New combo therapy aims to unmask cancer cells in Hard-to-Treat lymphoma
NCT ID NCT05507541
First seen Apr 28, 2026 · Last updated Apr 28, 2026
Summary
This study tests a combination of two drugs, TTI-622 and pembrolizumab, in people with diffuse large B-cell lymphoma that has returned or not responded to prior treatment. TTI-622 blocks a protein called CD47 that cancer cells use to hide from the immune system, while pembrolizumab helps immune cells attack the cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 10 adults with certain types of B-cell lymphoma will participate.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Mayo Clinic
Rochester, Minnesota, 55905, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
Conditions
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