New drug combo aims to shrink Hard-to-Treat salivary gland tumors

NCT ID NCT04895735

First seen Feb 02, 2026 · Last updated May 12, 2026 · Updated 14 times

Summary

This study tests whether combining the chemotherapy drug pemetrexed with the immunotherapy drug pembrolizumab can shrink or control advanced salivary gland cancer that has returned or spread. About 45 adults with this rare cancer will receive both drugs intravenously. The goal is to see how many patients benefit, either by tumor shrinkage or disease stabilization.

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Contacts and locations

Locations

  • Mayo Clinic in Arizona

    Scottsdale, Arizona, 85259, United States

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

Conditions

Explore the condition pages connected to this study.