PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Clinical trials for PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8 explained in plain language.
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Immune cell attack: new combo therapy targets brain tumors in advanced melanoma
Disease control Recruiting nowThis study tests a new treatment for people with stage IV melanoma that has spread to the brain. It combines a chemotherapy drug (temozolomide) with specially grown immune cells (NK cells) from a healthy donor. The goal is to see if this combination is safe and can shrink brain t…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1, PHASE2 • Sponsor: Kari Kendra • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New cancer drug IACS-6274 enters early human testing
Disease control Recruiting nowThis early-phase trial is testing a new drug called IACS-6274, either alone or combined with other cancer drugs, in 54 adults with advanced solid tumors (such as melanoma, ovarian, or head and neck cancers). The main goal is to find the safest dose and understand side effects. Th…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New drug combo aims to shrink brain tumors in advanced melanoma
Disease control Recruiting nowThis phase II trial is testing two oral drugs, binimetinib and encorafenib, in 35 adults with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The study aims to see if this combination can control the disease and improve surviva…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Engineered immune cells take on Hard-to-Treat cancers
Disease control Recruiting nowThis early-phase trial tests a new treatment for people with advanced melanoma or other solid tumors that have spread. Doctors take a patient's own immune cells, modify them in a lab to better recognize and attack cancer, and give them back after a short course of chemotherapy. T…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: Anusha Kalbasi • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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Promising new combo tackles melanoma brain metastases in phase 2 trial
Disease control Recruiting nowThis phase 2 trial compares two treatment combinations for people with BRAF-V600 mutant melanoma that has spread to the brain. One group gets a targeted therapy (encorafenib and binimetinib) plus an immunotherapy (nivolumab), while the other gets two immunotherapies (ipilimumab a…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jun 26, 2026 15:43 UTC
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Could a poop transplant fix cancer treatment side effects?
Knowledge-focused Recruiting nowThis study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…
Matched conditions: PATHOLOGIC STAGE IV CUTANEOUS MELANOMA AJCC V8
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC