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Birth control pills could reshape your cornea, study suggests

NCT ID NCT07693673

Knowledge-focused Sponsor: Elshimaa A.Mateen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study looks at whether taking combined oral contraceptive pills changes the shape and optical quality of the cornea — the clear front part of the eye. Researchers will measure corneal curvature and irregularities in women aged 18-40 before they start the pill and again after one year. The goal is to see if hormonal contraception affects vision or eye health in ways that are not yet well understood.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Combined oral contraceptive pills
What this could lead to
If changes are found, this could help eye doctors better understand how hormonal contraceptives affect vision and corneal health.
What could go wrong
This is a small observational study with only 40 participants. It may find no significant changes, and results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

40 people

The number who actually took part.

Started

Oct 2024

Finished

Mar 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Premenopausal women aged 18-40 years attending the Ophthalmology Department at Sohag University Hospital who are prescribed combined oral contraceptive pills by their gynecologist as part of routine clinical care. Participants will undergo corneal topography and tomography before starting treatment and after 1 year of oral contraceptive use.

Ages

18 to 40 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female participants aged 18-40 years. * Prescribed combined oral contraceptive pills as part of routine gynecological care. * Willing to undergo corneal topography/tomography before starting treatment and after 1 year. * No previous history of corneal disease or ocular surgery. * Able to provide informed consent. Exclusion Criteria: * Keratoconus or suspected corneal ectasia. * Corneal opacity, dystrophy, degeneration, or scarring. * Previous ocular surgery or significant ocular trauma. * Current contact lens use or recent contact lens use without adequate discontinuation period. * Active ocular surface disease or severe dry eye. * Glaucoma, uveitis, retinal disease, or other significant ocular pathology. * Diabetes mellitus, autoimmune disease, thyroid disease, pregnancy, or lactation. * Use of other hormonal therapy or systemic medications known to affect corneal parameters.

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Conditions

The condition(s) this trial relates to.

corneal disorder refractive error

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEA Refraction error

Contacts and locations

Locations

  • Ophthalmology Department, Sohag University Hospital, Faculty of Medicine, Sohag University

    Sohag, Sohag Governorate, 82524, Egypt

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