Could your child's penicillin allergy be a mistake? new study tests in-office solution

NCT ID NCT07002814

Recruiting now Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether private practice doctors can safely give children with suspected mild delayed allergies to beta-lactam antibiotics (like amoxicillin) a direct oral challenge. The challenge involves giving the child a small dose of the antibiotic and watching for a reaction. The goal is to see if this approach is feasible in a private practice setting, which could help more children get their allergy labels removed. The study will enroll 200 children aged 0 to 17 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to simpler, in-office allergy testing for children, reducing unnecessary antibiotic avoidance.
What could go wrong: This is a small feasibility study, not a large trial. Results may not apply to all settings, and mild reactions could still occur during the challenge.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

allergic disease drug allergy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALLERGY

Contacts and locations

Locations

Hôpital Necker - Enfants Malades
RECRUITING

Paris, 75015, France

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