Mayo Clinic

This early-stage study tested a custom-made vaccine for people with advanced ovarian, fallopian tube, or primary peritoneal cancer. The vaccine was made from each patient's own white blood cells and designed to train the immune system to attack cancer cells. The main goal was to …

This study tested a virtual world-based cardiac rehab program called 'Destination Cardiac Rehab' against traditional center-based rehab. Over 2,800 heart patients participated to see if the virtual program could match or beat standard care in improving diet, exercise, smoking, sl…

This study tested a combination of two drugs, auranofin and sirolimus, in 29 people with advanced or recurrent lung cancer who had run out of standard treatment options. The goal was to find the best dose and see if the combo could slow cancer growth. The trial focused on safety …

This early-phase study tested whether a special butyrate tablet (BKR-017) could help people with type 1 diabetes better manage their blood sugar and lower fats in the blood. Six adults with type 1 diabetes took the tablets for 28 days while researchers measured changes in insulin…

This study looked at how an inhaled drug called treprostinil affects exercise ability in people with pulmonary hypertension caused by interstitial lung disease. 29 participants took the drug for 3 months. Researchers measured heart function and breathing efficiency during exercis…

This study tested whether a home-based pulmonary rehabilitation program using new technology and health coaching helps people with COPD stick with their rehab after a hospital stay, compared to the usual referral to a center-based program. About 296 adults aged 40 and older who w…

This study tested a drug called alisertib, either alone or with another drug called fulvestrant, in 96 postmenopausal women with advanced breast cancer that had stopped responding to hormone therapy. The goal was to see if these treatments could shrink tumors. While the approach …

This study tested a treatment for HPV-related throat cancer using higher-frequency radiation plus the chemotherapy drug docetaxel. The goal was to improve tumor control and survival. 81 patients participated in this phase II trial at the Mayo Clinic.

This study tested a shorter, higher-dose radiation treatment given before breast cancer surgery in 25 people with early-stage breast cancer. The goal was to see if this approach could kill more tumor cells and reduce side effects. The main measure was how many patients had no or …

This study tested whether aiming a laser (SLT) at the nasal or inferior part of the eye works better to lower pressure in open-angle glaucoma. 13 adults with high eye pressure received one of the two treatments. The main goal was to see which location reduces eye pressure more ef…

This small early-phase study tested whether combining a topical skin cream (imiquimod) with an immunotherapy drug (pembrolizumab) is safe and effective for people with advanced melanoma that has spread. Seven participants with stage IIIB-IV melanoma were enrolled. The goal was to…

This study tested if it's safe and possible to do two heart procedures at the same time for people with atrial fibrillation (irregular heartbeat) and a severe leaky mitral valve. 25 participants received both a MitraClip to fix the valve and a Watchman device to prevent strokes f…

This study tested whether combining two non-surgical procedures (HAPC and ESG) helps people with obesity lose more weight than ESG alone. 45 adults with a BMI between 30 and 40 who had trouble losing weight with diet and exercise took part. The main goal was to see if the combine…

This study tested the drug PB to see if it can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced kidney damage, and polycystic kidney disease treated with tolvaptan. Thirty-six adults with…

This study tested a shorter course of radiation (hypofractionation) in 52 men with prostate cancer who had high-risk features after their prostate was removed. The goal was to see if giving higher doses over fewer sessions could better control the cancer and reduce side effects. …

This study tested a drug called obinutuzumab in 20 adults with a serious kidney disease called FSGS that did not get better with standard treatments. The goal was to see if the drug could lower protein levels in urine, a sign of kidney damage. The results may offer a new option f…

This study looked at whether doing cardiac rehab at home, or a mix of home and clinic visits, is as effective as going to the clinic for rehab. 206 adults with heart conditions took part. The goal was to see if remote options could improve access and outcomes.

This study looked at whether two types of diabetes medications (DPP4 and SGLT2 inhibitors) are safe and helpful for people with Parkinson's disease or Lewy body dementia who also have mild diabetes or pre-diabetes. 18 participants took the drugs for 4 weeks, and researchers measu…

This study tested the drug ibrutinib in 35 people with chronic lymphocytic leukemia (CLL) who still had small amounts of cancer after their first treatment. The goal was to see if ibrutinib could clear those leftover cells from the blood and bone marrow. Participants took ibrutin…

This study tested whether giving a combination of drugs (vemurafenib, cobimetinib, and atezolizumab) before surgery could help patients with high-risk stage III melanoma. The goal was to see if the treatment could shrink or eliminate tumors before surgical removal. The trial invo…

This study looked at 20 adults with stage 2-3 non-small cell lung cancer that could not be removed by surgery. Participants received standard chemotherapy along with different doses of proton beam therapy to find the safest and most effective dose. The goal was to improve cancer …

This study looked at whether taking simple sugars as a daily supplement can improve health in children with congenital disorders of glycosylation (CDG), a rare condition that affects how the body builds important sugar chains. Researchers measured growth, blood sugar, liver funct…

This study tested a shorter, more intense form of radiation therapy called proton-based SABR for men with early-stage prostate cancer. Instead of the usual eight weeks of daily treatments, patients received five treatments over two weeks. The goal was to see if this approach coul…

This study tested whether the drug sotatercept, given for 36 weeks, can improve how the heart works during exercise and enhance quality of life in people with pulmonary arterial hypertension (PAH). Thirty adults with PAH took part. The goal was to see if the drug helps the heart …

This study looked at kidney transplant patients taking either a once-daily or twice-daily version of the anti-rejection drug tacrolimus. The goal was to see if the once-daily pill led to fewer side effects, better medication adherence, and improved quality of life. 261 adults who…

This small pilot study tested a new way to treat low-risk prostate cancer using MRI-guided laser ablation. Seven men with early-stage prostate cancer received the treatment to see if it was safe and could successfully destroy tumors. The goal was to control the disease with fewer…

This study tested a new combination treatment for people with non-Hodgkin lymphoma that had come back. The approach used three steps: first, freezing the tumor to kill cancer cells; second, injecting a personalized vaccine made from the patient's own immune cells; and third, givi…

This study tested a combination of two drugs—futibatinib (which blocks cancer cell growth) and pembrolizumab (which helps the immune system attack cancer)—in 14 adults with advanced or spreading liver cancer that had not responded to prior treatment. The goal was to see if the co…

This study tested a combination of two targeted antibodies (pertuzumab and trastuzumab) plus a chemotherapy drug (enzalutamide) in 7 men with advanced prostate cancer that had spread and stopped responding to standard hormone treatments. The goal was to see if the combo could shr…

This study compared two breast imaging methods—molecular breast imaging (MBI) and digital breast tomosynthesis (DBT)—in over 3,000 women with dense breast tissue. The goal was to see if MBI could find more invasive cancers than DBT alone. Dense breast tissue can make mammograms h…

This study tested a new 3D ultrasound test called QTI to see if it works as well as MRI for breast cancer screening in women with a high lifetime risk. 26 women completed the study, and researchers compared how well each method detected potential cancers. The goal was to see if Q…

This study looked at whether MRI scans can help doctors diagnose rheumatoid arthritis (RA) sooner in people with joint swelling that doesn't yet have a clear cause. 75 adults with early symptoms were followed for a year. The goal was to see if MRI findings could predict who would…

This study tested whether women can collect their own vaginal samples to check for HPV (a virus that can cause cervical cancer). Researchers compared the accuracy of self-collected swabs to those taken by a doctor. The goal is to make screening easier and more accessible.

This study tested a new imaging method that uses a radioactive tracer (68Ga-PSMA) with PET/MRI or PET/CT scans to find liver cancer earlier and stage it more accurately. About 52 adults with liver cancer took part. The goal was to see if this approach works better than standard s…

This study tested a new way to diagnose inborn errors of metabolism, a group of rare genetic disorders. Researchers used a technique called global metabolomic profiling to analyze blood and urine samples from 240 participants. The goal was to see if this method works better than …

This study tested whether artificial intelligence (AI) can accurately read skin patch test results for contact dermatitis, just like a doctor would. 151 participants had patches applied to their skin to check for allergies, and the AI analyzed the reactions. The goal is to make r…

This study looked at whether people with a history of non-muscle invasive bladder cancer prefer a urine-based molecular test or a cystoscopy (a camera inserted into the bladder) for routine cancer surveillance. 107 participants tried both methods and reported their preference and…

This study tested a new ultra-low-dose chest CT technique to find abnormal blood vessels in the lungs of children with hereditary hemorrhagic telangiectasia (HHT). The goal was to see if the scan could use much less radiation than usual while still detecting these vessels clearly…

This study tested whether a special PET scan using 68Ga-PSMA can better detect and track advanced liver cancer. 29 adults with liver cancer that could not be removed by surgery received this imaging alongside standard treatment. The goal was to see if the scan improves how doctor…

This study tested whether a special PET/CT scan (PSMA PET) can help doctors see if treatment is working in people with metastatic adenoid cystic carcinoma, a rare salivary gland cancer that has spread. Six adults who already had this cancer and were in another study received two …

This study looked at 150 female athletes, ages 14-24, who had a first ACL tear and were at risk for a second one. Researchers used movement tests to identify high-risk athletes and tested different rehab programs to see which best prevents re-injury. The goal is to help athletes …

This study tested whether a shorter course of proton therapy (15 sessions) is as safe as the standard longer course (25 sessions) for women who had a mastectomy for breast cancer and need radiation to nearby lymph nodes. 88 women participated. The goal was to see if the shorter s…

This study tested whether the drug rimegepant can help prevent cluster headaches, a very painful type of headache that comes in cycles. Twenty adults with cluster headaches took rimegepant and recorded how often attacks happened and how severe the pain was. The goal was to see if…

This study tested if a special hypnotherapy program, delivered online, could help reduce bloating. 27 adults with ongoing bloating took part. Researchers measured changes in bloating severity and quality of life.

This study compared two ways to manage pain after a scheduled C-section: a single dose of intravenous methadone versus a spinal injection of morphine. Researchers measured how much extra pain medicine women needed in the first two days after delivery. The goal was to find which a…

This study tested whether weighted blankets can reduce agitation and other behavioral symptoms in people with dementia. Thirty patients from hospital and hospice settings participated. Researchers measured changes in agitation and overall symptom burden using standard scales. The…

This study looked at whether a specific stretch called the sleeper stretch can help CrossFit athletes with shoulder pain move better and perform stronger. 26 regular CrossFit participants were included, and the study measured shoulder range of motion, strength, and upper body per…

This study looked at how two different procedures for draining blocked bile ducts affect patients' quality of life. 121 people with benign or malignant blockages were included. They either had an endoscopic drainage (ERCP) or a percutaneous drainage (PTBD). The study measured cha…

This study tested two different numbing creams on 22 adults getting laser treatment for sun-damaged skin. Each person tried both creams on different sides of their face to see which one reduced pain more. The goal was to find the best way to make the laser procedure more comforta…

This study looked at whether gradually lowering opioid doses over time affects pain, quality of life, and mood in people with chronic non-cancer pain. Eighteen adults on stable opioid therapy were followed to compare slow tapering versus staying on their current dose. The goal wa…

This study tested whether an injection made from a person's own blood (called A2MRP) is safe and can reduce pain in people with moderate knee osteoarthritis. Twenty adults aged 18 to 65 with knee arthritis received the injection. Researchers tracked side effects and used pain que…

This small pilot study tested whether varenicline, a drug typically used to help people quit smoking, could change how the rectum senses pressure in people with irritable bowel syndrome (IBS) and chronic belly pain. Eight adults with IBS (but not constipation type) took part. The…

This study tested whether a 5-minute calming virtual reality (VR) experience can lower blood pressure and anxiety in adults whose blood pressure rises in a clinic setting (white coat hypertension). 79 participants had their blood pressure and anxiety measured before and after the…

This small study looked at whether adding brief lifestyle advice—like improving diet and physical activity—to standard insomnia therapy (CBT-I) could improve sleep quality. Five adults with chronic insomnia participated. The goal was to see if these simple changes could help peop…

This study tested a collaborative care program for 516 people with stage III or IV cancer to see if it could help them maintain physical function and reduce pain. Participants received targeted case management to support mobility and quality of life. The goal was to improve daily…

This study tested whether critically ill patients on breathing machines could safely control their own anxiety medication (dexmedetomidine) instead of having a nurse give it. 161 adults in the ICU were randomly assigned to either self-manage their sedation or receive standard nur…

This study tested whether a nasal spray made with rose geranium oil in sesame oil can improve nose symptoms like dryness, discomfort, bleeding, or scabbing in cancer patients receiving chemotherapy. About 106 adults with cancer and nose symptoms joined this phase III trial. Half …

This study tested a pain management program for 51 cancer survivors living in rural areas or who are Hispanic. The goal was to see if the program was easy to use and helpful for controlling cancer-related pain. Researchers measured how often participants used the program and how …

This study tested a health coaching program called BeWell360-CG for caregivers of people with advanced lung cancer. The goal was to see if coaching could reduce caregiver stress and improve their quality of life. About 55 caregivers took part, and researchers measured changes in …

This study tested a special pain program for breast cancer survivors who have joint and muscle pain caused by their hormone therapy (aromatase inhibitors). The program combined education, coping skills, and gentle movement to help 105 participants reduce pain, improve mood and da…

This pilot study tested whether vagal nerve stimulation could reduce fatigue and headaches in people with Post-COVID syndrome. 18 participants used the device and reported changes in their symptoms. The goal was to see if this approach is worth studying further.

This small pilot study looked at whether people with eosinophilic esophagitis (EoE) triggered by milk can safely eat baked milk without causing inflammation. Seven participants followed a 6-week diet including baked milk, and researchers checked for signs of remission using a les…

This study tested whether a headband that senses brain activity (Muse-S) could help midlife women with sleep problems like insomnia. 31 women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality and reduced stre…

This study tested a virtual program that combines mindfulness exercises with weight management for obese cancer survivors. The goal was to see if it could improve mood, reduce stress, and help with weight loss. Nineteen adults who had stage I-III cancer and a BMI of 30 or higher …

This pilot study looked at whether distance Reiki—a hands-off energy therapy—could improve quality of life and immune function in 30 adults with multiple myeloma who had a stem cell transplant. Participants were randomly assigned to receive real Reiki, fake (sham) Reiki, or no ex…

This pilot study tested whether acupressure, a non-invasive technique using finger pressure on specific body points, can help reduce anxiety in patients receiving chemotherapy. Thirty adults undergoing chemo at Mayo Clinic who reported at least mild anxiety took part. The study f…

This study looked at two treatments for severe fecal incontinence (accidental bowel leakage) in 275 adults. Participants first tried basic management like diet changes and exercises. Those who still had symptoms were randomly assigned to either biofeedback (retraining muscles) or…

This study looked at 50 adults having spine surgery to see if different ways of closing the wound affect blood flow around the cut. Doctors used a special camera and dye to measure blood flow after each closure method. The goal was simply to gather information, not to test a new …

This study looked at whether a simple mobile ECG device, combined with artificial intelligence, can help find early signs of dilated cardiomyopathy in close relatives of people who have the condition. About 119 adults took part, including patients with the disease and their first…

This study looked at how often patients experience lasting muscle weakness after liver transplant surgery when given a drug called Sugammadex. Researchers used a device on the thumb to measure muscle response. The goal was to better understand recovery and improve anesthesia care…

This study tested whether a simple breath analysis could help diagnose or predict liver disease, liver cancer, and COVID-19. Researchers collected breath samples from 46 participants to detect unique chemical patterns. The goal was to develop a non-invasive test for disease diagn…

This study looked at what happens in the skin when breast cancer patients get radiation therapy. Researchers took small skin samples from 20 patients to understand why some people get itchy, red, or swollen skin. The goal is to find better ways to prevent or treat these skin reac…

This study tested a portable headset that sends tiny electrical currents through the skin to help people hear sounds and speech. Researchers worked with 68 healthy volunteers (all Mayo Clinic employees) to find the best settings for different frequencies and environments. The goa…

This study involved 24 people with lung or esophageal cancer receiving radiation therapy near the heart. Researchers used a small implanted device to continuously monitor heart activity for up to a year. The goal was to detect early heart changes that might otherwise go unnoticed…

This study tested whether an EEG (a simple brain wave recording) can help diagnose Alzheimer's disease at different stages. Researchers collected EEG data from 29 people, including those with mild cognitive impairment, Alzheimer's, dementia with Lewy bodies, and healthy volunteer…

This study looked at whether wearing the InBody Band 3 fitness tracker could help Black prostate cancer survivors become more active, improve their body composition, and feel better overall. Thirteen people took part for six weeks. The goal was to see if using the tracker was pra…

This study looked at whether ultrasound can measure how tendons and nerves move inside the wrist's carpal tunnel. Researchers compared 257 people with and without carpal tunnel syndrome. The goal was to see if ultrasound can detect differences in tissue thickness and movement, wh…

This study looked at whether a wearable device that tracks vital signs and a smartphone app that asks about symptoms can work better than the usual checks done at the doctor's office. About 100 adults with certain cancers (like lung, head and neck, or blood cancers) took part. Th…

This study examined why African and Asian immigrants in Minnesota have higher rates of hepatitis B and C infections, which can lead to liver cancer. Researchers tested 892 participants for hepatitis markers and looked at viral genetics and immune responses. The goal was to better…

This study looked at 56 older adults (65+) with multiple myeloma to see if a comprehensive geriatric assessment—a series of questions and tests about physical and mental health—along with blood tests could help predict which patients would have more side effects from chemotherapy…

This study looked at whether brain tumor patients on oral chemotherapy prefer video visits or in-person checkups. 30 adults with glioma took part, alternating between telehealth and in-person appointments. The goal was to see which method patients liked more and if it affected th…

This study watched conversations between 37 lung cancer patients and their doctors to create a decision aid. The tool helps patients who have had surgery decide whether to have additional treatment. The goal is to make sure patients feel heard and satisfied with their choice.

This study looked at whether postmenopausal female endurance athletes have stiffer hearts and lower exercise capacity compared to premenopausal women and male athletes of similar age. Researchers measured heart stiffness using MRI and exercise capacity with stress echocardiograph…

This study looked at whether a special MRI technique called ZTE can make breast biopsy markers made of bone cement easier to see than the usual metal markers. Twenty adults with breast cancer took part. Two radiologists scored how well the markers showed up on the images. The goa…

This study looked at how surgery on unborn babies with birth defects like spina bifida affects the immune system of both the mother and the fetus. Researchers wanted to understand if immune system changes might cause some babies to be born too early. The study included 21 pregnan…

This study looked at over 2,400 people with rheumatic diseases who were taking methotrexate. Researchers wanted to see if getting lab tests less often was as safe as the usual schedule. They compared rates of serious problems like organ damage or death between the two groups. The…

This study tested a new way to use a breathing machine (ventilator) called VentCoach, which aims to better protect the lungs of patients with breathing failure. 18 adults in the ICU took part. Researchers compared VentCoach to standard care to see if it was easy to follow and if …

This study looked at whether voice and speech patterns change during manic episodes in people with Bipolar I Disorder. Researchers recorded and analyzed audio from 17 hospitalized participants, focusing on pitch, rhythm, response time, sentence structure, and word choice. The goa…

This small study looked at why some people get long-lasting headaches after a mild brain injury and whether a drug called erenumab could help. Six adults with recent post-traumatic headaches took either the drug or a placebo. The main goal was to see if the drug reduced the numbe…

This study followed 66 women for 3 months after a scheduled C-section to see how their health and pain changed over time. Researchers used simple scales to measure overall health and pain levels. The goal was to understand the typical recovery pattern, not to test a new treatment…

This study looked at whether using saliva instead of blood can help monitor cytomegalovirus (CMV) infection in people being treated for ovarian cancer. 49 participants provided both saliva and blood samples, either at the clinic or at home. The goal was to see if remote saliva co…

This study looked at how certain immune cells, called eosinophils, interact with fat tissue in people with obesity and insulin resistance. Four participants provided fat biopsies and blood samples to measure immune cell levels and markers of inflammation. The goal was to better u…

This study tested whether a simple pulse flow meter could detect active bleeding in 13 adults undergoing emergency endoscopy for gastrointestinal bleeding. Researchers compared pulse volume changes before and after the procedure to see if the device could predict high-risk bleedi…

This study gathered information from 105 breast cancer survivors and healthy volunteers to create a detailed database. The goal is to help doctors better diagnose cancer, predict long-term health, and develop new treatments. Researchers also want to learn how gut bacteria might a…

This study looked at medical records from over 386,000 adults with type 2 diabetes and moderate heart disease risk. Researchers compared four common second-line diabetes drugs to see which ones were safest for the heart. The goal was to help doctors and patients choose the best t…

This study looked at immune cells in the bone marrow and lymph nodes of kidney transplant donors and recipients. The goal was to create a detailed immune profile to better understand how the body reacts to a transplant. About 288 people took part, and the study did not test any n…

This study checked how well a computer-controlled treadmill can create precise balance disturbances. Twelve healthy adults walked on the treadmill while sensors measured belt movements. The goal was to see if the treadmill's commands matched what actually happened, not to treat a…

This study looked at 13 people undergoing a standard esophagus pressure test to see which breathing positions or maneuvers create the highest pressure at the junction between the esophagus and stomach. Higher pressure there may mean stronger diaphragm contraction, which could hel…

This study looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. Researchers measured changes in muscle strength, insulin response, and body composition in 58 adults aged 50-75. The go…

This study looked at whether certain genes make people more likely to develop Primary Biliary Cirrhosis (PBC), a progressive liver disease. Researchers enrolled 1,500 adults with PBC and their close relatives to map genetic risk factors. The goal is to better understand how PBC d…

This study looked at how the way blood samples are collected and processed affects the ability to detect tumor DNA in people with early-stage breast cancer. Researchers tested different blood collection tubes, storage conditions, and processing methods to see which best preserved…

This study looked at how the asthma drug mepolizumab affects gene activity in 20 adults with severe eosinophilic asthma. Researchers compared blood samples taken before and 12 weeks after starting the drug to find which genes changed. The goal was to better understand how the tre…

This study looked at the DNA of breast tumors from 140 people to understand why some cancers are destroyed by standard chemotherapy and others are not. Researchers compared genetic changes in the tumor to those in the patient's normal cells. The goal is to use this information to…

This study looked at whether a special PET scan (18F-DOPA) can better detect brain tumors in people with newly diagnosed gliomas who are about to start radiation therapy. Researchers compared results from standard scans and this PET scan to see if it helps plan more precise treat…

This study used special brain scans (PET) to look at a protein called tau in people with primary progressive aphasia (PPA) and frontotemporal dementia (FTD). The goal was to see how much tau buildup occurs in different types of these conditions. 81 adults with speech or behavior …

This study aimed to find the highest safe concentrations of midazolam, ketamine, and ondansetron for skin allergy testing. These drugs are commonly used before, during, and after surgery. Researchers tested 21 healthy volunteers to determine doses that would not cause false skin …

This study tested a device called SimPull that helps move patients from one bed to another. Researchers wanted to see if it was faster and needed fewer staff than current methods. 100 patients having heart procedures took part. The study also asked nurses if they felt safer using…

This study tested whether a special PET scan called 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part. The goal was to see if this scan gives useful information beyond standard MRI to …

This study looked at whether detergents found in everyday products like toothpaste can make the lining of the esophagus leaky and lead to allergic inflammation, a condition called eosinophilic esophagitis. Researchers tested 12 healthy adults by measuring changes in the esophagus…

This study looked at how obesity changes muscle fiber types and protein production. Researchers gave 48 volunteers exercise and amino acid infusions to see how their muscles responded. The goal was to understand the biological reasons behind muscle changes in obesity, not to test…

This study looked at how different levels of muscle relaxation affect the ease of placing a breathing tube during surgery. Researchers tested 170 patients to find the best time to insert the tube. The goal was to improve the process and reduce patient discomfort.