Mayo Clinic

This study tested whether the drug fenofibrate could prevent bile duct damage in people who received a liver from a donor after circulatory death. Only 6 patients took part before the study was stopped. The main goal was to see if patients could tolerate the drug without serious …

This study tested whether a tamoxifen skin gel works as well as the standard tamoxifen pill to lower breast cancer risk in women with atypical hyperplasia or lobular carcinoma in situ (LCIS). About 65 women were enrolled, but the study was stopped early. The goal was to see short…

This study tested a combination of two drugs, daratumumab and ibrutinib, in people whose chronic lymphocytic leukemia (CLL) had returned or stopped responding to prior treatment. The goal was to see if the combination could shrink or control the cancer better than ibrutinib alone…

This study tested a genetically modified measles virus designed to infect and kill cancer cells without harming healthy ones. It was compared to standard chemotherapy in 17 women with platinum-resistant ovarian, fallopian tube, or peritoneal cancer. The trial was terminated early…

This early-phase trial tested a drug called STI-3031, given directly into the lymph nodes or vessels using a special device, for people with in-transit melanoma (cancer that has spread through lymph channels but not yet to distant organs). The main goals were to find the safest d…

This study looked at patients leaving the hospital with a chest tube and valve for a prolonged air leak. Half received antibiotics and twice-weekly phone check-ins; the other half got standard care. The goal was to see if extra monitoring and antibiotics could reduce infections a…

This study tested a combination of two drugs, ibrutinib and ixazomib, in 21 people with Waldenström macroglobulinemia, a rare blood cancer. The goal was to see if the combo could shrink tumors or stop the cancer from growing. The study was stopped early, so results are limited, b…

This early-phase trial tested a specially modified virus (VSV-IFNb-TYRP1) in 12 people with advanced melanoma that had spread or couldn't be removed. The virus was injected directly into tumors and also into a vein, aiming to kill cancer cells and trigger the immune system. The m…

This study tested whether adding the immunotherapy drug bintrafusp alfa to standard chemotherapy (docetaxel) helps people with advanced non-small cell lung cancer whose disease worsened after prior treatment with immunotherapy and chemotherapy. The trial planned to enroll 10 adul…

This study tested whether a newer drug, obinutuzumab, works better than the standard drug rituximab for a rare disease that causes inflammation of blood vessels (ANCA-associated vasculitis). The goal was to see if patients could achieve remission and clear certain antibodies from…

This study tested a precise type of proton radiation for people with liver cancer. The goal was to see if it could control the cancer while limiting harm to the liver. Nine adults with early-stage or recurrent liver cancer took part. The trial was stopped early, but the results h…

This study tested a drug called P1101 in 11 people with early myelofibrosis, a bone marrow disorder. The goal was to see if it could shrink the spleen, improve symptoms, or slow the disease. The trial was stopped early, so results are limited.

This early-stage trial tested a new drug called NXP800 in 7 people with advanced bile duct cancer that had spread or stopped responding to standard treatments. The goal was to find a safe dose and see if the drug could slow tumor growth. The study was terminated early, so results…

This study tested a drug called abemaciclib in people with triple negative breast cancer that did not shrink with standard chemotherapy. The goal was to see if the drug could change the immune environment inside the tumor, making it more responsive. The trial was stopped early, b…

This early-phase study tested whether combining the immunotherapy drug durvalumab with a special type of radiation (grid therapy) could help treat non-small cell lung cancer that had stopped responding to standard treatment. Only 4 people were enrolled before the study was stoppe…

This small pilot study tested whether a special PET scan can find hidden heart inflammation in people receiving immune checkpoint inhibitors (a type of cancer immunotherapy). The goal was to see if this inflammation could be caught early before it becomes serious. Only 2 people t…

This study tested whether a special smartwatch (LIFELEAF) could accurately measure blood sugar, blood pressure, and heart signals without needles or cuffs. Researchers compared the watch's readings to standard hospital methods in 87 diabetic patients. The goal was to see if a sim…

This study compared a standard lung biopsy procedure (EBUS TBNA) with the same procedure plus a new imaging technique called nCLE, which uses a laser to see tissues in real time. The goal was to see if adding nCLE helps doctors diagnose lung cancer more accurately in people with …

This study looked at whether tiny bits of genetic material (extracellular RNA) found in the blood can help doctors diagnose liver cancer or other liver diseases. Researchers planned to enroll about 1,865 people with liver cancer, bile duct cancer, cirrhosis, or chronic liver dise…

This study tested whether a technique called axillary reverse mapping with lympho-venous bypass could prevent or reduce arm swelling (lymphedema) in people having lymph nodes removed for breast cancer or melanoma. The approach aimed to preserve or reroute the arm's lymph drainage…

This study aimed to find the best dose of a pain medicine (hydromorphone) given through a spinal injection to children having back surgery for scoliosis. Researchers wanted to balance good pain control with fewer side effects. The study was stopped early, but it included 31 child…

This study tested a device called SinuSonic that uses acoustic vibration and oscillating expiratory pressure to relieve facial pain and pressure from sinus headaches. It included 27 adults with facial pain lasting more than 3 months. Participants used either the active device or …

This study looked at whether a remote electrical stimulation device (Nerivio) could ease the pain of Botox injections in people with chronic migraine. About 80 adults who already get Botox for migraine prevention were to use the device during their injection appointments. The stu…

This study aimed to see if a paravertebral block (a type of nerve block) reduces pain after open pancreatic surgery compared to no block. Researchers planned to enroll many patients but stopped early with only 2 participants. The goal was to measure pain scores, hospital stay len…

This study aimed to see if the antibiotic rifaximin could reduce bloating in people with diabetic gastroparesis, a condition where the stomach empties slowly. Only 5 adults with diabetes and confirmed delayed stomach emptying joined before the study was stopped early. The main go…

This study tested the antibiotic rifaximin in 20 people with early-stage HER2-positive breast cancer who had stomach problems (like diarrhea and pain) from pertuzumab-based chemotherapy. The goal was to see if rifaximin could reduce these side effects so patients could stay on th…

This study aimed to find early markers of heart damage in people with sarcoma receiving a common chemotherapy drug (doxorubicin). Researchers used advanced heart ultrasound techniques to track changes over time. The goal was to identify which patients are at highest risk for hear…

This study looked at whether adding a genetic risk score to standard breast cancer risk assessments helps African American and Hispanic women decide about extra screening or prevention. The study enrolled 19 women at higher risk for breast cancer. The goal was to see if personali…

This study looked at how well the heart pumps blood and how quickly patients wake up from muscle relaxants used during surgery. Researchers measured heart function and recovery time in 7 adults having elective surgery. The study was stopped early, so results are limited.

This study aimed to find genetic changes in lung tissue and blood that could predict how squamous cell lung cancer progresses. Researchers planned to collect samples from 200 people undergoing lung procedures, but the study was stopped early with only 22 participants. No direct t…

This study aimed to see if using genome sequencing could help doctors choose better treatments for people with multiple lung adenocarcinoma tumors. Researchers planned to enroll 100 adults with early-stage, non-spread lung cancer. The study was terminated early, so results are li…

This study aimed to find out how often people with chronic hepatitis C have a blood condition called monoclonal B-cell lymphocytosis (MBL) and whether treating hepatitis C changes that. Researchers planned to compare blood samples from 29 participants before, during, and after he…