Blood RNA may reveal hidden liver cancers

NCT ID NCT02908048

Terminated Diagnosis Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether tiny bits of RNA in the blood can serve as markers for liver disease and liver cancer. Researchers collected blood samples from nearly 1,900 people with liver cancer, cirrhosis, or chronic liver disease. The goal was to see if these RNA markers could help diagnose cancer and predict how well a patient responds to treatment or if cancer returns after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple blood test to detect liver cancer earlier and monitor for recurrence after treatment.
What could go wrong: The study was terminated early, so results may be incomplete. It is an observational study, not a treatment trial, so no direct benefit to participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bile duct neoplasm biliary tract cancer Biliary Tract Neoplasms cholangiocarcinoma cirrhosis of liver Fibrosis hepatitis hepatocellular carcinoma liver disorder Liver Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT CANCER CIRRHOSIS HEPATOCELLULAR CARCINOMA LIVER DISEASES

Contacts and locations

Locations

Mayo Clinic

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
McGuire VA Medical Center

Richmond, Virginia, 23249, United States
The University of Chicago Medical Center

Chicago, Illinois, 60637, United States

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