Mayo Clinic

This study tests a combination of two drugs, pirtobrutinib and venetoclax, for people with untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The goal is to see if this treatment can reduce cancer to very low levels, measured by a sensitive blood test. The leng…

This study tests whether fisetin, a natural compound that clears aging cells, can prevent hospitalized COVID-19 patients from getting worse by calming excessive inflammation. About 80 adults aged 60+ (or younger with certain health conditions) will receive fisetin or a placebo. T…

This study tests if the hormone estradiol can slow or shrink tumors in people with a specific type of triple negative breast cancer that has spread. The cancer must have a protein called ER beta, which may make it sensitive to estrogen. The goal is to see if this treatment can co…

This study looks at whether a stem cell transplant can help people with CSF1R-related leukoencephalopathy, a rare genetic brain disease. Researchers will track 20 adults who are already scheduled for the transplant to see if their thinking and movement skills improve or stay stab…

This study looks at side effects of a 3-week radiation and chemotherapy treatment for people with pancreatic cancer that hasn't spread. It includes 103 adults with different stages of the disease. Researchers will also take blood samples to measure cancer DNA levels and see how t…

This study tests whether combining durvalumab (an immunotherapy) with lurbinectedin (a chemotherapy-like drug) can help control extensive stage small cell lung cancer that has returned or not responded to prior treatment. About 29 adults who have already had chemotherapy and immu…

This study tests whether a combination of four chemotherapy drugs can improve blood test results in people with high-risk multiple myeloma, an aggressive blood cancer. About 17 adults aged 18 to 80 with newly diagnosed disease are participating. The goal is to see if the treatmen…

This study tests a new combination of drugs for people with multiple myeloma that has returned and no longer responds to standard treatments. The main drug, selinexor, blocks a protein that helps cancer cells survive. It is given with pomalidomide, dexamethasone, and sometimes ca…

This study tests if a special camera and laser can safely treat a blocked bladder in unborn male babies. The condition, called LUTO, can damage the kidneys and lungs. Doctors will try to open the blockage using a tiny scope inserted into the fetus's bladder. The study includes 10…

This study tests a new drug called parsaclisib added to standard chemotherapy (R-CHOP) for people with newly diagnosed, high-risk diffuse large B-cell lymphoma. The goal is to find the best dose and see if the combination is safe and works better than standard treatment alone. Ab…

This early-phase trial tests a new treatment for multiple myeloma that has returned or stopped responding to standard therapies. The treatment uses a patient's own immune cells (T-cells) that are trained in the lab to recognize and attack cancer cells carrying the MUC1 protein. T…

This study compares two radiation methods—standard x-ray and proton beam—for women with breast cancer who have had surgery. The goal is to see which causes fewer serious side effects or unplanned surgeries over two years. About 146 women with stage I to III breast cancer are taki…

This study tests a combination of two drugs (TTI-622 and pembrolizumab) in about 10 adults whose diffuse large B-cell lymphoma has returned or stopped responding to treatment. TTI-622 blocks a protein called CD47 that cancer cells use to hide from the immune system, while pembrol…

This study tests a new treatment for ovarian, fallopian tube, or peritoneal cancer that has returned after standard therapy. It uses a patient's own stem cells to carry a modified measles virus directly to cancer cells, aiming to kill them. The trial involves 34 participants and …

This study looks at two standard treatments for infections that happen after hip or knee replacement surgery. About 490 people will be randomly assigned to have either one surgery or two planned surgeries, along with antibiotics and keeping the implant in place. Afterward, all pa…

This study tests whether MR-guided cryoablation — a technique that freezes tumors — can safely and effectively treat prostate cancer that has come back after initial treatment. About 107 participants with small, biopsy-confirmed tumors in the prostate bed will be followed for up …

This study tests a program where community paramedics visit adults with diabetes who have had a severe low blood sugar episode. The goal is to help them better manage their diabetes, prevent future emergencies, and improve their quality of life. About 150 participants from southe…

This study looks at whether using two fixation devices instead of one helps heal broken thigh bones near the knee. About 60 adults with this type of fracture will be enrolled. Researchers will measure surgery time, blood loss, hospital stay, and early complications to see which a…

This study looks at whether giving vitamin D supplements to cancer patients who have low vitamin D levels can improve their survival and delay the need for treatment. About 565 adults with certain types of lymphoma or leukemia are taking part. Researchers are comparing those who …

This study tests whether a special fish skin graft (Kerecis SurgiClose) can help close anal fistulas and stop draining wounds. About 20 adults with cryptoglandular fistulas will receive the graft and be checked at 6 months for healing. The goal is to see if this natural material …

This study tests whether the drug metyrapone is safe and effective for people with mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. About 30 adults will take the drug and be monitored for side effects. The goal is to see if metyrapone…

This study tests a new drug, iberdomide, combined with three standard treatments for people newly diagnosed with multiple myeloma. The goal is to find the best dose and see how well the combination kills cancer cells. About 49 adults will take part, and the study is currently act…

This study compares two treatments for eosinophilic esophagitis (EoE): swallowed budesonide (Eohilia) and injected dupilumab (Dupixent). The goal is to see which one better improves esophageal diameter and reduces scarring after 12 weeks. About 60 adults with active EoE will part…

This study offers girls from birth to age 17 the chance to freeze ovarian tissue before cancer treatment or other therapies that could harm their fertility. The goal is to see if the frozen tissue can later be transplanted back to allow pregnancy and live birth. The procedure is …

This study looks at two ways to fix a specific type of meniscus tear in the knee. One method is standard repair, the other adds a step called centralization. Researchers want to see which approach leads to less pain, better function, and fewer repeat surgeries. About 54 adults wi…

This early-phase trial tests a drug called WSD0922-FU in about 56 people with certain brain cancers (glioblastoma, anaplastic astrocytoma) or lung cancer that has spread to the brain or spinal cord. The drug blocks a protein called EGFR, which helps some cancers grow. The main go…

This early-phase trial is testing a combination of two drugs—selinexor and choline salicylate—in people with certain blood cancers (lymphoma and multiple myeloma) that came back or didn't respond to previous treatments. The main goal is to find the safest dose and see how well pa…

This early-phase study tests whether delivering a person's own fat-derived stem cells directly into an artery is safe for treating moderate to severe ulcerative colitis. About 20 adults aged 18-65 who have not responded to at least two standard medications will receive the treatm…

This study compares two types of radiation therapy after surgery for head and neck cancer: proton therapy (IMPT) and standard X-ray therapy (IMRT). The goal is to see if proton therapy can control cancer just as well while causing fewer side effects. About 174 adults with newly d…

This study tests whether a person's own stem cells can be safely injected into the spinal fluid to treat multiple system atrophy (MSA), a rare and serious brain disease. About 30 adults aged 30-80 with MSA will receive the treatment. The main goal is to check for side effects, an…

This early study tests whether stem cells taken from a patient's own belly fat can safely help heal pressure ulcers and diabetic foot ulcers. Twelve adults with these hard-to-treat wounds will have a small amount of fat removed, processed to extract stem cells, and then applied t…

This study tests whether adding an experimental FASN inhibitor (TVB-2640) to standard treatments (trastuzumab plus either paclitaxel or hormone therapy) can shrink tumors or slow disease in people with HER2-positive breast cancer that has spread and stopped responding to prior th…

This study tests a shorter, higher-dose radiation treatment given before surgery for soft tissue sarcoma in the arms, legs, or trunk. The goal is to see if this approach affects wound healing complications after surgery. About 120 adults with localized, removable tumors will take…

This study follows 55 adults aged 18-65 who have a specific type of meniscus tear (root tear) and undergo a repair surgery called transtibial pullout. The goal is to see if the surgery improves knee function and delays arthritis. Participants will be tracked for up to 2 years usi…

This study tests whether combining the chemotherapy drug pemetrexed with the immunotherapy drug pembrolizumab can shrink or control advanced salivary gland cancer that has returned or spread. About 45 adults with this rare cancer will receive both drugs intravenously. The goal is…

This study tests a small device placed in a heart vein to lower pressure inside the heart during exercise. It is for people with heart failure with preserved ejection fraction (HFpEF) and microvascular dysfunction. The study will enroll 35 adults at Mayo Clinic to see if the devi…

This study tests a new treatment for multiple system atrophy (MSA), a rare and deadly brain disease that gets worse quickly. Researchers are giving patients their own stem cells, taken from fat tissue, through a spinal injection to see if it can slow the disease. The trial involv…

This study tests whether transplanting a donor larynx (voice box) can safely restore function in people who have lost their larynx due to injury, disease, or surgery. Up to 10 adults with severe larynx problems will receive a transplant and be followed for at least one year to ch…

This study looks at people having a Whipple procedure, a major surgery for pancreatic diseases. A common complication is a leak from the pancreas, which can lengthen hospital stays. The trial compares giving antibiotics for a shorter time along with a drug called octreotide versu…

This study tests whether stem cells taken from a patient's own belly fat and injected into the spinal fluid can safely slow down ALS. 75 adults with ALS will receive four injections over a year. The goal is to see if this treatment can help control the disease and improve daily f…

This study tests if atorvastatin (Lipitor), a widely used cholesterol medicine, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo for several months.…

This early-phase trial tests a specially designed virus (VSV-hIFNbeta-NIS) that is meant to infect and kill cancer cells while leaving healthy cells alone. It is given intravenously to people with stage IV or recurrent endometrial cancer. The main goals are to find the safest dos…

This study looks at whether the beta-blocker carvedilol can prevent or treat heart problems in breast cancer patients receiving HER2-targeted therapy. About 184 adults with HER2-positive breast cancer are randomly assigned to start carvedilol either before or after signs of heart…

This study looks at whether sleeping longer (over 7 hours a night) for 8 weeks can lower blood pressure in people with prehypertension or mild hypertension who usually sleep 6.5 hours or less. About 110 adults aged 18 to 65 will either get sleep coaching or general health educati…

This study compares a short course of high-dose radiation to the standard longer course for people with glioblastoma, an aggressive brain cancer. The goal is to see if the shorter treatment is just as effective at keeping patients alive at 12 months while possibly causing fewer s…

This study aimed to see if a device called LabClasp could accurately estimate blood lactate levels without needles. It planned to test healthy adults during exercise and ICU patients. However, the study was withdrawn before any participants were enrolled.

This study tests a new, less invasive way to detect Barrett's esophagus and esophageal cancer using a sponge on a string. Participants swallow the sponge, which collects cells from the esophagus for lab analysis. The goal is to see if this simple test can accurately identify earl…

This study tests a new device called magnetocardiography (MCG) to see if it can quickly and accurately tell if chest pain is caused by reduced blood flow to the heart. Researchers will compare MCG results to standard tests in 1,000 emergency room patients. The goal is to speed up…

This study tests a new needle guide grid that helps doctors place biopsy needles more accurately during MRI-guided prostate biopsies. About 20 people scheduled for a biopsy or ablation will take part. The goal is to see if the technology improves needle placement and reduces the …

This study tests whether an Apple Watch, worn over time, can catch atrial fibrillation (a common heart rhythm problem) early in people who are at high risk but haven't been diagnosed yet. About 2,000 participants from Mayo Clinic will use the watch for long-term monitoring. The g…

This study looks for special DNA markers in blood, urine, and tissue that could help detect kidney tumors earlier. Researchers will collect samples from about 589 people with different types of kidney tumors and healthy volunteers. The goal is to find markers that can be used for…

This study tests a tool called DESI-MS that may help surgeons tell cancerous from healthy brain tissue during surgery. About 285 adults having brain tumor removal will take part. The goal is to see if this method can give faster, more accurate results than current lab tests.

This study tests whether a special PET/CT scan using a radioactive tracer called 68Ga-DOTATATE can better detect neuroendocrine tumors (like neuroblastoma) in children and young adults up to age 30. The scan is compared to the standard MIBG scan to see which one more clearly show…

This study tests a new ultrasound method that uses a contrast agent to create detailed images of blood vessels in the kidneys. Researchers want to see if this can help diagnose chronic kidney disease more accurately. The study includes both healthy volunteers and people with kidn…

This study looks at whether adding a polygenic risk score (a measure of many small genetic factors) to standard risk tools helps women ages 35-75 at high risk for breast cancer decide on prevention steps, such as taking medication, having risk-reducing surgery, or getting extra i…

This study looks at whether giving women a simple self-collection kit for HPV testing at Express Care clinics (which have evening and weekend hours) can increase the number of women who get screened for cervical cancer. About 500 women ages 30–63 who are overdue for screening wil…

This study tests whether giving heated chemotherapy directly into the abdomen during surgery can prevent stomach or gastroesophageal junction cancer from returning in the abdominal lining. It is for 16 patients at high risk of recurrence. The approach aims to kill any cancer cell…

This study tests whether taking an over-the-counter probiotic (VSL#3) can prevent colitis (colon inflammation and diarrhea) in cancer patients receiving immunotherapy. About 12 adults with solid tumors who are starting or have just started immunotherapy will take the probiotic da…

This study tests whether a short course of two drugs (glecaprevir/pibrentasvir and ezetimibe) can prevent hepatitis C infection in people who receive a kidney, heart, lung, or pancreas from a hepatitis C-positive donor. About 200 participants who are hepatitis C-negative and awai…

This study tests a wearable device that uses mild electrical stimulation to the inner ear to reduce motion sickness during virtual reality. Researchers at Mayo Clinic will enroll 40 adults aged 21 to 55. Participants will use the device while in VR, and their motion sickness symp…

This early study tests whether a combination of two drugs, dasatinib and quercetin, is safe and possible for people with mild cognitive impairment or Alzheimer's disease. The goal is to see if these drugs can clear aging cells from the brain. Twenty participants aged 55 and older…

This study looks at how many doses of the steroid dexamethasone are best to give before and after knee replacement surgery. The goal is to find the dose that reduces pain, lowers the need for strong painkillers (opioids), and decreases nausea and vomiting. About 339 adults having…

This study tests three types of wave therapies—focused shockwaves, radial pressure waves, and electromagnetic waves—to see if they help heal lower leg injuries like muscle strains, cartilage damage, and bone bruises. About 200 adults with a doctor-confirmed leg injury will receiv…

This study looks at whether using a 7-inch footstool while on the toilet can improve constipation symptoms. About 85 adults with chronic constipation will use either the real footstool or a very low sham version for several weeks. The goal is to see if the squatting posture helps…

This study explores whether a non-invasive brain stimulation technique called tDCS is practical and helpful for hospitalized adults with treatment-resistant depression. Ten participants will receive 10 sessions of tDCS alongside their usual care. The main goals are to see if pati…

This early-stage study tests whether injecting a patient's own lab-grown stem cells into the hip is safe and can reduce pain from osteoarthritis. About 24 adults aged 18-65 with hip arthritis will receive the injections. The main goal is to check for side effects and see if diffe…

This study was designed to test a device called JOGO for people with functional tremor, a condition where the body shakes without a clear physical cause. JOGO uses stickers on the skin to measure muscle activity and gives feedback to help control the tremor through training sessi…

This study tests a non-invasive treatment called High-Intensity Focused Electromagnetic (HIFEM) technology to help men recover bladder control faster after prostate surgery. About 2,100 men who have urinary leakage after radical prostatectomy or HoLEP will receive the treatment. …

This study tests if focused shockwave therapy can reduce front-of-knee pain in people who had ACL reconstruction using a tendon graft. Twenty adults who had this surgery will receive the treatment, and researchers will measure changes in knee function and pain using standard ques…

This study tests whether virtual reality (VR) meditation can reduce the impact of fibromyalgia, a chronic pain condition. About 40 adults with fibromyalgia will try both an active VR meditation program and a sham (fake) VR version, comparing how each affects their symptoms. The g…

This study looks at whether using virtual reality (VR) is safe and tolerable for people with gastroparesis, a condition where the stomach empties slowly causing nausea and pain. About 30 adults aged 18 to 75 with confirmed gastroparesis will try VR therapy. Researchers will track…

This study tests a 10-week home exercise program for endometrial cancer survivors who live in rural areas or are from underserved groups. Participants do strength training twice a week using a video call. The goal is to see if the program is practical and helps improve physical f…

This study tests whether using a virtual reality (VR) headset during knee or hip surgery can help patients feel less anxious and reduce the need for sedating drugs. About 50 adults will use VR along with their usual nerve-block anesthesia. The goal is to see if VR improves the su…

This study compares two ways of giving oxygen during an endoscopic ultrasound in patients with a high body mass index. The goal is to see if high flow nasal cannula helps patients wake up faster and reduces procedure interruptions. About 200 adults will take part at Mayo Clinic.

This study looks at whether giving ketamine during surgery can help reduce chronic nerve pain in people with brachial plexus injuries (nerve damage in the shoulder/arm area). About 100 adults scheduled for nerve repair surgery will be randomly assigned to receive ketamine or a pl…

This study looks at whether a supervised exercise program can improve heart function and quality of life for people with heart failure and pulmonary hypertension (high blood pressure in the lungs). Researchers will measure oxygen use during exercise and blood pressure in the lung…

This study looks at whether repairing the hip capsule during hip arthroscopy improves recovery compared to leaving it unrepaired. About 250 adults aged 18 to 50 with hip pain from femoroacetabular impingement (FAI) will be randomly assigned to one of two groups. The main goal is …

This study tests whether a slow-release painkiller (Exparel) works better than the standard one for pain after eye removal surgery. About 88 adults having their eye removed will be randomly assigned to get one of the two painkillers during surgery. The goal is to see if the slow-…

This study looks at whether whole-body aerobic exercise or leg weight training works better to improve symptoms and quality of life in people with Pulmonary Arterial Hypertension (PAH). About 45 adults with PAH will participate. Researchers will measure changes in oxygen use and …

This study looks at whether getting a paravertebral nerve block both before and after rib removal surgery helps control pain better than getting the block only before surgery. About 50 adults with thoracic outlet syndrome will take part. Researchers will measure pain levels and q…

This study tests whether using virtual reality (VR) goggles during heart procedures can help patients feel more comfortable and reduce the amount of sedation medication they need. Ten adults scheduled for a heart ablation will wear VR headsets as a distraction. The goal is to see…

This study tests whether a safe, non-invasive brain stimulation device (tDCS) used at home, combined with guided activities, can improve memory, language, and quality of life. It involves 55 adults who have had a stroke, brain tumor, or a neurodegenerative condition like Parkinso…

This study tests whether cutting a small nerve in the knee during a total knee replacement can lessen chronic pain after surgery. About 178 adults having their first knee replacement took part. The goal is to see if this extra step improves pain relief compared to the standard pr…

This study tracks how much symptoms improve after a procedure called radiofrequency ablation for thyroid nodules. Researchers will use a simple questionnaire to measure symptoms before and after the procedure. The goal is to better understand how well the treatment eases discomfo…

This study tests a wristband device that uses mild nerve stimulation to help reduce hand tremors in adults with essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. About 20 participants will use the device twice daily for three months. Researchers…

This study tests whether fisetin, a natural substance found in strawberries, can reduce frailty and inflammation in healthy women aged 70 and older. Forty participants will take fisetin or a placebo to see if it improves walking speed and other measures of physical function. The …

This study looks at whether having an empty bladder before CT simulation for prostate cancer radiation therapy leads to fewer urinary problems compared to the usual full bladder. About 168 men with prostate cancer will be randomly assigned to either empty or full bladder preparat…

This study tests whether using virtual reality (VR) can reduce anxiety, depression, and emotional distress in people with a terminal illness who are in palliative care. About 20 participants will use VR goggles and report their feelings before and after. The goal is to see if VR …

This study tests whether fisetin, a natural anti-inflammatory compound, can reduce frailty and blood markers of inflammation in adults aged 70 and older. About 40 participants will receive either fisetin or a placebo to see if it improves strength and reduces inflammation. The go…

This study tests a mobile health tool called iPREPARED that helps patients aged 60+ and their caregivers prepare for a hospital stay. The app provides tips to prevent or reduce delirium (sudden confusion) using simple activities like re-orientation and distraction. Researchers wa…

This study tests a new device designed to clear blockages in surgical drain tubes. Researchers want to see if it helps drains work better and reduces how long they need to stay in. The study involves 500 adults having abdominal surgery at Mayo Clinic, along with the nurses caring…

This study tests whether a virtual group therapy program can help caregivers of people with advanced cancer or serious life-limiting illness. Caregivers often feel hopeless, burdened, or lose their sense of meaning. The therapy focuses on helping them connect to purpose and reduc…

This pilot study from Mayo Clinic tests whether combining dry needling (a technique where thin needles are inserted into muscle knots) with therapeutic exercise can improve sleep in people with chronic neck pain and sleep problems. The study enrolls 28 adults aged 18-75 who have …

This study looks at whether eating fermented foods (like yogurt, kimchi, and sauerkraut) can increase the variety of good bacteria in the gut and help with long COVID symptoms such as fatigue, anxiety, and brain fog. Researchers will enroll 40 adults who had COVID in the past yea…

This study tests whether stem cells from donated bone marrow can safely reduce low back pain caused by worn-out facet joints. About 40 adults with chronic pain will receive the cells and be monitored for side effects and pain relief. The goal is to see if this approach can ease s…

This study looks at whether taking two pain medicines (tramadol and oxycodone) together works better than taking oxycodone alone after knee or hip replacement surgery. The goal is to see if the combination reduces the total amount of opioids needed and lowers side effects. About …

This study tests a new device called the Catheter Caps Case (C3) for people on dialysis who have a catheter. The goal is to see if it is more comfortable and easier to use than the usual gauze and tape. Ten adult patients with a tunneled dialysis catheter will try the device for …

This study tested whether taking kava extract, a natural supplement, could lower stress hormone levels and reduce burnout in nurses. Two hundred nurses from Mayo Clinic took part. Researchers measured changes in cortisol and burnout scores to see if kava helps ease work-related s…

This pilot study tests whether Electromagnetic Transduction Therapy (EMTT) can reduce pain and improve daily function in people with mid-foot osteoarthritis. About 20 adults with confirmed foot or ankle arthritis will receive the treatment. The goal is to see if this non-invasive…

This study tests whether using a smaller ureteral stent after kidney stone surgery reduces pain and discomfort. About 100 adults who need a stent on a string after their procedure will rate their pain daily until the stent is removed (usually 7-14 days). The goal is to find the b…

This study looks at two different ways to prescribe high-intensity interval training (HIIT) for people in cardiac rehab. The goal is to see which method better improves fitness, heart function, and how well muscles use oxygen. About 30 adults with heart conditions like a recent h…

This study tests a new imaging machine called StarGuide NextGen SPECT/CT to see how well it captures pictures used in nuclear medicine. About 100 people who are already scheduled for a nuclear medicine scan or therapy will also get an extra scan on this new system. Doctors will r…

This study aims to understand how social factors—like where someone comes from—affect how immigrant men from Sub-Saharan Africa and the Caribbean seek care and make decisions about prostate cancer. Researchers will interview 80 men to identify themes and build a model that explai…

This study tests a new MRI guidance software called Philips Interventional iSuite to see if it helps doctors place needles more quickly and accurately during biopsies and tumor ablations. About 12 people already scheduled for an MRI-guided procedure will take part. The goal is to…

This study collects blood samples from 18 people with cervical cancer to see if HPV DNA from the tumor can be detected in the blood. Researchers hope this information can help predict how well treatment works and catch cancer early if it comes back. The study is observational and…

This pilot study at Mayo Clinic tests whether personalized education and genetic counseling can increase genetic testing in people who have a first-degree relative with pancreatic cancer. About 40 participants aged 18-75 with a family history but no personal history of the diseas…

This study looks at whether a new scaffold material is safe to use when repairing a nerve after a biopsy. About 20 adults with nerve conditions like peripheral neuropathy will take part. The main goal is to see if using the scaffold causes fewer side effects like pain, swelling, …

This study is a long-term follow-up for people who already took part in the CREST-2 trial, which looked at treatments for narrowed carotid arteries. Researchers want to see how well those treatments worked over time by tracking strokes. No new treatments are given—just observatio…

This study aims to find 50 people with rare genetic diseases that currently have no good treatment. Researchers will collect blood and tissue samples to understand each person's unique genetic change. They hope to develop personalized drugs, called antisense oligonucleotides, tha…

This study aims to understand the molecular causes of spine deformities and degeneration by analyzing spinal tissue from 300 children and adults undergoing spine surgery. Researchers will measure RNA levels to identify potential targets for future treatments. This is an observati…

This study aims to find out how common a widened aorta (the main artery from the heart) is in people over 35 who have been weightlifting for at least 5 years. Researchers will use ultrasound to measure the aorta in bodybuilders, cross-fit athletes, and power lifters. The goal is …

This study surveys about 1,200 women at a Florida prison to understand their cancer screening history, risk factors, and barriers to care. The information will be used to create a digital education module on screenable cancers and guidelines. The goal is to improve health literac…

This study tests a new MRI method called MR elastography to measure brain stiffness, which may help detect high pressure inside the skull without invasive procedures. Researchers will compare these measurements with eye scans and standard MRI signs in 200 people with and without …

This study looks at whether people with early-onset Alzheimer's disease have hidden seizures or epilepsy. Twenty participants wear a portable brain wave monitor for 48 hours at home. The goal is simply to count how many people have seizure activity, not to test a treatment.

This study aims to create a large collection of blood and tumor samples from 300 people whose breast cancer has spread or returned. By linking these samples with medical information, researchers hope to learn why the cancer spreads and why people respond differently to treatments…

This study collects saliva, blood, and tissue samples from 100 adults with lymphedema to store for future research. No treatment or direct benefit is offered. The goal is to build a resource for discovering biomarkers that could improve microvascular treatments down the road.

This study looks at whether certain gene variants make people more likely to develop kidney stones. Researchers will analyze blood samples and lifestyle information from 2,900 adults with and without a history of calcium oxalate stones. The goal is to identify genetic and environ…

This study tests a new electric bandage that creates small amounts of hydrogen peroxide to help clean wounds and fight infection. Researchers at Mayo Clinic are putting the bandage on the healthy skin of 40 volunteers to see if it causes any irritation, discomfort, or allergic re…

This study looks at how homocysteine (a natural substance in the blood) and blood vessel function relate to kidney disease severity in people with early-stage Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers will measure these factors in 80 participants aged 15-4…

This study looks at better ways to detect heart damage in adult cancer survivors who received certain chemotherapy drugs. Researchers are testing if an AI-powered ECG and a simple blood test can find early signs of heart trouble. The goal is to gather information needed to create…

This study is for people with Autosomal Dominant Polycystic Kidney Disease (ADPKD). Researchers want to see if certain markers in the blood and urine can predict how fast the disease gets worse. About 100 people aged 15 to 70 will give samples and have MRI scans over time. No new…

This study tracks 50 cancer patients receiving immunotherapy to see if it affects their balance and hearing. Participants take standard hearing and balance tests before starting treatment and again at 3, 6, and 12 months. The goal is to better understand these potential side effe…

This study looks at whether children with metal implants (like plates, screws, or rods) have higher metal levels in their blood and tissues. Researchers want to understand if these metals cause any harm. The goal is to learn if removing the implants or using different metals coul…

This study looks at whether the type of education patients receive before ACL reconstruction surgery affects their satisfaction, anxiety, and recovery. About 105 adults with a first-time ACL tear will be randomly assigned to different education methods. The goal is to see if bett…

This study was designed to see if a computer program called CURE can help doctors write discharge summaries for heart patients leaving the hospital. The goal was to check if a larger study is possible, not to directly improve patient health. No patients were enrolled, so the stud…

This study looks at how radiation therapy changes certain markers in the blood of people with breast cancer. Researchers want to see if these markers can help tailor treatments for each patient. About 217 adults with breast cancer who are scheduled for radiation will participate.…

This early study at Mayo Clinic tests whether using an automated leg massage device each night can improve the brain's waste-clearing system in people over 50 with treated obstructive sleep apnea. Researchers will measure changes in blood markers linked to brain health and sleep …

This study aims to collect DNA, RNA, and other samples from 5,000 people with rare or undiagnosed diseases, plus their family members. Researchers will store these samples in a biobank to study what causes these conditions and how to treat them better. Participants must have a su…

This study follows 140 breast cancer patients who were part of the original BEAUTY study. Researchers will collect blood and tissue samples over time to learn why some breast cancers respond well to standard chemotherapy and others do not. The goal is to find clues that could lea…

This study collects blood and tissue samples from people who have at least two close relatives with pancreatic cancer, or one relative with pancreatic cancer and one with melanoma. The goal is to build a large, well-organized database and sample bank that researchers can use to b…

This study looks at women with hypothalamic amenorrhea (HA), a condition where periods stop for months or years due to stress, exercise, or weight loss. Researchers want to see if HA is linked to early signs of heart disease. About 90 women will wear FitBits and answer surveys to…

This study looks at whether fisetin, a natural compound, can improve stem cell function, reduce inflammation, and help with physical frailty in people with advanced chronic kidney disease. About 30 adults aged 40-80 with kidney disease will take fisetin or a placebo for 14 days. …

This study tests a new, noninvasive ultrasound technique to look at tiny blood vessels inside the kidneys of people with Autosomal Dominant Polycystic Kidney Disease (ADPKD) and healthy volunteers. Researchers want to see if this method can measure blood vessel health and help tr…

This study watches 500 acutely ill patients in a hospital telemetry unit to see how their heart rate, blood pressure, breathing, and oxygen levels change as their health gets worse. Researchers also track the medications and fluids patients receive. The goal is to better understa…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study follows 419 people who do not have pancreatic cancer but are at high risk due to family history or genetic mutations. Researchers collect blood samples and health information over time to see who develops cancer. The goal is to find blood markers that could predict or …

This study aims to learn more about symptoms of brain diseases like Parkinson's and frontotemporal dementia. Researchers will track 500 adults over time using brain scans and genetic analysis to see how the disease changes. The goal is to better understand these conditions, not t…

This study looks at lymph node tissue from 200 adults who have had any organ transplant. Researchers will measure certain proteins to see if they relate to how well the transplant works. The goal is to learn more, not to test a new treatment.

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like Parkinson's, Alzheimer's, and dementia. Researchers will compare scan results with clinical diagnoses in 500 adults aged 40-90. The goal is to improve understanding of these conditions…

This study aims to understand why minority cancer patients often do not take part in clinical trials. Researchers will survey 590 patients to learn about their challenges and preferences. The information will be used to create a personalized educational platform to help these pat…

This study was designed to find out if blood tests taken during and after pregnancy could help predict future heart problems in women with adult congenital heart disease. Researchers planned to follow pregnant participants and track heart-related events like arrhythmias or heart …

This study is collecting DNA samples from 110,000 Mayo Clinic patients to learn how genetic information can improve health care. Researchers will look for gene changes that raise disease risk and see if sharing these results helps people take action. The goal is to build a huge d…

This study tests a new ultrasound technique to measure stiffness in the wrist nerves and tissues of people with carpal tunnel syndrome. Researchers will check 20 adults before and after they receive either a steroid injection or surgery. The goal is to see if this ultrasound meth…

This study tests whether a brain implant (RC+S) and a handheld device can safely track seizures, mood, and thinking in 5 people with hard-to-treat epilepsy. The system records brain activity and can stimulate the brain to try to prevent seizures. The goal is to see if the approac…

This study looks at how well blood flows in the breast skin after radiation therapy and after a fat grafting procedure. Researchers will use a special ultrasound to measure blood supply in 15 breast cancer patients who had a mastectomy and are getting implant reconstruction. The …

This study tests kidney transplant patients for genetic mutations that increase cancer risk. Researchers want to see if genetic testing helps improve cancer screening. About 177 participants who have received a kidney or kidney-pancreas transplant will take part. The goal is to f…

This study aims to find the ideal level of muscle relaxation that makes placing a breathing tube (intubation) easiest and safest. Researchers will measure muscle twitch strength in 108 adults and compare three different relaxation levels to see which one leads to the best intubat…

This study uses an Apple Watch to monitor how the benefits of deep brain stimulation (DBS) change throughout the day in people with essential tremor. About 50 participants who already receive DBS at Mayo Clinic will perform simple tasks while the watch records movement. The goal …

This study follows 36 people with HER2-positive breast cancer who are receiving the drug T-DM1. The goal is to learn how often and how severely nerve damage (peripheral neuropathy) occurs, and how it changes over time. Participants fill out questionnaires about their symptoms, an…

This study collects blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD) to learn more about the condition. Researchers aim to use this information to improve how IBD is treated and managed. Participants must be between 18 and 85 years old and h…

This study looks at whether early support services can help people in Minnesota who are injured or ill stay at work or return to work sooner. Over 5,200 adults who recently became unable to work are taking part. The goal is to reduce long-term disability and keep people employed.

This study looks at tiny particles called extracellular vesicles that come from prostate cancer cells. Researchers want to see if levels of these particles in blood and urine change after surgery to remove the prostate. The goal is to learn if these particles can help doctors und…

This study tests whether a smartphone app that analyzes your voice can spot signs of depression and anxiety in people recovering from a heart attack. About 200 adults in cardiac rehab will use the app alongside their usual care. The goal is to see if the app helps improve emotion…

This study will collect samples from 10,000 Mayo Clinic patients to perform advanced genetic and biological testing. The goal is to build a large data resource that researchers can use to find links between genes, environment, and disease. Participants must be 18 or older and abl…

This study compares two ways to monitor muscle relaxation during robotic or laparoscopic surgery: electromyography (EMG) and acceleromyography (AMG). The goal is to see which method leads to using less muscle relaxant medication. About 400 adults having planned keyhole surgery wi…

This early-stage study tests a new type of marker that shows up brightly on ultrasound, called a twinkling marker, in people with breast cancer that has spread to lymph nodes. The marker is placed in the affected lymph node before chemotherapy and surgery to help surgeons find an…

This study was designed to see if a drug called AEO could help protect or restore brain function after radiation therapy for brain cancer. It planned to collect spinal fluid samples from adult patients to measure brain metabolism. However, the trial was withdrawn before enrolling…

This study aimed to see if using blood flow restriction (BFR) therapy during physical therapy helps people regain strength and movement after surgery for a biceps tendon tear or a kneecap dislocation. It planned to include adults aged 18 to 80. However, the study was withdrawn be…

This study is building a large group of 21,000 people newly diagnosed with non-Hodgkin lymphoma to track their health over time. Researchers will look at medical history, lifestyle, genetics, and treatments to find out what affects survival, side effects, and quality of life. The…

This study looks at how scoliosis treatment (surgery or bracing) changes children's muscle function and daily physical activity. Researchers will use wearable activity monitors and muscle stiffness tests to compare kids before and one year after treatment. The goal is to better u…

This study follows 260 adults with hypertrophic cardiomyopathy to learn how often they develop heart rhythm problems like atrial fibrillation and ventricular arrhythmias. Researchers also want to see if sleep apnea affects these risks. The goal is to better understand these elect…

This study aimed to see if a rapid whole genome sequencing test on amniotic fluid could give faster genetic diagnoses for unborn babies with suspected health problems. Researchers planned to compare results from amniotic fluid and blood samples from up to 90 families. However, th…

This study looks at whether the bacteria in your gut can help predict your risk of heart disease. Researchers will collect blood and stool samples from 700 adults having a heart catheterization to examine gut bacteria and signs of inflammation. The goal is to better understand th…

This study will follow 100,000 adults who have already received genetic testing through the Tapestry program at Mayo Clinic. Researchers want to see if knowing your genetic results changes how often you visit the doctor, stay in the hospital, or go to the ER, and whether it affec…

This study aimed to see if patients were more satisfied and had better-looking scars when their hand surgery wounds were closed with absorbable (dissolving) stitches versus non-absorbable (removable) stitches. The study planned to include adults having carpal tunnel or trigger fi…

This study screens 1000 adults aged 40 and older for MGUS, a condition where an abnormal protein is found in the blood. While MGUS itself is not cancer, it can sometimes develop into multiple myeloma, a blood cancer. Researchers aim to learn more about the genetic and immune fact…

This study looks at how amino acids change the way the body releases glucagon and insulin when blood sugar is high. Researchers will compare healthy people, those with type 2 diabetes, and people with obesity. The goal is to better understand these hormone responses, not to test …

This study from Mayo Clinic is creating a single, standard test to see how well people handle low oxygen (hypoxia) while exercising. Researchers will measure things like breathing, heart rate, and blood oxygen levels in 50 physically active adults. The goal is to find out why som…

This study uses special brain scans (tau PET) to measure how anti-amyloid immunotherapy changes tau protein buildup in people with mild Alzheimer's disease. Researchers will follow 135 patients at Mayo Clinic to see if the therapy affects tau levels and to monitor for side effect…

This study tests a new MRI method called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare 106 adults with and without chronic pain to see if this technique can spot differences in tissue st…

This study looks at how a mother's emotional health and lifestyle—like stress, sleep, and diet—might change the levels of melatonin and an immune protein called sIgA in her breast milk. Researchers will collect milk samples and survey 120 new mothers. The goal is to better unders…

This study looks at whether giving primary care doctors coaching or communication classes can make patients more satisfied and reduce doctor burnout. About 45 doctors from Mayo Clinic will take surveys before, right after, and two months after the training. The goal is to see if …

This study looks at whether regularly checking blood sugar levels without needles during early pregnancy can help predict two common problems: gestational diabetes and preeclampsia (high blood pressure). About 100 pregnant women at risk for these conditions will use a non-invasiv…

This study is testing a new blood test to see if it can find signs of bile duct cancer (cholangiocarcinoma) coming back or getting worse after treatment. Researchers will take blood samples before and after surgery or therapy to look for specific markers. The goal is to improve h…

This study tests a new MRI method to see if it can measure scarring in narrowed kidneys. Researchers will scan 24 people with high blood pressure and narrowed kidney arteries. The goal is to see if this MRI technique is reliable and can predict kidney recovery.

This study looks at how exercise changes fat tissue and how those changes might improve health as we age or if we have obesity. Researchers at Mayo Clinic will study 56 healthy adults, both younger and older, to measure immune cells and proteins in fat before and after exercise. …

This study tests a new device that records brain activity in people with epilepsy that doesn't respond to medication. The device aims to detect unusual brain signals and deliver small electrical pulses to prevent seizures. In this early phase, researchers are checking if the devi…

This study looks at metal levels (cobalt, chromium, titanium, nickel) in the blood of 60 adults after knee replacement surgery. Some had robotic-assisted surgery, others had the traditional method. The goal is to see if one approach leads to higher metal levels, which could affec…

This study tests how well two different muscle monitors work when a patient's arms are tucked during surgery. Researchers will compare the accuracy and precision of these devices in 40 people having procedures without muscle relaxants. The goal is to improve monitoring for safer …

This study enrolls 3,000 people who have at least two blood relatives with pancreatic cancer but do not have the disease themselves. Researchers will track their health every two years to learn how to better detect and understand pancreatic cancer in high-risk families. The goal …

This study tests new, improved fetoscopes (thin tools used to perform surgery on a baby while still in the womb) in 100 pregnant women. The goal is to see if these devices are safe and work well before they can be approved by the FDA. Researchers will track any side effects, devi…