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Hidden trigger? study probes whether common chemicals spark tumors in genetically vulnerable people

NCT ID NCT06408402

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study investigates whether exposure to certain chemicals found in the environment, home, or workplace can increase the risk of developing paraganglioma tumors in people who carry an inherited SDHx gene mutation. Researchers will compare chemical exposure histories between mutation carriers who have developed a tumor and those who have not. The goal is to identify preventable risk factors that could guide future screening or prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If an environmental link is found, this could lead to better prevention advice for people with SDHx mutations.
What could go wrong
This is an observational study, not a treatment trial. It can only show associations, not cause and effect, and results may take years to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,300 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

650 cases and 650 controls will be enrolled in different French referral centers where they are regularly managed and followed for a SDHx-related tumor risk. They will be matched on their date of birth

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor * Controls: SDHx mutation carriers with no SDHx-related tumor Exclusion Criteria: * Incapacity to exercise free and informed consent for the study * Patient under tutorship or guardianship or legal safeguard

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Conditions

The condition(s) this trial relates to.

hereditary pheochromocytoma-paraganglioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Environmental exposure SDH gene mutation SDH-related familial paraganglioma SDHX-related syndromes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Bretonneau

    ACTIVE_NOT_RECRUITING

    Tours, 37000, France

  • CHU Jean Minjoz Besançon

    ACTIVE_NOT_RECRUITING

    Besançon, 25030, France

  • CHU d'Angers

    ACTIVE_NOT_RECRUITING

    Angers, 49000, France

  • CHU de Caen

    ACTIVE_NOT_RECRUITING

    Caen, 14033, France

  • CHU de Lille - Hôpital HURIEZ

    ACTIVE_NOT_RECRUITING

    Lille, 59037, France

  • CHU de Montpellier - Hôpital Lapeyronie

    ACTIVE_NOT_RECRUITING

    Montpellier, 34295, France

  • CHU de Nantes

    ACTIVE_NOT_RECRUITING

    Nantes, 44093, France

  • CHU de Nice -Hôpital Archet 2

    ACTIVE_NOT_RECRUITING

    Nice, 06202, France

  • CHU de Poitiers

    ACTIVE_NOT_RECRUITING

    Poitiers, 86021, France

  • CHU de Rennes - Hôpital Sud

    ACTIVE_NOT_RECRUITING

    Rennes, 35000, France

  • CHU de Toulouse - Hôpita Larrey

    ACTIVE_NOT_RECRUITING

    Toulouse, 31059, France

  • Hopital de la Conception - Marseille

    ACTIVE_NOT_RECRUITING

    Marseille, 13385, France

  • Hôpital Cochin - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75014, France

  • Hôpital Louis Pradel

    ACTIVE_NOT_RECRUITING

    Bron, 69677, France

  • Hôpital Michalon - CHU Grenoble

    ACTIVE_NOT_RECRUITING

    Grenoble, 38043, France

  • Hôpital Pitié-Salpêtrière - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75013, France

  • Hôpital européen Georges Pompidou - APHP

    RECRUITING

    Paris, 75015, France

  • Hôpital européen Georges Pompidou - APHP

    ACTIVE_NOT_RECRUITING

    Paris, 75015, France

  • Hôpitaux universitaire de Strasbourg - Hôpital de Hautepierre

    ACTIVE_NOT_RECRUITING

    Strasbourg, 67098, France

  • Institut Gustave Roussy

    ACTIVE_NOT_RECRUITING

    Villejuif, 94805, France

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