normal hearing. Researchers compared brain scans (fMRI) and other tests in three groups of children aged 7-18: those diagnos…

This study tested whether CT scans could be as effective as endoscopy for finding foreign objects that children accidentally inhale into their lungs. Researchers compared results from both methods in 311 children aged 6 months to 16 years. They also measured the radiation exposur…

This study aimed to improve COVID-19 diagnosis and patient management by analyzing chest CT scans. Researchers collected over 10,000 scans to identify reliable visual signs of the disease and develop artificial intelligence tools. These tools were designed to help doctors diagnos…

This study tested a new blood test kit designed to detect a dangerous fungal infection called invasive aspergillosis in patients with blood cancers. The test also checks if the fungus is resistant to common antifungal drugs. Researchers enrolled 350 adult patients at high risk fo…

This study tested whether a whole-body MRI scan could accurately diagnose serious inflammatory muscle diseases like polymyositis and dermatomyositis. Researchers enrolled 139 patients with suspected muscle disease to compare MRI results against the standard muscle biopsy test. Th…

This study tested three new methods to diagnose bloodstream infections caused by central venous catheters in critically ill children. The goal was to find accurate ways to identify these infections without having to remove the catheter unnecessarily. Researchers compared the new …

This study tested whether a special type of MRI scan could be used to measure lung scarring (fibrosis) in people with scleroderma. Researchers wanted to see if this method, which doesn't use radiation, could be a better and more reproducible way to track the disease compared to c…

This study tested whether using a chest CT scan helps emergency room doctors diagnose community-acquired pneumonia more accurately than a standard chest X-ray. Researchers followed 339 adult patients in Paris emergency departments who showed signs of pneumonia. They measured if t…

This study aimed to see if a special type of PET scan could help doctors better manage a serious fungal infection called hepatosplenic candidiasis. The infection mainly affects the liver and spleen of cancer patients with weakened immune systems. Researchers tested if the scan co…

This study tested whether a special type of MRI scan could be used as a safe, non-invasive tool to detect problems with the placenta. The scan measures how oxygen levels change in the placenta and baby when the mother breathes extra oxygen. Researchers compared scans from 101 pre…

This study tested if a special type of MRI scan could help doctors diagnose autism in children. Researchers scanned the brains of 115 children, including those with autism, to see if they could find a reliable pattern of blood flow linked to the condition. The goal was to find a …

This study tested whether 3D ultrasound imaging could accurately measure the size of kidneys and kidney tumors. Researchers compared the 3D ultrasound measurements to the standard methods of CT and MRI scans in 53 adult patients. The goal was to see if this newer, often simpler i…

This study tested a new, gentle scanning method (called elastometry) to measure liver scarring (fibrosis) in children. The goal was to see if this scan could be as accurate as a standard liver biopsy, which is invasive and painful. If successful, this scan could help doctors moni…

This study aimed to understand how often problems with tiny storage compartments inside blood platelets (called dense granules) cause unexplained bleeding. Researchers enrolled 166 patients with bleeding issues where other common causes had been ruled out. They tested patients' p…

This study tested a new blood test to detect rejection in heart transplant patients. It aimed to see if measuring four specific molecules in the blood could accurately identify rejection, potentially replacing the need for frequent, invasive heart biopsies. The study involved 461…

This study tested a new medical decision rule (called PELICAN) designed to help doctors decide when a baby under 2 years old with a minor head bump needs a CT scan. The goal was to safely reduce the number of unnecessary CT scans, which expose young children to radiation, while s…

This study aimed to develop and test an artificial intelligence (AI) system to better predict the worsening of diabetic retinopathy, a common diabetes complication that can lead to vision loss. Researchers followed over 3,000 diabetic patients for up to three years, collecting ey…

This study tested a new type of MRI scan designed to safely image children's lungs without using radiation or injections. It involved 72 children aged 6-16 who needed a standard chest CT scan. Researchers compared the new MRI images to the CT scans to see if the safer method coul…

This study aimed to find early warning signs in a pregnant woman's body that could predict if she will deliver her baby too early. Researchers looked for specific molecules in cervical fluid that might signal the body is preparing for labor prematurely. The goal was to create a b…

This study aimed to check how reliable a standard diagnostic test is for acromegaly, a rare condition caused by too much growth hormone. Researchers tested 109 people, some with acromegaly and some without, to see if the test's results were consistent when repeated. They also com…

This study tested if using a rapid, one-hour diagnostic test for pneumonia, combined with expert advice, improves care for patients who develop pneumonia in the hospital. The goal was to help doctors choose the right antibiotic faster, potentially reducing the use of strong, broa…

This study tested a new method to detect prostate cancer cells in blood samples without needing invasive biopsies. Researchers worked with 127 men who were scheduled for prostate biopsies to see if the blood test could identify cancer cells before the biopsy procedure. The goal w…

This study tested a new, non-invasive blood test for pregnant women to detect Down syndrome (trisomy 21) in the first trimester. The goal was to see if analyzing fetal DNA found in the mother's blood could accurately identify the condition, providing a safer alternative to invasi…

This study aimed to see if measuring certain proteins in the blood could help doctors predict Alzheimer's disease. Researchers followed over 1,000 people with either mild memory problems or early Alzheimer's to see if their blood test results could forecast who would get worse or…

This study tested whether it was possible to quickly diagnose two related problems in newborns who fail their initial hearing test. Researchers wanted to see if they could confirm a congenital cytomegalovirus (CMV) infection and perform a full hearing assessment—both within the b…

This study tested whether using a lung ultrasound machine could be as good as a chest X-ray at checking if a breathing tube is in the right place in children. The goal was to find a faster, bedside method that avoids radiation. Researchers compared ultrasound results from two doc…

This study tested a simple method to predict if critically ill patients on breathing machines will benefit from receiving IV fluids. Doctors temporarily adjusted a ventilator setting to see if it mimicked the effect of giving fluids. The goal was to find a quick test to avoid giv…

This study aimed to see if a short, 10-minute screening test could reliably detect thinking and memory problems in adults with sickle cell disease. Researchers tested 65 adults with sickle cell disease, comparing the results of the quick screening test to a much longer, detailed …

This study tested two newer, lower-radiation scanning methods (an ultra-low-dose CT scan and a lung MRI) to see how well they could assess lung damage in adults with cystic fibrosis. Researchers compared these newer scans to the standard low-dose CT scan that is currently used. T…

This study tested whether a simple blood test from the mother could safely replace invasive procedures for detecting Down syndrome. Researchers compared the new blood test against standard invasive tests in over 2,000 pregnant women at higher risk. The goal was to see if the bloo…

This study tested a French version of a questionnaire designed to help diagnose balance disorders in children. Researchers worked with 85 children, some with dizziness and some without, to see if the translated questionnaire was reliable and effective. The goal is to give doctors…

This study aimed to create a better test to tell if a common skin bacteria found in a patient's blood is causing a real infection or is just contamination from the skin. Researchers compared the genetic makeup of bacteria from 320 hospitalized patients who either had a confirmed …

This study aimed to see if saliva tests could work as well as or better than the standard nasal swab test for finding COVID-19. Over 5,000 people who were getting a standard nasal swab test also provided a saliva sample. Researchers compared the results to see if the easier, more…

This study tested a new, quick, and non-invasive skin test to see if it could accurately detect nerve damage in children caused by chemotherapy. The test measures sweat gland function, which is linked to small nerve fibers often damaged by treatment. Researchers compared this new…

This study tested whether using a specific blood test (measuring the sFlt-1/PlGF ratio) could improve care for pregnant women with signs of possible preeclampsia. The goal was to see if the test helps doctors decide who truly needs hospital monitoring and who can safely avoid it,…

This study aimed to find better, painless ways to detect liver scarring (fibrosis) in children with cystic fibrosis. Researchers compared four different non-invasive tests—two types of ultrasound scans, a special MRI, and a blood test—to see how well they could identify liver dam…

This study tested if adding a special CT scan of the pelvis and legs to the standard lung scan helps doctors find more blood clots in women who have recently given birth and are suspected of having a dangerous lung clot (pulmonary embolism). Researchers enrolled 125 new mothers t…

This study tested a new microscope imaging technique called FFOCT to see if it could help doctors detect prostate cancer in biopsy samples. The goal was to see if this new method could work as well as the standard lab analysis, potentially giving results faster. The study involve…

This study tested a new blood test designed to quickly identify stroke patients who have a major blockage in a large brain artery. The goal is to help paramedics decide which hospital to take a patient to, so those who need specialized clot-removal surgery get there directly with…

This study tested if two special ultrasound methods (M-mode and color Doppler) could accurately confirm the correct placement of an epidural catheter in women during labor. The goal was to see if this imaging could help reduce the high rate of epidural failures, which leave mothe…

This study tested a new way to help doctors spot dangerous gut inflammation in premature babies earlier. Researchers checked a simple stool test for a protein called calprotectin in 122 very premature infants. The goal was to see if this test, combined with other routine checks, …

This study tested whether two special types of ultrasound scans could detect early signs of kidney transplant damage without needing invasive biopsies. Researchers followed 141 kidney transplant patients, performing the new scans at 15 days, 3 months, and 12 months after transpla…

This study tested whether stopping the labor-inducing drug oxytocin once active labor begins could reduce health problems in newborns. It involved 2,459 women who were already receiving oxytocin early in labor. Researchers compared outcomes for mothers whose oxytocin was stopped …

This study tested whether providing education about healthy eating and modest exercise to overweight or obese pregnant women could help prevent rapid weight gain in their children during the first two years of life. Researchers compared women who received this special education p…

This study tested whether using a special antiseptic dressing on the tubes of ECMO life support could prevent serious infections. It involved 270 critically ill adults with heart or lung failure who were on ECMO. Patients were randomly assigned to receive either the antiseptic dr…

This study tested whether a low-dose injection of a protein called IL-2 could help prevent miscarriage in women who have had multiple unexplained early pregnancy losses. The treatment aims to boost a specific type of calming immune cell that might help the mother's body better to…

This study tested whether a gentle, controlled pull on the umbilical cord after a baby is born helps deliver the placenta faster and reduces dangerous heavy bleeding. It involved over 4,300 women giving birth vaginally, comparing this method to waiting for natural signs the place…

This study tested whether two existing drugs, azithromycin and hydroxychloroquine, could prevent COVID-19 infection in hospital workers who were regularly exposed to the virus. Over 120 healthcare workers who did not have COVID-19 were randomly assigned to receive one of the drug…

This study aimed to prevent muscle injuries in elite French sprinters, rugby players, and bobsledders. Researchers analyzed each athlete's unique muscle mechanics and sprinting form to create personalized training and strengthening programs. The goal was to reduce the risk of low…

This study looked at whether giving a short course of antibiotics right after a severe injury could prevent pneumonia in patients who need a ventilator to breathe. It involved over 2,100 adult trauma patients who were put on a ventilator. The goal was to see if this early prevent…

This study tested whether melatonin, a natural sleep-regulating hormone, can prevent postoperative delirium—a common and serious state of confusion—in older adults having emergency surgery for broken hips or knees. Researchers gave 357 patients aged 70+ either melatonin or a plac…

This study tested two different vaccination approaches to prevent serious pneumococcal infections in people with lupus. Researchers compared giving two different vaccines in sequence versus giving just one standard vaccine to see which provides better immune protection. The trial…

This study aimed to find out if washing children in the intensive care unit with special antiseptic pads is better at reducing skin bacteria than washing with regular mild soap. It involved 34 children who were hospitalized for at least five days. Researchers took skin samples be…

This study tested a new two-step vaccination plan to help protect adults who have had their spleen removed. People without a spleen are at high risk for severe, fast-moving pneumococcal infections. Researchers gave 70 participants one type of vaccine, followed by a second type tw…

This study tested whether large indoor concerts could be held safely during the COVID-19 pandemic. Researchers wanted to see if requiring a negative rapid test within 3 days before the event would prevent virus transmission. They compared people who attended a concert with those …

This study tested whether giving stronger or extra doses of pneumonia vaccines could better protect patients with a rare autoimmune disease (ANCA-associated vasculitis) who are taking a drug called rituximab. Rituximab weakens the immune system, making these patients more prone t…

This study tested whether using hypnosis during a liver biopsy could reduce the pain and anxiety patients feel. Researchers compared a group receiving hypnosis to a group receiving standard, supportive care. The goal was to see if this safe, non-drug technique could make the comm…

This study tested whether offering immediate counseling to close family members after a loved one's sudden death improves their mental health. Researchers compared families who were offered a special counseling session by the emergency medical team to families who received the us…

This study tested a 12-week online educational program designed to help family members caring for someone with Alzheimer's disease. The program provided weekly information, stress-reduction techniques, and a forum to connect with other caregivers. Researchers measured whether usi…

This study tested whether a home-based brain stimulation device could help reduce the severe fatigue that often accompanies multiple sclerosis. Ten participants with MS used a safe, non-invasive device that delivers mild electrical currents to the scalp. Researchers measured chan…

This study tested whether a 6-week personalized program could improve quality of life for people with Long COVID. 80 participants with ongoing symptoms like fatigue, shortness of breath, and brain fog were randomly assigned to either receive the program immediately or be placed o…

This study tested whether a specific type of hands-on osteopathic treatment works better than a fake (placebo) version for people with ongoing low back pain. 400 adults with pain lasting weeks to months received either the real treatment or the placebo. Researchers measured how w…

This study tested whether a self-hypnosis smartphone app could help children with ADHD who were already taking medication. Researchers wanted to see if using the app for six weeks could reduce symptoms of inattention and anxiety. Forty-nine children aged 7 to 12 participated, usi…

This study tested whether a daily oral supplement containing resveratrol, a compound found in grapes, could reduce pain in people with knee osteoarthritis. In this large, completed Phase 3 trial, 142 adults with painful knee arthritis took either the resveratrol supplement or a p…

This small study looked at whether a surgical procedure to widen the upper jaw improves quality of life for adults with obstructive sleep apnea. Nine patients were followed for over a year after surgery. Researchers measured changes using sleep quality questionnaires and sleep st…

This study tested if using a special pain monitor during surgery could help doctors give the right amount of pain medicine. It involved 260 children having surgery to correct scoliosis. The goal was to see if the monitor could reduce the total amount of strong opioid painkillers …

This study tested whether listening to music during cataract surgery could help reduce patient anxiety and prevent spikes in blood pressure. It involved 313 adults who were awake for their surgery with only numbing eye drops. Researchers compared patients who listened to music du…

This study tested if a single, precise injection of Botox (botulinum toxin A) into the arthritic thumb joint, combined with wearing a splint, could reduce pain for people with thumb base osteoarthritis. It involved 60 participants and compared the effects of the Botox injection t…

This study tested whether a personalized rehabilitation program could improve daily life for people with systemic sclerosis (scleroderma), a disease that causes skin tightening and joint problems. It involved 220 patients who were randomly assigned to receive either the new rehab…

This study tested whether a drug called mangafodipir could protect against nerve damage, a common and often disabling side effect of the chemotherapy drug oxaliplatin. It involved 23 cancer patients who were already experiencing moderate nerve pain but needed to continue oxalipla…

This study tested whether a low-dose immune system drug called IL-2 could reduce allergy symptoms in people sensitive to birch pollen. Twenty-four adults with confirmed birch pollen allergy received either the drug or a placebo for 36 days. Researchers measured changes in nasal c…

This study compared two methods to reduce labor time during second-trimester pregnancy termination. Researchers tested whether using cervical dilators before standard medication could help more women deliver within 12 hours. The study involved 355 women in France and also examine…

This study followed up with 36 young adults who were treated with growth hormone as children for short stature. Researchers wanted to see if the treatment's positive effects on their emotional and social well-being as kids lasted into adulthood. They did this by having participan…

This study explored whether a virtual reality (VR) session with a hypnotic script could help reduce pain and anxiety for children experiencing a severe sickle cell pain crisis. Researchers observed 12 children over age 6 who were hospitalized for these crises. The goal was to see…

This study tested whether a purified cannabis extract (CBD) could safely reduce severe, chronic itching in children with a rare genetic skin-blistering disease. Ten children with the condition took CBD oil by mouth for one month to see if it lessened their itch, pain, and sleep p…

This study tested if using a PARO robot, which looks like a baby seal, could help reduce pain and distress for elderly people with moderate to severe dementia during daily nursing care. Ten participants living in care homes were involved. The idea was that the robot could provide…

This study tested whether adding a medication called droperidol to the standard two-drug combination (ondansetron and dexamethasone) works better at preventing vomiting after surgery in children. It involved 322 children aged 3-18 who were at high risk for post-surgery nausea. Th…

This study tested whether using a near-infrared light device helps nurses find veins more easily on the first try when drawing blood or inserting an IV line in children. It involved 163 children in emergency rooms and newborn units who needed these procedures. The goal was to see…

This study tested whether applying heat or cold packs during and after vaginal childbirth could reduce common perineal pain in the days following delivery. It involved 115 first-time mothers or women without prior vaginal births across multiple hospitals. Researchers compared the…

This study looked at whether allowing patients to eat and drink normally before cataract surgery could reduce their anxiety and improve comfort. It involved 126 adults having routine cataract surgery with just eye-numbing drops. Researchers measured anxiety levels, patient satisf…

This study tested whether a special program of exercises and education given to patients before knee replacement surgery could help them recover better and faster. It involved 262 adults with knee osteoarthritis who were scheduled for surgery. The main goal was to see if this pre…

This small, completed study explored if gardening could help people with long-term low back pain. Researchers compared 90-minute gardening sessions to 90-minute indoor craft sessions for 16 participants. They used brain scans to see if gardening reduced activity in a brain area l…

This study tested if a cross-legged sitting position is better than the traditional sitting position for placing an epidural catheter during labor. Researchers wanted to see if the cross-legged position helps get the catheter in correctly on the very first try, making the process…

This study tested whether adding a calming medication (midazolam) under the tongue improves pain relief when given with oral morphine to children with displaced arm fractures in the emergency department. 60 children aged 5-16 were randomly assigned to receive either morphine with…

This study looked at whether injecting Botox into a groin muscle could help reduce pain and improve daily life for athletes with long-term groin pain that didn't get better with standard treatments. Researchers followed 20 patients who received the injection and checked their pai…

This study tested whether a 14-month personalized medical care program could help people who report sensitivity to electromagnetic fields. Researchers followed 79 adults who believed they were sensitive to electromagnetic waves, tracking their symptoms, sensitivity levels, and qu…

This study tested whether adding art therapy to standard speech therapy could help people recover language after a stroke. Researchers worked with 15 recent stroke survivors who had moderate to severe difficulty speaking. They used brain scans to see if art activities could help …

This study tested a new group support program for people caring for a parent who has recently moved into a nursing home. The program aimed to help caregivers manage difficult feelings like anxiety, guilt, and sadness. It involved 73 caregivers and provided group sessions with pro…

This study explored whether group art and movement workshops could help children and teenagers who suffer from chronic pain linked to school bullying. Eight participants took part in sessions combining martial arts, dance, and creating a street-art mural. The goal was to see if t…

This study tested whether giving patients with incurable lung cancer more complete information about chemotherapy risks would change treatment decisions near the end of life. Researchers randomly assigned 123 patients to receive either standard information or additional details a…

This study tested whether a 6-week course of osteopathic treatment could reduce pain and improve quality of life for people with fibromyalgia. It involved 101 adults with long-term fibromyalgia who received either real osteopathic sessions or a standard treatment for comparison. …

This study tested whether a short, personalized program of education and physical rehabilitation could help people with persistent low back pain move better and fear movement less. It involved 100 adults who had back pain for over 6 weeks but were not severely disabled. The goal …

This study tested whether a single injection of a medication called infliximab could reduce sciatica pain caused by scar tissue that forms after back surgery. It involved 38 adults who still had significant pain more than 6 months after a discectomy, despite other treatments fail…

This study tested whether injecting a steroid medication directly into a painful spinal disc could reduce chronic lower back pain. It involved 137 adults in France whose pain hadn't improved with standard treatments and who had signs of disc inflammation on an MRI scan. Participa…

This study tested whether the drug rituximab could help reduce joint pain and swelling in people with systemic sclerosis (scleroderma) who had active arthritis. It involved 22 participants whose joint symptoms weren't controlled by standard medications. The main goal was to see i…

This study tested if adding common over-the-counter pain relievers (paracetamol/acetaminophen and ibuprofen) to morphine provides better pain relief for children with broken arm or leg bones in the emergency room. It involved 304 children aged 2 to 17 years. Researchers compared …

This study tested if wearing a weighted brace on the unaffected ankle could help people walk better after a stroke. It compared a weighted brace to a non-weighted one over three months. The goal was to see if the extra weight improved how far participants could walk in six minute…

This study tested whether applying a numbing cream called Ropivacaine to painful skin wounds could reduce pain during bath and dressing changes for children and young adults with Epidermolysis Bullosa. The goal was to improve quality of life by managing this severe, treatment-res…

This small study looked at whether a short, 1.5-day group program was a practical option for people with ongoing low back pain. The program involved education and exercises led by doctors and therapists. Researchers wanted to see if patients found it acceptable and if it helped r…

This study tested a new magnetic ureteral stent in children who needed one for kidney problems or transplants. The goal was to see if the stent could be safely removed in a clinic using a magnet, avoiding a second procedure under general anesthesia. Researchers also looked at cos…

This study tested whether using a virtual reality headset could help reduce chronic low back pain. 122 adults with persistent, treatment-resistant back pain were randomly assigned to either use the virtual reality system or not. The treatment group received three 17-minute virtua…

This study tested a non-invasive device that delivers mild electrical stimulation to the ear to see if it could reduce pain and inflammation in people with a severe, painful form of hand arthritis. For 12 weeks, 148 participants used either a real or a fake (sham) device to compa…

This study tested whether adding a relaxation technique called sophrology to standard pain treatment could help people with cystic fibrosis who have frequent or constant pain. Thirteen patients received the relaxation sessions at home along with their usual medications and psycho…

This study tested whether having a therapy dog present during dental appointments could help reduce anxiety in children with autism spectrum disorder. Researchers worked with 50 children aged 6-17 who had autism and high dental anxiety. They measured whether two sessions with a t…

This study looked at how starting the cystic fibrosis (CF) medication ORKAMBI affects the mental health and daily life of teens and young adults. Researchers followed 19 young people with CF for one year, comparing those taking ORKAMBI to those not taking it. They measured change…

This study followed 50 children with severe to profound deafness who received cochlear implants. Researchers compared measurements of the children's brain activity in response to sounds with their speech and language development over 3 to 6 years. The goal was to better understan…

This study aimed to understand if what very premature babies eat in the hospital affects their brain development later on. Researchers followed 206 infants born very early to see if the amount of mother's milk, specific fats, and iron they received was linked to their learning an…

This study looked back at the medical records of 70 children who had a stroke to see how well and how safely emergency clot-busting treatments worked for them. These treatments are standard for adults but there is very little data on using them in children. The goal was to gather…

This study aimed to find out how often children with a rare hormone condition called congenital adrenal insufficiency experience low blood sugar (hypoglycemia). Researchers followed 9 young children for a year, using special monitors to track their blood sugar levels continuously…

This study aimed to understand why some children develop severe hearing loss after receiving certain platinum-based chemotherapy drugs (cisplatin or carboplatin) for cancer. Researchers compared the genes of 60 children who developed this hearing loss with 120 children who did no…

This study aimed to understand why sepsis patients often develop weak immune systems, making them prone to new infections in the hospital. Researchers collected blood samples from 119 people, including sepsis patients, other critically ill patients, and healthy volunteers. They a…

This study looked back at medical records to understand if epidural pain relief during childbirth is linked to more infections in women with primary immunodeficiencies (weak immune systems). Researchers reviewed the records of 30 women from a national registry who gave birth over…

This study followed 25 women with MRKH syndrome, a rare condition where the uterus and vagina are underdeveloped, to see how their quality of life and psychological well-being changed over 8-10 years. Researchers used questionnaires and interviews to understand their experiences …

This study observed how fourth-year medical students learn communication skills during required training. Researchers interviewed 404 students and teachers and analyzed student work to understand the learning process. The goal was to gather information to help improve how these s…

This study aimed to find out if the seasonal flu vaccine is safe and effective for people with sarcoidosis, a chronic inflammatory disease. Researchers compared the immune response and any side effects in 190 people with sarcoidosis against healthy volunteers. The goal was to gat…

This study aimed to find a quick, objective way to measure anxiety in patients before day surgery. Researchers tested if changes in a person's heart rate and pupil size could reliably detect anxiety levels. The goal was to help medical staff better identify and support anxious pa…

This study aimed to understand the emotional impact on parents after their child was hospitalized in intensive care for a severe injury. Researchers followed 62 parents for 3 to 6 months after their child left the ICU to measure rates of anxiety, depression, and post-traumatic st…

This study aimed to adapt and validate three existing English questionnaires into French to better measure hearing performance and quality of life in deaf children and adolescents. It involved 101 participants, including children with deafness and a control group without hearing …

This study aimed to better understand congenital hypothyroidism, a rare condition where babies are born with an underactive thyroid. Researchers analyzed the genes of over 550 patients and their families to find out what causes the condition and if it's linked to other health pro…

This study aimed to understand whether smoking or using nicotine products affects a person's chance of getting COVID-19. Researchers compared 622 healthcare workers who tested positive for the virus with those who tested negative, asking about their tobacco and nicotine use. The …

This study compared different methods for measuring kidney function in 90 critically ill patients whose kidneys were clearing waste unusually fast. Researchers wanted to see if a special dye test (iohexol clearance) gave more accurate results than standard blood tests and formula…

This study aimed to understand the relationship between how well the kidneys concentrate urine and the stiffness of major arteries in people with high blood pressure. It involved 72 adults with high blood pressure who were already scheduled for a specialized check-up. Researchers…

This study aimed to understand why some children develop unexplained widening of their airways (bronchiectasis) by comparing how salt and fluid move across the airway lining. Researchers tested 42 children and young adults, including those with the condition, those with cystic fi…

This study aimed to understand how endometriosis affects the development and quality of a woman's eggs. Researchers analyzed fluid and cells from 16 women undergoing fertility treatment to look for biological differences. The goal was to find markers that could explain fertility …

This study aimed to better understand diabetes by measuring a hormone called pancreatic polypeptide in people with type 1 and type 3c diabetes. Researchers tested 36 adult participants after a meal to see if the entire pancreas is affected in type 1 diabetes, not just the insulin…

This study aimed to understand the causes of iron deficiency in young children in France. Researchers observed 830 healthy two-year-olds to see if drinking toddler milk formula was linked to better iron levels, while also considering diet and family background. The goal was to ga…

This study aimed to understand how endometriosis affects pregnancy outcomes. Researchers followed over 1,400 pregnant women, comparing those with endometriosis to those without. They tracked risks like preterm birth and other complications to help guide better pregnancy care for …

This study aimed to better understand how a specific spinal condition called dural ectasia affects people with Marfan syndrome. Researchers compared 90 adult patients, some with the condition and some without, to see how often they experienced back pain, headaches, and other symp…

This study aimed to understand why some people get very sick or die from listeria infections, a serious type of food poisoning. Researchers followed over 2,100 patients across France who had confirmed listeriosis, collecting their health information, dietary habits, and blood sam…

This study aimed to understand how a key HIV drug, tenofovir, passes from a pregnant person to the fetus through the placenta. Researchers used a lab model of the placenta to measure this transfer and see if other medications or natural body processes affect it. The goal was to g…

This study aimed to better understand the psychiatric symptoms experienced by people with FOXP1 syndrome, a rare genetic disorder. Researchers observed 25 participants to document conditions like ADHD, autism, anxiety, and psychosis that often accompany the syndrome. The goal was…

This study aimed to understand how the body's immune cells interact with melanoma tumors. Researchers analyzed tumor samples from 217 patients at different stages of the disease to see which immune cells were present and how they behaved. The goal was to learn why these cells som…

This study aimed to understand how doctors diagnose chronic muscle and bone pain in teenagers and young adults. Researchers interviewed 25 French healthcare professionals who specialize in this area. The goal was to use their experiences to build a better checklist or scale to he…

This study aims to understand the long-term health effects on children who experienced twin-to-twin transfusion syndrome (TTTS) during pregnancy. Researchers are following 179 children, aged 4-8 and later 12-16, to check their heart, kidney, and metabolic health. The goal is to s…

This study followed 100 people who had infectious endocarditis (a serious heart infection) to see how brain lesions found on MRI scans change over time. Researchers compared brain scans taken during the initial infection with follow-up scans to understand if these brain changes a…

This study aimed to see if a laboratory test on patients' own nasal cells could predict how well they would respond to the cystic fibrosis drug Orkambi. Researchers tested 91 patients with a specific genetic form of cystic fibrosis who were starting Orkambi treatment. They compar…

This study aimed to understand if a serious bacterial infection called listeriosis, contracted around the time of birth, causes long-term effects on a child's brain development. Researchers followed 53 children, comparing those who had the infection to healthy children, checking …

This study aimed to see if people with type 2 diabetes living in France could follow a Mediterranean diet for a year. Researchers enrolled 60 patients to learn about their eating habits, teach them the diet, and then check in at 3 and 12 months. The main goal was to see how many …

This study followed 80 people newly diagnosed with Cushing's disease for three years. Researchers tracked how the disease affected their hearts, bones, metabolism, and daily life before and after they received standard treatment. The goal was to better understand the full range o…

This study aimed to understand what happens in a child's body before type 1 diabetes develops. Researchers followed 512 babies born to parents with type 1 diabetes, who have a higher risk. They collected blood samples and health information over time to look for early immune syst…

This study aimed to better understand and diagnose insulin allergies, a rare but serious problem where a person's body reacts badly to the insulin they need to manage diabetes. Researchers worked with 55 adults who had diabetes—some with insulin allergies and some without—to test…

This study aimed to understand how the pressure from a breathing machine (ventilator) affects heart function in patients with Acute Respiratory Distress Syndrome (ARDS). Researchers monitored 50 adults and children with ARDS to see if specific pressure levels were linked to heart…

This study aimed to understand how consistently patients with a serious lung artery disease take their prescribed water pills (diuretics). Researchers followed 227 patients for a year to measure how often they took their medication and what factors made them miss doses. They also…

This research study aimed to better understand how a specific brain area is involved in social perception in people with autism. Researchers used a non-invasive magnetic stimulation technique on the brains of 97 adults (both with autism and healthy volunteers) while they looked a…

This study aimed to identify early signs in newborns that could predict which babies born with cytomegalovirus (CMV) infection would develop long-term hearing loss or brain problems. Researchers followed 254 infected babies from birth to age 2, tracking their health, brain scans,…

This study aimed to identify specific molecules produced by cells in the pregnancy membranes (the 'water bag') that could signal the start of labor too early. Researchers studied cells from 24 women with normal, full-term pregnancies to understand what changes occur when labor be…

This study aimed to understand how children with heart failure breathe and sleep, and to see if using a CPAP machine (a device that provides gentle air pressure) while awake could make breathing easier and potentially help their heart function. It involved 30 children, from infan…

This study aimed to understand why some babies born with profound deafness also show early warning signs of neurodevelopmental disorders like autism. Researchers analyzed video recordings and medical data from 22 deaf infants under 10 months old to identify common factors. The go…

This study aimed to understand how diet and lifestyle affect a couple's ability to conceive. Researchers compared 400 fertile and infertile couples, looking at their nutrition, body measurements, blood tests, and lifestyle habits. The goal was to find connections between what peo…

This study created a registry to collect medical information from patients with anti-phospholipid syndrome (APS) and/or systemic lupus erythematosus (SLE). It enrolled 868 participants to gather data about their conditions and treatments. The goal was to better understand these a…

This study aimed to understand how many children had been infected with COVID-19, often without showing symptoms, and what their immune response looked like. Researchers tested over 1,000 children and their parents for antibodies and the virus itself in blood, saliva, and stool s…

This study aimed to understand if certain proteins in the blood (IGF-I and IGFBP-3) are linked to Alzheimer's disease and memory problems. Researchers compared these protein levels in three groups: people with Alzheimer's, people with mild memory issues, and healthy elderly indiv…

This study aimed to understand how COVID-19 spread within families by measuring antibodies in children of hospital workers. Researchers tested 563 participants from hospital worker households to see if children developed COVID-19 antibodies when their parents had been exposed. Th…

This study aimed to understand why a particularly dangerous strain of Group B Strep bacteria (called CC-17) colonizes and causes severe infections in newborns. Researchers enrolled 151 mothers to investigate how factors like the baby's gut bacteria, diet, and immune system might …

This study looked back at medical records to understand how the COVID-19 pandemic and its safety rules, like masks and school closures, affected severe strep infections in children. Researchers analyzed data from 269 children hospitalized in Paris between 2018 and 2023. The goal …

This study aimed to understand how tiny air pollution particles inside taxis affect drivers' breathing. Researchers measured the air quality in the vehicles of 56 Parisian taxi drivers over their work shifts and tested the drivers' lung function before and after work. The goal wa…

This study aimed to see if a simple 6-minute walk test could help doctors predict the future health of adults with cystic fibrosis. Researchers followed 291 patients for three years to see if their walking distance or oxygen levels during the test were linked to their chance of n…

This study aimed to understand how blood flow and oxygen levels in the brain change when critically ill children are treated for shock or low blood pressure. Researchers monitored 27 children in intensive care using special ultrasound and light sensors on their heads. The goal wa…

This study aimed to understand if teens with restrictive eating disorders, like anorexia or ARFID, experience the world through their senses differently than other teens. Researchers compared a small group of 29 adolescents with these eating disorders to a control group without t…

This study aimed to understand the psychological and mental health challenges faced by people with Behcet's disease, a rare autoimmune condition. Researchers observed 20 patients to measure their levels of anxiety, depression, fatigue, and overall quality of life. The goal was to…

This study aims to understand why people with myotonic dystrophy type 1 (DM1) have a much higher risk of dangerous blood clots in their veins. Researchers will test the blood of 130 participants (100 with DM1 and 30 healthy volunteers) to see if their blood clots too easily. They…

This study aimed to understand and improve the supportive and palliative care given to infants with the most severe form of spinal muscular atrophy (SMA type 1), a condition with no cure. Researchers followed 39 infants and their families, using diaries to record symptoms, treatm…

This was a small, completed lab study that tested whether specially engineered versions of a natural immune protein (called IL-2 muteins) could selectively boost a type of calming immune cell (regulatory T cells) taken from patients with various autoimmune and inflammatory diseas…

This study observed 116 patients who survived a severe cardiac arrest outside the hospital and were saved using advanced heart-lung bypass machines. Researchers tracked how well the heart's main pumping chamber recovered at 28 days and 90 days after the event. The goal was to und…

This study aimed to find a better way to guide fluid treatment for children with severe septic shock, a life-threatening condition. Researchers tested whether giving a very small, quick fluid injection could predict if a child would benefit from receiving larger amounts of fluids…

This study aimed to understand the long-term recovery process for people who survived severe COVID-19 and needed intensive care. Researchers followed 85 patients from the hospital until they returned home, tracking their physical, mental, and cognitive challenges. They compared h…

This study aimed to better understand a rare and severe intestinal disease in children called tufting enteropathy. Researchers studied 41 children, from newborns to age 15, who had the disease or were suspected of having it. The goal was to describe the disease in detail and iden…

This study aimed to understand what factors influence how physically active adults with cystic fibrosis are in their daily lives. Researchers tracked 80 stable adult patients for a week using an armband monitor to measure their steps and activity levels. They also collected detai…

This study aimed to understand if a single dose of the antibiotic ertapenem reaches the prostate in high enough amounts to fight bacteria. Researchers measured drug levels in prostate tissue from 20 men undergoing surgery for enlarged prostate, comparing doses given 1 hour versus…

This study aimed to understand how often COVID-19 affects a critical part of the brain called the brainstem in severely ill patients. Researchers observed 52 sedated patients on ventilators in the ICU to measure brainstem function and see if it was linked to worse recovery. The g…

This study aimed to understand if certain proteins in a mother's and baby's blood at birth could predict which very premature babies would develop a serious lung disease called bronchopulmonary dysplasia. Researchers studied 33 babies born very early to mothers with preeclampsia,…

This study measured how burn patients process the antifungal drug caspofungin. Researchers gave a single dose to 2 burn patients and tracked drug levels in their blood over 5 days. The goal was to determine if standard dosing works for burn patients or if adjustments are needed.

This study aimed to understand why children and young adults with Moyamoya disease, a rare condition that causes strokes, often continue to have pain and headaches even after successful brain surgery. Researchers surveyed 21 patients and their parents to explore links between the…

This study aimed to understand how rare diseases affect people's oral health and daily life. Researchers interviewed 28 patients, both children and adults, with various rare conditions at a Paris hospital. The goal was to listen to their personal experiences and challenges, rathe…

This study aimed to find better ways to monitor future treatments for a rare, inherited disease that causes sudden, severe muscle breakdown. Researchers tested 27 patients to see if measurements taken during an exercise test, like oxygen use and heart function, could be useful fo…

This study tested a new prediction tool to help doctors decide when to safely stop dialysis (renal replacement therapy) in intensive care patients with sudden kidney failure. Researchers looked back at the medical records of nearly 6,000 ICU patients to see if a simple score, cal…

This completed study aimed to understand inherited kidney diseases that run in families. Researchers examined 225 adults with unexplained chronic kidney failure and family history of early gout or kidney problems. They collected genetic information and urine samples to identify w…

This study explored what it's like for children to have a parent with cystic fibrosis (CF). Researchers interviewed 27 children aged 6 and older to understand their experiences, feelings, and needs. The goal was to gather information to create better support programs for these fa…

This study aimed to understand how the body's immune system rebuilds itself after a stem cell transplant for blood cancers. Researchers followed 57 patients to see if measuring certain immune cells could predict serious complications like graft-versus-host disease (GVHD) or infec…

This study aimed to understand if low vitamin D levels early in pregnancy are connected to developing preeclampsia, a serious condition involving high blood pressure. Researchers followed over 3,000 pregnant women in France, measuring their vitamin D levels in the first and third…

This study aimed to find out if changing how prescriptions are written makes them easier for older adults to understand. Researchers asked 64 participants over age 75 to fill a pillbox using two different prescription formats—one 'optimized' for clarity and one with typical varia…

This study looked back at the medical records of 50 children who were on breathing machines in intensive care. Researchers wanted to see if using inhaled anesthetic gases for long-term sedation helped reduce the need for other strong sedative and pain medications. The goal was to…

This study aimed to understand how nephronophthisis, a rare genetic kidney disease, progresses over many years. Researchers followed 150 patients with specific gene mutations to track damage to their kidneys and other organs. The goal was to create a clearer picture of the diseas…

This study aimed to find the safest delivery method for twin pregnancies. It followed nearly 9,000 women in France to compare the risks of planned C-sections versus planned vaginal births for both the babies and the mother. The goal was to provide clear guidance to doctors on the…

This study aimed to understand how a specific type of white blood cell, called a neutrophil, behaves in people with granulomatosis with polyangiitis (GPA), a rare autoimmune disease. Researchers studied blood samples from 93 patients to see if changes in these cells could serve a…

This study aimed to gather opinions to guide the development of future AI tools for managing childhood asthma. Researchers asked 307 children with asthma, their parents, and their doctors to rank what goals are most important in daily care. The goal is to use this feedback to bui…

This study aimed to understand the connection between mind wandering (daydreaming) and obsessive thoughts in people with Obsessive-Compulsive Disorder (OCD). Researchers compared 40 students with OCD to 40 students without OCD. They used a new questionnaire to see if obsessive th…

This study observed how families use emergency asthma inhalers when children have symptoms at home. Researchers used smart inhalers to track medication use in 120 children with asthma. The goal was to gather real-world data to help create clearer, more consistent treatment guidel…

This study compared two different ways of organizing hospital networks to treat people with severe injuries. Researchers wanted to see if a new 'inclusive' system, where multiple hospitals work together based on patient needs, leads to fewer deaths within 28 days compared to the …

This study aimed to understand how common depression and anxiety are in teenagers with cystic fibrosis (CF) and their parents. Researchers surveyed 108 participants during routine clinic visits to measure these feelings. The goal was to see if depression or anxiety are linked to …

This study aimed to discover if specific genes cause Chiari malformation type 1, a condition where brain tissue extends into the spinal canal. Researchers analyzed blood samples from 40 people with the condition and their affected family members to look for shared genetic pattern…

This study aimed to understand how hearing aids and cochlear implants affect the daily life quality of children with hearing loss. Researchers gave a questionnaire to parents of 130 children, aged 2 to 10, who had used their devices for at least a month. The goal was to measure a…

This study aimed to create a standard checklist to measure how systemic sclerosis (scleroderma) affects a person's daily life and function. Researchers worked with 113 patients and medical experts to identify the most important challenges people face. The goal was to develop a pr…

This study tested whether training emergency room staff could reduce the number of unnecessary intravenous (IV) catheters placed in patients. Many catheters are inserted 'just in case' but never used, exposing patients to pain and potential complications like infections. The rese…

This study aimed to understand why people with cystic fibrosis (CF) are at higher risk for fragile bones (osteoporosis). Researchers took blood samples from 25 adult CF patients to study specific cells that can break down bone. They also tested in the lab whether CFTR modulator d…

This study observed whether it is effective and helpful for patients to hold their own oxygen mask before receiving general anesthesia for surgery. Researchers enrolled 110 healthy or mildly ill patients to see if this 'self-preoxygenation' successfully prepared their bodies with…

This study aimed to better understand the symptoms and genetic causes of Carney Complex and a related adrenal condition called PPNAD. Researchers followed 133 patients with these conditions or related symptoms for three years, performing regular check-ups and genetic tests. The g…

This study aimed to understand if specific fungi on the skin are linked to atopic dermatitis (eczema), especially on the head and neck. Researchers compared skin and blood samples from 30 adults with eczema to 15 healthy adults. The goal was to map the skin's fungal community and…

This small study aimed to understand how the body's immune system responds to two different types of COVID-19 booster vaccines. Researchers took tiny samples from the lymph nodes of 12 adults who had already received at least three mRNA vaccine doses. They compared a protein-base…

This study aimed to understand how a major spinal surgery affects walking in young patients with severe scoliosis. Researchers observed 6 patients under 18 years old, comparing their walking ability before surgery and again 6 months after. The goal was to gather information to he…

This study looked for a connection between a mother's vitamin D level in early pregnancy and her child's lung health years later. Researchers tested the lung function of 142 children aged 5-6 and compared it to their mothers' vitamin D measurements from pregnancy. The goal was to…

This study looked at why people with Parkinson's disease end up in the hospital through emergency rooms. Researchers examined medical records of 2,580 patients with Parkinson's and compared them to similar patients without the disease. The goal was to identify the main health pro…

This study looked at how different methods for starting labor affect mothers and babies in France. Researchers followed over 3,000 women who had labor induced to compare safety, complications, and outcomes between different induction techniques. They also examined whether doctors…

This study tested a special 3D MRI technique to create detailed maps of nerves in the face and neck of young children. The goal was to see if these maps could help surgeons better plan operations for tumors or birth defects in this delicate area. Seven children aged 1 to 5 who we…

This study aimed to test and validate a new questionnaire designed to measure breathlessness and how it limits daily activities in people with chronic lung diseases. Researchers enrolled 199 adults with conditions like COPD, cystic fibrosis, and pulmonary hypertension to see if t…

This study aimed to understand if differences in gut bacteria and bile acids are linked to coronary artery disease. Researchers compared 80 people undergoing a heart scan, dividing them into those with and without artery plaque. By analyzing stool and blood samples, they looked f…

This study looked at how weight-loss surgery might affect fertility in obese men. Researchers followed 46 men before and after surgery, checking their sperm quality, blood markers, and lifestyle factors. The goal was to understand if surgery improves fertility by measuring change…

This study followed 912 older adults in France who were hospitalized with serious bone fractures from osteoporosis. Researchers tracked these patients for up to 5 years to understand their recovery, how many experienced another serious fracture, and their survival rates. The goal…

This small study aimed to understand why patients with a rare genetic condition called Congenital Disorders of Glycosylation (CDG) sometimes have stroke-like episodes, especially during fevers. Researchers studied blood vessel cells from six patients to see how heat stress affect…

This study aimed to listen to and understand the experiences, needs, and concerns of people with cystic fibrosis (CF) who are parents. Researchers held small group discussions and individual interviews with 52 CF patients and their partners. The goal was to gather their real-life…

This study aimed to understand why aggressive childhood cancers called rhabdoid tumors often stop responding to treatment. Researchers analyzed individual cancer cells from 15 children to map the different cell types within each tumor. The goal was to discover how this cellular d…

This study followed people who called emergency psychological hotlines after major terrorist attacks in Paris, London, Barcelona, and Strasbourg. Researchers wanted to understand how their mental health symptoms changed over time and what kind of help they were looking for. The s…

This study aimed to understand why some women develop fevers during labor and how often these fevers signal a real infection. Researchers followed 422 women at three Paris hospitals who had fevers during childbirth, tracking whether infections were present in mothers or babies. T…

This study aimed to understand how kidney hypodysplasia, a condition where kidneys are small and underdeveloped, runs in families. Researchers collected DNA samples and performed kidney ultrasounds on 342 children with the condition and their family members. The goal was to ident…

This study collected blood samples from pregnant women with and without preeclampsia. The goal was to test a potential new treatment in the lab. The treatment aims to filter a harmful protein from the blood, which might help control the dangerous pregnancy condition.

This study looked at whether tracking levels of a common, harmless virus (TTV) in the blood could help predict infections or organ rejection in heart transplant patients. Researchers followed 60 patients for their first year after transplant, measuring the virus monthly. The goal…

This study analyzed existing medical records to understand how a rare, aggressive type of digestive neuroendocrine tumor behaves and responds to different chemotherapy treatments. Researchers looked at data from 168 adult patients in France who had this specific tumor type. The g…

This study aimed to understand how specific gene mutations affect the survival and disease progression of patients with myelodysplastic syndromes (MDS), a type of bone marrow disorder. Researchers followed 349 newly diagnosed patients for three years, using advanced genetic testi…

This study tested a special training program for 4th-year medical students, designed to help them maintain or improve their empathy and emotional skills. Researchers measured changes in the students' self-reported empathy and emotional intelligence before and after the training. …

This study aims to find out what normal levels of a blood protein called tryptase are in healthy children from birth to age 18. Researchers will test leftover blood samples from 402 children who had routine blood work done during surgery. The goal is to create accurate age-based …

This study tested whether a special type of scan (PET/CT) could show when a serious fungal lung infection was under control earlier than standard scans. Researchers followed 51 patients with blood cancers and this lung infection to see if the PET/CT scan results at 6 weeks could …

This study tested a new questionnaire called ORALQUEST, designed to help doctors better understand feeding and eating problems in young children. Researchers gave the questionnaire to parents of 338 children aged 9 months to 6 years who had chronic health conditions or specific e…

This study aimed to understand how a steroid drug called betamethasone, given to pregnant women at risk of early delivery, passes through the placenta to the baby. Researchers followed 127 women to measure drug levels in mother and baby and see how this transfer relates to the se…

This study aimed to understand what factors lead to serious complications in pregnant women at high risk for a condition called placenta accreta, where the placenta grows too deeply into the uterus. Researchers followed 674 women in France who had a previous C-section and a low-l…

This study aimed to understand how a specific type of white blood cell, called a neutrophil, behaves in people with cystic fibrosis (CF). Researchers compared blood samples from 47 CF patients to samples from healthy donors and patients with other inflammatory diseases. They anal…

This study looked back at medical records for 84 babies diagnosed with a rare fetal tumor called sacrococcygeal teratoma. The goal was to find patterns that could help predict the baby's health risks, both during pregnancy and after birth. Researchers hope this information will h…

This study analyzed blood and urine samples from 100 adults in Paris who reported suspected chemical submission (being drugged without consent). Researchers tested for psychoactive substances to determine how many cases involved actual drugging and which drugs were most commonly …

This study aimed to better understand hemophagocytic syndrome in adults, a rare and often fatal condition where the immune system attacks the body. Researchers collected medical information and samples from 204 patients to identify specific disease features and see if genetic imm…

This study aimed to understand how physical therapy and rehabilitation departments work by interviewing doctors, other health staff, patients, and hospital managers. Researchers talked to 63 people across three departments to identify problems in patient care and communication. T…

This study aimed to understand how cystinosis, a rare genetic disorder, affects muscle strength, breathing, and swallowing in older teens and adults. Researchers followed 20 patients for one year, performing detailed physical tests to track changes in their abilities. The goal wa…

This study aimed to find out how common chronic kidney disease is in teenagers who had surgery to fix a heart defect when they were younger. Researchers tested 120 patients aged 10-15 to check their kidney function. They also looked back at the patients' medical records to see if…

This study looked back at medical records to learn from the early, emergency use of the drug remdesivir in hospitalized COVID-19 patients. Researchers analyzed data from 84 adults across France who received the drug outside of formal trials. The goal was to understand which types…

This study is checking on children who were born very premature and were part of an earlier trial. That trial tested whether a medicine called hydrocortisone could help their lungs. Now, researchers are seeing if that medicine might have affected their blood pressure and heart he…

This study measured how many girls and young women with chronic diseases received the HPV vaccine compared to healthy peers. Researchers surveyed 223 participants aged 11-20 in France to understand vaccination rates and reasons for non-vaccination. The goal was to identify gaps i…

This study tested whether giving parents an information leaflet about fever while waiting in a pediatric emergency room improved their knowledge compared to a standard visit. Researchers enrolled 220 parents of children with fever to see if the leaflet helped them better understa…

This study aimed to understand why children with a severe, painful skin condition called epidermolysis Bullosa (EB) often do not take their prescribed pain medication before their daily, painful bandage changes. Researchers interviewed 10 children and their parents to learn about…

This study aimed to understand how common smell and taste problems are in people with cardiac amyloidosis, a serious heart disease. Researchers tested 51 patients to see if these sensory issues could be an early warning sign that might help doctors diagnose the heart condition so…

This study aimed to understand why some children get many cavities while others get none, by looking for possible genetic causes. Researchers compared saliva samples from 250 children with severe cavities to 160 young adults with no cavities. The goal was to find specific gene ch…

This study looked back at hospital records to understand why some adults with Haemophilus influenzae pneumonia get sick again soon after treatment. Researchers analyzed 203 adult patients treated across 13 hospitals over one year to identify what factors lead to relapse and sever…

This study tested a new method to help doctors decide when to give fluids to very sick babies in shock. Researchers temporarily paused the breathing machine for 15 seconds to see if it could predict whether the baby's heart would respond well to extra fluids. The goal was to avoi…

This study aimed to understand if melanoma skin cancer cells spread to nearby healthy-looking tissue very early in the disease. Researchers analyzed tissue samples from 226 patients with early-stage melanoma to look for hidden cancer cells. They wanted to see if finding these cel…

This study aimed to understand how cervical spondylosis (neck arthritis) affects the structure of the spinal cord. Researchers used a special type of MRI scan on 40 patients with varying symptoms and healthy volunteers to measure damage. They then compared these detailed images t…

This study aimed to better understand and predict which babies diagnosed with a rare lung malformation before birth would have serious breathing trouble after delivery. Researchers followed over 400 pregnant women across France, carefully tracking ultrasound measurements and birt…

This study aimed to understand if variations in a specific gene (ABCB1) are linked to a higher risk of Alzheimer's disease. Researchers compared the genes of 510 people with and without Alzheimer's to see if certain gene patterns were more common in those with the disease. The go…

This study aimed to understand why pregnant women decide to join or refuse a clinical trial about early screening for pre-eclampsia, a serious pregnancy complication. Researchers surveyed 472 eligible women to learn about their reasons and identify any common factors linked to th…

This study aimed to better understand how a rare and severe childhood brain disease, called Metachromatic Leukodystrophy (MLD), damages the brain over time. Researchers used advanced brain scans on 29 young children (some with MLD, some without) to track the disease's progression…

This study aimed to create better mathematical models to predict which patients with severe liver cirrhosis are most likely to die while waiting for a transplant. Researchers analyzed data from 501 patients on the national waitlist, testing new combinations of health measurements…

This study aimed to understand how children's bodies process the heart rhythm drug amiodarone. Researchers followed 57 children aged 0-18 who were already taking the medication. By measuring drug levels in the blood and checking for side effects, they hoped to find the best doses…

This study aimed to find markers that predict how well patients with blood cancers like leukemia and lymphoma respond to immunotherapy, and who might experience severe side effects. Researchers analyzed real-world data from 249 adult patients who received specific immunotherapies…

This study aimed to measure how much of the common pain relievers ibuprofen and ketoprofen pass into breast milk. Researchers tested milk samples from 35 breastfeeding mothers who were taking these medications. The goal was to provide clearer safety information to help doctors ad…

This study looked at whether a common weekly osteoporosis pill (alendronate) affects how well jaw bone heals after a tooth extraction. Researchers followed 66 postmenopausal women with osteoporosis, comparing those taking the drug to those not taking it. They measured bone fillin…

This study aimed to better understand kneecap pain by measuring how people walk and how their leg muscles work. Researchers studied 45 people with chronic kneecap pain, grouping them by different physical characteristics. They used special sensors to track knee motion during walk…

This study aimed to understand how often dangerous iron builds up in the heart of patients who need frequent blood transfusions for conditions like thalassemia, sickle cell disease, or myelodysplasia. Researchers observed 110 patients across 14 centers, using heart and liver MRI …

This study aimed to better understand a specific genetic cause of profound childhood deafness called DFNB9. Researchers followed 150 children with severe hearing loss to collect detailed hearing tests and genetic information. The goal was to create a database to improve diagnosis…

This study aimed to understand if a man's metabolic health—like cholesterol, blood pressure, and blood sugar—is connected to his sperm quality. Researchers examined 170 men from couples having trouble conceiving. They measured sperm counts and various health markers to look for p…

This study aimed to find chemical markers that reveal when an athlete has used their own stored blood for doping. Researchers gave small blood transfusions to healthy, active volunteers and compared their blood samples before and after. The goal was to develop better tests to det…

This study aimed to understand how a specific, potentially more harmful strain of Group B Streptococcus (GBS) bacteria spreads and persists in mothers and their newborn babies. Researchers followed 949 mother-newborn pairs, collecting samples from mothers and babies over 60 days …

This study aimed to understand how sperm quality changes over time in men with spinal cord injuries. Researchers followed 35 men for 18 months, collecting sperm samples to track health and look for factors like infections or inflammation that might cause damage. The goal was to g…

This study aimed to understand pregnancy experiences and outcomes for women with primary immune deficiencies. Researchers followed 99 adult women with these rare genetic immune disorders who had been pregnant. The goal was to gather information on infections, complications, and b…

This study aimed to see if using formal communication procedures helps emergency room patients better understand their medical information. Researchers observed over 1,800 adult patients across 14 French hospitals. Half the hospitals used special communication guidelines, while t…

This study looked at how doctors care for rheumatoid arthritis patients during virtual visits. Researchers first reviewed past telemedicine records to see how patients were assessed. Then, they tested whether having patients fill out a standard symptom questionnaire before their …

This study aimed to understand how a specific genetic mutation (in the MARS gene) causes a rare lung disease called pulmonary alveolar proteinosis (PAP) in children. Researchers compared immune cells from 20 children with and without this mutation to see if their cells could prop…

This study looked at whether patients recover enough from a muscle relaxant used during anesthesia to allow doctors to monitor important voice nerves during thyroid surgery. Researchers followed 50 non-obese adults having thyroid or parathyroid surgery to see if the timing betwee…

This study aimed to understand if people with a rare genetic condition called hypohidrotic ectodermal dysplasia (HED) have worse sleep than others. HED often causes an inability to sweat, which may affect the body's ability to cool down and regulate sleep. Researchers compared sl…

This study aimed to create reference measurements for normal speech patterns in French-speaking children aged 8-10. Researchers used a non-invasive device called a Nasometer to measure how much sound comes through the nose during speech. These reference measurements will help doc…

This study aimed to better understand the experiences of family members and friends who care for people with systemic sclerosis (scleroderma), a rare and serious autoimmune disease. Researchers surveyed 50 caregivers to learn about their quality of life, the challenges they face,…

This study tested a social robot named ARI in a hospital day care unit for older adults. Researchers wanted to see if patients, family members, and hospital staff found the robot acceptable and easy to use. The robot was used for tasks like welcoming people, giving directions, an…

This study aimed to find simpler blood and urine tests to measure how many insulin-producing cells remain in people recently diagnosed with type 1 diabetes. Researchers followed 156 children and adults for 30 months, collecting samples to see if immune cell activity or other mark…

This study aimed to find out if analyzing a person's blood after they survive a cardiac arrest can predict how well their brain will recover. Researchers collected blood samples from 60 patients immediately after hospital admission and again at 1 and 3 days later. They then check…

This study aimed to understand how the body processes the common steroid medication prednisone. Researchers followed 114 adults in Paris who were starting prednisone treatment for various inflammatory conditions. They collected blood samples during routine check-ups over six mont…

This study aimed to understand blood clotting patterns in people with congenital disorders of glycosylation (CDG), a rare genetic condition. Researchers tested 57 patients using advanced blood tests to see if their clotting system is balanced or tilted toward too much or too litt…

This study aimed to understand how adults with sickle cell disease manage their chronic and severe pain. Researchers surveyed 257 patients to learn how often they use strong painkillers (opioids) and cannabis or CBD at home, and to check for signs of addiction. The goal was to ga…

This study aimed to build a national database of children with cancer who also had developmental abnormalities, like birth defects or growth delays. Researchers enrolled 998 participants to look for patterns that might reveal new, inherited genetic syndromes that increase cancer …

This study aimed to understand if high iron levels in the blood are a risk factor for a serious eye condition called retinopathy of prematurity (ROP) in very premature infants. Researchers followed 175 babies born very early or with very low birth weight, measuring their blood ir…

This study aimed to better understand how a specific layer at the back of the eye functions in people with Neurofibromatosis Type 1 (NF1). Researchers tested 30 people with NF1 and some healthy volunteers using specialized eye tests. The goal was to see if the activity of this ey…

This study looked at children and young adults with serious, non-progressive neurological conditions like cerebral palsy or brain injuries. Researchers wanted to understand the best time to involve a pediatric palliative care team to support patients and families. They followed 1…

This study tested a new idea to help patients with severe Acute Respiratory Distress Syndrome (ARDS), a dangerous lung condition. Researchers applied gentle, continuous pressure to the front of the chest to see if it could improve how oxygen moves in the lungs and help the heart …

This study looked back at medical records to understand what factors lead to poor outcomes in patients hospitalized with severe kidney infections. Researchers analyzed data from 575 patients who needed intensive care for acute obstructive pyelonephritis between 2015 and 2022. The…

This study aimed to understand how different treatments affect the overall and sexual quality of life for women with Rokitansky syndrome, a rare condition where the uterus and part of the vagina are absent from birth. Researchers surveyed 138 French women over 18 who had received…

This study aimed to understand how the body's own immune system might be involved in causing or worsening pulmonary arterial hypertension (PAH), a serious condition of high blood pressure in the lungs. Researchers compared blood samples from over 600 people, including patients wi…

This study aimed to create a new questionnaire to measure how autoinflammatory diseases affect patients' quality of life. Researchers interviewed 39 patients and parents across different age groups to understand their daily challenges. The goal is to develop a tool that helps doc…

This study aimed to better understand the relationship between two specific angles inside the human eye. Researchers measured these angles in 70 healthy volunteers with no eye disorders. The goal was to gather basic knowledge to help improve future eye surgeries and clinical exam…

This study aimed to better understand a rare and aggressive type of childhood cancer called rhabdoid tumors. Researchers analyzed protein patterns in tumor samples from 44 children to identify potential new targets for future treatments. The goal was to find better ways to fight …

This study aimed to build a large database by following 708 adults with early inflammatory back pain for over five years. It did not test a treatment but collected detailed health information, scans, and blood samples. The goal was to help researchers better understand how this t…

This study looked back at the medical records of 40 children who received a life support treatment called ECMO. Researchers wanted to understand what brain complications can happen during this treatment and what factors might increase the risk. They also checked on the children's…

This small pilot study aimed to understand how dialysis treatment changes electrical signals measured in a patient's skin and muscle tissue. Researchers followed 18 adults on chronic dialysis, using a painless method to measure these signals before, during, and after their sessio…

This study aimed to discover the genetic and molecular causes of a rare birth defect called Congenital Cystic Adenomatoid Malformation (CCAM), which affects lung development. Researchers analyzed lung tissue samples from 45 children under 8 years old who had surgery to remove the…

This study followed teenagers who were born very premature with low birth weight to see how their lungs developed. Researchers measured their breathing and checked for ongoing problems like asthma. The goal was to understand the long-term effects of being born too early and ident…

This study aimed to understand if a part of the immune system called the 'complement system' is linked to a serious gut complication that can happen after a stem cell transplant. Researchers followed 70 adults who received a transplant for blood cancer, taking regular blood sampl…

This study looked back at 152 infants with rare, solid tumors in their chest, abdomen, or pelvis. The goal was to see how well prenatal scans predict the actual tumor type after birth and to understand how these tumors develop. By analyzing this information, researchers aim to cr…

This study aimed to find out how often blood clots form in the special IV lines placed in children in intensive care. Researchers used bedside ultrasound scans to check for clots in 81 children shortly after the line was placed. The goal was to gather information on how common th…

This study aimed to measure how much of a new antiviral drug called letermovir passes from a pregnant woman to her fetus. It involved 7 women in their second trimester who were already scheduled to end their pregnancies due to fetal abnormalities. Researchers gave the women the d…

This study aimed to validate a French translation of a questionnaire that measures how chronic sinusitis affects children's daily lives. Researchers tested the translated survey on 89 children, both with and without sinusitis, to see if it was reliable and easy to understand. The…

This study tested whether a simple phone checklist could reduce last-minute cancellations for outpatient surgeries. Researchers called over 4,000 patients a few days before their scheduled surgery to review a list of items. The goal was to catch potential problems early, improve …

This study aimed to better understand a rare immune condition called idiopathic CD4 lymphocytopenia (ICL), where patients have low levels of important infection-fighting cells. Researchers observed 47 French patients to describe their symptoms, immune system features, and disease…

This study aimed to understand if patients with advanced cancer would engage in structured discussions to plan their future care if their illness worsened. Researchers offered 71 patients two interviews to assess their wishes and begin these sensitive conversations. The goal was …

This study aimed to understand how children's bodies process and respond to common epilepsy medications. Researchers analyzed data from 753 children with epilepsy to learn how factors like age, weight, and genetics affect drug levels in the blood. The goal was to use this informa…

This study aimed to create normal reference ranges for blood flow in the placenta using MRI scans. It involved 135 women who were ending pregnancies for fetal reasons between 16 and 32 weeks. The goal was to establish a baseline of what 'normal' placental blood flow looks like at…

This study aimed to understand why some heart attacks cause sudden death while others do not. Researchers compared the age and makeup of blood clots collected from 380 people who survived a heart attack and those who died suddenly from a heart blockage. They tested the idea that …

This study looked back at 20 years of medical records for 72 children with a rare and dangerous form of Wilms tumor, a childhood kidney cancer, where the tumor had spread into a major blood vessel. The goal was to analyze past surgeries to find the best techniques and create clea…

This study aimed to understand how inflammation, measured by a blood protein called CRP, changes in people having a severe heart attack. Researchers tracked CRP levels in 35 patients from their first medical contact through their hospital stay after emergency artery-opening surge…

This study looked at whether certain powerful HIV medications taken during pregnancy affect a baby's immune system development at birth. Researchers compared 29 newborns exposed to these newer drugs against babies exposed to older HIV medications. The goal was to gather safety in…

This study aimed to understand how the spine stiffens over time in children with neuromuscular scoliosis who received a specific, less invasive surgery. Researchers used a special ultrasound technique called elastography to measure stiffness in the spinal discs and muscles of 36 …

This study observed 55 adults hospitalized with sudden, severe breathing failure. Researchers measured patients' breathlessness, how well different parts of their lungs were working, and the strength of their main breathing muscle (the diaphragm) over time. The goal was to learn …

This study tested whether an online decision support tool could help young women with breast cancer make more informed choices about preserving their fertility before starting cancer treatment. Researchers compared the online tool against the standard practice of receiving inform…

This study aimed to understand why children's bodies process common steroid medications (like prednisone) so differently from one another. Researchers observed 146 children already receiving these drugs for various conditions to measure drug levels in their blood and look for gen…

This study aimed to understand if a treated urethritis infection could lead to long-term inflammation and stress in the male reproductive tract, which might later affect sperm quality and fertility. Researchers compared 113 men who had been treated for urethritis to a control gro…

This study looked at whether waiting exactly three minutes after giving a standard muscle relaxant (atracurium) provides good conditions for safely placing a breathing tube in obese female patients during surgery. It involved 100 women having scheduled gynecological surgery to ga…

This study aimed to find the best and most cost-effective strategies for hospitals to improve how antibiotics are prescribed. Researchers surveyed 30 French hospitals to understand current practices and used computer models to compare different approaches. The goal was to help ho…

This study aimed to understand how the immune system fights off COVID-19 in people who have few or no symptoms. Researchers followed 57 adults with mild or asymptomatic infections to measure their immune responses and track how quickly they cleared the virus from their bodies. Th…

This study aimed to find the genetic causes of a specific type of congenital diaphragmatic hernia (CDH), a birth defect where there is a hole in the diaphragm muscle. Researchers analyzed the DNA of 73 children with this condition and their parents to look for new genetic changes…

This study looked back at the medical records of 20 children who were hospitalized with a serious heart condition called myocarditis while also having COVID-19. Researchers wanted to describe what happened to these children and figure out if the virus directly damaged their heart…

This study aimed to better understand how our eyes align by measuring specific angles and eye dominance in healthy people. Researchers enrolled 76 volunteers with no eye disorders to take detailed measurements. The goal was to gather basic knowledge that could help improve future…

This study aimed to find early signs that could predict which children with sickle cell disease are most at risk for a life-threatening complication called acute splenic sequestration, where blood gets trapped in the spleen. Researchers followed about 60 infants with sickle cell …

This study aimed to understand why people with Lowe syndrome, a rare genetic disorder, experience unusual bleeding problems. Researchers compared blood samples from 15 patients with Lowe syndrome to 15 healthy individuals to test how well their platelets (blood cells that help wi…

This study aimed to understand how children with a missing or underdeveloped ear (ear aplasia) experience their condition psychologically. Researchers followed 12 children aged 10-16 who were scheduled for reconstructive surgery to rebuild their outer ear. The goal was to learn a…

This study tested a new evaluation plan to check how well parents learn to care for children who need specialized nutrition delivered through a vein at home. Researchers wanted to see if this new assessment was useful for parents and their healthcare team before the child goes ho…

This study aimed to understand how common migraines are in women experiencing infertility and whether the hormone changes during in vitro fertilization (IVF) treatment affect migraine headaches. Researchers surveyed 137 women at a fertility clinic, asking about their headache his…

This study aimed to better understand eosinophilic esophagitis (EoE), a chronic swallowing disorder, by comparing children who have it to those who don't. Researchers analyzed small tissue samples taken during routine medical procedures to count specific immune cells and examine …

This French study followed 574 hospitalized patients with severe liver cirrhosis to understand if factors beyond medical need—like a history of alcohol use—affect who gets placed on the national liver transplant waiting list. Researchers tracked patients for two years, collecting…

This study aimed to understand the personal experiences of teenagers with anorexia nervosa when they are prescribed antidepressant medication. Researchers interviewed 15 adolescents to hear their stories and opinions directly. The goal was to gather insights to help improve care,…

This study looked back at blood test results from 65 children taking HIV medications. The goal was to understand how children's bodies process these drugs differently than adults. Researchers used this data to build models that could help doctors calculate more accurate, personal…

Obesity prevalence rapidly increased in the past decades in French population with multiple health consequences responsible for excess mortality. In the same period of time, the number of bariatric procedures have developed exponentially. Despite its great efficacy on weight loss…

Pulp necrosis is one of the main complication of dental trauma. When it happens on an immature tooth, pulp necrosis implies a lack of root maturation and apical closure. A therapy called apexification is required to induce the formation of a calcified apical barrier allowing a pe…