Mayo Clinic

This study is for people with advanced liver cancer that cannot be surgically removed. It tests whether giving a special immune cell treatment (made from the patient's own blood) along with a pneumonia vaccine and immunotherapy drugs after high-dose radiation is safe and can help…

This early-stage study tests a new treatment for ovarian cancer that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells (T cells) that are trained in a lab to recognize and attack a protein called MUC1 found on cancer cells. The ma…

This study tests whether training the muscles used for breathing in can improve exercise ability, quality of life, and short-term health in people who have had a lung transplant. About 30 participants will be randomly assigned to either a breathing training program or standard ca…

This study compares two types of heart pacing for people with heart failure: one guided by artificial intelligence (AI) and one using the standard method. The goal is to see if the AI-guided approach improves the heart's pumping ability more. About 224 adults with heart failure w…

This study is testing whether a single or repeated infusion of donor stem cells is safe for people with chronic kidney disease, including those who have had a kidney transplant. The stem cells are taken from bone marrow and given through a vein or directly into the kidney arterie…

This early-phase trial tests a modified measles virus (MV-s-NAP) injected directly into tumors of people with metastatic breast cancer. The virus is designed to kill cancer cells and boost the immune system. Researchers aim to find the safest dose and see if it shrinks tumors, bo…

This study tests whether a procedure called therapeutic plasma exchange (TPE) can make standard cancer drugs work again for people with advanced bladder or urinary tract cancer that has stopped responding to treatment. TPE filters the blood to remove certain components, then retu…

This study compares a reduced dose of radiation (3 treatments) against the standard 12 treatments for people with indolent non-Hodgkin lymphoma, a slow-growing blood cancer. The goal is to see if the shorter course is safer and still controls the disease. About 112 adults with ce…

This study tests a new drug (BMS-986340) combined with immunotherapy (nivolumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in people with advanced pancreatic cancer that has spread or returned. The goal is to see if the combination is safe and shrinks tumors. Ab…

This study tests whether the Mayo Clinic Diet helps people with obesity lose at least 5% of their body weight compared to standard care. Researchers will follow 250 adults for up to a year to see how well the diet works, what barriers people face, and whether weight loss lasts. T…

This study tests a shorter course of radiation (hypofractionated radiotherapy) given either before or after breast surgery for non-metastatic breast cancer. The goal is to see if giving radiation before surgery reduces side effects and treatment time while still being effective. …

This study tests whether using a patient's own continuous glucose monitor (CGM) during a hospital stay can help doctors and nurses give better insulin doses. About 150 adults with diabetes who already use a CGM at home will be enrolled. The goal is to reduce dangerous high and lo…

This early study tests a new pill called onvansertib for people with certain blood cancers (CMML or MDS/MPN) that have returned or stopped responding to other treatments. The goal is to find a safe dose and see if the drug can help control the cancer. About 25 adults will take pa…

This study compares two treatments for people with early-stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are at high risk of their disease getting worse. One group gets acalabrutinib alone, the other gets acalabrutinib plus obinutuzumab. The goal …

This study tests whether taking three oral drugs (methotrexate, erlotinib, and celecoxib) together is safe and practical for people with head and neck cancer that has come back or spread. The trial enrolls 25 adults in the rural Midwest and uses virtual visits to reduce travel bu…

This study tests a cryotherapy spray (Tru-Freeze) to treat gastric antral vascular ectasia (GAVE), a condition that causes bleeding in the stomach. Researchers will measure changes in hemoglobin levels and blood transfusion needs in 50 participants over 6 months. The goal is to s…

This study offers boys aged 0-17 the chance to freeze testicular tissue before starting treatments like chemotherapy or radiation that could cause infertility. The goal is to use this tissue later to help them have biological children. Researchers will track how many pregnancies …

This study tests whether the drug avacopan, combined with a low-dose steroid, can help people with a severe form of IgA nephropathy (a kidney disease). The goal is to reduce protein in the urine and protect kidney function. About 16 adults with active disease and high risk of wor…

This early-stage trial tests whether adding Tumor Treatment Fields (TTF) – a device that sends low-intensity electric fields to the tumor – to a three-drug chemotherapy regimen can help control metastatic pancreatic cancer. About 40 adults whose cancer has spread to the liver wil…

This early-stage trial is testing a drug called venetoclax alongside standard treatments for people with a specific genetic type of multiple myeloma (t(11;14)). The goal is to find the safest dose and see if the combination can better control the cancer. About 100 adults with act…

This early-stage trial tests if stem cells taken from body fat are safe for people with glioblastoma or astrocytoma that has returned after standard treatment. About 20 adults will receive the cells directly into the brain during surgery. The goal is to find the best dose and see…

This trial tests a procedure called TULSA that uses MRI-guided sound waves to heat and destroy prostate cancer cells. It is for men aged 45-80 with low to intermediate grade prostate cancer that hasn't spread. The goal is to see if this approach can control the cancer while helpi…

This study tests whether giving two drugs—golcadomide and rituximab—before CAR-T cell therapy can help control aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The goal is to keep the disease in check so more patients can qualify for and rec…

This study tests whether a smartphone app called FAITH! can help African-American adults with uncontrolled high blood pressure lower their numbers and improve heart-healthy habits. About 100 participants will use the app or receive standard care, and their blood pressure will be …

This study tests a low dose of osilodrostat in 15 adults with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. The goal is to see if the drug is safe and how it affects cortisol levels over 24 hours. Participants must have had abnorma…

This early-stage study looks at how the body processes a drug called avacopan in people with a rare autoimmune disease (ANCA vasculitis) that causes severe bleeding in the lungs. Only 6 patients who need a breathing machine will take the drug through a feeding tube. The goal is t…

This study tests a standard treatment of two drugs (enfortumab vedotin and pembrolizumab) followed by surgery to remove part or all of the bladder or urinary tract in people with advanced bladder cancer that has spread. The goal is to see if this approach helps patients live long…

This early-stage trial tests a specially modified virus (VSV-hIFNβ-NIS) combined with two immunotherapy drugs (ipilimumab and cemiplimab) in adults with relapsed or refractory T-cell lymphoma. The virus is designed to kill cancer cells while leaving healthy cells alone, and the i…

This study tests whether a blood test (NavDx) can help doctors decide the right amount of radiation for people with HPV-related throat cancer. The goal is to give enough treatment to control the cancer while reducing side effects. About 455 adults with certain stages of throat ca…

This study looks at whether a structured Mediterranean diet can help people who have had a liver transplant avoid gaining too much weight and keep their heart and new liver healthy. About 80 adults who recently received a liver transplant will follow a special diet plan. The goal…

This early-phase study tests whether giving a single, precise dose of radiation before surgery can improve control of high-grade gliomas (aggressive brain tumors) while reducing side effects. About 28 adults with newly diagnosed or previously biopsied high-grade glioma will recei…

This study tests a combination of three drugs (acalabrutinib, venetoclax, and durvalumab) in people with Richter transformation, a rare and fast-growing lymphoma that can develop from chronic lymphocytic leukemia (CLL). The goal is to see if this treatment can help control the di…

This early-phase trial tests a genetically modified virus (VSV-IFNβ-NIS) alone or with chemotherapy and immunotherapy drugs in people with blood cancers like multiple myeloma, acute myeloid leukemia, and lymphomas that have returned or not responded to treatment. The virus is des…

This study is testing whether a special clinic focused on heart health and weight management can help obese adults with heart disease lose weight and improve their health. Researchers will track weight, body mass index, and belly fat over 12 months. The study involves 60 particip…

This study looks at how often high blood pressure happens in people with B-cell blood cancers (like CLL or lymphoma) who are taking a type of targeted drug called a BTK inhibitor. The goal is to see if carefully managing that high blood pressure can prevent serious heart problems…

This study tests whether placing two small tubes (stents) into the gallbladder is better than one at preventing repeat gallbladder attacks in people who cannot have their gallbladder removed. About 30 adults with gallbladder inflammation or pain will be randomly assigned to get o…

This study tests different doses and schedules of belantamab mafodotin, a targeted therapy for multiple myeloma that has returned or not responded to prior treatments. The goal is to find a dosing plan that reduces serious eye problems while still controlling the cancer. About 62…

This early-stage trial tests whether combining a targeted liver radiation procedure (Y90 radioembolization) with two immunotherapy drugs (durvalumab and tremelimumab) is safe and shows promise for people with bile duct cancer that cannot be surgically removed. The study enrolls 1…

This study looks at whether a 12-week barbell strength training program can lower blood pressure and improve cholesterol in adults who are not very active. Researchers at Mayo Clinic will enroll 200 people aged 18-100 who do little to no exercise. Participants will do three super…

This study looks at whether a weight loss procedure called Endoscopic Sleeve Gastroplasty (ESG) is safe and effective for people with ulcerative colitis (UC) who are obese and need or have had colon removal surgery. About 12 participants will be enrolled. The goal is to help them…

This study is for people with high-risk prostate cancer that has spread to a few other spots. It tests whether giving less hormone therapy (based on each person's risk) along with radiation can control the cancer just as well as the standard longer hormone therapy. The goal is to…

This study looks at a device called the Coronary Sinus Reducer in people with heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD). The device is implanted to improve blood flow to the heart muscle. Researchers will use MRI scans to …

This study is for people with metastatic breast cancer whose disease has started to grow in a few spots while on a working treatment. It tests whether precisely targeted radiation to those spots can delay the need to switch to a different drug. The study will also look at whether…

This study tests whether a drug called sacubitril-valsartan can improve heart structure and function in adults with congenital heart disease. About 45 participants will receive either the drug or a placebo. Researchers will measure changes in heart imaging, blood markers, and qua…

This study tests whether offering financial rewards to both a smoker and a family member can help Alaska Native and American Indian adults quit smoking. About 1,312 participants will be randomly assigned to receive the family-based incentive or standard support. Success will be m…

This early-stage study tests whether it is possible to safely transplant a kidney and a bladder together in one surgery. It includes up to 30 people aged 1 to 60 who have chronic kidney disease and bladder problems. The main goal is to see if the new bladder works well and stays …

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors. The goal is to see if this combination is safe and helps the immune system fight cancer more effectively. A…

This study tests two drugs, GI-102 and pembrolizumab, given before surgery to people whose aggressive brain cancer (glioblastoma) has returned. The goal is to see if these drugs can shrink the tumor and help the immune system fight the cancer. About 36 adults will take part, and …

This study tests two immunotherapy drugs, efineptakin alfa and pembrolizumab, in people whose glioblastoma has returned after standard treatment. The goal is to see if this combination can help the immune system attack the tumor and improve survival. About 54 adults with recurren…

This program offers the drug ibudilast to people with ALS who cannot join other clinical trials. The goal is to see if ibudilast can slow down the disease. Participants must meet specific criteria, such as being over 18 and diagnosed with ALS.

This study tests if a smartphone app called SmartWell24 can help people with obstructive sleep apnea use their CPAP machine for at least 6 hours a night, 6 nights a week. Researchers will track CPAP usage and quality of life in 40 adults newly diagnosed with sleep apnea. The goal…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method uses standard doses but chooses them based on the patient's kidney function. The main goal is to see if this approach is easy for doctors to use and if it h…

This study tests whether a precise, short-course radiation therapy (SBRT) works as well as a slightly longer radiation approach (hypofractionated radiotherapy) for prostate cancer that has come back or spread to a few spots after surgery. About 118 men with low PSA levels will be…

This early study tests the safety and feasibility of combining four drugs (dasatinib, quercetin, fisetin, and temozolomide) for people with glioma that has residual disease after prior treatment. The goal is to see if this approach can be tailored to each patient. Ten adults with…

This study is testing a new way to deliver radiation called minibeam therapy for people with skin or soft tissue tumors that have come back or spread. The approach uses a special device to split a wide radiation beam into many tiny beams, which may allow higher doses to the tumor…

This study tests whether tadalafil, a drug that relaxes blood vessels, can improve blood flow and organ function in adults who had Fontan surgery for a single-ventricle heart defect. About 80 participants will receive either tadalafil or a placebo for several months. The goal is …

This early-phase study tests a drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goal is to find the safest dose and check for side effects. About 94 adults with recurrent g…

This study tests whether a continuous glucose monitor (CGM) can help people with glioblastoma manage their blood sugar and possibly live longer. High blood sugar during treatment is linked to worse outcomes, and steroids often cause it. The CGM device tracks glucose in real time,…

This study tests a new treatment for ovarian cancer that has returned after initial therapy. It combines a personalized dendritic cell vaccine (made from the patient's own blood cells) with the immunotherapy drug pembrolizumab. The goal is to safely boost the immune system to rec…

This study tests a drug called daratumumab for people with a rare kidney disease called PGNMID. The goal is to see if it can reduce protein in the urine and help the kidneys work better. About 40 adults with confirmed PGNMID and high urine protein levels will take part. The drug …

This study tests whether a combination eye drop (Rocklatan) lowers eye pressure better over a full day than a standard drop (Latanoprost) in people with open-angle glaucoma or high eye pressure. About 30 adults will use one drop of each medicine in different eyes nightly. The goa…

This study tests a drug called enfortumab vedotin for people with penile cancer that has spread or cannot be removed by surgery. The drug targets a protein on cancer cells to deliver a toxin that kills them. About 28 adults will take part to see if the drug can shrink tumors and …

This study tests whether starting plasma exchange early, rather than waiting as a rescue option, leads to better vision in severe optic neuritis and better mobility in severe transverse myelitis. About 382 adults with these inflammatory nerve conditions will be randomly assigned …

This study tests whether a mobile app can help people with glioma (a type of brain tumor) receive care and monitoring at home instead of traveling to a clinic. The goal is to make it easier for patients to stay connected with their care team and complete treatment. About 120 adul…

This study tests a treatment for unborn babies with severe kidney problems that cause low amniotic fluid, leading to underdeveloped lungs. Doctors will repeatedly add a sterile fluid into the womb to help the baby's lungs grow. The goal is to help these newborns survive long enou…

This study tests whether turkey tail mushrooms can slow or shrink breast tumors in post-menopausal women with a common type of breast cancer (HER2-negative, ER-positive). About 40 women will take the mushroom supplement between diagnosis and surgery. The main goal is to see if th…

This study tests a new drug called MTI-301 in people with advanced solid cancers that have spread or can't be removed by surgery and haven't responded to standard treatments. The drug blocks an enzyme (SCD1) that helps cancer grow. The main goals are to find the safest dose and c…

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab) plus standard chemotherapy. The goal is to see if this approach shri…

This study compares two common antibiotics, azithromycin and doxycycline, in adults hospitalized with community-acquired pneumonia who are also receiving beta-lactam antibiotics. The goal is to see which one helps patients leave the hospital sooner and reduces complications. Abou…

This early-stage trial tests a new treatment called sonodynamic therapy for people with glioblastoma that has come back or is getting worse. The treatment combines a drug (5-ALA) that makes tumor cells sensitive to sound waves, with focused ultrasound waves that target and destro…

This study tests a drug called PLX038 in people with ovarian, peritoneal, or fallopian tube cancer that has spread and no longer responds to platinum chemotherapy. The goal is to see if PLX038 can shrink tumors by blocking enzymes that help cancer cells grow. About 43 adults with…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor (meningioma) that cannot be surgically removed and has continued to grow after radiation therapy. The drug is given through a vein and aims to kill tumor cells. The goal is to see if it can…

This study is for people with pancreatic cancer that has spread to the lining of the abdomen. Doctors are testing a treatment called HIPEC, where heated chemotherapy drugs are placed directly into the belly during surgery. The goal is to see if this approach can help people live …

This study is for people with stage I to III esophageal or gastroesophageal junction cancer. It tests a shorter, higher-dose radiation schedule given with chemotherapy (FOLFOX) before surgery. The goal is to see if this approach can destroy more tumor cells and improve outcomes. …

This early-stage trial tests a new drug called Q702 in people with certain blood cancers and related diseases that have not responded to other treatments. The drug works by helping the immune system attack cancer cells and supporting normal blood cell production. The study aims t…

This study tests a vaccine made from a patient's own white blood cells, designed to train the immune system to attack ovarian cancer cells. It is for people with advanced stage III or IV ovarian, fallopian tube, or primary peritoneal cancer. The goal is to see if the vaccine can …

This study tests a new way of giving the chemotherapy drug capecitabine to people with metastatic ER+ breast cancer. Instead of a fixed dose, the dose is adjusted based on how the tumor responds on scans and blood tests. The goal is to control the cancer for as long as possible w…

This study is for people with prostate cancer that has returned after treatment and spread to other parts of the body. Researchers are testing whether focused radiation (SBRT) alone works as well as combining it with hormone-blocking drugs. They also want to see if giving radiati…

This study tests whether the drug ibrutinib can prevent chronic graft-versus-host disease (GVHD) in people who have received a donor stem cell transplant. Chronic GVHD is a common complication where donor cells attack the patient's body. Ibrutinib blocks a protein that activates …

This study tests whether a simple saliva test can predict how well people with obesity will respond to the weight-loss drug semaglutide. Researchers will compare weight loss in participants who have a specific biomarker in their saliva versus those who don't. The goal is to make …

This study tests a combination of four drugs (iberdomide, daratumumab, elotuzumab, and dexamethasone) in people whose multiple myeloma has returned after previous treatment. The goal is to find the safest dose and see how well the drugs work together to shrink or control the canc…

This study tests a new MRI technique called 3D DL oZTEo to see if it can better find bone erosions in the hands of people with inflammatory arthritis. About 25 adults who already need a hand MRI will take part. The goal is to improve how doctors detect bone changes that affect tr…

This study tests whether using artificial intelligence (AI) with a simple ECG and a focused heart ultrasound can help find heart disease in people who don't yet have symptoms. About 19,300 participants, including teens, adults, and pregnant women, will be screened. The goal is to…

This study tests a new imaging method called vibro-acoustography to find and tell apart benign and cancerous thyroid nodules. Researchers at Mayo Clinic will compare this technique to standard ultrasound in 650 people suspected of thyroid cancer. The goal is to improve diagnosis …

This study is testing a new blood and urine test that looks for DNA markers to detect cancer early and identify where it started. Researchers at Mayo Clinic will enroll about 6,150 people, including those with and without cancer. The goal is to see if this simple test can accurat…

This study tests whether adding a special amino acid PET/CT scan to standard imaging helps doctors better manage brain tumors in over half of cases. About 47 adults with brain tumors will receive the extra scan. The goal is to see if the new scan provides clearer information to g…

This study looks at whether a stool DNA test can accurately detect colorectal cancer or pre-cancerous growths in people with Lynch syndrome, a genetic condition that raises cancer risk. Researchers will collect blood and stool samples from 750 adults with Lynch syndrome or early-…

This study tests a pill-sized sponge on a string that people swallow to collect cells from the esophagus. The sample is then checked for signs of Barrett's esophagus, a condition that can lead to cancer. The goal is to see if this simple, low-cost method works as well as a standa…

This study tests a new, noninvasive exercise MRI technique to better diagnose and understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but still fails. Researchers will enroll 400 people, including those with HFpEF, those w…

This study tests whether a new type of PET/MRI scan can accurately detect if prostate cancer has spread to nearby lymph nodes. About 50 men with high-risk prostate cancer who are scheduled for prostate removal surgery will receive this scan beforehand. The goal is to see if the s…

This study tests new AI image-processing techniques to improve MRI scans for pelvic abnormalities like prostate and endometrial issues. Researchers want to see if these methods can produce clearer images in less time than current standard scans. The study involves 60 adults and a…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers by looking for specific DNA markers in vaginal fluid or blood. Researchers at Mayo Clinic will collect samples from over 3,000 women to see how well the test works. The goal is to make cance…

This study is testing whether new tests on blood, stool, and cyst fluid can find early signs of cancer in pancreatic cysts. Researchers will collect samples from 800 people with pancreatic cysts and check how accurate these tests are. The goal is to improve early detection and he…

This study tests a fluorescent dye called pafolacianine that makes tumor cells glow under a special camera during surgery. It aims to help surgeons more accurately find and remove solid tumors in children aged 6 months to 17 years. The dye targets a protein common on many cancer …

This study tests whether a special PET/MRI scan can find small pituitary tumors that standard MRI cannot see. About 5 adults with certain hormone disorders will receive the scan. If a tumor is found, surgery may be offered. The goal is to improve detection and guide treatment dec…

This study is testing a new, less invasive way to diagnose Barrett's esophagus and early esophageal cancer using a sponge capsule device. Participants swallow the capsule, which collects cells from the esophagus for analysis. The goal is to see if this method is accurate and safe…

This study tests whether taking a short course of hormone therapy (relugolix) before a PSMA PET/CT scan can make the scan better at finding prostate cancer that has spread. About 30 men with high-risk prostate cancer will get the hormone drug for 5, 10, or 15 days before their sc…

This study tests a new 3D ultrasound method to see if it can better diagnose breast lumps. About 125 women with solid breast lesions will get both standard and 3D ultrasound before their biopsy. The goal is to improve accuracy and reduce unnecessary procedures.

This study is testing a new way to use ultrasound during surgery to help doctors find pituitary adenomas (small tumors) in people with Cushing's disease and other pituitary tumors. About 110 adults having surgery through the nose will get a special contrast-enhanced ultrasound. T…

This study tests whether artificial intelligence (AI) can help doctors interpret heart ultrasound (echo) images more accurately and quickly. Researchers at Mayo Clinic will deploy AI tools to assist in diagnosing conditions like cardiomyopathy, coronary artery disease, and cardia…

This study tests whether a special PET scan using GA-68 PSMA-11 can tell the difference between a brain tumor coming back and harmless changes from past treatment. About 25 adults with aggressive gliomas who already need surgery will get this scan first. If it works, it could hel…

This study tests an artificial intelligence tool that helps doctors figure out if a narrowed bile duct is cancerous or not during a routine scope procedure. About 100 adults will take part. The AI analyzes live video from the scope to give an instant opinion, aiming to improve ac…

This study tests a new type of PET/CT scan called 18F-TFB to see if it can find thyroid cancer that has returned or spread. About 24 adults with papillary or follicular thyroid cancer will get this scan in addition to their usual iodine scan. The goal is to see if the new scan gi…

This study tests a new 3D ultrasound technology to see if it can better tell if lymph nodes in breast cancer patients are cancerous or not. About 55 adults who already need a lymph node biopsy or have a clip placed will get the new scan. The goal is to see if 3D ultrasound is mor…

This study is testing a new ultrasound technique called ultrasound microvessel imaging (UMI) to see if it can better detect small blood vessels in ovarian growths. Current methods often miss early signs of cancer. About 40 women who are already scheduled for surgery for ovarian l…

This study tests a special PET scan that uses a radioactive tracer to find early scarring in the small bowel of people with Crohn's disease. About 45 adults with Crohn's will be scanned to see if the tracer can spot fibrosis before it causes a blockage. The goal is to improve dia…

This study tests a new MRI technique to measure how cerebrospinal fluid (CSF) flows in the brain. Researchers will compare 50 healthy volunteers and patients with conditions like Alzheimer's disease or normal pressure hydrocephalus. The goal is to improve diagnosis and understand…

This study aims to develop a new, noninvasive ultrasound technique to detect peripheral arterial disease (PAD) earlier and monitor how the disease changes over time or after treatment. Researchers at Mayo Clinic will enroll 400 adults, including those with PAD symptoms and health…

This study tests whether taking low-dose aspirin can reduce inflammation and lower the risk of breast cancer in women who have given birth within the last 10 years. About 60 women planning a breast biopsy will take aspirin and have blood and tissue samples checked for changes in …

This study tests whether a structured home exercise plan focused on balance and strength can help people in cardiac rehabilitation improve their physical function and reduce their risk of falling. Researchers will measure changes in balance confidence, quality of life, and fall r…

This study aims to reduce colorectal cancer disparities by providing free, home-based screening tests and education to Black and underserved communities in the Phoenix area. About 450 people aged 45 or older who have not had a recent colonoscopy or stool test will participate. Th…

This early-phase trial is testing whether eating magnesium-rich foods and applying magnesium lotion can help lymphoma patients keep their magnesium levels in a healthy range. About 60 adults with lymphoma will try this approach for up to 12 weeks. Researchers will also check for …

This pilot study tests whether using a neck traction device at home can help people with neuropathic itch (itching caused by nerve issues) reduce their dose of gabapentin or pregabalin. The study will enroll 12 adults who have had a stable dose of these medications for at least 4…

This study looks at whether giving cancer treatment at home instead of in a clinic is safer and more satisfying for Black men with advanced or metastatic prostate cancer. About 38 participants will receive therapy both at home and in the clinic to compare side effects, quality of…

This study tests different doses of a medicine called dexmedetomidine to find the best one for stopping shivering in women having planned cesarean deliveries. Shivering is a common and uncomfortable side effect during and after C-sections. The goal is to stop shivering in 90% of …

This study looks at whether adding a minimally invasive hip procedure (arthroscopy) during a standard hip realignment surgery (PAO) helps people with hip dysplasia recover better. About 106 participants aged 15 to 55 with mild or no arthritis will be followed. The goal is to see …

This study tests whether a lifestyle behavior program can help people with chronic migraine have fewer and less severe headaches. Researchers will also look for biological markers linked to improvement. The goal is to see if this approach is practical and liked by participants, w…

This study tests whether wearing noise-cancelling headphones with music or a movie can help people stay calm and need less sedation during knee replacement surgery done with spinal anesthesia. About 200 adults having their first knee replacement will take part. The goal is to see…

This study tests whether two radiation treatments with adaptive technology cause fewer side effects than the usual five treatments for men with localized prostate cancer. About 144 participants will receive either the shorter or standard approach. The goal is to see if the shorte…

This study looks at whether a steroid called prednisone can help reduce pain after a procedure to remove kidney stones (ureteroscopy). About 90 adults who are having this surgery and getting a stent placed will be given prednisone along with their usual pain medicines. The goal i…

This study compares giving oral methadone before heart surgery versus intravenous methadone during anesthesia to see which better controls pain afterward. About 100 adults having elective heart surgery will take part at Mayo Clinic. The goal is to reduce the total amount of opioi…

This pilot study from Mayo Clinic tests whether virtual reality (VR) can safely reduce abdominal pain in people with Crohn's disease who are not currently experiencing active inflammation. The study will enroll 15 participants who have ongoing pain despite normal inflammation mar…

This study tests whether a new AI-assisted program, called Reflections: My Story, is practical and acceptable for people with serious illness. The program helps participants create a personal legacy, like a life story, to ease emotional distress. About 40 adults with a high-risk …

This study tests whether the drug pyridostigmine can improve symptoms of postural tachycardia syndrome (POTS), a condition that causes a rapid heart rate and dizziness when standing. Researchers will compare the drug to a placebo over 3 days in 50 adults with POTS. The goal is to…

This study tests whether pairing vagus nerve stimulation (a mild electrical pulse) with mobility training can help people who had a stroke at least 6 months ago walk faster and more safely. About 20 participants will receive the therapy in clinic. Researchers will track side effe…

This study tests whether injecting lidocaine around the sciatic nerve in the intact leg can reduce phantom or residual limb pain in people with lower-limb amputations. About 20 adults who have had pain for over 6 months despite other treatments will receive either the injection o…

This study looks at whether adding a saltwater rinse through a chest tube can help people with infected fluid around the lungs. Researchers will compare the standard treatment alone to standard treatment plus the rinse. About 60 adults with a confirmed or suspected pleural infect…

This study tests whether a custom 3D-printed external breast prosthesis feels better and fits better than standard options for people who had a breast removed (mastectomy) but did not have reconstruction. About 50 adults will receive a personalized prosthesis made from a 3D scan …

This study tests if a digital hypnotherapy program can reduce stomach symptoms like pain, bloating, and nausea. About 100 adults with upper gut disorders will use the program and report their symptom changes. The goal is to see if this mind-focused approach offers real relief wit…

This study from Mayo Clinic aims to better understand a type of constipation called dyssynergic defecation, where the muscles don't work together properly during a bowel movement. Researchers will test improved biofeedback treatments to help people retrain those muscles. The stud…

This study tests whether adding virtual reality (VR) therapy to standard IBS medication (linaclotide) helps adults with IBS and constipation feel better than medication alone. About 65 adults aged 18-70 with moderate-to-severe IBS symptoms will use either real VR or a sham VR ove…

This study looks at whether high-frequency spinal cord stimulation can reduce severe nerve pain in people who have had a brachial plexus injury (a serious shoulder nerve injury). About 20 adults with long-term nerve pain will receive the treatment and report their pain levels. Th…

This study is testing a new type of adjustable skin disk for feeding tubes. The goal is to see if it can safely help the skin heal better and cause fewer problems. About 20 adults getting a feeding tube placed will take part at Mayo Clinic.

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study compares giving cancer treatment at home versus in a clinic for people in the Florida Panhandle. The goal is to see if patients prefer home care and if it improves their experience. About 27 adults with various cancers will receive their usual treatment either at home …

This study tests whether acupressure, a non-invasive technique using finger pressure on specific body points, can reduce anxiety in cancer patients receiving chemotherapy. About 78 adults with cancer will be randomly assigned to real acupressure or a sham version. Participants wi…

This study compares two common injections for thumb arthritis: an NSAID (ketorolac) and a corticosteroid (triamcinolone). The goal is to see which one better eases pain and improves hand function. About 240 adults over 40 with moderate to advanced thumb arthritis will take part. …

This study tests whether phone-based health and wellness coaching can reduce stress and improve confidence for caregivers of people waiting for a heart or lung transplant. About 30 caregivers will take part. Researchers will measure changes in caregiver burden and self-efficacy u…

This study tests whether using virtual reality (VR) can improve symptoms of non-cardiac chest pain, a condition where people feel chest pain but tests show no heart problem. Ten adults with this condition will use VR sessions and report changes in pain, anxiety, and quality of li…

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This pilot study tests whether a mild electrical current applied to the scalp (tDCS) can safely reduce the number and intensity of seizures in people with epilepsy. About 30 adults whose seizures are not controlled by at least two medications will receive the stimulation and trac…

This study tests a surgical technique called neurotization, where a nerve graft is used to try to restore feeling in the nipple after a nipple-sparing mastectomy. About 20 women with early-stage breast cancer will be randomly assigned to receive either standard surgery or surgery…

This study tests whether dapagliflozin, a drug used for diabetes and heart failure, can lower vein pressure in adults born with a single heart ventricle who had the Fontan procedure. About 27 participants will take the drug or a placebo for 3 months to see if it reduces pressure …

This study tests whether a fuzzy compression sock can help wounds heal faster after a leg amputation due to poor blood flow. About 40 adults will either get the special sock or standard care. Researchers will track infections, pain, and how soon a prosthetic leg can be fitted.

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms better. Researchers will enroll 300 people who have had pain for at least 3 months and have trouble with daily activities. Participants use the app to lear…

This study tests whether a combination of two drugs, neostigmine and glycopyrrolate, can treat severe headaches that sometimes happen after an epidural is placed for labor pain relief. The goal is to see if this treatment can reduce the number of new mothers who need a procedure …

This study tests whether a personalized exercise program (aerobic and resistance training) done before CAR-T therapy can improve physical fitness and quality of life in adults aged 60 and older with multiple myeloma that has returned or not responded to treatment. About 20 partic…

This study tests whether fucoidan, a supplement from brown seaweed, can prevent or reduce fatigue caused by chemotherapy. About 34 adults with gastrointestinal or gynecologic cancer will take either fucoidan or a placebo daily for 16 weeks. Researchers will track fatigue levels u…

This early study tests whether blocking a specific vein in the lower back (lumbar vein) can safely reduce chronic headaches in people with nutcracker physiology. The procedure aims to relieve pressure buildup around the spine that may cause daily, pressure-like headaches. Only 4 …

This study tests two different anesthesia approaches to see which one causes less confusion and agitation (called emergence delirium) in children after surgery. About 400 children aged 2 to 7 will take part. One group gets isoflurane gas, the other gets sevoflurane gas plus a cal…

This study tests whether a diet rich in fermented foods (like yogurt, kimchi, and sauerkraut) is tolerable and can improve quality of life for survivors of critical illness, including severe COVID-19. Researchers will enroll 40 adults who spent more than 48 hours in the ICU and h…

This study tests whether training the muscles used for breathing can help people with heart failure exercise more easily. Researchers will measure blood flow to breathing and leg muscles, and how long participants can exercise. The study enrolls 68 adults with heart failure who a…

This study tests whether a long-acting numbing medication called EXPAREL® can reduce pain after rib cartilage removal for nasal surgery better than the standard numbing drug. About 60 adults having nasal surgery that requires rib cartilage will receive either EXPAREL® or the stan…

This study tests whether a low dose of growth hormone can reduce symptoms like nausea, fullness, and belly pain in people with gastroparesis (stomach paralysis). Ten adults whose symptoms have lasted over 6 months and haven't improved with standard care will receive the hormone a…

This study looks at whether 12 sessions of Latin dance can help people who have had a lung transplant feel better emotionally and physically. Researchers will measure changes in anxiety, depression, fear of movement, and balance. The study involves 52 adults who can walk and have…

This study tests whether injecting a numbing medication and a steroid into the nerves of the scalp can stop an active migraine and prevent future ones. Researchers will enroll 60 people who have episodic migraines (4 to 14 per month) and see if the treatment eliminates headache p…

This study tests whether the diabetes drug metformin, along with a wearable activity tracker, can reduce memory and thinking problems caused by radiation to the brain. About 100 adults who have had or will have cranial radiation for a brain tumor will take metformin or a placebo …

This study tests a therapy called accelerated resolution therapy (ART) to help older adults who are caring for a family member with a life expectancy of less than 12 months. Participants must have high levels of grief before their loved one passes. The goal is to see if ART can r…

This study looks at whether adding special breathing exercises (inspiratory muscle training) to standard cardiac rehabilitation can improve how well the heart and muscles work during exercise in people with heart failure. Researchers at Mayo Clinic will enroll 70 adults with hear…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce chronic dizziness. Researchers at Mayo Clinic will enroll 60 adults with a condition called Persistent Postural-Perceptual Dizziness (PPPD). Participants will use the device d…

This study tests whether adding low-intensity shockwave therapy to the standard Xiaflex treatment can further reduce penile curvature in men with Peyronie's disease. About 60 participants with stable symptoms and moderate curvature will be randomly assigned to receive either the …

This study tests whether a virtual mindfulness-based stress reduction (MBSR) program can help cancer patients in underserved rural areas of Minnesota feel less stressed and anxious. About 30 adults with a history of cancer who report high emotional distress will take the online c…

This study looks at whether stopping opioid use can reverse opioid-induced esophageal dysfunction, a condition that causes trouble swallowing and chest pain. Researchers will follow 26 adults enrolled in a pain rehabilitation center who are already planning to quit opioids. The m…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve damage from chemotherapy. About 300 people (survivors and their caregivers) will use the app at home to see if it reduces pain, numbness, and ti…

This study looks at whether using a handheld stress management device called CalmiGo, alongside standard cardiac rehab, can improve blood vessel health and lower stress in people who recently had a heart attack. About 100 adults will use the device for 12 weeks while researchers …

This study looks at whether injecting a foam into large, painful kidney or liver cysts can reduce pain and improve quality of life in people with autosomal dominant polycystic kidney or liver disease. About 100 adults with 1–3 large cysts causing symptoms will be followed for 12 …

This study tests a special pain management program that combines counseling and coping skills to help breast cancer survivors who have joint and muscle pain from their hormone medication. About 115 women will either join the program or receive usual care. The goal is to see if th…

This study tests whether a computer program called RapidPlan can create radiation treatment plans for prostate cancer that cause fewer severe side effects than plans made by human experts. About 108 adults with prostate cancer will be randomly assigned to receive radiation planne…

This study tests whether a headband that uses sound waves (acoustic resonance therapy) can improve sleep quality in people with moderate to severe chronic insomnia, compared to the standard behavioral therapy. About 60 adults will be randomly assigned to one of the two treatments…

This study tests whether using virtual reality can reduce stomach pain and other digestive symptoms in people with functional dyspepsia. About 30 adults with this condition will try VR sessions and report their symptom changes. The goal is to see if VR offers a safe, drug-free wa…

This study tests whether a pulmonary rehabilitation program can help people with COPD who live in rural areas. The program aims to improve breathing, reduce tiredness, and boost quality of life. Researchers will enroll 306 adults aged 40 and older who have been diagnosed with COP…

This study tests a program called ASCENT that helps cancer survivors manage pain using a digital guide and coaching from community health workers and pain specialists. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with cancer-…

This study tests whether giving chemotherapy directly into the bladder at home is safe and works as well as doing it in a clinic. About 40 people with early-stage bladder cancer will receive their usual treatment at home. The goal is to see if home treatment reduces disruption to…

This study tests a personalized approach to giving steroids to adults hospitalized with pneumonia. Instead of a standard dose, doctors will use a blood test (CRP) to decide the right amount for each patient. The goal is to reduce steroid side effects while still controlling lung …

This study looks at whether having a baby's first checkup and a breastfeeding consultation in one appointment helps mothers breastfeed longer. About 246 new mothers who plan to breastfeed will be split into two groups: one gets combined visits, the other separate visits. Research…

This study tests whether using virtual reality (VR) can help reduce pain and the need for painkillers in people hospitalized with broken bones. One hundred participants will use VR as part of their care, and researchers will track their pain medicine use, hospital stay length, an…

This study looks at what affects recovery after surgery for Cushing syndrome, a condition caused by too much cortisol. Researchers want to find out why some people have a harder time with withdrawal symptoms and whether a special program (MUSE) can help improve quality of life. T…

This early study is testing whether a wearable headband that tracks brain activity can help breast cancer survivors manage anxiety and insomnia. About 40 survivors who have had breast cancer in the past 10 years and currently struggle with anxiety and poor sleep will use the MUSE…

This study tests a home-based mindfulness physical activity program combined with telephone health coaching for people aged 65 and older with multiple myeloma. The goal is to see if this approach can reduce fatigue and improve quality of life. Participants will use remote monitor…

This Mayo Clinic pilot study tests whether controlled changes in oxygen and carbon dioxide levels can improve brain fog in people with Long COVID. About 45 participants will have their brain blood flow, heart rate, and brain fog symptoms measured. The goal is to see if this non-i…

This study tests whether a dietary supplement made from resistant potato starch can improve gut health and ease symptoms in 11 people with cirrhosis who have had episodes of hepatic encephalopathy (brain fog). Participants take the starch for 4 weeks while researchers measure cha…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the GPe can improve severe insomnia in people with Parkinson's disease. Ten participants aged 40-80 with Parkinson's for 7-20 years and severe insomnia will be enrolled. T…

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study tests whether artificial intelligence in Phonak hearing aids can improve speech understanding for people with hearing loss or cochlear implants. About 500 participants will listen to words and sentences in noisy settings to see if AI noise reduction helps them hear mor…

This study tests whether a lower dose of steroid injected into the knee works as well as the standard dose for pain and function in obese people with knee arthritis. Forty participants will receive either a low or standard dose and report their pain and knee function over time. T…

This study tests whether a plant-based, low-calorie diet that mimics fasting can reduce common side effects of immunotherapy, such as rash, diarrhea, and fatigue. Ten adults with advanced cancer will follow the diet while receiving treatment. The goal is to improve their quality …

This study looks at whether zavegepant (Zavzpret), a nasal spray already approved for migraines, works well and is safe for people who are already taking a CGRP-targeting preventive medication. About 200 adults with 2 to 8 migraines per month will use the spray at the start of an…

This study tests whether Wisconsin ginseng can reduce severe fatigue in people with solid tumors. Fatigue is a common and distressing side effect of cancer and its treatment. Researchers will compare ginseng to a placebo in 160 adults to see if it improves energy levels.

This study compares two pain medicines—methadone given through an IV and hydromorphone given near the spine—for women having surgery for gynecologic cancer. The goal is to see which provides better pain relief after surgery. About 140 participants will be enrolled, and their pain…

This study looks at two ways to deliver precise radiation to brain tumors that have spread from other cancers. One method gives all the radiation in a single session, while the other spreads it over several sessions. The goal is to find out which approach better controls the tumo…

This study tests a spinal cord stimulator to relieve chronic nerve pain caused by chemotherapy. About 20 adults who have had pain for over six months after chemo will receive the device. Researchers will track pain levels and quality of life for up to a year to see if the treatme…

This study is for people with a rare, aggressive brain tumor called diffuse midline glioma. Instead of the usual 6 weeks of daily radiation, researchers are testing a 2-week course. The goal is to see if the shorter treatment keeps the tumor from growing as long while also improv…

This study tests whether a specific probiotic (De Simone Formulation) can lower bile acid levels in stool and improve diarrhea in people with bile acid malabsorption. About 24 adults with confirmed bile acid diarrhea will take the probiotic or a placebo daily for several weeks. T…

This study tests whether Reishi mushroom extract can reduce fatigue and joint or muscle pain in breast cancer patients taking aromatase inhibitors. About 80 participants will receive either the mushroom extract or a placebo for 8 weeks. The goal is to improve quality of life with…

This study looks at whether structured breathing exercises can help healthcare workers feel less burned out, anxious, or stressed and sleep better. About 40 healthcare professionals from four Mayo Clinic sites who score high on a burnout survey will use a mobile app to guide thei…

This study compares an electronic massager called EMMA to a massage from a trained therapist. Researchers want to see if people find the machine just as satisfying and practical to use. About 20 adults will try both types of massage and share their feedback.

This study looks at how sleep apnea changes fat tissue and whether those changes increase the risk of heart disease. Researchers will take small fat samples from the belly and thigh of 120 adults with sleep apnea. The goal is to understand the link between sleep apnea, fat tissue…

This study compares noninvasive heart ultrasound (echocardiogram) with the standard invasive right heart catheterization in 3,000 people with suspected pulmonary hypertension or left heart disease. The goal is to see if ultrasound can accurately measure heart function and blood f…

This study looks at the gut microbiome (the bacteria living in the digestive system) in people with POEMS syndrome and other plasma cell disorders. Researchers will collect stool samples from 240 participants, including patients and healthy household members, to compare gut bacte…

This study looks at how insulin and glucagon interact to control blood sugar levels when you haven't eaten. Researchers will compare people with normal fasting glucose and those with impaired fasting glucose (a sign of prediabetes). The goal is to better understand what goes wron…

This study looks at how physical activity relates to memory and thinking in people who survived cancer as teens or young adults. Researchers will use computer-based brain games to measure cognitive performance. The goal is to understand these connections, not to test a new treatm…

This study collects blood and urine samples from 1500 people with bladder cancer. Researchers will use these samples to create simple, non-invasive tests that can find bladder cancer early. Participants must be over 18 and have had a recent evaluation for blood in the urine.

This study tracks how adults with curved spines move and walk before and after corrective surgery. About 50 participants will wear motion sensors and undergo lab tests to measure changes in walking, balance, and trunk stability. The goal is to better understand how surgery affect…

This study is for breast cancer patients receiving certain chemotherapies that can harm the heart. Researchers will collect blood samples to study a gene called TRPC6, looking for changes that might predict heart problems early. The goal is to find ways to prevent long-term heart…

This study tests new ways to improve MRI scans for prostate cancer. Researchers want to see if better computer methods can make images clearer without needing new equipment. About 1000 adults will join to help compare standard and new image-making techniques. The goal is to impro…

This study looks at whether recording personal messages of wisdom and hope can help maintain dignity for people with serious illnesses like cancer and their caregivers. About 40 adults with a chronic or progressive illness will make recordings and complete surveys before and afte…

This study looks at how hormone therapy for breast cancer affects blood sugar control and diabetes risk. Researchers will compare blood sugar levels in postmenopausal women taking aromatase inhibitors, tamoxifen, or no treatment. The goal is to understand if these therapies incre…

This study aims to find out how often women who have HPV-positive throat cancer, or whose partner has it, also get HPV infections in the genital area. Researchers will compare these rates to similar women without throat cancer. The goal is to better understand the risk of HPV-rel…

This study is testing a virtual robot assistant (ViRA) to help Black men who have just been diagnosed with prostate cancer. The goal is to see if men find the tool helpful and easy to use for getting support and information. About 53 participants will try the app and give feedbac…

This study looks at whether placing a small device called an Ommaya reservoir in the brain during tumor surgery is safe and works well. The reservoir lets doctors collect fluid from around the brain over time to study tumor markers. About 100 adults with brain tumors will take pa…

This study looks at how the body controls blood pressure after a spinal cord injury and whether those changes can predict future medical issues. Researchers will monitor 18 adults with recent or long-term injuries using simple tests. The goal is to better understand risks, not to…

This study uses special MRI scans to map electrical activity in the brain. Researchers will compare scans from healthy volunteers and people with brain tumors (glioma) to see if the new method can help improve diagnosis. The goal is to better understand how electrical signals tra…

This study looks at how doctors' words and actions affect distress in cancer patients receiving radiation therapy. Researchers will ask 5,000 adults about their experiences to find out which behaviors help or hurt. The goal is to improve how doctors communicate and support patien…

This early phase trial at Mayo Clinic is studying how two drugs, DFMO and AMXT 1501, change the metabolism of brain tumors (gliomas) in 18 adult patients. The goal is to measure molecules in the tumor's fluid to understand how these drugs affect tumor growth and survival. This st…

This study looks at whether the standard A1C blood sugar test is accurate for people with type 2 diabetes who have a Left Ventricular Assist Device (LVAD). Researchers will compare A1C results with data from a continuous glucose monitor (CGM) worn for 3 months. The goal is to see…

This study looks at how social factors, like having a way to get to the doctor, affect care for people with liver or bile duct cancer. Researchers will ask 400 patients about barriers they face. The goal is to understand risks and improve access to care.

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study aims to find out how common non-alcoholic fatty liver disease (NAFLD) and its more serious form, NASH, are in Olmsted County. Researchers will follow 800 adults over time to improve diagnosis and track long-term health issues like liver damage, heart problems, and canc…

This study sets up Community Living Labs at American Legion Posts to help Black men learn about and access prostate cancer screening and services. Community health workers will connect men with doctors and resources. The goal is to see if this approach improves health knowledge a…

This study looks at how the heart pumps blood and uses energy in healthy adults of different ages. Researchers will measure heart pressures and blood samples at rest and during exercise. The goal is to understand normal heart function, not to test a treatment. About 80 healthy vo…

This study looks at how short-term and long-term exercise affects the immune system of people with slow-growing blood cancers like chronic lymphocytic leukemia (CLL) and indolent non-Hodgkin lymphoma (NHL). Participants will undergo fitness tests and blood draws before and after …

This study tests a new device that uses an air-filled bladder to measure blood flow changes in the legs of people who may have deep vein clots. Researchers want to see if this non-invasive method can help detect blockages. About 500 adults who recently had a leg ultrasound for cl…

This study looks at how spinal cord stimulation helps the body manage blood pressure changes in people with spinal cord injuries. Researchers will measure heart rate, blood pressure, and immune function in 80 participants aged 18-50 with injuries between C6 and T8. The goal is to…

This study looks at whether taking a probiotic called Lactobacillus rhamnosus GG (LGG) can affect changes in gut bacteria caused by common acid reflux medicines (PPIs). Researchers will give 30 healthy adults either a probiotic or a placebo alongside a PPI and compare stool sampl…

This study tests a new neck-strengthening device (TopSpin360) in 60 healthy junior hockey players. Researchers want to see if using the device improves neck strength, reaction time, and brain function. Participants will be measured before and after training, but no treatment is g…

This study collects tissue samples from people with various advanced or early-stage cancers to train a new diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 partici…

This study uses mild electrical stimulation on the skin of the lower back to measure how nerves and muscles work in 30 children and teens with spina bifida. Researchers will test muscle strength, spasticity, walking, and coordination. The goal is to better understand nerve-relate…

This study looks at a program to help people in Minnesota who are injured or ill stay at work or return to work. About 1000 adults who live and work in Minnesota will take part. The program offers early support and connects workers with resources to reduce long-term disability.

This study aims to learn how the trillions of bacteria living in our bodies (the microbiota) influence health and disease. Researchers at Mayo Clinic will collect samples from 5,000 adults to compare differences in gut bacteria. No treatments or drugs are tested—the goal is simpl…

This study looks at whether a new, non-invasive heart scan called magnetocardiography (MCG) can help detect and monitor amyloidosis, a rare disease where abnormal proteins build up in organs. Researchers will compare MCG results to standard ECG in 500 adults. The goal is to see i…

This study tests whether a deep brain stimulation (DBS) system already implanted in the brain can detect seizures in people with drug-resistant epilepsy. Five adults will have their brain signals recorded and compared to standard video-EEG monitoring in a hospital. The goal is to…

This study looks at how opioids affect the diaphragm, the main muscle used for breathing. Researchers will measure diaphragm strength in 69 adults having leg surgery. The goal is to understand if opioids make it harder to take strong breaths, which could help improve safety for p…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy can help doctors safely collect fluid samples from the brain over time. The goal is to find markers in the fluid that could show how the tumor is growing or r…

This study aims to learn why high-risk endometrial cancer comes back by analyzing genetic information from tumor tissue and blood samples. Researchers will follow 100 adults undergoing complete surgical staging at Mayo Clinic to track recurrence-free survival and identify genetic…

This study aims to see if a simple blood test can measure organ damage and immune system changes in people with sepsis. Researchers will enroll 1000 participants and use advanced DNA analysis to track these changes over time. The goal is to better understand how sepsis affects th…

This study uses special brain scans to measure tau protein buildup in people with Progressive Supranuclear Palsy (PSP), a rare brain disorder. Researchers will track how tau levels change over time in 332 participants. The goal is to better understand the disease, not to test a t…

This study looks at the genetic changes in cancer cells from Indigenous American people in the Southwest. The goal is to learn more about these cancers to improve screening and treatment. Researchers will enroll 300 adults who have or had cancer and identify as Indigenous America…

This study gathers health information from 2,500 people who have had a spontaneous coronary artery dissection (SCAD), a type of heart attack. Researchers want to learn what causes SCAD, how it is treated, and what happens to patients over time. Participants share their medical hi…

This study looks at how sex affects the way the body controls blood pressure in people with untreated obstructive sleep apnea. Researchers will measure blood pressure, artery stiffness, and nerve activity in 60 adults aged 20-70. The goal is to understand differences between men …

This study tests whether a smartwatch and artificial intelligence can detect early signs of heart problems in people who have had lymphoma or sarcoma. About 250 participants will use a mobile device to record their heart's electrical activity, which an AI will analyze to find hid…

This study aims to find normal levels for a new blood and urine test that might one day help screen for cancer. Researchers at Mayo Clinic will collect samples from 10,000 people without cancer to establish a baseline. The goal is to improve early detection, not to treat or cure …

This study aims to find a biological marker (biomarker) in blood, tissue, or saliva that shows up only when a person has HPV-related oropharyngeal cancer. Researchers will compare samples from 560 participants, including cancer patients and healthy controls, to see if the marker …

This study looks at how losing a lot of weight and keeping it off changes the way the body breaks down fat in response to insulin. Researchers will measure fat tissue inflammation and insulin's ability to control fat release in 30 people before and after bariatric surgery. The go…

This study aims to see if voice recordings from a smartphone app can help detect heart disease. Up to 1 million adults will record short voice samples and share health data. Researchers will use artificial intelligence to look for links between voice patterns and heart health.

This study is testing a decision aid tool to help older patients (60+) and their doctors have better conversations about end-of-life care in the emergency department. The goal is to make these talks more common and less stressful. About 230 participants will give feedback to impr…

This study aims to understand why fat tissue in the belly area does not respond to insulin the same way as fat in other parts of the body. Researchers will measure how fat is released from different areas in overweight and lean adults. The findings may help explain why some peopl…

This study watches 212 people with low-risk uterine cancer to see if finding very small groups of cancer cells in the first lymph nodes (sentinel nodes) affects the chance of cancer coming back. Participants have already had surgery to remove the cancer and lymph nodes. The goal …

This study looks at how people feel and function after two different surgeries for bladder cancer: partial cystectomy (removing part of the bladder) and radical cystectomy (removing the whole bladder). Researchers will compare quality of life and urinary symptoms between the two …

This study looks at why older adults respond differently to strength training. Researchers will track 300 people aged 65 and older who are at risk for mobility problems. Participants will do progressive resistance training, and scientists will measure changes in physical function…

This study tests a new device placed under the scalp that tracks brain activity to predict seizures in people with drug-resistant epilepsy. Researchers want to see if it is safe and can give early warnings. Twelve adults with focal epilepsy will wear the device and other sensors …

This study looks at how long-term inflammation impacts muscle function and how older adults respond to exercise. Researchers will measure muscle protein building in 120 older adults. The goal is to better understand age-related muscle loss, not to test a new treatment.

This study looks at how chronic lymphocytic leukemia (CLL) and a related condition called monoclonal B-cell lymphocytosis (MBL) affect bone marrow function, especially the ability to fight infections. Researchers will compare samples from 50 participants, including people with CL…

This study is testing whether a small device called a microdialysis catheter can safely collect fluid samples from brain tumors during surgery. The goal is to measure biomarkers—natural substances that show how the tumor behaves. Researchers hope this information will lead to bet…

This study looks at how renin, a protein in the blood, changes when the heart-lung machine is used during open heart surgery. Researchers will measure renin levels in 100 adults before, during, and after surgery. The goal is to see if renin can help doctors decide when to give me…

This study is looking at 2,000 people who have early warning signs of blood cancers or bone marrow failure, like unexplained low blood counts or certain genetic changes. Researchers use a special genetic test to find markers linked to these conditions. The goal is to better under…

This study aims to find ways to predict who will develop acid reflux after sleeve gastrectomy, a common weight-loss surgery. Researchers will use a special probe to measure the stomach's function during surgery. The goal is to help doctors identify at-risk patients and improve ou…

This study places cameras, microphones, and temperature sensors in hospital rooms to monitor cancer patients. The goal is to detect early signs of confusion, falls, sleep troubles, and mood changes. Researchers hope this technology helps nurses and doctors provide safer, more com…

This study looks at how tiny organisms in the gut (the microbiome) might influence the growth of brain tumors. Researchers will collect stool, urine, blood, saliva, and tissue samples from 100 patients with brain tumors to build a special biobank. The goal is to understand the co…

This study aims to see if blood samples from cancer patients can be used to create personalized stem cells that mimic how each person reacts to cancer treatments. Researchers will compare cells from patients who had severe side effects to those who did not. The goal is to better …

This study collects tumor samples and medical information from 2000 adults with breast cancer that has spread or come back. The goal is to create a resource that helps researchers learn how the disease changes and responds to treatments. Participants provide samples and data but …

This study surveys up to 5000 people who have been treated for adolescent idiopathic scoliosis, along with their families. The goal is to understand what influences the choice between observation, bracing, and surgery. Researchers will use the results to create a decision aid tha…

This study from Mayo Clinic talks to 20 breast cancer patients about their experience with skin irritation (radiation dermatitis) during or after radiotherapy. Researchers want to learn how it affects patients physically, emotionally, and socially. The goal is to better understan…

This study aims to understand how the body's immune cells react to a new type of vaccine (neoantigen vaccine) that helps the immune system recognize and fight cancer. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune cel…

This study aims to understand how the autonomic nervous system (which controls things like blood pressure and sweating) works after a spinal cord injury. Researchers will test about 69 people with and without spinal cord injury using simple lab exercises and smartwatches that tra…

This study looks at whether a longer fasting period before an upper endoscopy can lower the risk of food or liquid entering the lungs (aspiration) in people taking GLP-1 receptor agonists like Ozempic or Wegovy. About 150 adults having a planned upper endoscopy will follow a modi…

This study aims to find the most effective brain stimulation settings for people with epilepsy who already have a deep brain stimulation device implanted. Researchers will compare low-frequency and high-frequency stimulation to see which reduces seizures better. The study involve…

This study looks at how the body handles stress and damage in the early stages of a genetic kidney disease called ADPKD. Researchers will measure certain substances in blood and urine from 40 adults aged 18-30. The goal is to find markers that could help track the disease better …

This study is collecting data from 150 patients with complex aortic aneurysms who are having open surgery. The goal is to see how their quality of life changes after the operation. No new treatments are being tested; it is purely an observation study.

This study takes leftover breast cancer tissue from patients who still have cancer after initial treatment and grows it in the lab. The goal is to create models that help researchers understand why some cancers resist treatment and test new drug combinations. Participants are adu…

This study tests a special ultrasound that takes detailed pictures of tiny blood vessels around chronic wounds. Researchers want to see if these images can help track wound healing over time. About 10 adults with diabetic foot ulcers or leg ulcers that have not healed for at leas…

This study looks at how brain changes relate to speech and language problems in people with progressive apraxia of speech (AOS). About 50 participants will have regular brain scans and speech tests over time. The goal is to better understand the disease, not to test a treatment.

This study aims to understand why some cancer patients develop heart issues after chemotherapy while others do not. Researchers will collect blood samples from 1,000 adults who have had chemotherapy for any type of cancer. The goal is to find biological markers that could predict…

This study looks at how well the heart works during exercise compared to at rest in people with congenital heart disease. Researchers will measure blood flow and pressures inside the heart while participants exercise. The goal is to find problems that only show up during physical…

This study follows 120 adults with pulmonary hypertension who are already taking the drug sotatercept. Researchers will track quality of life, hospital visits, medication changes, and side effects like bleeding. The goal is to see how well the drug works in everyday medical pract…

This study at Mayo Clinic aims to test two new imaging methods to measure the strength and movement of the aorta, the body's main artery. Researchers will compare results from 30 people with and without an abdominal aortic aneurysm. The goal is to better understand how the aorta …

This pilot study at Mayo Clinic will test whether combining cardiac CT and MRI can help predict which patients with severe mitral regurgitation are at risk for developing weak heart pumping after mitral valve repair. About 30 adults undergoing robotic mitral annuloplasty will be …

This study is testing a special PET scan that uses a tracer called 68Ga-FAPI to look at heart muscle changes in people with a type of heart failure called HFpEF (heart failure with preserved ejection fraction). About 35 adults aged 30 and older with shortness of breath and a BMI …

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers aim to build a biobank to improve cancer prevention, early detection, and treatment. Participants must have a con…

This study aims to learn more about Gastric Antral Vascular Ectasia (GAVE), a condition where stomach blood vessels enlarge and may bleed, causing pain and nausea. Researchers will use questionnaires and a breath test to measure symptoms and stomach function in 30 adults with GAV…

This study tests whether a video camera can help measure delirium severity in ICU patients aged 50 and older. Researchers will record patients 24/7 and compare the footage with standard assessments. The goal is to create a tool that makes delirium monitoring easier and more accur…

This study is building a large registry of 15,000 people who received radiation therapy for cancer at Mayo Clinic. Researchers will collect medical information and biological samples to see how treatment affects side effects, quality of life, and survival. The goal is to learn fr…

This study collects spinal fluid from 400 adults with brain or central nervous system tumors. Researchers will analyze the fluid to find biomarkers—natural signs of disease—that could lead to better ways to diagnose, monitor, and treat these tumors. The goal is to build a resourc…

This study aims to understand how common cancer-related gene changes are in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumor cancers to see if genetic testing can help identify those at higher risk. The goal is to improve cance…

This study looks at whether fluid taken from a newborn's stomach right after birth can help predict if they will need breathing support for more than 6 hours. Researchers will test the fluid with a special device and compare the results to what actually happens. The goal is to im…

This study uses a safe, noninvasive light-based device (fNIRS) to measure brain activity in 200 adults with depression, bipolar disorder, or mild cognitive impairment. By comparing brain patterns across groups, researchers hope to better understand how these conditions affect the…

This study looks at how inflammation in fat tissue is connected to fat buildup in the liver and insulin resistance in people with severe obesity. Researchers will measure liver stiffness and markers of inflammation in 60 adults who are having gastric bypass surgery. The goal is t…

This study aims to see if a new ultrasound method (shear-wave elastography) can accurately measure the forces generated by the diaphragm, the main breathing muscle. Researchers will compare this technique to standard breathing tests in 24 healthy adults. The goal is to develop a …

This study is collecting blood and tissue samples from 200 people who are having a procedure to treat a narrowed carotid artery. The goal is to gather information about the plaque that builds up in the artery. No new treatments are being tested. The study simply aims to help rese…

This study looks at how well African American and rural White men understand genetic information related to prostate cancer. Researchers will use educational videos and surveys to measure genetic literacy and knowledge. The goal is to help men make more informed treatment decisio…

This study looks at how people with spontaneous coronary artery dissection (SCAD) and fibromuscular dysplasia (FMD) respond to different types of exercise. Researchers will measure changes in blood pressure, breathing, and symptoms during and after exercise. The goal is to better…

This study looks at how drinking whole-fat milk changes heart and metabolic risk factors in 40 adults with metabolic syndrome. Participants will have blood tests and artery function checks. The goal is to see if dairy can improve cholesterol, blood sugar, and blood vessel health.

This study enrolls 5,000 people at high risk for pancreatic cancer to collect blood, pancreatic juice, and medical images over 10 years. Researchers will use this information to develop and validate tests for early detection. Participants must be 18 or older, have no personal his…

This study collects blood samples from people with interstitial lung disease (ILD), pneumonia, and healthy volunteers to create a repository for future research. The goal is to find reliable biomarkers that could guide treatment decisions. No new treatments are being tested; this…

This study looks at sleep issues in healthy Somali Americans and how they might affect blood pressure. Researchers will measure sleep quality and blood pressure in 240 adults. The goal is to find hidden sleep problems that could raise hypertension risk in this community.

This early-stage study tests a new type of marker that shows up better on ultrasound for people with breast cancer that has spread to lymph nodes. The marker is placed in the affected node to help doctors find and remove it during surgery. The goal is to see if this marker is saf…

This study tests whether special breathing exercises can improve brain and mental health in people with multiple sclerosis or cancer, and their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connecti…

This study is a patient registry for people with or suspected of having 24-hydroxylase deficiency, a rare condition that affects calcium levels. Researchers at Mayo Clinic will collect health information from up to 600 participants to better understand the disease's symptoms and …

This study looks at why insulin fails to properly control fat breakdown in people with upper body obesity. Researchers will test how the diabetes drug pioglitazone affects fat cell proteins compared to a placebo. The study involves 64 adults, both non-obese and obese, to understa…

This study creates a collection of blood, urine, stool, and other samples from up to 9,150 people with cholestatic liver diseases like primary biliary cholangitis and primary sclerosing cholangitis. The samples and health data will be used by researchers to better understand thes…

This study looks at how the body's internal clock affects fat tissue in people with and without obesity. Researchers will compare fat samples from 40 volunteers to see how eating patterns and body weight change these daily rhythms. The goal is to better understand obesity, not to…

This study looks at how tiny changes in RNA, a molecule in your cells, might help predict whether depression treatments will work. Researchers at Mayo Clinic will follow 120 adults with unipolar or bipolar depression to see if these RNA changes relate to improvements in mood. The…

This study looks at how a device that stimulates the vagus nerve (used for depression or epilepsy) changes how the stomach works. Researchers will measure stomach emptying and capacity in 16 adults who already have the device. The goal is to understand the connection, not to test…

This study follows 350 adults with stage III-IV melanoma for two years after diagnosis to understand their quality of life and mental health. Researchers will also test whether a type of talk therapy called cognitive behavioral therapy (CBT) can help reduce cancer-related distres…

This study looks at how gender-affirming hormone therapy changes muscle metabolism and function in transgender and gender-diverse people. Researchers will measure energy use in muscle cells and overall physical health. The goal is to understand these effects better, not to test a…

This study aims to create a large registry of women with Functional Hypothalamic Amenorrhea (FHA), a condition where the body stops producing estrogen early due to stress, low weight, or excessive exercise. Researchers will track up to 100,000 participants over time to learn how …

This study aims to find out if certain substances in urine and blood can help measure how severe kidney disease is in people with early autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect samples from 60 participants aged 15 to 40 and use MRI to measure…

This study tests whether real-time video calls with a newborn specialist (teleneonatology) can improve survival and reduce serious health problems in at-risk babies born at community hospitals. About 947 newborns and their doctors will take part. The main goal is to see if this a…

This study collects blood, tissue, and health information from up to 20,000 people with pancreas diseases like pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to build a large database and sample bank that researchers can use to better understand these condition…

This study tests whether a virtual community health educator (vCHE) can help more cancer patients and their caregivers learn about and sign up for clinical trials. The vCHE is a computer character that speaks English or Spanish and offers personalized guidance. The goal is to inc…

This study looks at why some patients with end-stage liver disease are less likely to be placed on a transplant waiting list or receive a new liver. Researchers will track 100 patients to understand individual and social factors that create these differences. The goal is to use t…

This study looks at whether a blood test called DiviTumTKa can help doctors know early on if a treatment for hormone-receptor-positive (HR+) metastatic breast cancer is no longer working. About 100 people starting or continuing standard therapies (endocrine therapy with or withou…

This study aims to identify and distinguish two different types of Progressive Apraxia of Speech, a disorder that makes it hard to speak clearly. Researchers will use brain imaging and speech tests to tell the types apart. The study involves 47 adults with speech difficulties and…

This study is testing a new questionnaire to better understand and track symptoms in people with upper digestive diseases or who have had esophageal surgery. Researchers will ask 1000 patients to complete the survey at different times. The goal is to create a standard tool that h…

This study looks at whether giving patients a genetic test before they start a new common drug can lower their risk of side effects like muscle pain, falls, or fainting. About 66 adults in primary care will get the test, and doctors will use the results to choose safer drugs or d…

This study compares heart and lung blood pressure in healthy adults and those with congenital heart disease. Researchers will measure how the heart's blood vessels respond to exercise using MRI and a small tube in the heart. The goal is to collect data that helps doctors better u…

This study looks at whether mindfulness and meditation techniques can help mothers of premature babies in the NICU produce more breastmilk and feel less stressed. About 40 mothers will learn these techniques and researchers will measure changes in milk volume, stress hormones, an…

This study looks at how often patients develop dangerously high ammonia levels while being treated with recombinant Erwinia asparaginase for blood cancers like leukemia. Researchers will monitor ammonia through regular blood tests during the first two treatment cycles. The goal i…

This study aims to understand why fat tissue in the belly area doesn't respond normally to signals that 'turn on' fat cells in people with obesity. Researchers will measure how fat is released from different parts of the body in 24 adults, comparing those with and without excess …

This study aims to learn why some women with benign (non-cancerous) breast disease later develop breast cancer. Researchers will analyze tissue samples, mammograms, and genetic information from 4500 women who had a benign breast biopsy at Mayo Clinic. The goal is to improve risk …

This study uses a special MRI technique called MR elastography to see how muscles and connective tissues move and respond to pressure. Researchers want to find out if these scans can show changes after a hands-on therapy called Tuina, compared to standard care. About 78 adults wi…

This study looks at whether a video and a special doctor's visit can help young adults (ages 18-39) with advanced solid tumors or high-grade brain tumors start planning their future medical care early. The goal is to see if these tools are helpful and easy to use. About 50 people…

This study looks at how the brain, memory, thinking, and movement change over time in people with Lewy body disease, Alzheimer disease, and healthy volunteers. Researchers will use brain scans and brain-wave tests to learn more about these disorders. The goal is to better underst…

This study looks at how the natural bacteria in your gut (the microbiome) can change the way cancer treatments work. Researchers will collect samples from 3,000 cancer patients to find links between gut bacteria and treatment success. No new drugs are tested—the goal is to learn …

This study aims to understand how healthy bone marrow plasma cells use a nutrient called glutamine. Researchers will give a special labeled form of glutamine to 20 healthy adults and then take a small bone marrow sample to measure how it's processed. This is a pilot study to test…

This study looks at how common low vitamin D levels are in Black men with prostate cancer and how it affects their immune system. Researchers will give vitamin D supplements to those with low levels and check if their immune function improves. The goal is to learn more about vita…

This study looks at how often people with metastatic non-small cell lung cancer have trouble sleeping. Researchers will ask 60 participants to fill out a sleep questionnaire to measure insomnia severity. The goal is to better understand sleep problems in this group, not to test a…

This study aims to see if a special MRI technique called magnetic resonance elastography (MRE) can measure stiffness in the hearts of people with cardiac amyloidosis, a condition where abnormal proteins build up and stiffen the heart. About 20 adults with this condition will unde…

This study looks at how controlling blood sugar and using a GLP-1 drug (liraglutide) changes the way cells in the pancreas work in people with type 1 or type 2 diabetes. Researchers want to understand a natural hormone called GLP-1 that helps manage blood sugar. About 60 adults o…

This study at Mayo Clinic is testing whether robotic biopsies can collect enough lung tumor tissue to analyze its genes. The goal is to learn more about hereditary and cancer-related genetic changes, and to build a databank for future research. About 40 adults at risk for lung ca…

This study looks at whether offering cancer treatment at home instead of a hospital is practical and preferred by Black men with advanced prostate cancer. About 77 participants will share their thoughts on convenience, safety, and comfort. The goal is to reduce healthcare dispari…

This study watches how the esophagus changes in people getting radiofrequency ablation for Barrett's esophagus, a condition that can lead to cancer. Ten adults will have extra measurements taken during their routine endoscopies. The goal is to gather information that could help p…

This study from Mayo Clinic is watching how a blood test that can detect many types of cancer is used in everyday doctor visits. About 500 adults who have already had or are scheduled for this test will take surveys about their feelings, satisfaction, and the costs that follow. T…

This study looks at how the hormone glucagon changes insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high fasting b…

This study looks at whether drinking beetroot juice (which contains natural nitrates) before bed can improve sleep quality and how well your brain and blood vessels work at night. Researchers at Mayo Clinic will study 60 healthy adults, both younger (18-35) and older (65-80). Par…

This study looks at how gene changes (called germline and somatic variants) affect low blood cell counts after CAR-T therapy in people with multiple myeloma or certain lymphomas. About one-third of patients have low blood counts that last more than 30 days after treatment. Resear…

This study aims to learn how common obstructive sleep apnea is among Somali-American adults and how it may affect heart health. Researchers will compare Somali participants with and without sleep apnea to people of other ethnic backgrounds. The goal is to find genetic or physical…

This study follows 200 people with sinonasal cancer to see how well treatments work and how they affect quality of life. Researchers will also analyze tumor tissue to learn about the genetic changes that drive this cancer. The goal is to better understand the disease and improve …

This study looks at how often people who take proton pump inhibitors (PPIs) for acid reflux develop a condition called small intestinal bacterial overgrowth (SIBO). Researchers will use breath tests and symptom questionnaires to measure this in 50 adults. The goal is to better un…

This study aims to collect and analyze pancreatic fluid from healthy volunteers after they receive an injection of human secretin. Researchers will measure the levels of bicarbonate, sodium, potassium, and chloride in the fluid. The goal is to understand normal pancreatic fluid c…

This study looks at how different types of fat affect muscle insulin resistance, a key factor in obesity and type 2 diabetes. Healthy adults receive a special fat infusion through a tube into the small intestine overnight, then undergo tests to measure how their muscles process f…