New eye drops show promise for healing corneal damage
NCT ID NCT04909450
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested an experimental eye drop called CSB-001 in 131 people with neurotrophic keratitis, a rare condition where the cornea loses sensation and can develop ulcers. Participants used the drops four times daily for 8 weeks. The goal was to see if the drops could fully heal the cornea better than a placebo.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- CSB-001 ophthalmic solution (a growth factor protein)
- What this could lead to
- If it works, this could lead to a new treatment that helps heal corneal damage in people with neurotrophic keratitis.
- What could go wrong
- This is an early-phase trial with only 131 people, so results may not hold up in larger studies. The condition is rare, and the treatment may not work for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Research
Boynton Beach, Florida, 33437, United States
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Atlantis Eyecare
Torrance, California, 90505, United States
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BLINK Research Center, LLC
Memphis, Tennessee, 38119, United States
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Bascom Palmer Eye Institute at Palm Beach Gardens
Palm Beach, Florida, 33418, United States
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Bowden Eye and Associates
Jacksonville, Florida, 32256, United States
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California Eye Specialists Medical Group Inc.
Pasadena, California, 91107, United States
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Carolina Cataract & Laser Center
Ladson, South Carolina, 29456, United States
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Cincinnati Eye Institute
Edgewood, Kentucky, 41017, United States
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Cornea Consultants of Albany
Slingerlands, New York, 12159, United States
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Cornea and Contact Lens Institute of Minnesota
Edina, Minnesota, 55436, United States
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Corneal Consultants of Colorado
Littleton, Colorado, 80120, United States
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Devers Eye Institute
Portland, Oregon, 97210, United States
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Dr. Gregory Moloney
Vancouver, British Columbia, V5Z 1K1, Canada
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Duke Eye Center
Durham, North Carolina, 27710, United States
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Eye Care North
Cave Creek, Arizona, 85331, United States
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Eye Consultants of Atlanta
Atlanta, Georgia, 30339, United States
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Eye Consultants of North Dakota
Fargo, North Dakota, 58104, United States
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Global Research Foundation
Los Angeles, California, 90041, United States
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Gordon Schanzlin New Vision Institute
San Diego, California, 92122, United States
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Hazleton Eye Specialists
Hazle Township, Pennsylvania, 18202, United States
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International Eye Associates, PA
Ormond Beach, Florida, 32174, United States
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International Research Center
Tampa, Florida, 33603, United States
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States
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Kensington Eye Institute
Toronto, Ontario, M5T 3A9, Canada
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Kentucky Eye Institute
Lexington, Kentucky, 40517, United States
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LoBue Laser and Eye Medical Center, Inc.
Murrieta, California, 92562, United States
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Loma Linda University Eye Institute
Loma Linda, California, 92354, United States
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Martel Eye Medical Group
Rancho Cordova, California, 95670, United States
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Metropolitan Eye Research and Surgery Institute
Palisades Park, New Jersey, 07650, United States
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Midwest Cornea Associates, LLC
Carmel, Indiana, 46290, United States
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Minnesota Eye Consultants
Minnetonka, Minnesota, 55305, United States
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Nvision Clinical Research, LLC
Los Angeles, California, 90013, United States
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Ophthalmology Associates
St Louis, Missouri, 63131, United States
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Precision Cornea Centre
Ottawa, Ontario, K1G 5L1, Canada
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Price Vision Group
Indianapolis, Indiana, 46260, United States
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Scheie Eye Institute
Philadelphia, Pennsylvania, 19104, United States
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SightMD
Babylon, New York, 11702, United States
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Stuart A. Terry, MD PA
San Antonio, Texas, 78212, United States
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Tauber Eye Center
Kansas City, Missouri, 64111, United States
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The Ohio State University, Department of Ophthalmology and Visual Sciences
Columbus, Ohio, 43212, United States
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Tufts Medical Center
Boston, Massachusetts, 02111, United States
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UCLA Stein Eye Institute
Los Angeles, California, 90095, United States
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UPMC Eye Center
Pittsburgh, Pennsylvania, 15213, United States
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University of Colorado - Dept. of Ophthalmology
Aurora, Colorado, 80045, United States
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University of Texas at Austin; The Mitchel and Shannon Wong Eye Institute
Austin, Texas, 78712, United States
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Vance Thompson Vision
Sioux Falls, South Dakota, 57108, United States
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Virginia Eye Consultants
Norfolk, Virginia, 23502, United States
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Vision Institute
Colorado Springs, Colorado, 80907, United States
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Other studies related to the condition(s) this trial covers.
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