New protocol aims to save more premature babies from severe complications

NCT ID NCT05248477

Ongoing Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new care protocol (EXPRIM) for extremely preterm infants born between 22 and 26 weeks. The protocol involves early counseling, standardized steroid use, and team-based decisions. Researchers will compare survival without severe health problems in 2377 babies across multiple hospitals. The goal is to see if this organized approach improves outcomes compared to usual care.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: new care protocol (EXPRIM protocol)
What this could lead to: If successful, this could establish a better standard of care for extremely preterm infants, reducing severe complications like brain bleeding or lung disease.
What could go wrong: This is a large trial but tests a complex organizational change, not a drug. Results depend on how well hospitals adopt the protocol, and benefits may vary across centers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTREME PREMATURITY NEWBORN PRETRM INFANTS

Contacts and locations

Locations

Hôpital Cochin

Paris, 75014, France

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