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Hidden trigger? study probes whether common chemicals spark tumors in genetically vulnerable people

NCT ID NCT06408402

Recruiting now Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates whether exposure to certain chemicals found in the environment, home, or workplace can increase the risk of developing paraganglioma tumors in people who carry an inherited SDHx gene mutation. Researchers will compare chemical exposure histories between mutation carriers who have developed a tumor and those who have not. The goal is to identify preventable risk factors that could guide future screening or prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If an environmental link is found, this could lead to better prevention advice for people with SDHx mutations.
What could go wrong
This is an observational study, not a treatment trial. It can only show associations, not cause and effect, and results may take years to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary pheochromocytoma-paraganglioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENVIRONMENTAL EXPOSURE SDH GENE MUTATION SDH-RELATED FAMILIAL PARAGANGLIOMA SDHX-RELATED SYNDROMES

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • CHU Bretonneau

    ACTIVE_NOT_RECRUITING

    Tours, 37000, France

  • CHU Jean Minjoz Besançon

    ACTIVE_NOT_RECRUITING

    Besançon, 25030, France

  • CHU d'Angers

    ACTIVE_NOT_RECRUITING

    Angers, 49000, France

  • CHU de Caen

    ACTIVE_NOT_RECRUITING

    Caen, 14033, France

  • CHU de Lille - Hôpital HURIEZ

    ACTIVE_NOT_RECRUITING

    Lille, 59037, France

  • CHU de Montpellier - Hôpital Lapeyronie

    ACTIVE_NOT_RECRUITING

    Montpellier, 34295, France

  • CHU de Nantes

    ACTIVE_NOT_RECRUITING

    Nantes, 44093, France

  • CHU de Nice -Hôpital Archet 2

    ACTIVE_NOT_RECRUITING

    Nice, 06202, France

  • CHU de Poitiers

    ACTIVE_NOT_RECRUITING

    Poitiers, 86021, France

  • CHU de Rennes - Hôpital Sud

    ACTIVE_NOT_RECRUITING

    Rennes, 35000, France

  • CHU de Toulouse - Hôpita Larrey

    ACTIVE_NOT_RECRUITING

    Toulouse, 31059, France

  • Hopital de la Conception - Marseille

    ACTIVE_NOT_RECRUITING

    Marseille, 13385, France

  • Hôpital Cochin - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75014, France

  • Hôpital Louis Pradel

    ACTIVE_NOT_RECRUITING

    Bron, 69677, France

  • Hôpital Michalon - CHU Grenoble

    ACTIVE_NOT_RECRUITING

    Grenoble, 38043, France

  • Hôpital Pitié-Salpêtrière - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75013, France

  • Hôpital européen Georges Pompidou - APHP

    RECRUITING

    Paris, 75015, France

  • Hôpital européen Georges Pompidou - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75015, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpitaux universitaire de Strasbourg - Hôpital de Hautepierre

    ACTIVE_NOT_RECRUITING

    Strasbourg, 67098, France

  • Institut Gustave Roussy

    ACTIVE_NOT_RECRUITING

    Villejuif, 94805, France

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