Daily eyedrops may curb worsening nearsightedness in kids

NCT ID NCT03334253

Completed Disease control Sponsor: Jaeb Center for Health Research Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests whether daily low-dose atropine eyedrops (0.01%) can slow the progression of myopia (nearsightedness) in children aged 5 to 12. Participants receive either atropine or placebo drops for two years, followed by six months off treatment to see if any benefit lasts. The goal is to find a safe, easy way to reduce how quickly children's eyesight worsens.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Atropine (0.01% eyedrops)
What this could lead to: If effective, this could provide a simple, daily eyedrop treatment to slow worsening nearsightedness in children, potentially reducing the need for stronger glasses or future eye problems.
What could go wrong: This is a Phase 3 trial, but results may show only a modest effect or no benefit over placebo. Side effects from atropine, such as light sensitivity or blurry near vision, are possible. The treatment requires daily adherence for years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

myopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOPIA

Contacts and locations

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Locations

Boston Children's Hospital Waltham

Boston, Massachusetts, 02453, United States
Casey Eye Institute

Portland, Oregon, 97239, United States
Dean A. McGee Eye Institute, University of Oklahoma

Oklahoma City, Oklahoma, 73104, United States
Eye Care Associates, Inc.

Poland, Ohio, 44514, United States
Illinois College of Optometry

Chicago, Illinois, 60616, United States
Pediatric Ophthalmology Associates, Inc.

Columbus, Ohio, 43205, United States
Rocky Mountain Eye Care Associates

Salt Lake City, Utah, 84107, United States
St Luke's Hospital

Boise, Idaho, 83702, United States
The Emory Eye Center Dept of Ophthalmology

Atlanta, Georgia, 30322, United States
Ticho Eye Associates

Chicago Ridge, Illinois, 60415, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States
University of Houston College of Optometry

Houston, Texas, 77204, United States
Vanderbilt University Medical Center - Vanderbilt Eye Institute

Nashville, Tennessee, 37232, United States

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