Chronic pain syndrome

This study tests a telemonitoring device called ANTALGEEK® that helps people manage acute pain at home after outpatient surgery. The device tracks pain levels and guides medication use, aiming to improve recovery and lower the risk of chronic pain. About 150 adults having surgery…

This study tests a new way to help people with chronic non-cancer pain who have been on long-term opioids. Instead of usual care, a team of doctors, pharmacists, physiotherapists, and psychologists works with the patient to create a personalized plan. The goal is to reduce pain i…

This study tests whether counseling plus a muscle relaxant (tizanidine) can help adults who have used opioids for a long time reduce their pain medication after elective surgery. About 375 participants will be randomly assigned to one of three groups: the combo treatment, counsel…

This pilot study tests whether a 14-day course of prednisone, an anti-inflammatory steroid, can prevent complex regional pain syndrome (CRPS) after wrist fracture surgery. CRPS is a painful complication that can lead to long-term disability and increased opioid use. The study wil…

This study tests a non-invasive brain stimulation technique (tDCS plus ultrasound) to help people with opioid use disorder and chronic pain reduce drug use. Researchers will compare active stimulation to a sham (fake) treatment in 126 adults already on methadone. The goal is to s…

This study tests whether daily text reminders and mindfulness messages can help people taking medication for opioid use disorder stay on track with their treatment. About 60 adults who recently started or restarted methadone or buprenorphine will receive texts for up to 6 months …

This study is testing whether switching to very low nicotine cigarettes can reduce cravings, withdrawal, and pain in people who smoke daily, have chronic pain, and are on buprenorphine for opioid use disorder. Sixty participants will be randomly assigned to either very low nicoti…

This study follows 2,000 people with chronic pain who are implanted with Abbott neurostimulators (spinal cord or dorsal root ganglion stimulators). Researchers will track side effects, device problems, and how well the devices control pain over time. It is an observational study,…

This study tests whether reducing PTSD symptoms can prevent acute pain from turning into chronic pain. Researchers will give 345 adults either a nerve block injection (stellate ganglion block) or trauma-focused talk therapy (cognitive processing therapy). The goal is to see if th…

This pilot study tests whether artificial intelligence can recognize pain by analyzing facial expressions in people with fibromyalgia. Researchers will compare 61 fibromyalgia patients with 61 healthy volunteers. They will also check saliva samples for biological markers of pain.…

This large Phase 3 trial tests whether giving lidocaine (a numbing medicine) through an IV during breast cancer surgery can prevent persistent pain that often follows. Over 1,600 adults having lumpectomy or mastectomy will be randomly assigned to receive lidocaine or a placebo. T…

This study tests whether a nerve block given before mastectomy can prevent depression and chronic pain afterward. Researchers will compare 140 women who receive the block to those who do not. The goal is to see if this simple procedure can improve recovery and quality of life.

This study compares an online program called Veteran ACT for Chronic Pain (VACT-CP) to another online pain program, Online Pain School, for veterans with chronic pain. The goal is to see which program better helps veterans improve their daily functioning, manage pain, and enhance…

This study tests whether a non-invasive device that stimulates a nerve in the ear can help people with fibromyalgia. Participants use the device for 30 minutes daily over four weeks. The goal is to see if it reduces pain, fatigue, and other symptoms by calming the body's stress r…

This phase 3 trial tests whether the drug neridronate, given as four IV infusions over 10 days, can reduce pain and other symptoms of complex regional pain syndrome type 1 (CRPS-1). About 270 adults with CRPS in one limb will receive either the drug or a placebo. The main goal is…

This study tests whether a program that addresses chronic pain can help teens with obesity stay in weight management treatment. Fifty adolescents aged 12-18 with both obesity and musculoskeletal pain will either receive the Pain and Weight Treatment (PAW) plus standard care, or p…

This early-phase study tests whether MDMA-assisted therapy can reduce pain in 20 adults with fibromyalgia. Participants receive MDMA combined with psychotherapy and undergo brain scans to see how the drug affects pain and the bond between patient and therapist. The goal is to und…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This study tests whether taking vitamin C around the time of knee replacement surgery can reduce long-term pain. About 400 adults having knee replacement will be randomly assigned to receive vitamin C or a placebo for 8 weeks. The main goal is to see if a larger study is possible…

This study tests whether core shamanism—sessions with drumming, rattling, and discussion—can help reduce pain and other symptoms in women with fibromyalgia. Twenty-five participants will attend up to five sessions while researchers measure pain, heart rate, breathing, and brain a…

This study tests whether transcranial magnetic stimulation (TMS) can reduce pain and improve thinking, mood, and physical function in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either real TMS or a sham treatment for two days. Researche…

This study compares two drugs, pregabalin and mirogabalin, to see which works better for fibromyalgia pain. About 674 adults with moderate to severe fibromyalgia who haven't tried these medications will take one of the drugs for several weeks. The main goal is to see how many peo…

This study investigates whether drinking plasma-activated water—water treated with light and nano gold particles to create smaller water clusters—can safely improve symptoms in people with fibromyalgia, a condition causing widespread pain. Researchers will measure changes in bloo…

This study tests whether a non-invasive brain stimulation technique called tDCS can reduce pain in people with Complex Regional Pain Syndrome (CRPS). Thirty-two adults with active CRPS will receive either real or sham stimulation over several sessions. The goal is to see if this …

This study tests a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) for people who have ongoing pain after a serious orthopedic injury. Researchers want to see if it's possible to run a larger study by checking how many people sign up, attend sessions…

This study is testing whether open-label placebo pills—capsules with no active ingredients that patients know are fake—can reduce chronic pain and improve sleep in people with temporomandibular disorder (TMD). About 111 participants will be split into three groups: one gets the p…

This study tests whether a mobile app that teaches cognitive behavioral therapy (CBT) can reduce chronic pain and improve daily functioning in adolescent survivors of childhood cancer. Researchers will compare the app to standard pain education in 228 participants (teens and thei…

This study tests whether dance therapy can help teens aged 12-20 with chronic pain feel better and move more freely. 160 participants will either attend weekly dance sessions for 15 weeks or receive standard care. The goal is to see if dancing reduces pain intensity and fear of m…

This study tests whether sleeping with a weighted blanket (about 10% of your body weight) can help adults with chronic pain feel better. About 44 people will use the blanket every night for 5 weeks and report changes in pain, sleep, and daily activities. The goal is to see if thi…

This study tests whether giving people with chronic pain a placebo pill—told openly that it's a placebo—can help them safely reduce their opioid painkiller use. 86 participants will either receive the placebo alongside a mind-body program or just electronic monitoring for 6 weeks…

This study tests whether a special laser (MLS class IV) can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos syndrome (hEDS), a condition that causes loose joints and widespread pain. Twenty-five adults will receive 10 laser sessions over 5 weeks, with pai…

This study tests three types of injections for people with chronic neck and shoulder muscle pain caused by trigger points. It compares platelet-rich plasma (PRP), a mix of PRP and steroid, and steroid alone to see which works best. 150 adults aged 18-65 with a single active trigg…

This study tests two non-invasive treatments—connective tissue massage and vagus nerve stimulation—alone or together, in 66 women with fibromyalgia. The goal is to see if these methods improve pain, sleep, fatigue, and quality of life. Participants will be randomly assigned to on…

This pilot study is testing a 12-session virtual therapy that combines two proven treatments—one for PTSD and one for chronic pain—into a single program. Researchers want to see if this integrated approach is feasible and acceptable for adults who suffer from both conditions. The…

This study tests whether acupuncture can make opioid painkillers more effective for people with fibromyalgia. About 45 adults who already take daily opioids will receive either real acupuncture or a sham (fake) version. Researchers will measure pain changes after an opioid dose t…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or injury. Half the teens get the real patch, the other half get a placebo dressing. Pain leve…

This study is testing a psychological treatment for chronic pain that is adapted to the culture of American Indian and Alaska Native peoples. About 30 adults with chronic pain will take part to see if the program is acceptable and helpful. The goal is to gather information for a …

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce pain and depression in people with fibromyalgia. About 36 adults with chronic pain, some also depressed, will receive either real or sham (fake) rTMS to two brain areas. Researchers will tr…

This study tests a 6-week video program called Reclaim Your Day, where older adults with chronic pain watch peers share how they cope and improve their lives. 100 participants aged 55+ will be randomly assigned to watch either these peer stories or general health videos. The goal…

This study tests whether group-based pain management can help low-income adults with chronic pain feel better and more supported. About 360 people from safety-net clinics will join group sessions that address pain, stigma, and social isolation. The goal is to reduce pain's impact…

This pilot study is testing whether a one-time, 45-minute virtual reality (VR) session guided by an AI coach can help people with chronic pain who also misuse opioids. The session includes a check-in, pain coping skills training, and a stress reduction exercise. The study involve…

This study tests whether a coaching program combined with a decision aid can help Black patients with long-term muscle and joint pain and depression use non-drug treatments like physical therapy or counseling. 304 patients will be randomly assigned to either the coaching program …

This study tests whether a non-invasive procedure called vestibulocortical stimulation (VCS) can reduce pain and improve quality of life in people with fibromyalgia. VCS involves gently irrigating the ear canal with temperate water using a plastic syringe. The trial will compare …

This study tests a new pain self-management program designed specifically for Black adults aged 50 to 92 who have long-term muscle or joint pain (like arthritis or back pain). The program aims to reduce pain during movement and improve daily life. Researchers will compare pain le…

This early study is testing whether metformin, a common diabetes medicine, can reduce pain and help heal chronic Achilles tendon problems. Forty people with long-term tendon pain will take either metformin or a placebo pill for 16 weeks, along with a home exercise program. Resear…

This study is testing a new way to use an already-approved spinal cord stimulator to treat chronic, hard-to-manage back and leg pain. The device sends mild electrical pulses to the spine, and the new setting (called TVP-SCS) varies the timing of those pulses. Researchers will enr…

This study tests whether using a bright light device for one hour each morning, combined with a consistent sleep schedule, can improve symptoms of fibromyalgia—a condition causing widespread pain and fatigue. Researchers at the University of Michigan are recruiting 390 adults wit…

This study tests whether adding foot reflexology to standard physical therapy can reduce pain and improve sleep in women with fibromyalgia. Sixty women aged 18–65 will receive either standard therapy alone or standard therapy plus foot reflexology twice a week for six weeks. Rese…

This study tests whether a noninvasive ultrasound device can reduce pain in people with fibromyalgia. 180 adults will receive either real or sham ultrasound to a brain area linked to pain, over four sessions in one month. Researchers will track pain scores and symptom impact for …

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests whether cannabidiol (CBD), a compound from cannabis, can ease chronic pain in 468 veterans. Participants take either CBD or a placebo for 28 days and report their pain levels. The goal is to see if CBD improves pain symptoms better than a dummy pill.

This study tests four virtual coaching sessions to help veterans with chronic pain use their own cannabis products more effectively. Researchers aim to see if coaching improves pain, anxiety, and overall well-being. The trial is recruiting 468 veterans across the U.S.

This study looks at two types of nerve blocks given before mastectomy to see which one better prevents chronic pain. About 132 adults having a mastectomy will be randomly assigned to receive either an erector spinae block or a paravertebral block. Researchers will track pain, opi…

This study tests whether a pharmacist-led program can help patients reduce their opioid use by about half in the weeks before knee or hip replacement surgery. 45 adults on stable, moderate-dose opioids will work with a pharmacist to create a taper plan and get weekly check-ins. T…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This study is testing two holistic, non-drug programs to help military members manage chronic musculoskeletal pain. About 608 participants will be randomly assigned to either a single-session class called Empowered Relief, a multi-session program called Move to Health, or usual c…

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests an internet-based guided self-help program for adults with chronic pain. The program uses Acceptance and Commitment Therapy (ACT) to help participants accept their pain and focus on meaningful activities. Over seven weeks, participants complete weekly online modu…

This study tests a new spinal cord stimulator device for people with long-term pain in the trunk or limbs. The device uses closed-loop technology to adjust stimulation based on nerve signals. Researchers will enroll 200 participants to see if the new features improve pain control…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests a device called the Sana Pain Reliever, a mask with earbuds that delivers pulses of light and sound for 15 minutes at a time. Researchers want to see if it can reduce chronic pain and improve sleep in people with post-treatment Lyme disease syndrome. The trial in…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This study tests whether a synthetic THC drug (dronabinol) can safely reduce chronic low back pain. About 75 adults with pain lasting at least 3 months will take either the drug or a placebo daily for 8 weeks. The goal is to see if the drug is safe enough for larger trials.

This study tests a 9-week online program called RAMP that teaches mind-body skills to help rural veterans manage chronic pain. Participants attend weekly group sessions with videos, skill practice, and discussions. The goal is to see if the program reduces how much pain interfere…

This study tests whether taking oral magnesium can reduce pain and other symptoms in people with fibromyalgia who haven't gotten better with standard treatments. About 86 adults aged 18-65 will be randomly assigned to receive magnesium or a placebo. The main goal is to see if mag…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which works better for reducing pain intensity and interference. The study will enroll…

This study tests four different approaches—behavioral therapy, physical therapy, medication changes, and buprenorphine rotation—to help cancer survivors reduce their opioid use while keeping pain under control. It involves 294 veterans who have finished cancer treatment but still…

This study tests a short behavioral treatment delivered over Zoom to help adults with fibromyalgia, lupus, chronic pelvic pain, or chronic low back pain. The goal is to reduce pain, disability, and related issues like anxiety or depression. Participants will learn strategies to m…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all method, researchers will use each participant's brain signals to tailor the treatment. The goal is to improve pain relief and quality of life for th…

This study tests whether personalized health coaching can reduce chronic muscle and joint pain in people aged 60 and older. 268 participants will either receive four face-to-face coaching sessions focused on exercise, diet, stress, sleep, social support, and avoiding risky substa…

This study looks at whether adding esketamine to standard fibromyalgia treatments can reduce pain more quickly and effectively. About 92 adults with fibromyalgia who haven't gotten enough relief from other treatments will take part. Researchers will compare pain levels between th…

This study tests a psychosomatic program for people with fibromyalgia, a condition causing widespread pain. The program combines group talks to reframe how patients think about their symptoms, plus museum therapy. Researchers aim to see if this approach reduces distress and impro…

This study tests a pain acceptance training program for adults with chronic pain and emotional distress. The training uses dialectical thinking to help participants accept pain while still wanting it to end. Researchers will measure changes in pain levels, self-efficacy, and depr…

This study tests whether a virtual reality (VR) program can help adults with long-term non-cancer pain keep their pain from getting worse. 44 participants will either use a VR-based pain self-management program or receive usual care. The goal is to see if VR can reduce pain inten…

This study is tracking 970 adults with chronic pain who receive an Inceptiv™ spinal cord stimulator, a device that sends mild electrical pulses to the spine to block pain signals. Researchers want to see if at least half of patients get significant pain relief and better quality …

This study tests whether a device that gently stimulates a nerve in the ear (transcutaneous vagus nerve stimulation) can help people with chronic fatigue from fibromyalgia or long COVID get more benefit from exercise. 60 adults who still feel very tired after a standard exercise …

This study tests whether avoiding opioids during breast cancer surgery can reduce pain and side effects afterward. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard anesthesia. Researchers will measure pain leve…

This study explores whether structured dog-assisted therapy can reduce pain, anxiety, and depression in people with fibromyalgia. Sixty adults with confirmed fibromyalgia will attend 10 sessions with a therapy dog and complete surveys on pain, mood, and daily function. Researcher…

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This study tests a program called the Transitional Pain Service Program for adults who have chronic pain and take opioids before surgery. The program includes pain education, therapy, and a mobile app to help patients manage pain and safely reduce opioid use. Researchers will com…

This pilot study is testing a smartphone app called Mindful Journey that teaches mindfulness skills. The goal is to see if it is practical and acceptable for adults who are in treatment for opioid use disorder and also have chronic pain. Ten participants will use the app for 8 we…

This study tests whether a traditional Chinese herbal formula called Yishen Shujin Decoction can reduce pain and improve quality of life in people with fibromyalgia. One hundred adults with fibromyalgia will receive either the herbal formula or a placebo for 12 weeks, and researc…

This study tests whether an 8-week program of mindfulness and body awareness, held in a university museum, can reduce pain and improve quality of life for women with fibromyalgia. About 44 women will be randomly assigned to either the museum program or a control group. The goal i…

This early study tests a small device temporarily implanted in the breast during mastectomy. The device sends tiny electrical pulses to nerves to try to restore touch sensation and reduce chronic pain. Only 8 people having both breasts removed will take part, to see if the idea i…

This study looks at whether yoga-based occupational therapy can improve body awareness and daily function in adolescents aged 11-21 with chronic pain. Participants will attend 8-12 weekly yoga sessions and complete questionnaires before and after treatment. The goal is to see if …

This study is testing whether a weighted blanket can help veterans with chronic pain and sleep problems. 160 veterans will use either a light (3-pound) or heavy (15-pound) blanket at home for 6 weeks. Researchers will track changes in pain, sleep quality, and medication use to se…

This study is testing whether a group music therapy program, called POPSINGER, is practical and well-liked by people with chronic pain. The program includes both in-person and online sessions. Researchers will track how many people stay in the study and attend sessions to see if …

This study tests two experimental drugs, siltuximab and erenumab, to see if they can safely reduce chronic pain in people with schwannomatosis, a condition that causes painful nerve tumors. About 40 adults with moderate-to-severe pain will receive either a drug or a placebo. The …

This study compares two behavioral programs for people with chronic pain, chronic insomnia, and long-term opioid use. One program uses cognitive behavioral therapy for insomnia (CBT-I), the other is standard treatment. The goal is to see if improving sleep can also reduce opioid …

This study tests a program called PATH-Pain in 100 older adults (60+) who have mild cognitive impairment or early Alzheimer's, along with chronic pain and depression. The program teaches problem-solving and uses memory aids like checklists and a tablet app to help manage emotions…

This study tests whether a 6-week music program—including drumming and rhythm exercises—can reduce stress, anxiety, depression, and chronic pain in adults living in rural residential care facilities. Sixty participants will attend weekly hour-long sessions and complete surveys be…

This study looks at whether adding osteopathic care (a type of hands-on therapy) to a flexible low-FODMAP diet can further reduce IBS symptoms in people with fibromyalgia. About 96 adults will receive either real or sham osteopathic sessions alongside the diet. Researchers will t…

This early-stage study tests if a single infusion of donor stem cells can reduce long-term pain from chronic pancreatitis. Researchers will enroll 48 adults with persistent pain and track changes in pain scores, opioid use, and quality of life over 6 months. The goal is to see if…

This early-phase study at Yale tests whether cannabidiol (CBD) is safe and can reduce pain and opioid cravings in 34 adults with opioid use disorder and chronic pain. Participants are already on methadone or buprenorphine and will receive different doses of CBD or a placebo in a …

This study tests a group-based parent training program called SPACE-Pain, originally developed for anxiety, to see if it is feasible and acceptable for parents of children aged 10-17 with chronic pain. The program teaches parents to reduce accommodation while staying warm and sup…

This study is testing whether a painless brain stimulation technique called tDCS can reduce chronic pain in 100 military members and veterans. Participants will receive tDCS while taking part in a behavioral health program, and researchers will track changes in pain levels and da…

This study tests whether very short, controlled exercise sessions (called microdoses) can help women with fibromyalgia feel better. Researchers will measure changes in muscle strength, pain, and quality of life in 36 women. The goal is to find a gentle, effective exercise plan th…

This study tests whether a small, home-use device that gently stimulates a nerve in the ear can help young adults (ages 18-29) manage pain and other symptoms of irritable bowel syndrome (IBS). Eighty participants will use either the active device or a sham (inactive) version twic…

This study is testing a trilingual smartphone app and telehealth coaching program to help Black, Chinese, and Latinx people with chronic pain find non-drug ways to feel better. About 586 adults in the San Francisco Bay Area will join, using the app and getting coaching for 12 mon…

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This early-stage trial tests whether stem cells taken from a patient's own bone marrow can reduce pain caused by chronic pancreatitis and possibly improve pancreas function. Forty adults with long-term painful pancreatitis will receive either the stem cells or a placebo. The stud…

This study tests whether a 2-week, fully remote program combining mild brain stimulation (tDCS) with prolonged exposure therapy can reduce chronic pain and PTSD symptoms. About 146 adults with both conditions will receive either real or sham stimulation alongside therapy, all fro…

This study looks at whether adding a Whole Health Coach to standard pain management teams helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will work with a coach to set personal health goals and learn self-management strategies. The mai…

This study looks at how three different levels of physical activity—45, 90, or 150 minutes per week—affect arthritis symptoms like pain and mobility. Researchers will enroll 285 adults with arthritis, rheumatoid arthritis, gout, fibromyalgia, osteoarthritis, or lupus. Participant…

This study tests two types of virtual reality therapy to see if they can reduce pain and improve daily function in people with chronic low back pain. Two hundred adults aged 18 to 85 with back pain lasting at least 6 months will use VR headsets for 8 weeks. Researchers will track…

This study tests whether a newer therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for veterans with chronic back or neck pain. About 360 veterans will be randomly assigned to one of three groups and complet…

This study tests whether low-dose metformin, a common diabetes drug, can improve symptoms of fibromyalgia by reducing inflammation in the nervous system. 72 adults with fibromyalgia will take metformin or a placebo daily for 8 weeks. Researchers will measure changes in pain, fati…

This study tests a high-CBD, low-THC sublingual product against a placebo in 25 adults with chronic pain conditions like arthritis or injury-related pain. Over 9 weeks, researchers will track pain levels, medication use, quality of life, and thinking skills to see if CBD offers r…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests if adding online pain education to standard physical therapy helps people with chronic low back pain. Sixty adults aged 20-60 will be split into two groups: one gets physiotherapy plus six weekly online sessions about how pain works, and the other gets physiother…

This study looks at whether spinal cord stimulation (SCS) actually reduces chronic pain or if it's just a placebo effect. Researchers will compare pain ratings from 25 patients when their SCS device is on, off, or when they are told it's on but it isn't. The goal is to understand…

This study tests whether a 6-week group pain education program can help people with chronic pain become more active, feel less pain, and have lower depression. Fifty adults with pain lasting over 3 months will attend weekly 2-hour sessions covering sleep, stress, exercise, pain s…

This study tests whether listening to a brief mindfulness audio recording while waiting for an orthopedic appointment can help reduce pain. 400 adults will be randomly assigned to hear either a mindfulness practice or a standard pain management recording. The goal is to see if a …

This study tests Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT uses eight weekly video sessions to help retrain how the brain processes pain. Researchers will compare PRT to usual care in 110 participants to see which better…

This study tests a faster form of brain stimulation (accelerated TMS) for people with long-term chronic pain that hasn't improved with medication. Researchers will use a smart algorithm to choose the best spot to stimulate each person's brain, based on their individual pain patte…

This study compares two different exercise programs combined with dietary advice to see which better reduces symptoms in people who have both fibromyalgia and irritable bowel syndrome. Researchers will enroll 30 adults aged 30 to 65 with moderate to severe IBS and confirmed fibro…

This study tests a non-invasive brain stimulation technique called deep rTMS to see if it can reduce chronic pain from nerve damage or fibromyalgia. About 70 adults with daily pain will receive either real or fake (sham) treatment over 3 months. The goal is to measure pain relief…

This study tests whether mind-body techniques can help people with chronic back pain feel better and move more easily. Researchers will compare two different mind-body programs to usual care in 150 adults. The goal is to see if these approaches reduce pain-related disability and …

This small study tests a mind-body intervention for people with chronic migraines. Ten adults with frequent headaches will attend educational sessions and get personalized coaching. The goal is to see if the program is feasible and whether it can reduce migraine-related disabilit…

This study compares two phone-based programs—Brief Behavioral Treatment for Insomnia and Brief Mindfulness Training—to see which one better improves sleep, reduces chronic pain, and slows biological aging in 200 adults with HIV and ongoing pain. Participants must be 25-65, have H…

This study is testing whether a single injection of botulinum toxin (similar to Botox) around major nerves can safely reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic condition causing severe pain and disability. Twenty adults with CRPS in one arm or le…

This study tests whether a digital sleep therapy program (Sleepio) can improve quality of life and movement in 142 adults with fibromyalgia who also have trouble sleeping. Participants will use the program at home for 10 weeks and wear devices to track sleep and activity. Researc…

This early-stage study tests whether psilocybin, the active ingredient in magic mushrooms, can help reduce pain, fatigue, and other symptoms in people with fibromyalgia. Researchers will enroll 30 women aged 25-65 who have had widespread pain for at least a year. The goal is to s…

This study looks at whether combining mindfulness training (MBSR) with an open-label placebo—a pill that patients know has no active drug—is a practical way to help people with chronic pain. Researchers will randomly assign 45 adults to receive either mindfulness alone, the place…

This study tests a program called SCOOP for older adults (60+) living in rural areas who have chronic pain and feel lonely. Participants watch short videos and have up to 7 weekly coaching sessions with a community health worker to learn pain management and social connection stra…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study compares two types of nerve blocks (pectoral nerve block vs. paravertebral block) given during mastectomy to see which better prevents chronic pain. Ninety women aged 20-65 undergoing mastectomy will be randomly assigned to one of the two blocks. The goal is to reduce …

This study compares two treatments for chronic shoulder pain: injections of platelet-rich plasma (PRP) made from your own blood, versus standard steroid shots. Both groups also do personalized exercises. The goal is to see if PRP provides better and longer-lasting pain relief. Th…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This study tests a walking program for people with painful hip or knee osteoarthritis. Participants take a nonsteroidal anti-inflammatory drug (NSAID) only before planned walks to reduce pain while avoiding long-term side effects. The program also includes proper footwear, educat…

This study tests a stepped care approach that uses complementary health treatments (like acupuncture or yoga) for people with both chronic pain and PTSD. About 60 adults from two primary care clinics will either receive this stepped care or their usual treatment. Researchers want…

This study looks at whether walking outdoors, with help from a treadmill and a mobile app, can improve heart and lung function and quality of life in women with fibromyalgia. About 54 women aged 25-55 who haven't exercised regularly will take part. The goal is to see if this appr…

This study compares two treatments for chronic tailbone pain (coccydynia): osteopathic manual therapy (a hands-on approach) and a nerve block injection. Researchers will enroll 100 adults who have had tailbone pain for at least 3 months and have not gotten relief from other treat…

This study tests whether virtual reality exercises can reduce neck pain and disability better than standard physical therapy. Seventy-two adults with chronic neck pain or whiplash will do 12 sessions over six weeks. Half will use VR, the other half will do the same exercises with…

This study tests a non-invasive brain stimulation technique called HD-tDCS for people with chronic pain that hasn't improved with other treatments. 144 participants will be randomly assigned to receive either real (anodal or cathodal) or sham (placebo) stimulation over five sessi…

This study tests whether personalized exercise and a gentle nerve stimulation device can reduce pain, improve sleep, and ease fatigue in people with fibromyalgia. About 75 adults with fibromyalgia and chronic fatigue will be split into three groups: one gets exercise plus standar…

This study tests whether task-based mirror therapy can reduce pain, swelling, and improve arm function in stroke survivors who develop shoulder-hand syndrome. Thirty-four participants aged 45-75 will be split into two groups: one doing mirror therapy plus standard exercises, the …

This study tests if freezing the nerves around the knee (cryoneurolysis) one day before total knee replacement surgery can lower pain and help patients move better afterward. About 100 adults with knee arthritis will be randomly assigned to get the freezing procedure plus surgery…

This study tests whether a painless brain stimulation technique (tDCS plus ultrasound) can reduce chronic pain in people with carpal tunnel syndrome. About 95 adults with long-term wrist pain will receive either real or fake (sham) stimulation to see if it lowers their pain score…

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests whether a 13-week mind-body program can help people with chronic wrist, elbow, or shoulder pain from repetitive stress. Participants attend twice-weekly sessions for the first month, then weekly sessions, learning techniques to reduce pain and improve arm functio…

This study tests an internet-based therapy called acceptance and commitment therapy (iACT) for people with both PTSD and chronic pain. Forty adults will either receive the therapy immediately or join a waitlist. The program includes mindfulness, value-based exercises, and written…

This study is testing a mobile app called Diet4painrelief that helps people with chronic pain improve their eating habits. About 200 adults with chronic pain and a BMI of 25 or higher will take part. The goal is to see if the app can reduce pain, improve sleep, and make daily lif…

This study tests whether a team of five pain specialists—including doctors, psychologists, pharmacists, dietitians, and physical therapists—can help veterans with chronic pain feel better and get more out of life. About 150 veterans will either join the program right away or wait…

This pilot study tests whether internet-based Acceptance and Commitment Therapy (ACT) can help people with endometriosis cope with chronic pain. Ten participants will receive online sessions focused on mindfulness, acceptance, and value-based behavior change, with phone support f…

This study tests whether a smartphone-based mindfulness program is practical and liked by teens and young adults (ages 15-39) with sickle cell disease who have chronic pain or sleep problems. Participants use a guided meditation app for about 8 weeks. The goal is to see if people…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for easing fibromyalgia pain. Over 1,100 adults with moderate to severe fibromyalgia will take one of the two drugs, and researchers will measure how many get at least …

This study tests whether a non-steroidal anti-inflammatory drug (diclofenac) can reduce the need for opioid painkillers after a minimally invasive elbow procedure. 92 adults with chronic elbow pain will receive either diclofenac or tramadol, with rescue medication available. The …

This study tests whether a smartphone app can help Black and LGBTQ+ adults with long-term chronic pain manage their symptoms and improve daily life. Participants will use the app for pain self-management and report changes in pain interference and confidence. The goal is to see i…

This Phase 3 study tests whether AXS-14 (esreboxetine) can help manage fibromyalgia symptoms like pain and fatigue. About 620 adults with fibromyalgia will take the drug or a placebo daily. The study uses a 'randomized withdrawal' design to see how long the drug's effects last.

This study tests whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness (like schizophrenia or bipolar disorder) who also have chronic low back pain. Researchers will measure changes in pain interference, quality of life, and pain severity after …

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests whether a noninvasive procedure called transcutaneous pulsed radiofrequency can reduce chronic pain from postherpetic neuralgia, a complication of shingles. The procedure delivers electrical pulses through electrodes placed on the skin over the painful area. Rese…

This study looks at whether adding magnesium sulfate to a standard lidocaine injection can better relieve pain and improve muscle function in people with myofascial pain dysfunction syndrome (chronic jaw muscle pain). About 28 adults with active trigger points will receive either…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. Researchers will enroll 25 adults with painful diabetic neuropathy and …

This study tests whether a single, 2-hour group class called Empowered Relief can help reduce pain and improve recovery after elective orthopedic surgery compared to standard care. The class teaches pain education, self-regulation skills, and mindfulness. Researchers will follow …

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will be randomly assigned to one of the two dosing schedules. Researchers will trac…

This study helps people with ongoing back pain after surgery compare two treatments: spinal cord stimulation (a device that sends electrical pulses) and a pain pump (which delivers medicine directly to the spine). Participants try both treatments temporarily and choose which one …

This study tests a smartphone app called QoLibri designed to help people with chronic pain manage their symptoms and improve their quality of life. About 410 adults with moderate or worse pain lasting over 3 months will be randomly assigned to use the app right away or after a wa…

This study compares two online programs—yoga and Acceptance and Commitment Therapy (ACT)—to see which better helps veterans manage long-term muscle and bone pain. About 274 veterans with chronic pain for over 6 months will participate. The goal is to find which approach reduces p…

This study tests a brief, 4-session cognitive behavioral therapy (CBT) program for people with urologic chronic pelvic pain syndrome (UCPPS), including interstitial cystitis and chronic prostatitis. The treatment is mostly home-based with minimal therapist contact, teaching skill…

This study is testing a new, noninvasive ultrasound device to see if it can reduce pain and other symptoms in people with fibromyalgia. About 50 adults with fibromyalgia will receive 6 treatment sessions over 2 weeks. Researchers will measure pain levels and symptom impact using …

This study looks at whether using a nerve stimulator in short bursts (30 seconds on, 90 seconds off) can provide the same or better pain relief as continuous stimulation. It involves 30 adults who have had a dorsal root ganglion stimulator for at least a year and report at least …

This study tests whether a 12-week progressive resistance exercise program can reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist control group. The goal is to see if exercise provides a mea…

This study compares taking pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will enroll 750 adults wit…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This phase 2 study at Yale University is testing whether a combination of THC and CBD can reduce both pain sensitivity and opioid cravings in people who have opioid use disorder and chronic low back pain. The 147 participants are all on methadone therapy and will receive either a…

This study compares a video-based exercise program (using Nintendo Switch Ring Fit Adventure) to a standard home exercise program in women aged 30-70 with fibromyalgia. The goal is to see if the game-based approach improves pain, balance, mobility, and quality of life more than t…

This study tests a new method for placing spinal cord stimulators in people with chronic back pain. The device uses electrical recordings to confirm the lead is in the right spot. Twenty adults with long-term back pain will take part, and researchers will measure pain relief and …

This study looks at whether teaching older adults about how pain works, combined with supervised exercise, can reduce chronic pain and improve daily life. One hundred people aged 65 and older with pain lasting over 3 months will be split into three groups: exercise only, exercise…

This study compares a home-use brain stimulation device (tDCS) to the drug duloxetine for treating fibromyalgia in 610 women. Participants use the device daily for 4 weeks or take duloxetine, both combined with exercise and pain education. The goal is to see if tDCS works as well…

This study tests if a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can help reduce widespread pain in people with lupus. Thirty adults with lupus and fibromyalgia or chronic pain will attend 8 weekly online sessions. Researchers will check if the …

This study tests a single online class called Empowered Relief, delivered in Spanish to adults with chronic pain. The class teaches pain relief skills, and participants fill out surveys right after, at 2 weeks, and at 1 month. The goal is to see if the class is helpful and satisf…

This study tests whether two natural supplements—silymarin (from milk thistle) and a hesperidin/diosmin combination (from citrus)—can reduce pain and improve quality of life in people with fibromyalgia. About 90 adults with fibromyalgia will take one of the supplements or a place…

This study is testing a smartphone app called Digital SPA, designed with input from teens, to help adolescents aged 12–17 manage chronic pain. The app uses Acceptance and Commitment Therapy techniques to reduce pain interference and emergency room visits. About 195 teens and thei…

This study tests whether adding a non-invasive brain stimulation technique called tDCS to a structured exercise program can reduce pain and disability in adults with chronic spinal pain that hasn't improved with usual care. Forty-two participants will be randomly assigned to rece…

This study tests whether adding a sugar solution (dextrose) to numbing injections around the knee nerves provides better pain relief than numbing medicine alone for people with chronic knee osteoarthritis. Sixty adults with knee arthritis will receive a series of three injections…

This study tests whether a spinal cord stimulator can reduce long-term leg pain in people who still have pain after lumbar spine surgery. Fifty adults aged 18-70 who have not improved with other treatments will receive either active stimulation or sham (no stimulation) for 3 mont…

This study tests whether a combination of psilocybin (the active ingredient in magic mushrooms) and talk therapy can help adults with chronic pain safely reduce or stop their opioid painkillers. Ten participants will receive one or two psilocybin sessions over 8 weeks, with follo…

This study tests a personalized approach to magnetic brain stimulation for people with chronic pain. Instead of a one-size-fits-all treatment, researchers will use each person's brain signals to customize the stimulation. The goal is to improve pain relief for the 90 participants…

This small study looks at whether combining chiropractic care with group medical visits is a practical way to help adults 65 and older who have chronic neck or back pain. Ten participants will receive both chiropractic adjustments and virtual group support sessions. The goal is t…

This study tests whether adding a nasal spray drug called dexmedetomidine to the standard medication pregabalin can better relieve pain in people with fibromyalgia. The trial will enroll 400 adults with moderate to severe fibromyalgia who haven't found relief from non-drug treatm…

This study tests a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain and reduce reliance on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part. The goal is to see …

This study tests whether using opioid-free anesthesia during mastectomy can reduce chronic pain one year after surgery. 230 breast cancer patients will be randomly assigned to receive either opioid-free or standard opioid-based anesthesia. Researchers will also look at how psycho…

This study tests whether adding a gentle, non-invasive brain stimulation technique called tDCS to a structured pain coping program can help people with fibromyalgia feel better. About 68 adults with fibromyalgia will take part. They will all go through the same program of pain ed…

This study tests a 10-week program called GetActive+ that combines gentle walking with mind-body techniques to help older adults (55+) with long-term muscle or joint pain. Researchers want to see if it improves physical function, mood, and daily activity compared to usual care. T…

This study compares pregabalin alone versus pregabalin plus desvenlafaxine for treating fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't improved with non-drug treatments. The goal is to see…

This study compares pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers will enroll 384 adults with moderate to severe pain that hasn't responded to non-drug treatments. The goal is to see if th…

This study tests whether a 6-week virtual reality exercise program can help people with fibromyalgia manage their symptoms better than standard exercise. 80 adults with fibromyalgia will be randomly assigned to either the VR exercise group or a regular exercise group. The goal is…

This study tests a remote program called Move-MORE for people with sciatica (nerve pain from the lower back into the leg). The program combines mindfulness, gentle movement, and motivational coaching to help manage pain and improve daily function. Researchers will enroll 32 adult…

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study tests whether using a closed-loop spinal cord stimulator early in complex regional pain syndrome (CRPS) works better than waiting until the chronic phase. The device automatically adjusts its settings based on the body's signals. Researchers will enroll 32 adults with …

This study compares two short behavioral therapies—mindfulness (B-MORE) and cognitive-behavioral therapy (CBT)—for adults with chronic pain. Both treatments are just two hours long and offered in English or Spanish. The goal is to see if these brief programs are practical and acc…

This study is testing whether low-intensity focused ultrasound (LIFU) — a noninvasive device that sends sound waves to the brain — can help people with chronic back pain, opioid cravings, and anxiety. Researchers will enroll 25 adults and measure safety, mood, heart rate, and oth…

This study tests whether energy healing (a hands-off therapy that aims to balance the body's energy) can reduce pain in women with fibromyalgia. Twenty-five participants will receive both real and fake (sham) energy healing while their brain activity is scanned with fMRI. The goa…

This study tests whether combining cognitive training with electroacupuncture can reduce pain in people with fibromyalgia. Researchers will use brain scans to see if the treatment improves how patient and clinician brains sync up. The trial enrolls 100 adults with fibromyalgia an…

This study tests whether high-frequency spinal cord stimulation can reduce leg pain and improve quality of life in people with both peripheral arterial disease (PAD) and painful diabetic neuropathy. Fifteen adults who already have a spinal cord stimulator implanted will receive t…

This study is for active-duty military members and their families who have chronic back or neck pain. It will test treatments like acupuncture, laser therapy, and shockwave therapy to see if they reduce pain and improve daily life. The goal is to find safer, non-drug options to h…

This study tests whether wearing compression garments (gloves or sleeves) can reduce nerve pain in people with Complex Regional Pain Syndrome (CRPS) of the upper limbs. Sixty participants will either receive usual care plus the garment or usual care alone for three months. Pain l…

This study tests whether combining brain stimulation (rTMS), personalized physical therapy, and medication adjustments can reduce pain and improve daily function in people with Complex Regional Pain Syndrome (CRPS). Researchers will enroll 156 adults whose symptoms began within t…

This study tests a new program called PREP-Y, designed to help adolescents aged 12-17 with chronic musculoskeletal pain become more physically active and better manage their pain. The program includes four weekly virtual sessions teaching resilience skills like motivation and cop…

This pilot study tests a mindfulness-based program called Quiet Focus, adapted for older Black adults (age 50+) who have both chronic pain and mild depression. Researchers want to see if it's feasible and acceptable, and whether it can improve quality of life and reduce pain inte…

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study tests a 4-week program that teaches people in rural areas to use ear acupressure (a non-needle technique) to manage chronic musculoskeletal pain like back, neck, or knee pain. Participants use a smartphone app to learn self-treatment, with some receiving in-person trai…

This study tests whether a personalized rehabilitation program helps people with persistent spinal pain syndrome type II (failed back surgery syndrome) return to work after receiving a spinal cord stimulator. 112 participants will be randomly assigned to either the personalized p…

This study is testing whether herbal medicine and vitamin IV therapy can reduce symptoms of anxiety, fibromyalgia, arthritis, chronic pain, and high blood pressure. Researchers plan to enroll 25 people and measure improvements in health and quality of life. The approach uses natu…

This study looks at a telephone-based program called SUSTAIN that helps older adults (65+) manage depression, anxiety, and chronic pain. Participants receive brief phone assessments and care management over 12 weeks. Researchers want to see what factors influence treatment succes…

This study is testing whether a focused muscle contraction exercise program called the GH Method can improve body composition, physical abilities, and overall well-being in U.S. veterans. Twenty-five veterans with pain, fatigue, or low energy will do 90 exercise sessions over 18 …

This study tests whether a non-invasive brain stimulation technique called rTMS can improve symptoms of major depression and chronic pain at the same time. Fifty-four adults with moderate depression and pain will receive 30 sessions of active rTMS over several weeks. Researchers …

This pilot study tests Scrambler Therapy, a non-invasive device that sends electrical signals through the skin to retrain the brain's pain response. Forty adults with chronic pancreatitis and persistent abdominal pain will receive 5-10 daily sessions. Researchers will measure pai…

This study tests whether low doses of psilocybin, the active ingredient in magic mushrooms, can reduce pain in people with fibromyalgia. Thirty-five adults will receive a placebo and two different low doses on separate days. Researchers will measure pain tolerance and self-report…

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-…

This study is testing a full-body suit that delivers mild electrical pulses to muscles. The goal is to see if it safely reduces spasticity, overactive reflexes, and pain in people with neurological conditions like multiple sclerosis or fibromyalgia. Fifteen adults will try both t…

This study tests whether a stellate ganglion block—a numbing injection near a nerve cluster in the neck—can reduce pain and improve arm function in stroke patients who develop complex regional pain syndrome. About 32 adults will receive the injection plus standard physical therap…

This study tests whether adding shiatsu—a gentle Japanese bodywork therapy—to standard medical care can improve quality of life for children aged 10 to 18 with chronic non-inflammatory pain. About 40 participants will receive one 30-minute shiatsu session per week for six weeks a…

This study tests whether a 7-minute guided mindfulness exercise can help reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation for spine pain. Half of the 80 participants will do the mindfulness exercise, while the other half will receive standard pa…

This study tests whether a gentle hands-on treatment called osteopathic manual therapy can reduce jaw pain and improve jaw function in people with fibromyalgia. About 114 adults with both conditions will receive either real or sham therapy. Researchers will measure pain, jaw move…

This study follows 105 adults with chronic pain, nerve damage, or slow wound healing from cancer treatments. They receive ozone therapy as an add-on to their usual care. Researchers track changes in quality of life, anxiety, and depression to see if ozone therapy helps.

This study evaluates a questionnaire called the Emotional Allodynia Questionnaire (AEQ), which measures how people with fibromyalgia react emotionally to everyday social cues. Researchers want to see if the tool can reliably identify fibromyalgia and tell it apart from other type…

This study uses MRI scans to look at brain and spinal cord structure and function in people with cerebral palsy who experience chronic pain. Researchers hope to find patterns in the brain that are linked to pain and sensory issues. Participants aged 8 and older with cerebral pals…

This study asks 200 adults with chronic pain about their preferences between pain relief and common side effects like drowsiness, nausea, or addiction risk. Participants rate how much each side effect bothers them compared to the benefit of pain relief. The goal is to help doctor…

This study tests whether a special band-aid (called the A-Band) and a smartwatch can measure pain in women with chronic pain using AI. About 115 women with chronic pain and healthy women will wear the devices for a week and report their pain levels. The goal is to see if the devi…

This study looks at how emotional intelligence—the ability to understand and manage emotions—relates to chronic orofacial pain (pain in the face or mouth lasting over three months). Researchers will compare 88 adults with and without this pain using questionnaires about emotions,…

This study will look at the medical records of 15,000 people with chronic pain to see how well different treatments, like spinal cord stimulation, worked for them. The goal is to learn which approaches provide the best pain relief. No new treatments are being tested; instead, res…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how mindfulness meditation and self-hypnosis work in the brains of adults aged 60 and older who have had chronic pain for at least 3 months. Participants will be randomly assigned to mindfulness, hypnosis, or story listening, and will undergo brain scans and E…

This study looks at how the brain naturally reduces pain signals and whether that ability affects how well a lumbar medial branch block (a common injection for back pain) works. Researchers will test 40 adults with chronic low back pain using heat, pressure, and other sensations …

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study looks at how long-term opioid therapy changes brain and spinal cord activity in women with chronic pain. Researchers will compare brain scans of women with chronic pain and/or opioid use to healthy women. The goal is to find new ways to treat chronic pain without relyi…

This study uses a special PET scan to measure brain inflammation in people with fibromyalgia, chronic fatigue syndrome, multiple sclerosis, and healthy volunteers. Researchers want to see if those with pain and fatigue have higher levels of brain inflammation. The study does not …

This study compares two widely used drug classes—anti-convulsants and anti-depressants—for treating chronic pain in 450 real-world patients. Unlike typical trials that exclude many patients, this one includes people with other health issues to get results that apply to more peopl…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study explores how dopamine, a brain chemical linked to motivation, influences chronic pain. Ten adults with chronic pain will receive two dopamine-boosting drugs (methylphenidate and carbidopa-levodopa) or a placebo, then undergo brain scans to measure changes in key pain-r…

This study investigates how colored light affects pain by scanning the brains of 60 people—half with chronic musculoskeletal pain (like fibromyalgia) and half healthy. Participants will view different light patterns while their brain activity is measured, and some will also recei…

This study aims to find out why some people with sickle cell disease develop severe, disabling chronic pain while others do not. Researchers will enroll 70 participants aged 15 to 40 and use surveys, virtual visits, and in-person pain sensitivity tests to track pain and related o…

This study is testing a mobile app called Wysa for Chronic Pain, designed to support people aged 45 and older who have chronic pain along with depression or anxiety. Researchers want to see if personalized in-app notifications can encourage people to use the app more often. Parti…

This study looks at whether a type of IV line called a midline catheter can be used safely and effectively for repeated lidocaine infusions in an outpatient clinic. About 500 adults with chronic pain will receive ten lidocaine infusions through a midline catheter. Researchers wil…

This study looks at how pain is processed in people with fibromyalgia and rheumatoid arthritis, two conditions that cause long-term pain. Researchers will measure pressure pain thresholds in 150 adults to compare pain mechanisms. The goal is to better understand the differences a…

This study looks at why exercise often makes pain and fatigue worse for people with chronic widespread pain or fibromyalgia. Researchers will test if applying a mild electrical current to the brain (tDCS) during exercise can change how pain-related genes work. 120 participants (6…

This study looks at whether forward head posture (a common issue) is linked to worse fibromyalgia symptoms. Researchers will measure the angle of the neck in 134 adults with fibromyalgia and compare it to their symptom severity using a questionnaire. The goal is to better underst…

This study looks at two proteins in the blood—S100B and BDNF—to see if they are linked to pain sensitivity and poor sleep in people with fibromyalgia. Researchers will compare 60 women with fibromyalgia to healthy women. The goal is to better understand what causes fibromyalgia s…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This observational study is working to create a more objective way to measure pain in children with juvenile idiopathic arthritis, lupus, or fibromyalgia. Researchers will follow 90 participants for one year, collecting data during regular clinic visits. The goal is to develop a …

This pilot study looks at how lowering doses of pain medications like opioids and gabapentinoids changes the way the spinal cord responds to closed-loop spinal cord stimulation. Twenty adults with failed back surgery syndrome will be followed during a 21-day trial and up to 6 mon…

This study aims to create a large e-cohort of 5,000 chronic pain patients using a smartphone app called eDOL. The app lets patients report their pain, treatments, and daily life, while doctors can monitor them through a web platform. The goal is to better understand chronic pain …

This study will enroll 200 adults who have ongoing low back pain for at least 3 months after back surgery. Researchers will classify each person's pain as nerve-related, muscle/joint-related, or other, and then compare how these pain types affect pain severity, disability, and qu…

This study watches how daily emotional stress impacts memory and thinking in adults aged 60 and older living in Seoul, Korea. Participants use a smartphone app to report their feelings and do quick brain games, wear a smartwatch, and give blood samples. Researchers will check in …

This study follows 20,000 adolescents aged 12-17 who receive opioids after major surgery. Researchers track pain, opioid use, and other factors for one year to identify early warning signs of opioid use disorder. Participants complete surveys and allow access to their medical rec…

This study uses virtual reality to explore how people with upper limb exclusion (non-use of an arm or hand) perceive the space around them. Researchers will compare 60 participants—those with the condition and healthy controls—as they judge whether virtual objects are reachable. …

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study is observing 120 people with chronic pain to learn how to design a more effective pain clinic. Researchers will track pain levels, medication use, and overall well-being. The goal is to understand what patients need, not to test a new treatment.

This study looks at how different pain medications change the way the spinal cord responds to a special type of spinal cord stimulator. The device automatically adjusts its stimulation based on nerve signals. Researchers will follow 50 people with chronic back pain who are either…

This study tests a training program called the Pain Identification and Communication Toolkit (PICT) for family caregivers of people with Alzheimer's disease or related dementias. The program teaches caregivers how to spot signs of pain and talk about it with doctors. Researchers …

This study aims to understand why people with chronic pain or opioid use disorder often have worse pain after spine surgery. Researchers will analyze blood and skin samples from 40 participants to look for unique immune and genetic markers linked to pain. The goal is to find bett…

This study tests whether spinal cord stimulation can create artificial sensations, like tingling, and how changing stimulation settings affects those sensations. Ten adults with chronic pain who are already scheduled for spinal cord stimulation will participate. The goal is to be…

This observational study looks at why some people with knee osteoarthritis have worse pain than others, even when their knee damage looks similar on X-rays. Researchers will study 300 adults aged 45-80 with chronic knee pain. Participants will complete surveys, physical tests, kn…

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which p…

This study looks at whether people with HIV have chronic pain because their bodies don't make enough natural painkillers (opioid peptides). Researchers will test pain sensitivity in 200 adults (with and without HIV) using heat, touch, and pressure. The goal is to understand the c…

This study is testing whether conversational AI software can effectively collect health information from people with chronic pain. Participants will chat with a digital tool that asks about their physical symptoms, emotions, and social life. The goal is to see if patients find th…

This study looks at whether mothers who have fibromyalgia and also care for a child with ADHD experience a higher disease burden. Researchers will compare 50 such mothers with 50 mothers who have fibromyalgia but whose children have no psychiatric conditions. The goal is to under…

This study aims to find out if spinal cord stimulation (SCS) truly reduces pain or if the effect is just due to patients' expectations. Twenty-five adults with chronic pain who already have an SCS implant will take part in four test sessions. During each session, the stimulator w…

This study looks at whether taking prescription opioids for chronic pain changes the brain structure of adults aged 65 and older. Researchers will use MRI scans to measure brain changes over time. The goal is to understand the risks of long-term opioid use on brain health.

This study looks at why people with long-term nerve pain often feel less motivated. Researchers will use brain scans (fMRI) and a reward-learning task to compare 50 chronic pain patients with healthy volunteers. The goal is to understand brain changes linked to motivation, not to…

This study looks at whether a special pain test called Pancreatic Quantitative Sensory Testing (P-QST) can predict how well people with chronic pancreatitis will respond to treatments like endoscopy or surgery. About 150 adults with chronic pancreatitis and ongoing pain will take…

This study looks at how the brain and eye nerves change after corneal crosslinking (CXL), a procedure for keratoconus. Researchers will use brain scans (fMRI) and eye imaging to track pain and nerve healing. The goal is to better understand recovery, not to test a new treatment.

This study uses a technique called Quantitative Sensory Testing (QST) to understand different pain patterns in people with chronic pancreatitis. By mapping how the nervous system processes pain, researchers hope to predict which patients will benefit from specific treatments like…

This study looks at how oxytocin, a natural hormone, affects the part of your nervous system that controls rest and digestion. Researchers will give a single injection of oxytocin or a placebo to 38 people (some with knee arthritis, some healthy) and measure tiny changes in pupil…

This study looks at how chronic knee pain and fibromyalgia change the way nerves talk to muscles. Researchers will test pain sensitivity, muscle activity, and physical function in 135 adults. No treatment is given—the goal is to better understand the role of the central nervous s…

This study tests a new way to adjust spinal cord stimulation in 15 adults with chronic pain who already have spinal cord implants. Researchers will use electrical recordings called ECAPs to find the best stimulation settings. The goal is to see if this approach is feasible and ac…

This study follows 800 adults who spent at least 48 hours in the ICU to understand why some develop chronic pain. Researchers will call participants at 90 and 180 days after discharge to ask about pain, sleep, and quality of life. A smaller group will also have a detailed physica…

This study uses a special thermal camera to take pictures of the feet of people with complex regional pain syndrome (CRPS) before and after they receive spinal cord stimulation. The goal is to see if the stimulation changes blood flow and temperature in the painful limb. Research…

This study looks at how quitting smoking temporarily increases pain in people with chronic pain, and how the brain processes this. Researchers will use brain scans and daily reports from 132 smokers—some with chronic back pain, some without—to understand these changes. The goal i…

This study is testing how well a culturally adapted screening and brief counseling program works for American Indian and Alaska Native adults who have chronic pain or misuse opioids. Researchers will work with three clinics to see if the program is easy to use and helpful. The go…

This study looks at whether keeping a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will measure changes in sleep timing, blood pressure, heart rate, and other health ma…

This study looks at whether the bacteria in your gut are linked to the severity and recovery of Complex Regional Pain Syndrome (CRPS), a chronic pain condition. Researchers will compare gut microbiome samples from people with CRPS and their household members. They also aim to pre…

This study tests whether people with fibromyalgia can learn to control their own brain activity using real-time brain scans (fMRI) to reduce pain. Participants will either receive cognitive behavioral therapy or fibromyalgia education over 8 weeks. The goal is to see if self-regu…

This study looks at how mood, brain inflammation, and exercise are linked to pain in 60 veterans with fibromyalgia. Participants will do a 6-week supervised walking program and complete pain, mood, and blood tests. The goal is to understand these connections and design a better e…

This study follows 5,000 children aged 0-16 before and up to one year after surgery to learn how many develop chronic pain and why. Parents and children fill out questionnaires about pain, anxiety, and recovery. The goal is to find risk factors so doctors can better prevent long-…

This study looks at whether using a CPAP machine for obstructive sleep apnea can also help people with chronic pain. Researchers will follow 80 adults newly diagnosed with sleep apnea who are starting CPAP therapy. Participants will fill out pain and sleep questionnaires at the s…

This study explores whether a sham (fake) neurofeedback system in virtual reality can change brain activity related to attention. About 35 adults with rumination or chronic pain will undergo EEG recordings while experiencing positive, negative, or no feedback. The goal is to see …

This study follows 700 people with chronic diseases like arthritis, diabetes, or heart disease for 4 years. Participants wear a small movement sensor for 5 days, three times a year, to track their physical activity and sedentary time. Researchers want to see if a person's unique …

This study is testing whether a supplement called Boswellia serrata (also known as frankincense) can change how healthy people feel pain. Twelve volunteers will take either the supplement or a placebo for a short time, then have a small amount of capsaicin (the stuff that makes c…

This study checks if a computer algorithm can correctly identify the cause of chronic pain, just like a pain specialist would. About 200 adults with pain lasting at least one month will have their symptoms and history analyzed by both the algorithm and a doctor. The goal is to se…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study looks at how chronic pain affects sleep in teenagers aged 15-17. Researchers will test whether listening to a relaxing story before falling asleep can improve sleep quality and help process emotions related to pain. Twenty teens with persistent pain will have their sle…

This study looks at how central sensitization—a heightened pain response common in fibromyalgia—might be linked to cognitive problems like memory and concentration issues. Researchers will assess 100 adults with fibromyalgia using questionnaires and cognitive tests. The goal is t…

This study aims to find out how common small fiber neuropathy is in people with fibromyalgia compared to those with other chronic pain conditions and healthy volunteers. Researchers will use skin biopsies and other tests to check for nerve damage. The goal is to better understand…

This study looks at how central sensitization—a heightened pain response in the brain—relates to balance problems in people with fibromyalgia. Researchers will compare 75 fibromyalgia patients to healthy individuals using pain tests and a special balance device. The goal is to un…

This study looks at how brain circuits are connected in people with chronic temporomandibular joint (TMD) pain compared to pain-free individuals. Researchers will use MRI scans to map brain activity and structure in 95 female participants. The goal is to find patterns that could …

This study aims to objectively measure how internet-based exposure-based cognitive behavioral therapy (Exp-CBT) affects pain regulation in people with fibromyalgia. About 45 participants will undergo pain tests before and after 10 weeks of online therapy to see if their pain thre…

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…

This study looks at how spinal cord stimulation (SCS) changes certain molecules in the blood and spinal fluid of people with long-term nerve pain. Researchers will measure inflammatory markers and other signaling molecules before and after SCS in 30 adults. The goal is to underst…