Neurotrophic keratopathy

This study tests whether eye drops made from a patient's own blood (called autologous platelet-rich plasma, or APRP) can heal the cornea better than standard artificial tears in people with neurotrophic keratopathy, a condition where the cornea loses feeling and cannot heal prope…

This study tests whether eye drops made from a patient's own blood (platelet-rich plasma) can heal persistent corneal ulcers faster than standard lubricants. 54 adults with ulcers that haven't healed after two weeks will be randomly assigned to one of three treatments. The goal i…

This study tests an experimental eye drop called STSP-0902 for people with neurotrophic keratitis, a rare condition where the cornea loses sensation and can develop ulcers. The trial will enroll 48 adults with moderate to severe disease. Participants will receive either the activ…

This study tests a new gene therapy called KB801 for people with stage 2 or 3 neurotrophic keratitis, a rare eye disease where the cornea cannot heal itself. The treatment uses a harmless virus to deliver nerve growth factor directly to the eye. About 60 participants will receive…

This Phase 3 study tests whether RGN-259 eye drops can heal persistent corneal defects in people with neurotrophic keratopathy, a condition where the cornea loses sensation and doesn't heal properly. About 70 adults will use the drops five times daily for 28 days or a placebo. Th…

This study tests whether injecting stem cells into the eye can help heal corneal ulcers that haven't improved with standard treatments. The stem cells are donated from healthy volunteers and processed in a lab. About 38 adults with persistent eye surface damage will receive the i…

This Phase 2 trial tests Lacripep eye drops in 54 people with neurotrophic keratitis, a condition where the cornea loses feeling and can get damaged. The study compares the drops to a placebo to see if they safely improve eye surface health, vision, and quality of life over 8 wee…

This study tests whether a new eye drop called acoltremon can help people with a specific type of dry eye caused by early nerve damage (stage 1 neurotrophic keratopathy). The study will include 50 adults who have both decreased tear production and reduced corneal sensation. Resea…

This study screens people with eye diseases to see if they can join other research studies at the National Eye Institute. No treatment is given. Participants undergo eye exams, blood tests, and other procedures to diagnose or evaluate their condition. The goal is simply to determ…

This study tests a special camera that takes super-detailed pictures of the back of the eye (the retina). The goal is to see if this technology can find eye diseases earlier than standard methods. Up to 1,000 people aged 12 and older, with or without eye disease, will have their …

This study aims to learn more about eye diseases by observing and providing standard care to up to 1,000 people over 5 years. Participants receive regular eye exams, tests, and treatments as needed. The goal is to better understand how eye diseases progress and are inherited, not…

This study tests whether artificial intelligence can create simple summaries of eye doctor notes that are easier for patients to understand. About 460 English-speaking adults receiving eye care will get either standard notes or notes plus an AI-generated plain language summary. P…

This study tests a new 4D microscope-integrated OCT system for the first time in people during eye surgery. Researchers want to see if the system is easy to use, safe, and can clearly show eye structures. Five adults having eye surgery will take part. The goal is to improve imagi…

This study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…

This study tests a new, more comfortable eye camera (WiSLO) designed for children and adults. Researchers want to see if it takes better pictures and is less bothersome than current cameras. About 42 people with or without eye disease will have their eyes photographed with both t…