Mayo Clinic

This study tests whether a nurse-led education program can reduce hospital readmissions for patients undergoing hip or knee replacement who also have conditions like heart failure, COPD, or kidney problems. About 300 participants will either receive the extra nurse support or sta…

This study tests a smartphone app designed to help people with bipolar disorder who also struggle with alcohol or drug use. About 40 participants will use the app to connect with care teams and track their progress. The goal is to see if the app is easy to use and helps reduce su…

This study tests whether adding a lab-modified virus (VSV-IFNβ-NIS) to standard immunotherapy drugs (ipilimumab and nivolumab) can shrink tumors in people with advanced or metastatic clear cell renal cell carcinoma. The virus is designed to kill cancer cells without harming norma…

This study tests whether the drug Bimzelx (bimekizumab) can improve skin symptoms in adults with pityriasis rubra pilaris, a rare condition causing red, scaly patches. About 12 participants will receive the drug for 24 weeks, and doctors will measure how much the skin clears. The…

This study tests whether adding daily lung ultrasound and vein pressure checks to standard care can help people with acute heart failure leave the hospital sooner and reduce the chance of coming back. About 500 adults admitted to the hospital with heart failure will be randomly a…

This study follows 80 babies with a severe birth defect called congenital diaphragmatic hernia (CDH) who had a special surgery (FETO) while still in the womb. Researchers want to see if these babies survive more often and have fewer long-term health problems compared to babies wi…

This study tests a new drug called ABBV-383 in people with Waldenström macroglobulinemia, a rare blood cancer that has come back or stopped responding to other treatments. The drug is a monoclonal antibody designed to block cancer cell growth. The trial has two phases: first, fin…

This study tests whether adding the drug axatilimab to standard care can prevent graft-versus-host disease (GVHD) in blood cancer patients receiving a stem cell transplant from a donor. GVHD occurs when donor cells attack the patient's body, causing symptoms like skin rash, dry e…

This study tests whether a cannabis-based drug (Dronabinol) can help control blood pressure and heart function. Researchers at Mayo Clinic will enroll 50 healthy adults aged 21-40 who use cannabis occasionally. The goal is to see how the drug affects blood pressure and related bo…

This study tests a new digital device that measures how well you see (visual acuity). Researchers will compare its results to standard eye exams in 150 adults. They will also collect voice recordings of people saying letters to improve speech recognition for future eye tests.

This study tests three gentler methods to find Barrett's esophagus, a condition that can lead to esophageal cancer. The methods include an AI tool that checks health records, a sponge-on-a-string test that collects cells from the throat, and nurse help to guide patients through s…

This study looks for unique proteins in urine and blood that can tell apart different types of kidney cancer without needing a biopsy. Researchers will test stored urine samples and collect blood before and after kidney removal surgery in 300 high-risk patients. The goal is to de…

This study tests whether offering cervical cancer screening (via a self-collection kit) and HPV vaccination in the Emergency Department can reach women who might otherwise miss these preventive services. Researchers will enroll 100 women aged 18-65 and track how many choose to pa…

This study tests whether taking low-dose aspirin can lower inflammation in the womb lining and help prevent endometrial cancer. It involves 25 postmenopausal women who have certain tissue changes and pain. Participants will be randomly assigned to take aspirin or not, and researc…

This study looks at whether adding a neutral shoe insert to standard physical therapy can reduce pain and improve function in people with long-term lateral hip pain (greater trochanteric pain syndrome). About 36 adults with hip pain lasting over 3 months will be randomly assigned…

This study tests whether taking dronabinol (a synthetic cannabis-like drug) before bed helps people with moderate to severe sleep apnea use their CPAP machine more consistently. Researchers will also check if combining CPAP with dronabinol improves sleep quality and blood pressur…

This pilot study at Mayo Clinic tests whether daily light therapy can reduce behavioral and psychological symptoms like agitation in people with dementia. Researchers will enroll 70 inpatients and measure how well they tolerate and complete the 5-day light sessions. The goal is t…

This study compares a physical activity program to a health education program to see if exercise can improve memory and attention in Hispanic women aged 50 and older who have been treated for early-stage breast cancer. Researchers will measure changes in thinking skills and brain…

This study tests whether using a device that stimulates the vagus nerve, along with nicotine replacement therapy (like patches or gum), can help people stop smoking. About 150 adults who smoke at least 10 cigarettes a day and want to quit will receive the nerve stimulation plus s…

This study tests whether THC (with or without CBD) can improve sleep in people with solid organ cancer who have insomnia. About 69 participants will receive either THC, a THC/CBD mix, or a placebo. The goal is to see if these cannabis-based treatments can ease insomnia symptoms a…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis who still have an intact rotator cuff. About 108 participants will be randomly assigned to one surgery and followed for a year to see which leads to better should…

This study tests a virtual reality assistant (ViRA) designed to help Black men who have just been diagnosed with prostate cancer. The ViRA provides emotional support, education, and help finding resources like food or housing. Researchers want to see if using this tool improves w…

This study tests whether taking tranexamic acid pills for a few days after hip replacement surgery can reduce pain, help people walk sooner, and lower the risk of complications. About 101 adults having their first hip replacement will take either the drug or a placebo. The goal i…

This study tests whether dry needling with electrical stimulation can improve sleep and reduce symptoms in people with restless legs syndrome. Researchers will measure sleep quality, leg movements, and symptom severity in 20 adults aged 18-75. The treatment involves inserting thi…

This study compares two common medicines, sodium bicarbonate and THAM, used to treat metabolic acidosis (too much acid in the blood) during heart surgery. About 250 adults having heart surgery with a heart-lung machine will take part. The goal is to see if both drugs work equally…

This study looks at how a specific gene change (rs7903146) affects the body's ability to produce a hormone called GLP-1 inside the pancreas. Researchers will give 80 healthy adults a drug that blocks GLP-1 and measure changes in blood sugar, insulin, and glucagon. The goal is to …

This study aims to see how well pulse oximeters measure oxygen levels compared to the gold standard—blood samples. Researchers will enroll 20 healthy adults, including people with dark skin, to check if skin tone affects accuracy. Participants will breathe different oxygen mixtur…

This study uses a special PET scan with an investigational drug called C-11 ER176 to look for signs of inflammation in the brains of people with Post-COVID Syndrome (Long COVID). Researchers hope to learn more about what causes ongoing symptoms after a COVID-19 infection. The stu…

This study looks at how menopausal hormone therapy (MHT) affects the heart's ability to pump blood. Researchers will compare heart function in postmenopausal women who use MHT and those who don't. The goal is to understand the role of the nervous system in controlling heart perfo…

This study looks at how fat tissue in the upper body reacts after a meal, comparing normal-weight people to those with obesity. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue works, not…

This study looks at whether people with spontaneous coronary artery dissection (SCAD) feel comfortable talking to an AI avatar instead of a human clinician before their appointment. About 150 patients at Mayo Clinic will try the avatar and rate their satisfaction. The goal is to …

This study aims to understand how resistance exercise training helps muscles use insulin better to control blood sugar. Researchers at Mayo Clinic will study 16 sedentary adults to measure changes in muscle protein production. The goal is to uncover the biological mechanisms behi…

This study looks at how long the drug calaspargase pegol stays active in the blood of children with acute lymphoblastic leukemia or lymphoma. Researchers want to know if higher drug levels are linked to more side effects. About 20 children will take part, and the goal is to bette…

This study looks at how chemotherapy drugs like 5-FU and capecitabine affect blood vessels in people with gastrointestinal cancer. Some patients experience chest pain or heart problems due to blood vessel spasms. Researchers will use a device called EndoPAT to measure blood vesse…

This study will test whether using ultrasound to find the ulnar nerve is better than using body landmarks for placing stimulating electrodes. Forty healthy adults will take part at Mayo Clinic. The goal is to see which method delivers more reliable nerve stimulation to hand muscl…

This study looks at how insulin affects muscle, blood, and the body in people with type 1 diabetes. Researchers will measure protein changes when insulin is low and blood sugar is high. About 70 adults with type 1 diabetes will take part. No treatment is tested; the goal is to le…

This study observes 100 patients having elective brain surgery to clip an aneurysm. Some take daily aspirin, some don't. Researchers track bleeding during surgery, blood changes, and CT scans afterward to understand the risks. The goal is to help doctors decide whether to stop or…

This early study tests if a small device can safely collect fluid from the brain during planned surgery for glioma (a type of brain tumor) or epilepsy. Six adults will have the device placed temporarily during their operation. The main goals are to see if the procedure is safe an…

This study compares a new heart monitoring technique called magnetocardiography (MCG) to the standard ECG in 100 adults with atrial fibrillation and Long QT syndrome who are starting a heart rhythm medication. The goal is to see if MCG can more accurately predict who will have a …

This study looks at 600 adults with heart valve disease who are scheduled for valve surgery. Researchers want to understand how different types of lung blood vessel problems affect recovery of the heart's right side and tricuspid valve. The goal is to find patterns that help pred…