Blood test may spare kidney transplant patients from painful biopsies

NCT ID NCT06406179

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether a blood test that measures donor DNA (dd-cfDNA) can safely guide follow-up care for kidney transplant patients, potentially reducing the need for invasive biopsies. 500 adult kidney transplant recipients will be randomly assigned to standard care or a strategy where doctors use dd-cfDNA results to decide whether a biopsy is needed. The goal is to see if this approach maintains kidney function while avoiding unnecessary procedures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Donor-derived cell-free DNA (dd-cfDNA) blood test
What this could lead to: If successful, this could reduce the need for invasive biopsies in kidney transplant patients, making monitoring safer and more comfortable.
What could go wrong: This is a Phase 2-like trial with 500 participants, so results may not apply to all patients. The blood test may not catch all rejection cases, and some biopsies may still be needed.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RENAL TRANSPLANTATION

Contacts and locations

Locations

AP-HP - Hôpital Tenon
ACTIVE_NOT_RECRUITING

Paris, France
CHU Toulouse
NOT_YET_RECRUITING

Toulouse, France
Georges Pompidou European Hospital
ACTIVE_NOT_RECRUITING

Paris, 75015, France
Hopital Saint Louis
RECRUITING

Paris, Île-de-France Region, 75010, France
Hôpital Necker-Enfants Malades
ACTIVE_NOT_RECRUITING

Paris, 75015, France
Hôpital de la Salpêtrière hôpital à Paris
RECRUITING

Paris, Île-de-France Region, 75013, France

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