New drug combo may bridge more patients to lifesaving CAR-T therapy

NCT ID NCT06834373

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 30 times

Summary

This study tests whether giving two drugs—golcadomide and rituximab—before CAR-T cell therapy can help control aggressive B-cell non-Hodgkin lymphoma that has returned or not responded to treatment. The goal is to keep the disease in check so more patients can qualify for and receive CAR-T therapy, which offers a chance for long-term control. About 41 adults with relapsed or refractory lymphoma will take part.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mayo Clinic Health System in Albert Lea

    RECRUITING

    Albert Lea, Minnesota, 56007, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic Health System-Eau Claire Clinic

    RECRUITING

    Eau Claire, Wisconsin, 54701, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic Health System-Franciscan Healthcare

    RECRUITING

    La Crosse, Wisconsin, 54601, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic Health Systems-Mankato

    RECRUITING

    Mankato, Minnesota, 56001, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Mayo Clinic in Arizona

    RECRUITING

    Scottsdale, Arizona, 85259, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic in Florida

    RECRUITING

    Jacksonville, Florida, 32224-9980, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Mayo Clinic in Rochester

    RECRUITING

    Rochester, Minnesota, 55905, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT RECURRENT AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA RECURRENT ALK-POSITIVE LARGE B-CELL LYMPHOMA RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT GRADE 3B FOLLICULAR LYMPHOMA RECURRENT GRADE 3B FOLLICULAR LYMPHOMA RECURRENT HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS RECURRENT HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED RECURRENT INTRAVASCULAR LARGE B-CELL LYMPHOMA RECURRENT PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG TYPE RECURRENT PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA RECURRENT T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA RECURRENT TRANSFORMED NON-HODGKIN LYMPHOMA REFRACTORY AGGRESSIVE B-CELL NON-HODGKIN LYMPHOMA REFRACTORY ALK-POSITIVE LARGE B-CELL LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA ACTIVATED B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA ASSOCIATED WITH CHRONIC INFLAMMATION REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA GERMINAL CENTER B-CELL TYPE REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY GRADE 3B FOLLICULAR LYMPHOMA REFRACTORY GRADE 3B FOLLICULAR LYMPHOMA REFRACTORY HIGH GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS REFRACTORY HIGH GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED REFRACTORY INTRAVASCULAR LARGE B-CELL LYMPHOMA REFRACTORY PRIMARY CUTANEOUS DIFFUSE LARGE B-CELL LYMPHOMA, LEG TYPE REFRACTORY PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA REFRACTORY T-CELL/HISTIOCYTE-RICH LARGE B-CELL LYMPHOMA REFRACTORY TRANSFORMED NON-HODGKIN LYMPHOMA