Chronic pain syndrome

This study tests a smoking cessation program designed for veterans who have chronic pain. Participants receive counseling over the phone plus nightly automated calls to report their smoking and pain levels. The goal is to see if this approach helps more veterans quit smoking comp…

This study compares two common stitch materials—absorbable Vicryl and non-absorbable Prolene—for closing the abdominal wall after surgery. Researchers will track 156 patients in Pakistan for 6 months to see which suture leads to fewer hernias, infections, and less pain. The goal …

This study tests whether adding an ultrasound-guided nerve block (Pecs block) to a ketamine infusion can prevent chronic pain after breast cancer surgery. 120 women scheduled for mastectomy will be randomly assigned to receive either ketamine alone or ketamine plus the nerve bloc…

This study tests a mobile app called DockTales, designed for adults with chronic pain. The app lets users track pain and sleep through short diaries, body maps, and journaling, with an optional AI feature for reflection. Researchers want to see if the app is easy to use and engag…

This study investigates whether major ozone autohemotherapy — a procedure where a small amount of blood is mixed with ozone and returned to the body — can improve pain, fatigue, sleep, and muscle health in women with fibromyalgia. Sixty participants will receive either exercise a…

This study tests whether an artificial intelligence (AI) and computer vision system can help people with fibromyalgia perform effective exercise at home. Participants use a smartphone or tablet app that watches their movements and gives real-time feedback, with or without added r…

This trial tests a program called ENCompaSS that combines education, phone coaching, and self-management tips to help Veterans with long-term back pain. Participants are randomly assigned to either the program plus usual care or usual care alone. The study measures whether the pr…

This study tests whether injecting a numbing medicine (bupivacaine) into the surgical site during sling surgery for stress urinary incontinence can reduce pelvic and thigh pain after the operation. Sixty women will be randomly assigned to receive either the numbing medicine or a …

This pilot study tests whether injecting hyaluronic acid directly into the bladder wall is safe and can reduce pain and frequent urination in people with interstitial cystitis (bladder pain syndrome). Fifteen adults who haven't improved after standard treatments will receive the …

This study tests a self-guided digital psychology app, called Manage My Pain, along with weekly email reminders, for people with fibromyalgia or chronic pelvic pain who are on a waitlist for specialized pain care. The goal is to see if this approach is feasible and acceptable, an…

This study tests a new device called the EpiFaith™ Syringe, which gives a clear visual signal when a doctor reaches the right spot for an epidural pain injection. Currently, doctors rely on feel alone, which can lead to multiple needle sticks or mistakes. The study will compare t…

This study will test whether a 24-week Tai Chi program can reduce chronic pain, improve thinking and mobility, and lower fall risk in older adults (65+) who have pain in multiple body areas and are at risk for falls. 266 participants will be randomly assigned to Tai Chi or light …

This study will test whether guided walks in a forest can reduce chronic pain and improve quality of life in 70 adults with fibromyalgia. Participants will take slow, sensory-focused walks in nature, while researchers measure pain levels and medication use. The goal is to see if …

This study tests a program that combines a pain education class with immersive virtual reality sessions to help older adults with chronic pain overcome their fear of movement. Participants will be randomly assigned to receive either the education alone or the education plus up to…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study looks at whether semi-permanent ear acupuncture can help women with fibromyalgia feel less pain and improve how their nervous system works. Thirty women aged 35 to 64 will get weekly treatments for five weeks. Researchers will measure pain sensitivity and heart rate ch…

This Phase 2 trial tests an oral drug called LY4065967 in 150 people with chronic low back pain lasting at least 3 months. Half will get the drug, half a placebo, to see if it safely reduces pain and improves daily function. The study is not yet recruiting.

This study tests a hands-on technique called manual diaphragmatic release in 60 women with fibromyalgia who are not very active. The goal is to see if it improves exercise capacity, breathing muscle strength, symptoms, and quality of life. Participants will be randomly assigned t…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study tests whether a newer form of spinal cord stimulation (paresthesia-free SCS) actually reduces chronic pain or if its benefits are just a placebo effect. Ninety adults with severe neuropathic pain will receive both active and placebo stimulation for six weeks each, with…

This early-phase study at Yale will test whether a single 25mg dose of psilocybin is safe and well-tolerated in 10 veterans who smoke daily and have chronic pain. Researchers will monitor side effects and explore whether the drug can improve pain and boost motivation to quit smok…

This study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study tests a device called Scrambler Therapy to relieve nerve pain in children with cancer that has spread to the bone. The treatment is non-invasive and aims to lower pain levels and reduce the need for pain medications. About 70 children who can describe their pain will t…

This study tests whether a high-dose version of a gentle brain-stimulation device (tDCS) can reduce pain and other symptoms in 250 people with fibromyalgia. Participants will use the device at home, either on the motor cortex or the prefrontal cortex, and researchers will compare…

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 400 adults having elective heart surgery. The goal is to see if avoiding opioids can reduce both short-term and long-term pain, while also lowering side effects like delirium and nausea. Patients wi…

This study will test whether sensory motor training for neck muscles, combined with nerve gliding exercises, can improve hand grip strength in 50 post-menopausal women with fibromyalgia-related neck pain. Participants will do laser-guided neck movements and nerve stretches for fo…

This early study tests whether a non-invasive brain stimulation technique called TMS can help reduce pain, fatigue, and brain fog in people with fibromyalgia. About 30 adults will receive multiple TMS sessions and undergo MRI scans to see how the brain changes. The goal is to gat…

Stanford University is testing a wearable ultrasound device that targets peripheral nerves to reduce chronic pain. The device is placed on the skin over the painful area and delivers focused ultrasound waves. In this early study, 90 adults with nerve-related pain will attend a si…

This study looks at whether adding sodium bicarbonate (baking soda) to a standard lidocaine injection can provide better pain relief for people with myofascial pain syndrome, a condition causing muscle pain and trigger points. Thirty adults will be randomly assigned to receive ei…

This study tests whether listening to a 1- or 2-minute guided mindfulness audio can reduce pain in people waiting for orthopedic care. 300 adults will be randomly assigned to one of two mindfulness exercises or a control. The goal is to see if a brief, easy-to-use technique can m…

This study tests whether listening to self-selected music before, during, and after interventional pain procedures can reduce anxiety, pain catastrophising, and acute pain in adults with chronic pain. 110 participants will be randomly assigned to either music therapy or standard …

This study compares two ways of treating chronic musculoskeletal pain: one focused on reducing pain, and another focused on improving daily function. About 24 adults with long-term pain will attend weekly sessions for 3 months, including education, exercise, and goal-setting. The…

This study tests whether ketamine injections combined with psychotherapy can help people with treatment-resistant depression. Researchers will use brain scans to see if changes in brain activity link to improvements. About 25 adults will receive 1-2 doses of ketamine and several …

This study tests whether a safe electrical stimulation device placed on the ear (taVNS) can relieve chronic pain in people with fibromyalgia. Sixty participants will use the device twice daily for four weeks. Researchers will measure changes in pain, mood, and daily function to s…

This study tests whether a stronger laser (high-intensity) works better than a standard low-level laser for reducing pain and improving jaw movement in people with chronic jaw muscle pain. Forty adults will receive 12 laser sessions over one month and be followed for six months. …

This study tests whether combining virtual reality with motor imagery exercises can reduce pain and improve quality of life in people with fibromyalgia. Twenty-eight adults with fibromyalgia will be randomly assigned to either conventional exercise alone or conventional exercise …

This study will test whether different diets—a very low-calorie ketogenic diet, a Mediterranean diet, or a Mediterranean diet with added probiotics—can reduce pain and improve quality of life in women with fibromyalgia who are overweight or mildly obese. Researchers will track pa…

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

This study tests whether a 10-week virtual mindfulness program can improve quality of life for people with endometriosis-related chronic pelvic pain. Researchers will enroll 124 adults aged 18-50 with a diagnosis of endometriosis. Participants will attend online mindfulness works…

This study will test whether giving a single dose of ketamine during open-heart surgery can reduce chronic pain that often lingers for months after the operation. Researchers will compare 100 adults who receive either ketamine or a placebo during surgery, then track their pain le…

This study tests a non-drug treatment called transcranial electrical stimulation (tES) for people who have both depression and chronic pain. 240 adults will receive one of four types of brain stimulation or a fake treatment for two weeks. Researchers will check if it reduces pain…

This study tests whether using a smartwatch and mobile app, along with standard care, can help adults with chronic low back pain manage their symptoms better. Eighty adults will be split into two groups: one gets standard treatment alone, the other also uses a smartwatch and app …

This study tests a personalized health coaching program for veterans with chronic musculoskeletal pain. The goal is to help them develop and stick with self-care plans. Thirty veterans will participate to see if the program is feasible and acceptable.

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people with severe Complex Regional Pain Syndrome (CRPS). Researchers will measure pain levels, wrist movement, and daily function in 60 adults with CRPS. The goal is to s…

This study tests whether a 6-week virtual reality (VR) program can help adults with chronic pain learn about pain science and manage their symptoms. Fifty participants will use VR headsets for one hour each week to watch educational content and do guided exercises. The goal is to…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study tests an internet-based therapy program for people with chronic pain who also feel anxious or depressed. About 10 adults will try a 5-week online course with phone support from a psychologist. The goal is to see if the program helps reduce pain's impact on daily life a…

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

Chronic pain affects over 60% of people with spinal cord injuries, and standard treatments often fall short. The EmpowerSpine program is a 10-week online course that teaches pain biology, daily activity strategies, and resilience skills. This study will test 100 participants to f…

This study looks at whether a 12-month exercise program can reduce chronic pain in postmenopausal women. The program includes walking or cycling, strength training, and gentle yoga. Researchers think that improving insulin resistance and reducing inflammation might be how exercis…

This study looks at whether a traditional fermented grape drink called hardaliye can reduce pain and inflammation in women with fibromyalgia. About 45 women aged 20-40 will be split into three groups: one gets a personalized diet plus the drink, one gets only the diet, and one ge…

This study looks at whether adding special brain exercises to online Pilates classes can improve memory, attention, and pain in women with fibromyalgia. Thirty women will do Pilates twice a week for 8 weeks, with some also doing kinesthetic brain exercises. Researchers will measu…

This study tests whether adding tizanidine (a muscle relaxant) to pregabalin (a standard pain drug) works better than pregabalin alone for fibromyalgia pain. About 164 adults with daily pain will be followed for 12 weeks. The goal is to see if the combination reduces pain and imp…

This Phase 3 trial will test a web-based program called IMPACT for 250 veterans who have both opioid use disorder and chronic pain. The program includes 9 online modules and weekly feedback from a coach, all done from home. The goal is to see if it reduces how much pain interfere…

This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several week…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests whether combining high-intensity interval training (HIIT) with a gentle brain stimulation technique called tDCS can reduce pain, fatigue, and sleep problems in women with fibromyalgia. Forty women will be assigned to HIIT plus real tDCS, HIIT plus a sham device, …

This study tests a 12-week home program that combines AI-guided exercises with pain education for adults with fibromyalgia. Half of the 50 participants will use the digital program, while the other half receives usual care. The goal is to see if this approach reduces pain and imp…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This pilot study tests whether simply imagining doing back extension exercises can reduce pain and improve movement in 40 adults with chronic low back pain who prefer extension. Participants will lie down and mentally rehearse press-up movements guided by a script. The study meas…

This study tests whether doctors can safely perform ultrasound-guided pain procedures, like nerve blocks, at home for patients with chronic or cancer pain. It includes 100 adults already receiving home hospital care. The goal is to see if this approach reduces pain, cuts down on …

This study tests whether a simple breathing exercise, called inspiratory muscle training, can improve the body's stress response and reduce symptoms like pain, fatigue, and sleep problems in women with fibromyalgia. Fifty-one women will be randomly assigned to real training, a sh…

This study will test a treatment called rTMS, which uses magnetic pulses to stimulate parts of the brain, in 20 women with fibromyalgia. The goal is to see if stimulating the motor cortex changes brain activity and reduces pain. Researchers will use MRI scans to compare effects o…

This pilot study will test if the Nerivio device, a wearable armband that stimulates nerves to help the brain reduce pain, can improve symptoms in 40 children aged 8-18 with Amplified Musculoskeletal Pain Syndrome (AMPS). Half the participants will use the device every other day …

This study tests a one-week course of brain stimulation (called iTBS) for veterans who have both PTSD and chronic pain. Thirty veterans will receive 5-6 short sessions each day for five days, with no placebo group. Researchers will track changes in PTSD symptoms, pain, mood, and …

This study tests whether a smartphone app that plays personalized music can help people with HIV manage chronic pain. Sixty participants will either use the music app daily for 3 months or receive educational materials about pain. The main goal is to see if the app is practical a…

This European study will test a new type of spinal cord stimulation device in 200 people with persistent back and leg pain after failed back surgery. The device uses a special stimulation pattern to try to reduce pain. Researchers will track pain levels and device settings to see…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

This study tests a non-invasive device that gently stimulates the vagus nerve through the ear to see if it can reduce pain in people with fibromyalgia. Researchers will enroll 152 adults with fibromyalgia to measure changes in pain severity. The approach is portable, safe, and lo…

This study tests whether a program of pain education and physical exercise, delivered by physiotherapists in primary care, can improve quality of life for people with chronic spinal pain. 135 adults aged 18-70 with long-term back or neck pain will be split into three groups: one …

This study will test whether using a mind-body mobile app combined with a guided, gentle movement program can help people with chronic pain. One hundred adults aged 19 to 75 with persistent pain for at least 6 months will use the app daily and follow audio-guided movement session…

This study tests whether taking butyrate and taurine supplements daily can prevent chronic pain after heart surgery. 216 adults having elective heart surgery will receive either the supplements or a placebo for three months after their operation. Researchers will track pain level…

This study adapts the Pain and Smoking Inventory (PSI) for Turkish-speaking adults who have chronic pain and smoke daily. Researchers will test whether the translated version is reliable and accurate by comparing it with other measures of pain and nicotine dependence. The goal is…

This study translates and tests a 9-question scale called BITEC, which measures what people with chronic pain expect from their treatment. Researchers will enroll 250 adults in Turkey who have had pain for at least three months. Participants fill out surveys about their pain, exp…

This study follows 800 people who are already scheduled to receive ketamine infusions for chronic pain as part of their regular care. Researchers will use surveys to track pain levels, opioid use, and overall well-being for up to 16 weeks. A comparison group includes patients who…

This study explores whether a noninvasive technique called transcranial electrical stimulation can reduce pain and improve quality of life in people with fibromyalgia. Participants receive daily sessions of mild electrical pulses to the scalp over four weeks, targeting different …

This study looks at how women with fibromyalgia experience pain, focusing on the brain's ability to control pain signals. Researchers will measure pain thresholds and responses to repeated stimuli in 82 participants. The goal is to better understand the condition, not to test a n…

This study will check how often people with ADHD also have fibromyalgia, and vice versa. Researchers will collect blood and urine samples from 100 adults to look for shared biological markers. The goal is to better understand why these two conditions often occur together.

This study looks at how whole-body heat therapy (hyperthermia) changes body temperature, pain sensitivity, and pain during movement in 60 people—half with chronic widespread pain (like fibromyalgia) and half healthy. Participants will receive six heat sessions over three weeks. T…

This study looks at how resilience and pain sensitivity influence physical function in people with fibromyalgia compared to healthy volunteers. Researchers will measure walking distance using a 6-minute walk test and compare it to self-reported resilience scores. No treatment is …

This study will test a customized online health program for Canadian women Veterans and their families. The program includes health missions, peer support, and social connection to encourage physical activity and healthy habits. Researchers will track how many people complete the…

This study looks at 180 adults getting a heart device (like a pacemaker) for the first time. Researchers will track their pain and quality of life for a year, using surveys and a pressure gauge. The goal is to build an AI system that can predict who is at risk for long-term pain,…

This observational study looks at how people with chronic pain experience pleasant touch and how often they encounter it in daily life. Researchers want to see if these experiences are linked to pain sensitivity and body awareness. About 100 adults referred to a pain clinic in Sw…

This study looks at whether using a stomach ultrasound before sedation can help anesthesiologists make safer decisions for chronic pain patients. These patients often take opioids or have other conditions that slow stomach emptying, raising the risk of food or liquid entering the…

This study will follow 220 adults having knee replacement surgery to see if a short burst of pain after a nerve block (called rebound pain) is linked to chronic pain that lasts for months. Participants will keep pain diaries and answer surveys at 3 and 6 months after surgery. No …

This study tests whether green light therapy can reduce pain in people with fibromyalgia by calming brain inflammation. Researchers will use brain scans and spinal fluid tests to see how the light affects pain pathways. The trial involves 70 adults with moderate to severe pain wh…

This observational study looks at how adults with chronic pelvic pain understand their pain and cope with it, and how these factors relate to their sexual function. Researchers will ask 50 participants to fill out questionnaires about pain knowledge, coping strategies, and sexual…

This study follows 150 adults with severe arm or leg injuries to see if developing a blood clot raises the risk of long-term pain. Participants are enrolled within 72 hours of hospital admission and monitored for six months. The goal is to understand how blood clots and pain are …

This study uses artificial intelligence to understand how sleep quality, fatigue, and emotional well-being affect the severity of fibromyalgia. Researchers will collect data from 150 adults with fibromyalgia through questionnaires. The goal is to build a model that predicts disea…

This study tests a new way of organizing care for people with long-term pain who are seeing a physical therapist. The goal is to see if a personalized care model can improve how well different healthcare providers work together. About 66 adults with chronic pain will take part, a…

This study follows 100 adults who had a mild to moderate combat-related traumatic brain injury to see who develops long-term pain. Researchers will track pain levels, mental health, and physical factors for 6 months. The goal is to create a tool that can predict chronic pain risk…

This study will compare women with fibromyalgia to healthy women to see how their symptoms, mental health, sleep, eating habits, and stomach issues differ. Researchers will use questionnaires and surveys to gather information from 80 women. The goal is to better understand the ma…

This study looks at how being sedentary versus active affects people with fibromyalgia. Researchers will compare 66 adults on body awareness, breathing strength, fear of movement, pain sensitivity, daily function, and sleep quality. The goal is to understand how inactivity may wo…

This study looks at whether virtual reality (VR) versions of two common mobility tests—the five times sit-to-stand test and the timed up and go test—are valid and reliable for women with fibromyalgia. Researchers will enroll 51 women aged 30-60 and compare VR-based results to sta…

This study will translate the Pain Metacognitions Questionnaire into Turkish and check if it is a reliable tool for adults with chronic non-cancer pain. About 210 participants who have had pain for at least three months will fill out surveys once. The goal is to provide a valid w…

This study gathers information from 40 adults with long-lasting, severe pain who are already planning to use an FDA-approved spinal cord stimulator. Researchers will analyze data from the device to see how well it works and how it affects pain, sleep, mood, and daily life. The go…

This study tests whether a 10-15 minute educational session about the neuroscience of pain can improve memory and change how people with chronic pain sense their body. Fifty adults with pain lasting more than a year will take memory tests and draw their pain on a body chart befor…

This observational study from the University of Nottingham aims to find out which factors predict chronic pain after a serious limb injury. Researchers will follow 450 major trauma patients with at least one broken limb for 6 months, asking them about their pain at 3 and 6 months…

This study will check how often fibromyalgia occurs in women with polycystic ovary syndrome (PCOS) and how pain relates to mood and insulin resistance. About 140 women aged 18-40 with PCOS and a healthy control group will answer questionnaires and have pain thresholds measured. T…

This study looks at whether a single session of intense aerobic exercise can temporarily reduce pain sensitivity in 66 young people with and without chronic pain. Participants will walk or run on a treadmill, and researchers will measure how their pain perception changes. The goa…

This study compares how well people with chronic jaw pain (TMD) and healthy volunteers can detect thin foils placed between their teeth. Researchers will test 80 participants to see if TMD reduces bite sensitivity. The goal is to better understand how jaw pain affects daily funct…