Inside the epileptic brain: scientists hunt for hidden clues in human tissue

NCT ID NCT06022055

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study gathers blood and leftover brain tissue from 300 adults with focal drug-resistant epilepsy who are undergoing surgery. Researchers will analyze the samples using multiple methods — including immune cell staining, electrical recordings, and gene expression — to identify what makes certain brain regions trigger seizures. The goal is to uncover new disease mechanisms that could lead to better treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this research could reveal new biological pathways involved in drug-resistant epilepsy, pointing toward future treatments.
What could go wrong
This is an observational tissue-collection study, not a treatment trial. It may not directly lead to new therapies, and findings may take years to translate into clinical practice.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière Hospital

    RECRUITING

    Paris, 75013, France

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