Neurotrophic keratopathy
MONDO:0015290Neurotrophic keratopathy is a rare degenerative disease of the cornea characterized by reduction or loss of corneal sensitivity that can be asymptomatic or present with red-eye and, during the early stages of the disease, a minor decrease in visual acuity. It eventually leads to loss of vision.
Also known as: neurotrophic keratitis
17 clinical trials for this condition and its sub-types.
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Could your own blood heal a numb cornea? new trial tests Platelet-Rich eye drops
Disease control Recruiting nowThis study tests whether eye drops made from a patient's own blood (called autologous platelet-rich plasma, or APRP) can heal the cornea better than standard artificial tears in people with neurotrophic keratopathy, a condition where the cornea loses feeling and cannot heal prope…
Sponsor: Universidad Autonoma de Nuevo Leon • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Could your own blood heal a stubborn eye ulcer?
Disease control Recruiting nowThis study tests whether eye drops made from a patient's own blood (platelet-rich plasma) can heal persistent corneal ulcers faster than standard lubricants. 54 adults with ulcers that haven't healed after two weeks will be randomly assigned to one of three treatments. The goal i…
Sponsor: Universidad Autonoma de Nuevo Leon • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New eye drops aim to heal corneal damage and restore sensation
Disease control Recruiting nowThis study tests an experimental eye drop called STSP-0902 for people with neurotrophic keratitis, a rare condition where the cornea loses sensation and can develop ulcers. The trial will enroll 48 adults with moderate to severe disease. Participants will receive either the activ…
Phase 2 • Sponsor: Staidson (Beijing) Biopharmaceuticals Co., Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Gene therapy eye drops aim to heal corneas in rare nerve disorder
Disease control Recruiting nowThis study tests a new gene therapy called KB801 for people with stage 2 or 3 neurotrophic keratitis, a rare eye disease where the cornea cannot heal itself. The treatment uses a harmless virus to deliver nerve growth factor directly to the eye. About 60 participants will receive…
Phase 1/2 • Sponsor: Krystal Biotech, Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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New eye drops aim to heal corneal damage in rare disease
Disease control Recruiting nowThis Phase 3 study tests whether RGN-259 eye drops can heal persistent corneal defects in people with neurotrophic keratopathy, a condition where the cornea loses sensation and doesn't heal properly. About 70 adults will use the drops five times daily for 28 days or a placebo. Th…
Phase 3 • Sponsor: ReGenTree, LLC • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Stem cells offer new hope for stubborn eye ulcers
Disease control Recruiting nowThis study tests whether injecting stem cells into the eye can help heal corneal ulcers that haven't improved with standard treatments. The stem cells are donated from healthy volunteers and processed in a lab. About 38 adults with persistent eye surface damage will receive the i…
Phase 2 • Sponsor: University of Illinois at Chicago • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New eye drop hopes to bring tears to dry eyes
Symptom relief Recruiting nowThis study tests whether a new eye drop called acoltremon can help people with a specific type of dry eye caused by early nerve damage (stage 1 neurotrophic keratopathy). The study will include 50 adults who have both decreased tear production and reduced corneal sensation. Resea…
Phase 4 • Sponsor: University of South Florida • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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Could a simple ingredient boost dry eye drops?
Symptom relief Recruiting nowThis study tests if adding sodium hyaluronate (a common moisturizer in artificial tears) to autologous serum eye drops provides better relief for moderate-to-severe dry eye disease. About 20 adults with dry eye from conditions like Sjögren's syndrome will use the new mix in one e…
Phase 2 • Sponsor: University of Miami • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
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New eye drops aim to heal damaged corneas
Symptom relief Recruiting nowThis Phase 2 trial tests Lacripep eye drops in 54 people with neurotrophic keratitis, a condition where the cornea loses feeling and can get damaged. The study compares the drops to a placebo to see if they safely improve eye surface health, vision, and quality of life over 8 wee…
Phase 2 • Sponsor: TearSolutions, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Scientists hunt for biomarkers to unlock rare eye disease treatments
Knowledge-focused Recruiting nowThis study aims to find biological markers (biomarkers) in blood, tears, and eye cells from 110 adults with seven rare eye diseases. Researchers will compare these markers between patients and healthy controls to see if they differ and if they relate to disease symptoms. The goal…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC