Astigmatism

This study is testing a new type of artificial lens, called the Clareon TruPlus, for people having cataract surgery. The lens is placed inside the eye to replace the cloudy natural lens and help restore clear vision. About 122 adults with cataracts and astigmatism will receive th…

This study tests whether a custom-made lens implanted during cataract surgery can better correct vision in people with irregularly shaped corneas. Fifteen adults with significant astigmatism will receive the special lens. The goal is to reduce total astigmatism and improve visual…

This study tests whether making tiny arcuate incisions on the cornea during cataract surgery, combined with a special light-adjustable lens, can better correct pre-existing astigmatism. About 60 adults will receive this treatment and be followed to see how much their vision impro…

This study compares two types of trifocal toric lens implants used during cataract surgery to correct both cataracts and astigmatism. About 138 adults with cataracts and regular astigmatism will receive one of the two lenses. The main goal is to see which lens provides better int…

This study compares a new type of LASIK (Ray-Tracing Guided) with three other common laser eye surgeries (SMILE, Wavefront Optimized LASIK, and Topography Guided LASIK) to see which one provides the best vision after surgery. Researchers will enroll 120 people with nearsightednes…

This study tests whether Total30 multifocal toric contact lenses are more comfortable and provide better vision than current lenses for people with presbyopia (age-related blurry near vision). 32 adults aged 40 and older who already wear toric contacts will try the new lenses for…

This study looks at whether Systane COMPLETE artificial tears can improve dry eye symptoms and help doctors better predict cataract surgery outcomes. About 140 cataract patients with dry eye will use the drops before and after surgery. Researchers will measure changes in eye shap…

This study looks at how comfortable daily disposable contact lenses are for people with astigmatism when worn for long hours. Researchers will ask 40 current soft toric lens wearers to rate their comfort. The goal is to see if these lenses work well for long days.

This study will test how comfortable and clear TOTAL30 Multifocal contact lenses feel after wearing them for up to 16 hours. About 36 adults who already wear multifocal contacts will rate their comfort and vision at several points during the day over one month. The goal is to see…

This study compares two LASIK techniques to see which one corrects nearsightedness and astigmatism better. 70 adults aged 22 and older with healthy eyes will have one eye treated with each method. The goal is to find out if one approach leads to sharper vision without glasses.

This study is testing a new type of daily disposable contact lens called UNICON. It will involve 35 adults who already wear soft contact lenses. Participants will wear the test lenses for up to 13 weeks to see if they are safe and comfortable for correcting nearsightedness.

This study looks at whether people who are happy with their current Acuvue Oasys for Astigmatism contact lenses would like to switch to PRECISION7® for Astigmatism lenses. About 40 adults aged 18 to 40 who wear Acuvue Oasys lenses will try the new lenses and answer questions abou…

This study tests whether Wavelight Plus LASIK, an advanced laser eye surgery, improves vision in both normal and dim lighting for people with nearsightedness and astigmatism. Fifty adults will receive the surgery and be followed for 3 months. Researchers will measure visual sharp…

This study tracks how satisfied 52 people with nearsightedness and astigmatism are after getting Wavelight Plus LASIK, a personalized laser eye surgery. Researchers will measure vision quality, daily life impact, and any visual symptoms like glare or halos for up to 3 months afte…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study looks at whether dry eye disease affects the accuracy of corneal measurements needed for cataract surgery planning. 400 cataract patients will be divided into those with and without dry eye. Those with dry eye will use sodium hyaluronate eye drops for two weeks. Resear…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study is developing imaging and computer simulation tools to predict how a person's cornea (the clear front part of the eye) will change after treatments like crosslinking for keratoconus or LASIK for vision correction. Researchers will take detailed images of the eyes of 60…

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study tests whether using a special calculation tool (called a nomogram) helps doctors correct astigmatism more precisely during laser eye surgery. One hundred adults with astigmatism will be treated, and their vision will be checked over three months. The goal is to see if …

This study tracks 400 adults with cataracts to see how three different toric intraocular lenses rotate after surgery. Rotation is measured at several follow-up visits over three months. The goal is to find which lens stays most stable and help doctors choose the best option for e…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study is testing whether a computer program called EpiMaster can accurately predict how well laser eye surgery (PTK-PRK) will correct nearsightedness. Researchers will compare the software's predictions to the actual vision results in 150 patients six months after surgery. T…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…

This study tests three AI chatbots—ChatGPT 4o, GPT-5, and DeepSeek—on their ability to read eye scans from 100 cataract patients. The AI will try to extract key measurements, recommend the right lens implant, and predict vision after surgery. No treatment is given; the goal is to…

This study is testing whether a special eye scanner (OCT) can help fit scleral contact lenses more accurately than the usual method. Researchers will enroll 258 people with conditions like keratoconus or scarred corneas. Each participant will have lenses fitted both the standard …