Promising CLL combo study halted early – only 8 patients enrolled

NCT ID NCT04230304

First seen Nov 03, 2025 · Last updated May 14, 2026 · Updated 19 times

Summary

This study tested a combination of two drugs, daratumumab and ibrutinib, in people whose chronic lymphocytic leukemia (CLL) had returned or stopped responding to prior treatment. The goal was to see if the combination could shrink or control the cancer better than ibrutinib alone. The trial was terminated early and enrolled only 8 participants, so results are limited.

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Contacts and locations

Locations

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

Conditions

Explore the condition pages connected to this study.