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Can a simple protein improve recovery from heated chemo surgery?

NCT ID NCT06351475

Recruiting now Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a protein called albumin to standard IV fluids during a major cancer surgery (cytoreduction with heated chemotherapy) can reduce complications. 140 adults undergoing this surgery will be randomly assigned to receive either standard fluids or standard fluids plus albumin. The main goal is to see if the albumin group has fewer complications 28 days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
20% human albumin
What this could lead to
If it works, this could lead to a safer fluid management strategy during complex cancer surgery, reducing postoperative complications.
What could go wrong
This is a relatively small, early-stage trial (140 patients) testing a well-known drug in a new setting. The benefit may be small or not seen at all, and albumin is expensive with potential allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

peritoneal carcinomatosis peritoneal neoplasm Postoperative Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FLUID THERAPY HYPERTHERMIC INTRAPERITONEAL CHEMOTHERAPY INTRAOPERATIVE CARE PERITONEAL NEOPLASMS POSTOPERATIVE COMPLICATIONS

Contacts and locations

Locations

  • Gustave Roussy Institute

    RECRUITING

    Villejuif, France

  • Hôpital Hautepierre / UIC ARMO

    RECRUITING

    Strasbourg, France

  • Institut régional du Cancer de Montpellier

    RECRUITING

    Montpellier, France

  • La Pitié Salpetriere hospital

    RECRUITING

    Paris, 75013, France

  • Lariboisière hospital

    RECRUITING

    Paris, France

  • Robert Debré hospital

    RECRUITING

    Reims, France

  • Saint Louis hospital

    RECRUITING

    Paris, France

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