Eye disorder

This trial tests a gene therapy for people with a rare inherited eye disease called Leber congenital amaurosis, caused by mutations in the RPE65 gene. A harmless virus is used to deliver a working copy of the gene into cells under the retina. The goal is to restore vision with a …

This early feasibility trial tests a new retinal implant called PRIMA in 5 people with advanced dry age-related macular degeneration who have lost central vision. The device is surgically placed in the eye to stimulate remaining retinal cells. Researchers are checking if it is sa…

This trial compares two surgical techniques for removing a pterygium, a fleshy growth on the eye's surface that can distort vision. Researchers are testing whether using a piece of the patient's own conjunctiva (the clear tissue covering the eye) or a preserved amniotic membrane …

This trial tests whether insulin eye drops can improve the ocular surface in people with moderate-to-severe dry eye disease. Participants will receive either insulin eye drops or artificial tears for up to a year. The study measures changes in dry eye symptoms and tear production…

This study tested cyclosporin 0.1% eye drops in 25 adults with moderate to severe dry eye disease that didn't get better with artificial tears. The goal was to see if the drops reduce eye dryness and redness. Participants used the drops alongside their usual tear substitutes for …

This study tested a new type of artificial lens, called the AT ELANA 841P, for people having cataract surgery. 284 adults with cataracts in both eyes received either the new lens or a standard lens. Researchers measured how well patients could see at different distances and check…

This trial is testing whether a piece of the patient's own eye tissue, called Tenon's capsule, can help close large or recurrent macular holes—tears in the center of the retina that can blur or distort vision. During standard vitrectomy surgery, the tissue is harvested and placed…

This trial tests whether giving anti-VEGF injections 3, 7, or 14 days before surgery makes a difference for people with proliferative diabetic retinopathy, a complication of diabetes that causes abnormal blood vessels in the eye. Participants are randomly assigned to one of three…

This trial investigates whether a sterile gauze infused with natural plant extracts can reduce bacteria on the eyelid margin in people with bilateral anterior blepharitis. Each participant receives the plant-based gauze on one eye and a standard gauze on the other, allowing direc…

This trial compares two operations for primary acquired nasolacrimal duct obstruction, a condition where tears cannot drain normally from the eye into the nose, causing persistent tearing. One surgery uses a small skin incision near the inner corner of the eye, while the other go…

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This pilot study tests a new laser device for treating open-angle glaucoma and ocular hypertension. The device uses a laser through the sclera (the white of the eye) to lower eye pressure, avoiding the need for a lens to touch the cornea. Researchers will check how safe the proce…

This clinical trial is testing whether an investigational eye drop called STN1010904 can improve vision in people with Fuchs endothelial corneal dystrophy (FECD), a condition that damages the cornea's inner layer and can lead to blurry vision. The study will compare two different…

This early-stage trial is testing an experimental drug called AEB1102 in people with advanced solid tumors that have not responded to standard treatments or for which no standard treatment exists. The main goal is to find the highest dose that is safe and to understand the drug's…

This study tests whether a laser-guided system can mark the correct position for a toric intraocular lens more accurately than the traditional manual ink method during cataract surgery. The trial involves 30 patients with corneal astigmatism who are having femtosecond laser-assis…

This study tests whether a home eye-scanning device can improve care for people with wet age-related macular degeneration (AMD) who are switching to the medication faricimab. Participants will scan their own retinas at home several times a week, and the images will be sent to the…

This clinical trial is testing whether an experimental eye injection called ONS-5010 (bevacizumab) can help preserve vision in people with wet age-related macular degeneration (AMD), a leading cause of vision loss. The study will compare ONS-5010 to an existing treatment, ranibiz…

This trial is testing MYL-1701P, a proposed biosimilar to the existing eye medication Eylea, in people with diabetic macular edema who have already completed an earlier study with the same drug. The goal is to see if continued treatment with MYL-1701P is safe and effective over a…

This study tests whether daily low-dose atropine eyedrops (0.01%) can slow the progression of myopia (nearsightedness) in children aged 5 to 12. Participants receive either atropine or placebo drops for two years, followed by six months off treatment to see if any benefit lasts. …

This trial investigates whether adding a dexamethasone implant (Ozurdex) to standard aflibercept (Eylea) injections can better control diabetic macular edema that has not responded to anti-VEGF therapy alone. Adults with persistent retinal swelling will receive either the combina…

This study tests a new device called the VW-50, a small implant designed to drain fluid from the eye and lower pressure in people with glaucoma. The trial will enroll 10 adults whose eye pressure remains high despite medication. Surgeons will implant the device and rate how easy …

This study tests whether a combination eye drop (netarsudil/latanoprost) can improve vision and reduce corneal thickness in people with glaucoma and a condition called pseudophakic bullous keratopathy, where the cornea swells after cataract surgery. Half of the 50 participants re…

This trial tests whether a single drop of timolol maleate, given just before Nd:YAG laser capsulotomy, can prevent a short-term rise in eye pressure. The study includes adults who developed clouding of the lens capsule months after cataract surgery. Half receive the timolol drop;…

This trial tests whether an experimental drug called ONS-5010 (a form of bevacizumab) works as well as an approved drug, Lucentis, for treating wet age-related macular degeneration (AMD). Wet AMD causes rapid vision loss due to abnormal blood vessels leaking fluid in the eye. Abo…

This trial investigates whether an injection of ranibizumab, a drug that blocks abnormal blood vessel growth, can effectively treat aggressive posterior retinopathy of prematurity (AP-ROP) in premature infants. AP-ROP is a fast-progressing eye condition that can lead to retinal d…

This trial tests a new type of intraocular lens, the CT LUCIA 621P, designed to improve vision after cataract surgery. The lens has a special shape that may correct vision more precisely than standard lenses. Researchers will measure how well people see at distance and intermedia…

This trial investigates how well a new multifocal intraocular lens, the AT ELANA, improves vision in people having cataract or refractive lens exchange surgery. About 69 participants will receive the lens in both eyes and be followed for 12 months to measure visual sharpness and …

This study compares two surgical approaches for treating a serious eye infection (endophthalmitis) that can occur after an injection into the eye. One group receives a combined surgery that removes the eye's natural lens along with infected vitreous gel (phacovitrectomy), while t…

This study examines how wearing Ortho-K contact lenses overnight changes the optical quality of the cornea in children and young adults aged 8 to 21 with mild to moderate nearsightedness and astigmatism. Participants wear the lenses for 8–10 hours each night, and researchers meas…

This study tests the safety of an experimental eye injection called ONS-5010 (bevacizumab) in people with vision loss from wet age-related macular degeneration, diabetic macular edema, or branch retinal vein occlusion. Participants receive the injection and are monitored for side…

This trial compares two ways to correct nearsightedness: implanting a small lens inside the eye (EVO+ ICL) and reshaping the cornea with a laser (LASIK). Researchers are measuring how well each procedure improves vision, as well as side effects like glare, dry eye, and night visi…

This study tests whether switching to a higher dose (8mg) of aflibercept can help people with wet age-related macular degeneration (AMD) who have not responded well to standard treatments like faricimab or the usual 2mg dose of aflibercept. Participants receive up to three inject…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This study compares two ways of creating scleral tunnels during flanged intrascleral intraocular lens (IOL) fixation surgery, a procedure used when the eye's natural lens support is missing or damaged. Researchers are testing whether making the tunnel horizontally (parallel to th…

This trial tests an investigational drug called BAT5906, given as an eye injection, for people with diabetic macular edema—a condition where fluid builds up in the retina and blurs vision. The study compares two doses (2.5 mg and 4 mg) given multiple times to see which works best…

This study looks at a modified surgical technique for children with primary congenital glaucoma, a condition that causes high eye pressure and can lead to blindness if untreated. The surgery combines two procedures to create a better drainage channel for fluid inside the eye. Res…

This study tests the safety of a single injection of PST-611, a DNA-based therapy, in people aged 50 and older with dry age-related macular degeneration (AMD). The therapy is designed to make the eye produce a protein that may protect against vision loss. Participants receive one…

This study investigates whether a non-invasive light treatment called photobiomodulation can improve vision and slow vision loss in people with dry age-related macular degeneration (AMD). Participants receive either active light therapy or a sham (inactive) treatment over 12 mont…

This study tests whether progressive addition lenses (PALs), like bifocals without a visible line, can slow the progression of low myopia (nearsightedness) in children who have certain focusing traits. About 118 children with low myopia and specific vision characteristics were ra…

This study tests whether injections of ranibizumab, a drug that blocks abnormal blood vessel growth, can help clear bleeding inside the eye in people with diabetes. The bleeding, called diabetic vitreous hemorrhage, can blur or block vision. Participants receive the injection and…

This study tested whether cleaning the eyelids with wipes containing chlorhexidine can treat blepharitis caused by Demodex mites. 106 adults with the condition used the wipes twice daily for four weeks. Researchers measured mite counts and eyelash debris before and after treatmen…

This trial investigates whether combining two immunotherapy drugs (ipilimumab and nivolumab) with a procedure called immunoembolization can help people whose uveal melanoma has spread to the liver. The drugs help the immune system attack cancer cells, while immunoembolization cut…

This study tests whether Miebo eye drops, used before and after cataract surgery, can improve the accuracy of lens measurements and final vision in people with dry eye. Participants apply the drops four times daily for about 30 days before surgery and again for 30 days after. The…

This study follows people with two inherited eye conditions—choroideremia and X-linked retinitis pigmentosa—who previously received gene therapy. Researchers monitor their safety and vision over several years to see if the treatment remains safe and helps preserve sight. Particip…

This phase 3 trial tested whether a yeast-derived immune stimulant (GM-CSF) and a peptide vaccine, alone or together, could prevent melanoma from returning after surgery. 815 patients with no visible cancer after complete surgical removal of advanced melanoma were randomly assign…

This study looked at whether placing a tiny device called iStent during cataract surgery helps lower eye pressure in people with primary open-angle glaucoma. Researchers compared 80 patients who got the implant plus cataract surgery to those who had cataract surgery alone. The go…

This study examines how well a biosimilar (a lower-cost copy) of the drug ranibizumab works for diabetic macular edema, a condition that causes vision loss in people with diabetes. Researchers will review medical records of 60 adults who received at least one injection of the bio…

This phase 3 trial tested a new type of corneal cross-linking that does not require removing the surface layer of the eye. It involved 398 people aged 8 to 45 with keratoconus, a condition that thins and bulges the cornea. The treatment uses riboflavin eye drops and ultraviolet l…

This trial tests two different contact lenses designed to slow down the progression of myopia (nearsightedness) in children aged 6 to 11. Each child wears one type of lens on each eye for six months, then switches, so researchers can compare how well each lens controls eye growth…

This phase 3 trial tested a new way to treat keratoconus, a condition where the cornea thins and bulges, causing blurry vision. The treatment uses special eye drops and ultraviolet light to strengthen the cornea without removing its outer layer. 396 people aged 8 to 45 took part …

This completed study tested a special lens called HAL for people with nearsightedness (myopia). 88 participants wore either the HAL lens or a standard single vision lens. Researchers measured reading speed and how well they could see at different distances and contrasts. The goal…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tested two types of advanced glasses—lenslet spectacles and violet filter glasses—against standard single-vision lenses to see if they could slow the worsening of nearsightedness (myopia) in 90 people aged 8 to 20. Participants wore the glasses during all waking hours …

This study tested a new lens called 621 in 105 adults having cataract surgery. The lens was implanted during standard surgery to replace the cloudy natural lens. Researchers checked how well patients could see 6 months after surgery and monitored for any safety issues. The goal w…

This study tests whether a graft made from a patient's own or donor stem cells can repair the cornea's surface in people with limbal stem cell deficiency, a condition that causes pain, scarring, and vision loss. A small biopsy of limbal tissue is taken from a healthy eye or donor…

This study tests a drug called faricimab (VABYSMO) in people with diabetic macular edema, a condition where diabetes causes fluid buildup in the center of the retina, leading to vision loss. Participants receive injections of faricimab into the eye every four weeks. The goal is t…

This study tests a device called the ELIOS System to safely lower eye pressure in adults with mild to moderate open-angle glaucoma. The procedure is done alone, without other surgeries, and aims to reduce pressure by at least 20% while possibly using fewer medications. Researcher…

This study tested three low doses of atropine eye drops (0.01%, 0.03%, and 0.05%) in 95 children aged 6–18 with nearsightedness. The goal was to see which dose best slowed the worsening of myopia with the fewest side effects. Over 18 months, the 0.05% dose worked best at controll…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study compared two surgical methods to correct exotropia, a condition where one eye turns outward. In one group, a piece of the inner eye muscle was removed and reattached; in the other, the muscle was folded and shortened. Both groups also had the outer eye muscle loosened.…

This study tested an eye drop called RMP-A03 in 77 healthy volunteers and people with pterygium, a fleshy growth on the eye. The goal was to see if it safely reduces redness and controls the condition. Participants received either a low dose, high dose, or placebo drops, and rese…

This study looked at whether tocilizumab, a drug that calms the immune system, can help people with active moderate-to-severe thyroid eye disease that did not get better with steroids. Thirty-two adults received the drug every four weeks. Researchers measured improvements in eye …

This study tested a gene therapy called voretigene neparvovec in 4 Japanese patients with a rare inherited eye disease that causes vision loss. The treatment was given as an injection under the retina to replace the faulty gene. The goal was to see if it could safely improve ligh…

This study tested a new implant called PER-001 placed inside the eye to treat open-angle glaucoma. The trial included 33 adults and checked for safety and how well it controlled eye pressure. The implant is designed to release medication over time, potentially reducing the need f…

This study tested a new eye implant called PER-001 in 27 people with diabetic retinopathy, a diabetes complication that can damage vision. The implant is placed inside the eye and releases medication over time. The main goal was to check safety and how well people tolerate it, lo…

This study looked at how well enVista Aspire intraocular lenses work in real-world cataract surgery. 335 adults received the lenses during routine cataract removal. Researchers measured vision sharpness and how satisfied patients and surgeons were with the results.

This study tested a combination of two drugs, sitravatinib (a pill) and tislelizumab (an IV infusion), in 16 people with a rare eye cancer (uveal melanoma) that had spread to the liver. The goal was to see if the combo could shrink liver tumors better than current treatments. Par…

This study tested the safety of a drug called maralixibat in 27 infants under 12 months old with Alagille syndrome or progressive familial intrahepatic cholestasis (PFIC), two rare liver diseases that cause bile buildup. The drug is given as an oral solution and aims to reduce bi…

This study compared two small eye implants, Hydrus and iStent, placed during cataract surgery to help lower eye pressure in people with open-angle glaucoma. 65 patients were followed long-term to see which device worked better and was safer. The goal was to reduce the need for gl…

This study looked at whether adding bifocal glasses to daily atropine eye drops works better than atropine alone to slow down nearsightedness (myopia) in children. 210 kids aged 4-16 with worsening myopia took part. The main goal was to measure changes in their vision prescriptio…

This early-stage study tested the safety of a new drug called VP-001, given as an injection into the eye, for people with a rare genetic eye disease (PRPF31 mutation) that causes vision loss. Six participants aged 12 and older received multiple doses. The main goal was to check f…

This early-stage study tested a new drug, VP-001, given as an injection into the eye to see if it is safe for people with a rare genetic eye disease caused by a PRPF31 mutation. Seventeen adults took part. The main goal was to check for side effects, not to measure vision improve…

This study tested a pre-filled syringe containing a high dose (8 mg) of the drug aflibercept for two eye conditions: diabetic macular edema and wet age-related macular degeneration. The main goal was to see if retina specialists could prepare and inject the drug easily and safely…

This study tested a new eye medication called PRO-169 against a standard drug (ranibizumab) for people with diabetic macular edema, a condition that causes vision loss in people with diabetes. About 509 adults with diabetes took part, receiving injections into the eye over one ye…

This phase 2 trial tested a biologic drug called RC18 in 42 people with primary Sjögren's syndrome, an autoimmune disease that causes dry eyes and mouth. Participants received weekly injections of either RC18 (at 160 mg or 240 mg) or a placebo for 24 weeks. The goal was to see if…

This study tested whether ripasudil eye drops can help people with Fuchs endothelial corneal dystrophy recover vision faster after a specific cornea procedure called descemetorhexis. The trial involved 107 adults and compared the drops to a placebo over 12 weeks of treatment, fol…

This phase 3 trial tested TRS01 eye drops in 142 people with active non-infectious anterior uveitis, an inflammatory eye condition that can cause pain and vision loss. Participants used the drops four times a day, and researchers measured how well the drug reduced inflammation co…

This Phase 2 trial tested a drug called CFZ533 (iscalimab) in 273 adults with Sjögren's syndrome, an autoimmune disease causing dryness, pain, and fatigue. Participants received either the drug or a placebo for 24 weeks. The study measured changes in disease activity and symptoms…

This study checks the long-term safety of an eye injection called avacincaptad pegol for people with geographic atrophy, a form of advanced age-related macular degeneration that causes vision loss. About 278 adults who finished a previous study of this drug will receive the injec…

This study compared two treatments for advanced open-angle glaucoma: a gentle laser (subthreshold diode laser) and a surgical procedure (trabeculotomy). 80 adults with severe glaucoma that was not controlled by maximum medications took part. The goal was to see which treatment be…

This study tested an experimental eye drop called CSB-001 in 131 people with neurotrophic keratitis, a rare condition where the cornea loses sensation and can develop ulcers. Participants used the drops four times daily for 8 weeks. The goal was to see if the drops could fully he…

This study tested an oral drug called AZ-3102 in 13 people with GM2 gangliosidosis (Tay-Sachs or Sandhoff disease) or Niemann-Pick type C disease. The main goal was to check safety and how the drug moves through the body over 12 weeks. It was a randomized, double-blind, placebo-c…

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This phase 3 study tested the long-term safety of LNZ101 eye drops, a combination of aceclidine and brimonidine, in 362 adults aged 45-75 with presbyopia (age-related blurry near vision). Participants used the drops regularly and were monitored for side effects. The study is comp…

This study tested a new way to seal the small cuts made in the eye during cataract surgery. The technique, called posterior flap hydration, uses a special cannula to add fluid to the back of the wound. Researchers checked how tight the seal was right after surgery and looked at t…

This completed study tested whether bright light therapy, special glasses that create myopic defocus, low-dose atropine eye drops, or combinations of these can slow the progression of nearsightedness in schoolchildren. A total of 577 children aged 7-12 with myopia participated. T…

This study looked at the best ways to treat a rare but serious eye infection called acanthamoeba keratitis, which is caused by a parasite. 49 people took part. In the first part, they received either one drug or a combination of two drugs. In the second part, they were given ster…

This study tested two gel-like devices, Eyefill SC and Eyefill MB, used during cataract surgery to protect the eye. Researchers followed 148 adults who had cataract surgery with these devices to see if they were safe and worked as intended. The main focus was on changes in the ey…

This study tested an oral drug called ADX-629 in 8 people with Sjögren-Larsson syndrome, a rare inherited disorder that causes harmful fatty substances to build up in the skin, brain, and eyes. The main goals were to see if the drug is safe and can reduce these fatty aldehydes. P…

This study compared two types of glaucoma surgery—standard trabeculectomy and a smaller 'micro' version—to see which one lowers eye pressure better and causes fewer complications. Researchers followed 100 patients for 3 months after surgery. The goal is to find out if the smaller…

This study tested if injecting the antifungal drug fluconazole directly into the cornea is safe and effective for treating fungal keratitis, a serious eye infection. 40 patients with lab-confirmed fungal infections that were sensitive to fluconazole took part. The researchers mea…

This study tested whether adding a special amniotic membrane containing riboflavin and moxifloxacin to standard PACK-CXL therapy helps heal infected corneal ulcers faster. 32 adults with moderate-to-severe ulcers took part. The goal was to see if the membrane improves corneal hea…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study tested whether eye drops made from a patient's own blood or from donated umbilical cord blood can improve dry eye disease. Eighty adults with dry eye from conditions like Sjogren's syndrome or after using glaucoma drops were randomly assigned to one of the two types of…

This early-stage study tested whether infliximab, a drug usually given through a vein, can be safely used as eye drops for sterile corneal melt. This condition causes the clear front part of the eye to thin, which can lead to blindness. Seven adults with this condition received t…

This study tested whether a pre-filled syringe of the medicine SB11 (a biosimilar to ranibizumab) is easy for eye doctors to use. Thirty adults with wet age-related macular degeneration, macular edema from retinal vein occlusion, or myopic choroidal neovascularization received on…

This phase II trial tested an experimental drug called ADX-2191 in 8 adults with retinitis pigmentosa caused by specific genetic mutations. Participants received monthly injections into one eye for up to six months. The main goal was to check safety, but researchers also looked a…

This phase 2 trial tested the drug crizanlizumab in 18 people with RVCL, a rare and fatal genetic condition that damages small blood vessels in the brain and eyes. There is currently no treatment for RVCL. The study measured changes in brain lesions on MRI scans to see if the dru…

This study tested a minimally invasive surgery called GATT in 30 children who developed glaucoma after cataract surgery. The procedure aims to lower eye pressure by improving fluid drainage inside the eye. Researchers measured changes in eye pressure and the number of glaucoma me…

This phase 2 trial tested the drug darovasertib in 15 people with high-risk uveal melanoma (a rare eye cancer) who were scheduled for eye removal surgery. Participants took the drug for up to 4 weeks before surgery, and some continued for 6 months afterward. The main goals were t…

This study compared two types of tube shunts (Baerveldt 350 and Ahmed ClearPath 250) in 80 adults with glaucoma that was not controlled by other treatments. The goal was to see which device lowers eye pressure better and is safer. Both implants are used to drain fluid and protect…

This study tested a new anti-infective eyedrop called SCH1 in 30 adults with acute infectious conjunctivitis (pink eye). Participants received either the active eyedrop or a placebo. The goal was to see if the drug could completely clear redness and discharge. The trial is comple…

This study tested an experimental drug called Zimura in 121 people with Stargardt disease, a genetic condition that causes vision loss. Participants received either Zimura injections or a sham procedure. The goal was to see if Zimura could safely slow damage to the retina over 18…

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study looked at whether faricimab injections can help people with diabetic retinopathy, a diabetes-related eye disease. Over 12 months, 60 patients received the treatment and doctors measured changes in the back of the eye. The goal was to see if the drug could reduce abnorm…

This study tested three different doses of SYL1801 eye drops in 99 people with wet age-related macular degeneration (AMD). The goal was to see if the drops are safe and can improve or maintain vision. Participants used the drops for a set period, and their vision was measured aft…

This early-stage trial tested an experimental eye drop called STSP-0902 in 82 healthy volunteers to see if it is safe and how the body processes it. The study involved single and multiple doses, with some participants getting a placebo. The goal is to eventually treat neurotrophi…

This early-stage trial tested a gene therapy called EXG102-031 in 12 people with wet age-related macular degeneration (nAMD), a condition where abnormal blood vessels damage central vision. The therapy was injected into the eye to block these vessels. The main goal was to check s…

This Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…

This study tested a tiny implant called the PRIMA Bionic Vision System in 5 people with advanced dry age-related macular degeneration who had lost central vision. The implant is placed under the retina and uses electrical stimulation to replace damaged light-sensing cells. The go…

This completed Phase 1 trial tested the VisuMax femtosecond laser to correct nearsightedness (myopia) in 357 adults aged 22 and older. The procedure removes a small lens-shaped piece of the cornea to reshape the eye and improve vision. Researchers measured how well the treatment …

This study tested a new eye drop called QLS-111 in 37 people with normal tension glaucoma, a type of glaucoma where eye pressure is not high but vision still gets damaged. The goal was to see if QLS-111 is safe and can lower eye pressure better than a standard drop called timolol…

This early-phase trial tested a gene therapy called ZM-01 in 2 boys aged 3 to 18 with X-linked retinoschisis, a rare genetic eye condition that causes vision loss. Each boy received an injection of the therapy into one eye. The main goal was to check safety, but researchers also …

This study tested a new, less invasive surgery called MIMS for people with glaucoma. The goal was to see if it lowers eye pressure as well as traditional surgery but with fewer side effects. 23 adults with glaucoma took part. The results will help doctors understand if MIMS is a …

This study tested two different steroid eye drops—loteprednol and prednisolone—in 66 children with inflammatory nodules in the front part of the eye. The goal was to see if loteprednol could control inflammation as well as prednisolone while causing fewer increases in eye pressur…

This study tested whether a new eye drop called AR-15512 can improve the health of the eye surface in people with dry eye disease. 80 participants received either the new drops or artificial tears. The main goal was to see if the drops increased the number of goblet cells, which …

This study tested the safety and effectiveness of atorvastatin (Lipitor) in 15 children with Alagille syndrome who had skin cholesterol deposits called xanthomas. The children took the drug for 6 months, and doctors graded the size and number of the lumps. The goal was to see if …

This study tested whether a steroid eye drop (fluorometholone) given for four weeks after trachoma surgery could stop eyelashes from growing back and rubbing against the eye. Over 2,400 people aged 15 and older took part. The goal was to see if this simple, low-cost addition to s…

This study looked at the long-term safety and performance of AcrySof PanOptix trifocal lenses in 211 people who had them implanted in both eyes 3 to 5 years earlier. Researchers checked vision and recorded any eye problems or device issues. The goal was to make sure these lenses …

This study tested a drug called faricimab in 179 people with non-proliferative diabetic retinopathy, a condition where diabetes damages blood vessels in the eye. The goal was to see if the drug could improve blood flow in the retina over 48 weeks. Participants received either mon…

This study looked at 70 people with mild to moderate glaucoma or high eye pressure. All received a laser treatment called selective laser trabeculoplasty (SLT). Afterward, half used Rocklatan eye drops and half used artificial tears. The goal was to see if Rocklatan lowered eye p…

This study tested a new drug called IMCgp100 in 378 adults with a specific genetic type (HLA-A*0201) of advanced uveal melanoma, a rare eye cancer. Participants received either IMCgp100 or one of three standard treatments (dacarbazine, ipilimumab, or pembrolizumab). The main goal…

This study from the Mayo Clinic tested a laser procedure called MP-TSCPC in 65 glaucoma patients to see how well it lowers eye pressure. Researchers tracked patients for one year after the procedure, measuring changes in eye pressure, medication use, and vision. The goal was to e…

This study tested a special laser (femtosecond laser) to adjust an artificial lens already placed inside the eye after cataract surgery. The goal was to correct leftover blurriness or astigmatism so people need glasses less. Twelve adults with at least one diopter of remaining re…

This early-phase trial tested an investigational eye injection called OLN324 in 164 adults with either wet age-related macular degeneration (AMD) or diabetic macular edema (DME). The main goal was to check safety and how the drug moves in the body, with a preliminary look at whet…

This study tested the safety and effectiveness of the EVO/EVO+ Visian Implantable Collamer Lens (ICL) in 327 adults with moderate to high nearsightedness (with or without astigmatism). The lens is surgically placed inside the eye to correct vision. Researchers tracked side effect…

This completed trial tested whether a specially designed spectacle lens (CARE1.02) can slow the progression of myopia (nearsightedness) in teenagers aged 12 to 17. About 796 teens in Guangzhou, China, wore either the CARE1.02 lens or a standard single-vision lens for one year. Re…

This study tested adding lenalidomide to a standard chemotherapy regimen (EPOCH-R) in 55 people with aggressive B-cell lymphomas linked to the MYC gene. The goal was to find the best dose and see if the combination improves how long patients live without their cancer getting wors…

This study tested three strengths of atropine eye drops (0.01%, 0.04%, and 0.1%) in 219 children with high myopia (severe nearsightedness). The goal was to see which dose best slows the worsening of vision and eye growth over two years. Children received one drop in each eye ever…

This study tested whether a new type of spectacle lens (partition multi-point defocus lens) is as good as another advanced lens (aspherical lenslets) at slowing the progression of nearsightedness (myopia) in children. 194 children aged 8 to 13 years wore the lenses for two years.…

This study tested whether baricitinib, a drug already used for rheumatoid arthritis, can help people with active Sjogren's syndrome. 87 participants were randomly assigned to receive either hydroxychloroquine alone or baricitinib plus hydroxychloroquine for 24 weeks. The goal was…

This study looked at how well a special lens implant, called the Visian Toric ICL, works over two years for people with nearsightedness and astigmatism. A total of 125 participants received the implant, which sits behind the iris. The main goal was to see if the lens stays in pla…

This study tested special glasses called C.A.R.E. lenses in 100 children aged 6-12 with nearsightedness. The lenses have rings that change how light hits the eye to slow down eye growth. After 12 months, researchers measured changes in eye length and prescription strength to see …

This study tested a new medicine called LASN01 in 41 adults with thyroid eye disease, a condition that causes eye bulging and discomfort. The goal was to see if LASN01 could safely reduce eye bulging compared to a placebo. Participants received either LASN01 or a dummy treatment …

This early study tested combining the immunotherapy drug pembrolizumab with precise radiation (stereotactic radiosurgery) in 25 people with melanoma or lung cancer that had spread to the brain. The main goal was to check for serious side effects. Researchers also tracked how long…

This completed study in Japan looked at the safety and effectiveness of the drug VPRIV (velaglucerase alfa) in 63 people with Gaucher disease. Participants were either new to treatment or switching from another Gaucher therapy. The main goal was to track side effects and serious …

This early-stage trial tested a personalized vaccine made from a patient's own immune cells and tumor material for people with metastatic uveal melanoma, a rare eye cancer that has spread. The vaccine was added to standard treatments like immunotherapy or chemotherapy. The main g…

This study tested an experimental drug called ENV-101 (taladegib) in 20 adults with advanced solid tumors that have a specific genetic mutation (PTCH1 loss-of-function). The drug works by blocking a growth pathway in cancer cells. Researchers measured how many patients' tumors sh…

This study looked at how often eye pressure rises after getting an EVO ICL lens implant to correct nearsightedness and astigmatism. Researchers measured pressure in 205 people right after surgery. The goal was to see how many eyes had high pressure, which can be a risk after this…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This phase 3 trial tested a single injection of GS010 gene therapy in 39 people with Leber Hereditary Optic Neuropathy (LHON) who had vision loss for 6 months or less. The treatment aims to improve vision by delivering a working copy of the ND4 gene to the eye. Results measured c…

This study tested a one-time gene therapy injection, GS010, in 37 adults with Leber Hereditary Optic Neuropathy (LHON), a genetic condition that causes rapid vision loss. Participants had vision loss for 6 to 12 months before treatment. The goal was to see if the therapy could im…

This study tested a gene therapy called GS010 in 19 adults with Leber Hereditary Optic Neuropathy (LHON), a rare inherited eye disease that causes rapid vision loss. The main goal was to see if the treatment is safe and tolerable at different doses. The therapy uses a harmless vi…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study tested a modified version of corneal collagen cross-linking, a procedure to strengthen the cornea, in 39 people with keratoconus who had thin corneas. Before the standard treatment, doctors added a small air bubble into the cornea to protect the inner layer. The goal w…

This study tested whether injecting a concentrated form of a patient's own blood, called platelet-rich plasma (PRP), into the eye could slow the progression of advanced dry age-related macular degeneration (AMD). Fourteen people with advanced dry AMD received three PRP injections…

This study tested a modified surgical technique for open-angle glaucoma, adding a tiny mattress stitch to the standard deep sclerectomy procedure. 26 adults with glaucoma that was not controlled by eye drops were randomly assigned to receive either the standard or modified surger…

This study looked at whether early surgery (vitrectomy) or waiting with ultrasound monitoring is better for people with sudden, dense bleeding inside the eye. The goal was to see if early surgery could lower the chance of the retina detaching. Only 8 adults with recent bleeding f…

This study looked at the long-term safety of efgartigimod in 24 adults with primary Sjögren's syndrome who had already completed a prior trial. Efgartigimod works by lowering certain antibodies that may drive the disease. The main goal was to track side effects over 48 weeks, wit…

This study tested an experimental drug called KUS121, given as an eye injection, for people who suddenly lost vision due to a blocked artery in the eye (central retinal artery occlusion). The goal was to see if the injection could improve vision better than a sham procedure. The …

This study tested the drug sorafenib (Nexavar) in 32 adults with uveal melanoma that had spread to other parts of the body. The goal was to see if the drug could stop tumors from growing for at least 24 weeks. Sorafenib is already used for other cancers, and researchers wanted to…

This study tested whether a combination of two drugs, nivolumab and relatlimab, can shrink tumors in people with metastatic uveal melanoma, a rare eye cancer that has spread. Twenty-seven participants received the treatment to see how many responded. The goal was to control the d…

This study looked at 30 people with Vogt-Koyanagi-Harada (VKH) disease, a rare autoimmune condition that causes eye inflammation and can lead to vision loss. Researchers compared two initial treatments: oral prednisolone (steroid pills) and steroid injections near the eye. They c…

This study tested whether combining low-dose atropine eye drops with special soft contact lenses can slow the progression of high myopia (severe nearsightedness) in children aged 6-12. 120 children were split into three groups: one got the combo therapy, one got atropine alone wi…

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study looked at the long-term safety of faricimab, a medicine injected into the eye, for people with diabetic macular edema (DME). About 1,500 patients who had completed earlier studies received faricimab at personalized intervals. The main goal was to track side effects, no…

This study followed 30 uveitis patients who received a fluocinolone acetonide implant to control eye inflammation. Researchers used advanced imaging (OCT, OCTA, fluorescein angiography) to track changes in inflammation over 12 months. The goal was to see if imaging could better m…

This study tested a new medicine called JL14002 against a standard treatment (ranibizumab) for wet age-related macular degeneration, a leading cause of vision loss. 443 adults aged 50-80 with active disease received injections into the eye. The main goal was to see if JL14002 imp…

This study is testing whether a blood test can tell apart the DNA from a vanishing twin and the living twin in pregnancies where one twin stops developing. The goal is to improve non-invasive prenatal screening for chromosome conditions like trisomy 21, 18, and 13 in the survivin…

This study compares two visual field tests used to monitor glaucoma: the current standard Humphrey Visual Field Analyzer and the newer iCare COMPASS. About 28 people with glaucoma or related eye conditions will take both tests in the same visit, with the order alternating between…

This study tests whether a modified action camera can take clear images inside the nose, compared to the standard large camera system. Forty adults with tearing or sinus issues will have both types of images taken during their routine exam. Doctors will rate the image quality to …

This trial tests whether the Icare200, a handheld rebound tonometer, measures eye pressure as accurately as the Goldmann applanation tonometer, the current gold standard. Adults needing eye-pressure checks will have their pressure measured with both devices, plus an air-puff tono…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study tested a new method called metagenomic deep sequencing (MDS) to find the cause of eye infections. 100 adults with suspected infectious uveitis or endophthalmitis were randomly assigned to have their doctors receive MDS results or not, in addition to standard tests. The…

This study tested an AI tool called VeriSee GLC that analyzes color images of the back of the eye to find signs of glaucoma. Researchers looked at 773 adults' existing eye images to see how well the AI could identify people who might have glaucoma, comparing its results to a pane…

This trial compares a telemedical device called Occyo One to the standard slit lamp exam for detecting complications after cataract surgery. About 365 patients scheduled for cataract surgery will have their eyes imaged with Occyo One before and after surgery. A remote ophthalmolo…

This study tested whether a high-resolution eye scan called SD-OCT can diagnose glaucoma more accurately than standard methods. Researchers compared 109 people with and without glaucoma using the scan. The goal was to see if this technology could catch the disease earlier, before…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested two new devices that automatically measure vision in children aged 6 to 16. The devices use special lenses that adjust themselves, avoiding the need for eye drops that dilate the pupils. Researchers compared the results from 43 children to the standard dilation …

This study tested an artificial intelligence (AI) algorithm designed to analyze images of minor salivary gland biopsies to help diagnose Sjogren's syndrome. Researchers used 1,000 biopsy samples from patients with suspected Sjogren's to see if the AI could accurately count immune…

This study compared three different devices that measure side vision in people with glaucoma. Fifty-four adults each took all three tests in one visit. Researchers timed how long each test took and checked how well the results matched. The goal is to find which test is fastest an…

This study tested a new smart contact lens called miLens that records eye pressure patterns over 24 hours in 86 adults with glaucoma and healthy volunteers. Participants wore the lens in one eye and took smartphone readings every 15 minutes while awake. Researchers compared the l…

This study tested an artificial intelligence tool called RetinAIcheck to see if it can accurately detect and grade hypertensive retinopathy—eye damage caused by high blood pressure. Researchers used 729 patients' eye photos and compared the AI's results to assessments by eye doct…

This study tested a software called OPTDR01 that automatically checks retinal images for signs of diabetic retinopathy, a leading cause of vision loss. Researchers enrolled 300 adults with diabetes to see if the tool is easy to use and practical in a clinic setting. The goal is t…

This study tested a new imaging device called the P200TE on 53 people with glaucoma. The goal was simply to see how well it could capture images of the back of the eye. It was not a treatment study, so there were no health benefits or risks for participants.

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This trial tests whether a higher dose of nepafenac eye drops is better than a lower dose at preventing macular edema—a swelling of the central retina—after cataract surgery. Adults aged 18 to 60 scheduled for cataract surgery will receive either a 0.3% solution once daily or a 0…

This study compares four different anti-inflammatory eye drop schedules to prevent cystoid macular edema, a common cause of blurred vision after cataract surgery. About 88 adults having routine cataract surgery receive one of four NSAID regimens for 2 or 4 weeks after the procedu…

This study tests a new type of lens implant (extended depth of focus IOL) for people with age-related cataracts. The lens is designed to provide clear vision at multiple distances, potentially reducing the need for glasses after surgery. About 220 adults will be randomly assigned…

This trial tests whether listening to personalized music during cataract surgery can reduce anxiety and pain. About 100 patients having surgery under local anesthesia will either receive standard care or also listen to their preferred instrumental music (60-100 beats per minute) …

This study is testing a new eye drop that combines trehalose, sodium hyaluronate, and NAAGA without preservatives. It will enroll 30 adults with dry eye disease who are either new to treatment or unhappy with their current drops. Over 6 months, researchers will track changes in s…

This completed Phase 3 trial tested whether phentolamine eye drops (Nyxol) can improve near vision in people with presbyopia, the age-related loss of ability to focus on close objects. 569 adults aged 45 to 64 used the drops or a placebo once daily for 8 days. The main goal was t…

This trial tests whether listening to preferred music or squeezing a stress ball during cataract surgery can reduce patients' pain and anxiety. About 240 adults having their first cataract surgery will be assigned to one of these two simple, drug-free techniques or to standard ca…

This phase 3 trial tests whether CTO0307, a pilocarpine eye drop, can improve near vision in adults aged 40 to 64 with presbyopia — the age-related difficulty seeing up close. Participants receive either the active drop or a placebo for four weeks. The main question is whether mo…

This study is testing two new artificial tear formulas to see if they are safe and well-tolerated in people with moderate dry eye disease. Researchers will monitor for side effects and eye health in 148 participants who already use artificial tears. The goal is to find better opt…

This study compares two eye drops—SYSTANE PRO and MIEBO—to see if SYSTANE PRO works as well as MIEBO for treating dry eye disease. About 260 adults with moderate dry eye will use one of the two drops for one month. The main goal is to measure changes in dry eye symptoms using a s…

This trial tests whether a new daily disposable multifocal contact lens (kalifilcon A) can provide clear vision at both distance and near compared to an existing lens (samfilcon A) in people with presbyopia, the age-related loss of near vision. Adults aged 40 and older who alread…

This study tests whether patching the stronger eye in the morning (8-10 AM) or evening (5-7 PM) works better for improving vision in children with lazy eye (amblyopia). About 100 children aged 4-8 will wear an eye patch for 2-6 hours daily over 6 months. The goal is to see if tim…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the real surgery. About 260 adults scheduled for cataract surgery will either use VR glasses to experience the sights and…

This study tests whether letting cataract surgery patients watch a virtual reality (VR) simulation of the procedure beforehand can reduce their anxiety during the actual surgery. Sixty adults scheduled for cataract surgery will either watch the VR video or receive standard care. …

This trial tests whether adding nepafenac eye drops before and after surgery for epiretinal membrane (a wrinkle on the retina) can help the eye heal faster. Sixty adults with this condition will either receive the drops plus standard care or standard care alone. Researchers will …

This study looks at how satisfied people are with their vision six months after having WaveLight Plus LASIK surgery to correct nearsightedness. It also measures vision sharpness and how the surgery affects daily life. Sixty participants will fill out questionnaires and have their…

This trial investigates whether using Systane Complete eye drops twice a day works as well as using Thealoz Duo eye drops four times a day for adults with mild to moderate dry eye disease. Over 30 days, participants will use one of the two regimens and report symptom changes thro…

This trial tests whether a telemedicine follow-up — a simple online survey with photos and a vision check — can safely replace the first in-person visit after low-risk eyelid procedures like droopy eyelid repair or skin cancer removal. Adults undergoing these surgeries will eithe…

This trial tests whether wavefront-guided LASIK, set to create monovision in one eye for near vision and the other for distance, can improve vision and reduce the need for reading glasses in people with presbyopia. About 219 participants aged 40 and older with mild to moderate ne…

This study tested whether giving mannitol (a sugar solution) through a vein before cataract surgery improves eye pressure and the depth of the front chamber of the eye. Sixty adults aged 30-80 who were having cataract surgery took part. Half received mannitol and half received a …

This study tests whether wearing a compression dressing for 24 hours after upper eyelid blepharoplasty (eyelid lift) reduces swelling, bruising, and pain. Each participant has both eyelids operated on; one eye gets the dressing, the other does not. Masked observers assess recover…

This study compared two ways to control pain during laser treatment for diabetic retinopathy: a numbing injection around the eye versus standard numbing eye drops. Fifty adults with diabetes were split into two groups to receive either the injection or a sham injection with drops…

This pilot study compares two sedation approaches for cataract surgery: one uses oral medication to reduce anxiety, the other uses a placebo. The goal is to see which approach leads to higher patient satisfaction and better recovery. The study involves 23 adults aged 60 and older…

This study compared two types of soft contact lenses to see which one people liked better for vision and comfort. 52 adults who wear contacts took part. They rated the lenses on a scale from 0 to 100. The goal was to find out if one lens performed better in everyday use.

This study tested whether adding dexmedetomidine or dexamethasone to a local anesthetic mixture improves pain control and patient satisfaction during cataract surgery. 75 adults undergoing eye surgery received one of the two additives or a placebo. The main goal was to see how lo…

This Phase 3 trial tested rebamipide eye drops in 762 people with dry eye lasting at least 6 months. Participants received either rebamipide or placebo drops for 26 weeks. The goal was to see if the drops could reduce eye surface damage and discomfort better than placebo.

This early study tested a dexamethasone eye insert placed by a doctor against a standard steroid gel for treating allergy and dry eye symptoms in 36 people with keratoconus who wear gas permeable contact lenses. The goal was to see if the insert improves signs like eyelid bumps a…

This completed study tested whether taking anti-aging compound capsules twice daily for four weeks could reduce eye fatigue and discomfort in 25 healthy adults aged 20 to 60. The capsules contained a mix of botanical extracts, omega-3s, vitamins, and minerals. Researchers measure…

This study tested a cream made from green tea extract (Veregen) on 6 people with lamellar ichthyosis, a rare genetic condition that causes severe dry, scaly skin. Participants applied the cream to one side of their body and a standard moisturizer to the other for 4 weeks. The goa…

This study tested whether using Systane PRO eye drops consistently for 30 days can relieve symptoms of dry eye disease and improve daily functioning. Thirty-three adults with mild to moderate dry eye took part. The main goal was to see if their eye comfort scores improved from th…

This completed early-phase study tested a daily drink called Baby Drink, which contains lutein, blueberry extract, vitamins, and minerals, in 20 adults with mild myopia (nearsightedness less than 700 degrees). Participants took one 20 ml pack per day for one month. Researchers tr…

This study looked at 43 cataract surgery patients to see if a special lens (low cylinder toric IOL) improves vision more than a standard lens. The goal was to find out if the toric lens leads to better eyesight without glasses. Results focus on distance vision and how much astigm…

This Phase 3 trial tested rebamipide eye drops in 755 people with dry eye for at least 6 months. Participants received either rebamipide or placebo drops for up to 52 weeks. The goal was to see if the drops could reduce eye surface damage and ease discomfort.

This pilot study tested whether a TENS device, placed on the forehead, is safe and practical for treating chronic eye pain in 39 veterans. Participants used the device at home for 6 months. The goal was to see if it reduces pain and to prepare for a larger trial.

This early study tests whether RCI001 eye drops are safe and tolerable in 40 healthy adult men. Participants receive either the active eye drops or a placebo, and researchers monitor for side effects and how the drug behaves in the body. This is a first step toward possibly devel…

This study tested whether CAM-101 eye drops are safe and can help relieve dry eye in people who developed the condition after a bone marrow transplant (graft-versus-host disease). 64 adults received either a low or high dose of CAM-101 or a placebo drop four times a day for six w…

This study tested whether a dietary supplement called Nutritears, containing lutein, zeaxanthin, curcuminoids, and vitamin D3, can improve dry eye symptoms. 131 adults with dry eye syndrome took either the supplement or a placebo daily for 8 weeks. Researchers measured tear produ…

This study tested two ways to warm the eyelids for people with dry eyes caused by meibomian gland dysfunction. Fifteen adults used a USB-powered warm compress and a self-heating eye mask for two weeks each. Both devices improved tear stability and comfort, but the USB-powered ver…

This study checked the safety and effectiveness of the CorVision microlens, a tiny implant placed in the cornea to help with presbyopia (age-related difficulty seeing up close). About 95 people who had the implant in an earlier study came back for a single 4-year follow-up visit.…

This completed Phase 3 trial tested a new eye drop containing brimonidine and sodium hyaluronate against Lumify for reducing eye redness in 578 adults. Participants used the drops four times daily, and redness was measured over several hours. The goal was to see if the new drop w…

This study tested whether a stronger (5%) or weaker (3%) saltwater eye drop works better to reduce corneal swelling after cataract surgery. 70 adults who developed swelling after surgery received one of the two treatments. The main goal was to see which drop thinned the cornea mo…

This study tested two strengths of a topical isotretinoin ointment (TMB-001) in 34 people aged 9 and older with congenital ichthyosis, a rare genetic skin condition causing severe scaling. The main goal was to see if the ointment could reduce scaling by at least 50% compared to a…

This study tested how comfortable two prescription steroid eye drops feel right after use. Forty adults with eye inflammation or dry eye received one drop of Flarex in one eye and one drop of Lotemax SM in the other. They rated comfort and vision impact at 30 seconds, 5 minutes, …

This study tested an eye drop called LNZ101 to help people with presbyopia (age-related trouble seeing up close) read without glasses. 469 adults aged 45-75 received the drops, and researchers measured how many gained clear near vision without losing distance vision on the first …

This study tested an eye drop called reproxalap in 131 adults with moderate-to-severe seasonal eye allergies. Participants were exposed to ragweed pollen in a special chamber to trigger symptoms. The eye drop was compared to a placebo (no active ingredient) to see if it reduced i…

This study looked at whether a supplement called citicoline can improve vision in people with glaucoma after they have eye surgery. Six adults took either citicoline or a placebo for a short time. The goal was to see if citicoline could help protect the optic nerve and improve vi…

This pilot study tested whether a wheat-free and milk-free diet could reduce symptoms in people with Sjogren's syndrome, an autoimmune disease. Thirty participants were randomly assigned to either the special diet or a control diet. After two months, those on the wheat-free diet …

This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after …

This study tested whether electroacupuncture (a type of acupuncture with mild electric pulses) can improve symptoms of mild-to-moderate dry eye. 168 adults received either real or sham electroacupuncture. Researchers measured tear film stability and other eye health markers to se…

This study looked at whether a melt tablet containing midazolam and ketamine works as well as IV sedation for keeping people calm and pain-free during cataract surgery. Over 1,100 adults aged 55-80 took part. Researchers measured sedation levels, pain scores, and whether extra pa…

This study tested whether a single steroid injection given during cataract surgery works as well as standard steroid eye drops to control inflammation afterward. 72 adults aged 50 and older having routine cataract surgery took part. The goal was to see if the injection could simp…

This study tested whether BRM421 eye drops can safely reduce the signs and symptoms of dry eye compared to a placebo. 220 adults with dry eye for at least 6 months received either the active drops or a placebo. The main outcomes were changes in corneal staining (eye surface damag…

This study tested whether BRM421 eye drops can safely ease the signs and symptoms of dry eye. 157 adults with dry eye for at least 6 months received either the active drops or a placebo. The trial measured changes in corneal staining and discomfort scores. Results suggest the dro…

This study tested whether far infrared eye masks placed on acupoints around the eyes could improve dry eye symptoms. Thirty-one adults with dry eye disease used the masks, and researchers measured tear film stability, gland health, and symptom scores before and after one month of…

This study tested an eye drop called HBM9036 in 577 Chinese adults with moderate to severe dry eye. The goal was to see if it reduces eye surface damage and improves symptoms better than a placebo. Participants used the drops for about two months, and doctors measured changes in …

This early-stage trial tested an experimental eyedrop called INV-102 in 84 adults with moderate dry eye disease. The study had two parts: first, checking safety at different doses, and second, seeing if the drops improve eye dryness symptoms after two weeks. Participants used the…

This study compared two types of lasers used to create the flap in LASIK eye surgery for nearsightedness. 120 adults each had one eye treated with the Intralase laser and the other with the Visumax laser. The goal was to see which laser caused less discomfort during surgery and l…

This study tested a numbing injection given around both eyes to see if it safely controls pain during cataract surgery. Fifty adults received the injection, and researchers measured their pain and satisfaction. The goal was to find a better way to keep patients comfortable during…

This study tested a nursing intervention designed to help patients relax and feel more comfortable during diabetic retinal laser surgery. 136 adults received either standard care or extra support including guided breathing, clear communication, and reassurance. The goal was to se…

This study tested three types of artificial lenses implanted during cataract surgery to see which gives the best vision at far, middle, and near distances. 197 people with cataracts in both eyes received one of the three lens types. The goal was to improve vision and reduce the n…

This early study tested a tiny dexamethasone insert placed in the tear duct of 15 children after retinal surgery or laser treatment. The goal was to see if it could safely reduce pain and eye inflammation. Researchers measured pain using a standard scale and tracked any side effe…

This study tested whether giving EXACYL before surgery can reduce bleeding during and after jaw realignment surgery. 157 adults took part in a double-blind, placebo-controlled Phase 3 trial. The goal was to see if the drug makes surgery safer and more comfortable.

This study looked at the safety and effectiveness of a special lens (aspicio™) implanted during cataract surgery. Thirty adults who already had the lens were checked at least 3 months after surgery. The goal was to see how well they could see at different distances and if there w…

This study tested whether scleral lenses treated with a special coating called Hydra-PEG can improve comfort and reduce dryness in people with dry eye. 46 participants wore two types of lenses over several weeks and rated their comfort on a scale. The goal was to see if the coate…

This study compared two types of soft multifocal contact lenses (Proclear 1 Day and Clariti 1 Day) to see which one people liked better. 67 adults who already wore contact lenses and needed reading glasses tried both lenses and rated their overall satisfaction. The goal was to he…

This study tested how comfortable two different daily soft contact lenses feel right after putting them in. 45 adults who already wear contacts and have mild to moderate nearsightedness rated each lens on a 0-100 comfort scale. The goal was to see if one lens feels better than th…

This study tested two types of soft contact lenses—Proclear 1 Day and MyDay sphere—to see which one feels more comfortable. 44 adults who already wear contact lenses rated comfort on a scale from 0 to 100. The goal was simply to compare the lenses, not to treat or cure any eye di…

This study tested two types of soft contact lenses—Myday Sphere and Myday Toric—in 32 people who already wear spherical lenses but have low astigmatism. Participants wore each lens type for one week and rated comfort on a 0-100 scale. The goal was to see if the toric lens offers …

This study tested whether a low-immunogenic oat variety called Saul is well-tolerated by adults with celiac disease who are in remission. Forty participants ate 50 grams of gluten-free Saul oat flakes daily for 14 days. Researchers tracked symptoms and blood markers to see if the…

This study tested a new antiseptic called IRX-101 against the standard povidone-iodine in 155 people receiving eye injections for retinal disease. The goal was to see if IRX-101 reduces pain and corneal damage after the injection. Researchers measured safety and corneal staining …

This study tested whether a smartphone meditation app (Calm Health) could help reduce anxiety and depression in 100 adults with non-infectious uveitis, an inflammatory eye disease. Participants used the app and reported their symptoms. The goal was to see if digital mindfulness c…

This Phase 2 trial tested three different eye drop formulas—BRIMOCHOL, BRIMOCHOL F, and carbachol alone—to see if they could improve near vision in people with presbyopia (age-related difficulty seeing up close). The study enrolled 18 adults who received a single drop in each eye…

This study tested four different ways of giving dilating eye drops to 84 diabetic patients who needed eye exams for diabetic retinopathy. The goal was to find which method works best to get the pupil large enough for a good exam. Researchers measured pupil size and watched for si…

This pilot study tested whether Tixel, a device used to treat wrinkles around the eyes, could also improve dry eye symptoms. 75 adults with mild to moderate wrinkles and dry eye received the standard Tixel treatment. Researchers measured tear film stability and dry eye questionna…

This study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The g…

This study tested two types of stenfilcon A contact lenses to see if one reduces eye strain from digital screens better than the other. Thirty adults who already wear contacts and have computer vision syndrome wore each lens design for five days. The lenses were compared using qu…

This study looked at whether regular aerobic exercise, like walking, can reduce fatigue in women with primary Sjögren's syndrome. Forty-five women participated in a 16-week program. Researchers measured changes in fatigue, mood, and physical fitness.

This study tested three treatments for meibomian gland dysfunction, a common cause of dry eye. 374 adults with mild-to-moderate dry eye were randomly assigned to receive either vectored thermal pulsation (a device that heats and massages the eyelids), intense pulsed light therapy…

This study compared two types of laser eye surgery—FS-LASIK and single-step TransPRK—for correcting mixed astigmatism, a condition where the eye's shape causes blurry vision at all distances. Thirty-nine people received one of the two procedures, and researchers measured their vi…

This study tested the safety of AR-15512 eye drops in 55 people with dry eye disease. Participants received the drops at different temperatures and with eyes open or closed to see if these factors affect side effects. The goal was to measure how many people had eye-related side e…

This study tested a new contact lens designed to help people with presbyopia (age-related blurry near vision) see clearly at both far and close distances, potentially reducing the need for bifocals or reading glasses. 78 adults aged 45 to 70 who already wear soft contact lenses t…

This study tested whether a fine mist made from traditional Chinese herbs can help people with dry eye disease. 200 adults received either the herbal mist, a placebo mist, or standard eye drops for 4 months. Researchers measured symptom scores and tear film stability to see if th…

This study tested a mobile app that teaches Acceptance and Commitment Therapy (ACT) to help people with glaucoma cope with anxiety, depression, and emotional distress. Researchers worked with 28 patients to see if the app was acceptable and easy to use. The goal was to lay the gr…

This study tested a special lens implant (EVO+ Visian ICL) to improve near vision in 41 adults with presbyopia, an age-related condition that makes it hard to see up close. The lens is placed behind the iris and in front of the eye's natural lens. Six months after surgery, most e…

This early-phase trial tested YM-101 eye drops in 30 adults with dry eye syndrome. Participants received either high or low dose YM-101 plus artificial tears, then switched to placebo after a washout period. The study measured changes in corneal staining, tear break-up time, and …

This study tested whether eye drops made from a patient's own blood (autologous serum) can relieve severe dry eye better than standard artificial tears. 46 adults with severe dry eye tried both diluted (20%) and full-strength (100%) serum drops, as well as artificial tears. The m…

This study tested a special lens implanted during cataract surgery to see if it improves vision at far, middle, and close distances. Thirty adults with cataracts received the lens in both eyes. Researchers measured their vision and satisfaction 1 and 3 months after surgery.

This study tested if insulin eye drops can safely and effectively treat moderate to severe dry eye disease. 116 adults received either insulin drops, standard cyclosporin drops, or artificial tears (placebo) for 6 months. The main goal was to see if insulin drops improved corneal…

This Phase 2 study tested three different dosing schedules of Lagricel Ofteno eye drops (sodium hyaluronate 0.4%) in 141 people with mild to moderate dry eye. Participants used the drops either twice, four times, or six times a day. The main goal was to see which schedule best im…

This study tested whether giving older adults structured education on eye drop use and self-care after cataract surgery improves recovery. Eighty participants aged 65 to 85 were split into two groups: one received routine care, the other added periodic education sessions. Researc…

This study tested a special type of artificial lens (TECNIS Eyhance IOL) in 62 adults aged 45-75 who had cataract surgery. The goal was to see how well the lens helps people see clearly at different distances, from close up to far away. Researchers measured vision at nine distanc…

This study looked at 40 people over 45 who had cataract surgery with a special lens that helps with both near and far vision. Half of them had the surgery with digital assistance, and half without. The goal was to see if the digital help led to better vision or more satisfaction …

This Phase 3 trial tested LNZ101 eye drops in 229 people aged 45-75 with presbyopia, a condition that makes it hard to see up close. The drops combine aceclidine and brimonidine to temporarily improve near vision. The main goal was to see if participants could read three lines be…

This study tested two types of soft contact lenses in 73 children and teenagers (ages 8 to 18) with nearsightedness. Researchers checked how well the lenses stayed centered on the eye and moved with each blink after at least three hours of wear. The goal was to see which lens per…

This study tested whether a numbing gel (lidocaine) works as well as a needle injection for pain relief during pterygium surgery. 41 adults having pterygium removal took part. The goal was to see if the gel causes less pain and eye dryness after surgery.

This completed study compared two types of soft toric contact lenses for people with astigmatism. Forty-two participants wore each lens briefly and rated them on comfort, vision, and overall satisfaction. The goal was to see which lens performed better in the short term.

This completed study tested whether Reinnerva/Lubristil+G eye drops work better than Vismed for people with dry eyes. Forty adults with dry eye symptoms used one drop in each eye twice daily (Reinnerva/Lubristil+G) or four times daily (Vismed) for 60 days. Researchers measured te…

This study looked at whether a treatment called transscleral lutein iontophoresis (TSLI) is safe and helpful for people with a specific type of age-related macular degeneration (AMD) that includes reticular pseudodrusen. Thirty participants received the treatment, and their visio…

This study tested a new eye drop formula in 188 adults with mild to moderate dry eye disease. Participants used the drops for 30 days and reported how much their symptoms bothered them. The goal was to see if the drops safely improve comfort.

This study tested whether silicone gel helps reduce scarring after eyelid surgery. 132 patients applied silicone gel to one eye and a placebo (Aquaphor) to the other, without knowing which was which. Doctors and patients rated scar redness, elevation, and pigmentation over 6 mont…

This study looked at whether a structured counseling session over the phone before cataract surgery could lower patients' anxiety and improve their recovery. 128 adults scheduled for cataract surgery took part. Half received the extra phone counseling, while the other half got st…

This study tested a new medicated eyelid wipe called IVW-1001 in 150 adults with dry eye disease. Participants used either a low dose, a higher dose, or a placebo wipe. The goal was to see if the wipe is safe and can improve tear production and eye comfort.

This study tested two different eye drop treatments for people with dry eye disease who were having cataract surgery. One group used a single medication (rebamipide), while the other used a combination of two medications (diquafosol and cyclosporine). The goal was to see which ap…

This completed Phase 3b trial tested AR-15512 eye drops in 81 adults with dry eye disease. The goal was to see if a single dose could quickly increase tear production, measured by tear meniscus height. The study was open-label, meaning everyone knew they were getting the active d…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at the natural bacteria in the gut of 131 adults with and without uveitis, an inflammatory eye disease. Researchers collected stool and blood samples and performed eye exams to see if differences in gut bacteria are linked to eye inflammation. No treatment was g…

This completed study used PET and MRI scans to compare brain dopamine function in people with Gaucher disease or Parkinson disease, their family members, and healthy volunteers. Researchers aimed to see if certain genetic mutations cause early changes in dopamine storage. The stu…

This study looks at X-linked juvenile retinoschisis (XLRS), a rare inherited eye disease that causes vision loss in young males. Researchers will examine 351 participants, including affected males and female carriers, using eye exams, retinal photos, and genetic tests. The goal i…

This study followed 57 people with age-related macular degeneration (AMD) for up to 5 years to see how their eyes adjust to darkness. Participants had yearly eye exams and dark adaptation tests, where they sat in a dark room and pressed a button when they saw a light. The goal wa…

This completed study followed 26 adults aged 55 and older with early age-related macular degeneration (AMD) or healthy eyes for up to 5 years. Researchers used eye exams, imaging, and vision tests to track changes in the retina and visual function. The goal was to better understa…

This study investigates whether using a lower, more natural eye pressure during cataract surgery reduces trauma to the cornea compared to traditional high-pressure methods. The Active Sentry device helps maintain stable pressure by sensing changes in the eye. Researchers will mea…

This study followed 20 adults aged 55 and older with geographic atrophy, an advanced form of age-related macular degeneration that causes central vision loss. Researchers measured how the damaged area in the eye changed over nearly 4 years using eye exams and photos. The goal was…

This study follows nearly 90,000 farmers and their spouses to track long-term health effects of pesticides, crops, and animals. Participants report new medical conditions, which researchers then confirm through medical records and genetic samples. The goal is to better understand…

This study aims to measure how common glaucoma is among people aged 50 and older in the Bangkoknoi district of Bangkok, Thailand. Researchers will examine about 1,470 volunteers using standard eye tests and advanced imaging to detect signs of glaucoma and gather normal eye measur…

This study collects information from about 889 people with inherited retinal diseases (IRDs) to understand how vision changes over time. Participants have their eyesight and visual field tested regularly. The goal is to learn more about the natural course of these rare eye condit…

This study looks at how oral isotretinoin, a common acne treatment, affects the surface of the eye and the meibomian glands, which produce the oily layer of tears. Researchers will measure tear film stability, gland structure, and dry eye symptoms in 60 acne patients before and a…

This study compares three different methods for prescribing eyeglasses in people with keratoconus, a condition that thins and bulges the cornea, causing blurry vision. The goal is to see if the best method depends on the shape of the cornea, as measured by corneal topography. Res…

This study investigates whether measurements from eye imaging devices can predict the tilt (misalignment) of an artificial lens implanted during cataract surgery. Researchers will use OCT and Scheimpflug cameras to measure the eye before and after surgery in about 110 adults. The…

This study follows 103 adults with a genetic eye condition called retinitis pigmentosa caused by EYS mutations. Researchers will track changes in vision and eye structure over 4 years. The goal is to better understand how the disease progresses so that future clinical trials can …

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

This study looked at whether a simple test measuring how fast eyes recover in the dark can help track early to middle dry age-related macular degeneration (AMD). Researchers followed 217 adults aged 50 and older, with or without AMD, for up to 5 years. The goal was to see if chan…

This study tests a microscope that has an OCT scanner built directly into it, allowing surgeons to take detailed cross-sectional images of the eye during surgery. The goal is to see if this setup is practical and whether the extra visual information helps guide surgical decisions…

This study is looking at thousands of premature and low-birth-weight babies in China to understand how common retinopathy of prematurity (ROP) is today. ROP is an eye condition that can lead to blindness if not caught early. The researchers want to find out the best time and crit…

This trial tests whether trypan blue, a dye sometimes used to stain the lens capsule during cataract surgery, affects the number of corneal endothelial cells — the inner layer of the cornea that keeps it clear. Sixty adults aged 45 to 75 with age-related cataracts will be randoml…

This study tests whether a special camera called the OcuMet Beacon can detect stressed cells in the retina of people with geographic atrophy, an advanced form of age-related macular degeneration. Researchers want to see if the patterns of stress match areas of damage seen on stan…

This study reviews published research on artificial intelligence models that analyze retinal images to predict how well patients with diabetic macular edema will respond to treatments like anti-VEGF injections or laser therapy. By evaluating the accuracy of these AI tools, the re…

This study is a systematic review that gathers and analyzes existing research on digital eye strain among people who learn or work online. It aims to find out how common the condition is, what factors increase the risk, and what strategies can help prevent or manage it. The revie…

This study looks at immune cell patterns in people with three types of nephrotic syndrome—membranous nephropathy, minimal change disease, and focal segmental glomerulosclerosis. Researchers aim to see if certain immune cells can serve as biomarkers to track how well a patient res…

This study looks at how residual astigmatism affects vision in people who have already received the Clareon Vivity extended vision intraocular lens (IOL) during cataract surgery. Researchers will temporarily induce astigmatism using trial lenses and measure changes in distance, i…

This study compared two different eye imaging machines (Clarus and Optos) to see how well they measure geographic atrophy, a form of vision loss from age-related macular degeneration. Researchers enrolled 62 patients and took images with each device, then compared the measurement…

This observational study looks at people who have already had cataract surgery with a Clareon Vivity lens implant. Researchers want to see if the lens's position—how centered and tilted it is—affects how well patients see. Participants will have their eyes examined and their medi…

This study looks at whether taking combined oral contraceptive pills changes the shape and optical quality of the cornea — the clear front part of the eye. Researchers will measure corneal curvature and irregularities in women aged 18-40 before they start the pill and again after…

This study looks at why some women develop a condition called Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery. IFIS makes the iris unstable, complicating surgery and raising risks. Researchers are examining factors beyond medication—such as medical history and …

This study follows people with Sturge-Weber syndrome, a rare condition that can cause seizures, strokes, and brain damage. Researchers collect medical records, brain scans, and blood samples over time to spot patterns linked to worsening symptoms. The goal is to find biological m…

This study looks at how isotretinoin, a vitamin A-based acne medication, affects eye structures and tear production in people with severe cystic acne. Participants receive standard treatment and undergo eye exams, including dry eye tests and advanced imaging, before and during th…

This study looks at whether being more fit is linked to lower eye pressure in healthy adults. Researchers measured eye pressure and fitness in nearly 3,000 people aged 18 to 70. The goal is to see if better cardiorespiratory fitness might help protect eye health.

This study investigates how low doses of atropine eye drops (0.01%, 0.02%, and 0.05%) affect pupil size and the eye's ability to focus in healthy adults aged 18 to 40. Researchers aim to compare different dosing methods and recovery times, and to see if iris color influences the …

This study looked at 54 people with primary Sjögren's syndrome who also had muscle inflammation. Researchers wanted to see how many met the official criteria for inflammatory myopathies. The goal was to better understand and classify muscle disease in Sjögren's patients.

This trial tests a new device called P200TxE that takes detailed images of the back of the eye. Researchers want to see how well it captures images in people with retinal diseases like glaucoma or macular degeneration. The study involves adults aged 22 and older who have been dia…

This study looks at what people with age-related macular degeneration (AMD) know about their disease and what they need to manage it better. Researchers will survey and interview 118 patients to understand their knowledge, daily challenges, and support needs. The goal is to use t…

Cataracts cloud the eye's lens and can lead to blindness if untreated. This study compared two common surgical techniques—Divide-and-Conquer and Subluxation—to see which causes less damage to the cornea's inner cell layer. 294 adults having cataract surgery took part, and researc…

This study watched 50 doctors from different specialties as they treated a mannequin pretending to be in a coma. The goal was to see how well their actions matched current medical guidelines. The results could help improve training and recommendations for real-life coma care.

This study tested whether artificial intelligence (AI) can help doctors detect retinal diseases from ultra-widefield eye images. 462 images were read by four eye doctors with different experience levels, both with and without AI assistance. The goal was to see if AI improves accu…

This study examined 39 people with severe nearsightedness to see if lower levels of a natural eye pigment (macular pigment) are linked to tiny cracks in the back of the eye called lacquer cracks. These cracks can lead to vision loss. The researchers measured the pigment's optical…

This study checked if a smartphone app called VisionApp can accurately measure vision problems like nearsightedness and presbyopia (age-related reading difficulty). Sixteen adults aged 40 and older used the app at home, and their results were compared to standard eye exams. The g…

This study looks back at 20 years of medical records from 25 people who had a freezing treatment (cryotherapy) for retinal hemangioblastoma, a rare eye tumor often linked to von Hippel-Lindau disease. Researchers want to see how well the treatment controlled the tumors and affect…

This study used MRI to measure blood flow in the eye's main artery in 20 adults with untreated glaucoma and compared it to healthy people. The goal was to understand how blood flow problems might contribute to glaucoma damage. Participants had one MRI scan, and no treatment was g…

This study used high-powered 3-Tesla MRI to compare the visual pathways in the brains of 114 people with glaucoma and healthy volunteers. Researchers looked at the structure and volume of brain areas involved in vision to see if glaucoma causes damage beyond the eye. The goal was…

This study looked at 100 people with primary Sjögren's syndrome to understand how the disease affects their physical, emotional, and social well-being. Researchers used questionnaires and simple tests to measure symptoms like fatigue, pain, swallowing problems, and mood. A health…

This study tested whether doctors could safely and correctly use a new prefilled syringe (SCD411) for eye injections. It included 33 adults with wet age-related macular degeneration, retinal vein occlusion, diabetic macular edema, or diabetic retinopathy. The main goal was to see…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study followed 248 children with nearsightedness who wore soft bifocal contact lenses for two years and then switched to regular lenses for a third year. Researchers measured eye growth, light exposure, and pupil responses to understand why some children's nearsightedness ge…

This study looked at 20 adults who wear an artificial eye to see if it causes more dry eye symptoms and damage to the tiny oil glands in the eyelids. Researchers compared the artificial eye side with the healthy eye side using special imaging and questionnaires. The goal was to u…

This study involved 10 adults with severe dry eye disease who did not respond to standard treatments. Researchers measured levels of growth factors and vitamins in autologous serum eye drops before and after filtration, to see if filtering reduces their concentration. The goal is…

This study tested a new questionnaire to better understand eye rubbing habits in people with or suspected keratoconus, a condition where the cornea thins and bulges. Researchers enrolled 292 participants to see if the questionnaire is reliable and useful. The goal is to improve h…

This study looked at how people with autoimmune diseases like multiple sclerosis or blistering skin conditions respond to COVID-19 vaccines while on B-cell depleting therapies. Researchers measured antibody levels and T-cell activity over time to understand vaccine effectiveness …

This study checked how accurate a new formula (Barrett TAL) is at picking the right lens power for cataract surgery. Over 500 people had their vision measured before and after surgery. The goal was to see if the formula helps more people get near-perfect vision without glasses af…

This study looked at how nearsightedness (myopia) affects the quality of life of children and adults. Researchers surveyed parents of nearsighted children and adults with long-term complications from myopia. The goal was to understand the real-world impact of the condition, not t…

This study looked at how eye pressure changes when breath-hold divers hold their breath. Forty divers had their eye pressure, oxygen levels, heart rate, and blood pressure measured before, during, and after holding their breath. The goal was to understand these changes and how th…

This completed study looked at how 26 premature infants and babies with Pierre Robin sequence suck. The goal was to better understand their feeding challenges so doctors and families can offer better support. Researchers used a special device to measure sucking patterns, aiming t…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at whether monitoring moderate diabetic retinopathy (an eye condition caused by diabetes) through tele-expertise (remote specialist review) works as well as the usual in-person eye doctor visits. Researchers followed 97 patients with diabetes and moderate retino…

This study looked at whether immune cells from the intestine play a role in Sjogren's syndrome, an autoimmune disease that causes dry eyes and mouth. Researchers examined saliva gland samples from 57 adults suspected of having Sjogren's. The goal was to better understand the dise…

This pilot study looked at how weight loss affects bone density in overweight or obese men. 44 men either followed a reduced-calorie diet to lose weight or maintained their weight for 6 months. Researchers measured changes in bone density and quality to see if weight loss has any…

This study followed 326 people newly diagnosed with glaucoma or high eye pressure to see how many got worse over 2 to 4 years of standard monitoring in hospital eye clinics. Researchers measured the rate of disease progression and looked for factors that might predict worsening. …

This study followed 516 older adults in France for 8 years to see how many develop age-related macular degeneration (AMD), a leading cause of blindness. Researchers used eye exams and imaging to track the disease and look for risk factors like genetics and lifestyle. The goal is …

This study looked at how the position of a patient's arms during spinal anesthesia affects pressure inside the eye. Sixty adults having hernia repair were randomly placed with arms at their sides or hands on their chest. Eye pressure was measured before and after anesthesia to se…

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

This study compared two devices that measure the eye before cataract surgery to help pick the right lens implant. 144 Thai adults had both measurements taken on the same day. The goal was to see which device more accurately predicted the patient's vision one month after surgery.

This study examined how vision loss progresses in people with geographic atrophy, an advanced form of dry age-related macular degeneration. Researchers analyzed past medical records and eye images from 60 patients to see which retinal changes are linked to faster vision decline. …

This study looked at whether using eye drops to dilate (widen) the pupils before measuring vision leads to better eyeglass prescriptions for people with Down syndrome. 42 participants had their vision tested with and without dilation. The goal was to see which method gives sharpe…

This study looked at a rare disease called IgG4-related disease, which causes swelling and scarring in organs. Researchers compared immune cells in the blood of 75 people: those with the disease, those with Sjogren syndrome, and healthy volunteers. The goal was to better understa…

This study looked at whether a food safety training program helps food service employees improve their knowledge, attitudes, and practices around safe food handling. About 200 adult workers took part, and the training covered personal hygiene and safe food preparation. The goal w…

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study tested four different approaches to find and treat eye diseases like cataracts, glaucoma, and diabetic retinopathy in communities in Nepal. Over 87,000 people aged 50 and older took part. The goal was to see which method—comprehensive screening, cataract camps, communi…

This study looked at 100 adults with atopic dermatitis (eczema) who were prescribed tralokinumab. Researchers tracked how many developed eye problems like conjunctivitis within 4 months of starting the drug. The goal was to better understand these side effects in real-world use, …

This study tested dexamethasone eye drops in 11 premature infants at risk of blindness from retinopathy of prematurity. Researchers measured how the drug enters the blood and saliva, and monitored for side effects. The goal was to gather safety and dosing information, not to prov…

This study compared two types of cornea transplant surgery (DSAEK and DMEK) for people with Fuchs' endothelial dystrophy, a condition that clouds the cornea. Researchers measured vision and tracked side effects like swelling and eye pressure in 112 participants. The goal was to f…

This study used a special eye camera (adaptive optics) to look at blood vessel inflammation in the retina of 50 people with multiple sclerosis (MS) and healthy volunteers. The goal was to see if this inflammation differs between MS types and could serve as an early marker of dise…

This study looked at the costs of cataract surgery done in a doctor's office versus an ambulatory surgery center. Researchers analyzed data from 76 patients who had routine cataract surgery. The goal was to see which setting is more cost-effective.

This study looked back at 170 adults with a serious eye infection called endophthalmitis to see if early surgery (within 48 hours) helps vision more than starting with medicine alone. Researchers compared how well people could see one month after treatment. The goal is to find ou…

This study looked at 30 men taking alpha-blocker drugs for urinary symptoms who were scheduled for cataract surgery. Researchers used a special eye scan to measure the thickness of iris muscles and pupil size. The goal was to see if these measurements could predict intraoperative…

This completed study looked at how well people see and how satisfied they are after getting the TECNIS Odyssey lens in both eyes during cataract surgery. Forty patients aged 50 and older were checked at least three months after surgery. Researchers measured vision at different di…

This study looked at how much of a burden patients feel from repeated anti-VEGF eye injections for three different eye diseases: wet age-related macular degeneration, retinal vein occlusion, and diabetic macular edema. Researchers surveyed 393 patients about their treatment burde…

This study looked at how often people with primary Sjögren's syndrome have digestive issues. Researchers asked 151 patients about 10 different digestive symptoms using a simple questionnaire. The goal was to understand which symptoms are most common and how they relate to how lon…

This study checked how well two different devices (OA-2000 and Pentacam AXL) agree when measuring the eye before cataract surgery. 94 cataract patients had their eyes measured once with each device. The goal was to see if the devices give the same numbers for lens power and eye s…

This study looked at 78 people in Pakistan who had surgery for a detached retina. Doctors compared two types of fillers used inside the eye after surgery—gas or silicone oil—to see if one caused more shifting of the retina afterward. The goal was to learn how the choice of filler…

This study looked at the DNA changes (mutations) in eye cancers called ocular melanoma. Researchers analyzed tumor samples from 58 patients to understand how these cancers develop and spread. The goal was to identify key mutations that could lead to better treatments in the futur…

This completed study looked at 80 people having routine cataract surgery in both eyes. Researchers compared two different phacoemulsification devices (Quatera 700 and Centurion) to see how they affected corneal thickness and how long it took to remove the lens. The goal was to ga…

This study tested a new device called the EYESTAR 900, which uses light to take detailed measurements of the eye's shape. 29 people with healthy eyes, corneal scarring, or irregular astigmatism took part. The goal was to see how well the new scanner measures eye geometry compared…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study looked at 31 people with dry eye to see if measuring corneal sensitivity (how well the eye feels touch) can detect early-stage neurotrophic keratopathy, a condition where the cornea loses sensation. Researchers aimed to find out which dry eye patients might l…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study looked at proteins in the eye fluid of 100 people with wet age-related macular degeneration (AMD). The goal was to measure certain growth factors that might explain why about 37% of patients do not respond well to standard anti-VEGF injections. Researchers collected a …

This completed study looked at how satisfied 300 people were with their vision at least one year after having Wavelight LASIK surgery for nearsightedness (myopia). Researchers also checked for dry eye symptoms using standard questionnaires. The goal was to understand real-world p…

This study looked at data from 1100 people who had SMILE laser eye surgery to fix nearsightedness. Researchers used a computer model to predict how well patients would see one year after surgery. The goal was to see if the model could give more accurate results than the usual pla…

This study looked at two different eye scanners (ARGOS and IOLMaster 700) used to measure the length of the eye in people with dense cataracts. Researchers wanted to see if the newer scanner could get accurate measurements more often, potentially reducing the need for a more invo…

This study compared gum health and levels of inflammatory substances in the mouth and blood of 25 people with non-infectious uveitis (an eye inflammation) and 27 healthy individuals. Researchers measured gum pocket depth, bleeding, and cytokines like TNF-α and IL-10. The goal was…

This study tested whether using an indoor air purifier changes health measures like heart rate, sleep, and oxygen levels. 42 healthy adults wore Apple Watches while using a real or fake (sham) air purifier at home. The goal was to see if cleaner air makes a short-term difference …

This study followed 609 nearsighted adults who had lens surgery to see if a natural eye change called posterior vitreous detachment (PVD) affects their risk of retinal detachment. Participants were grouped by whether they had PVD before surgery or not, and were monitored for up t…

This study looked at 154 people with keratoconus, a condition that thins and bulges the cornea, to understand why it is often worse in one eye than the other. Researchers compared those with uneven severity to those with similar severity in both eyes, focusing on eye rubbing habi…

This pilot study tested whether a patient navigator—a person who helps coordinate medical care—could increase eye exam rates in 35 adults with diabetes who were at high risk for blindness. Participants met with a navigator quarterly to overcome barriers to care. The study measure…

This study tested a new type of camera that can see individual cells in the retina, which standard clinical cameras cannot do. Five people with retinal disease (inherited degeneration or toxicity) had their eyes scanned with the device. The goal was to compare image quality and o…

This study tested a digital color scale to objectively measure scarring of the eye's surface in people with recurrent pterygium, a growth that can come back after surgery. Researchers took photos of 25 patients' eyes and used software to analyze the scar tissue. The goal was to s…

This study looked at whether the amount of propofol (anesthesia medicine) in a child's breath matches the amount in their blood during eye surgery. 32 children took part, and the researchers compared breath measurements with blood samples and brain activity. The goal was to see i…

This study looked at 14 adults with melanoma who were taking a combination of BRAF and MEK inhibitor drugs. The goal was to understand how these drugs can affect the retina, the light-sensitive part of the eye. Researchers used eye exams and special imaging to track changes over …

This study looked at how the eye produces and drains fluid to understand why glaucoma medications lower eye pressure more in some people than others. Researchers measured eye fluid production, drainage, and pressure in 59 adults with glaucoma or high eye pressure before and after…

This study looked at 44 people with a rare inherited eye condition called Leber Hereditary Optic Neuropathy (LHON) that causes vision loss. Researchers reviewed medical records and asked participants about their vision, health, and quality of life. The goal was to better understa…

This study followed 10 people with late onset Tay-Sachs disease to see how their symptoms and body chemistry changed over six months. Researchers measured balance, coordination, and brain chemicals. The goal was to gather information that will help design better clinical trials f…

This study measured three substances in the blood (endocan, alarin, and galanin-like peptide) in people with and without diabetic retinopathy, an eye complication of diabetes. Researchers compared these levels across different stages of the disease and looked at how they relate t…

This study compared two different optical devices that measure the eye before cataract or presbyopia surgery. 133 patients had their eyes measured with both devices to see if the measurements matched. The goal was to help doctors choose the best tool for planning lens implants.

This study looked at how well the Clareon Vivity and Vivity Toric intraocular lenses work in people who already had cataract surgery. Researchers measured vision at different distances in 155 participants. The goal was to confirm the lenses perform as expected and support their u…

This study tested a device called IOLMASTER 700 TK to see if it can more accurately measure the eye's curvature in people who had laser vision correction and now need cataract surgery. Researchers compared four different lens calculation methods in 155 adults. The goal was to imp…

This study looked for two rare genetic diseases, Gaucher disease and acid sphingomyelinase deficiency (ASMD), in 122 adults with an unexplained enlarged spleen or who had their spleen removed for unknown reasons. Researchers used a simple blood spot test to check enzyme activity …

This study created a nationwide registry to track long-term results of corneal surgeries and diseases. Researchers collected images and data from 19 participants to help understand what makes corneal transplants successful. The goal is to use this information to develop AI that c…

This study examined how common PCOS treatments (birth control pills and clomiphene citrate) affect the eyes. Researchers measured dry eye signs and retinal blood vessels in 60 women with PCOS and compared them to 30 healthy women. The goal was to see if these treatments cause cha…

This study looked at how accurately the Alcon Vision Suite with Argos biometer predicts the right lens power for people having cataract surgery. 106 adults aged 45 and older who chose either Clareon PanOptix or AcrySof Vivity lenses took part. The goal was to see if the device he…

This study analyzed tear and eye fluid samples from 100 cataract surgery patients to find biomarkers that could predict dry eye disease after surgery. Researchers used advanced chemical analysis to look for clues in the eye's surface cells and inner fluid. The goal is to better u…

This study looked at 91 people with a type of bleeding in the eye caused by age-related macular degeneration (AMD). It compared two treatments: surgery followed by anti-VEGF injections, or a gas injection followed by anti-VEGF injections. The goal was to see which approach helps …

This study looked at 360,000 French patients who received eye injections for conditions like age-related macular degeneration. The goal was to find out how often a serious eye infection called endophthalmitis happens within 28 days after the injection. Researchers analyzed data f…

This study looked at 202 people who had surgery for retinal detachment, a condition where the light-sensitive layer at the back of the eye pulls away. Researchers used high-resolution eye scans and vision tests to see how the eye heals over a year. The goal was to better understa…

This study explored whether the amount of omega-3 fatty acids in premature babies' bodies is linked to a serious eye condition called retinopathy of prematurity (ROP). Researchers measured omega-3 levels in 62 premature newborns born before 29 weeks. The goal was to see if lower …