Engineered virus takes on deadly skin cancer in early trial

NCT ID NCT03865212

First seen Jan 09, 2026 · Last updated May 14, 2026 · Updated 20 times

Summary

This early-phase trial tested a specially modified virus (VSV-IFNb-TYRP1) in 12 people with advanced melanoma that had spread or couldn't be removed. The virus was injected directly into tumors and also into a vein, aiming to kill cancer cells and trigger the immune system. The main goals were to find the safest dose and understand side effects. The study was terminated early, so results are limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Mayo Clinic in Florida

    Jacksonville, Florida, 32224-9980, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

Conditions

Explore the condition pages connected to this study.