Can a nightly eye drop tame severe nearsightedness in kids?

NCT ID NCT04699357

Completed Disease control Sponsor: Shanghai Eye Disease Prevention and Treatment Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested three strengths of atropine eye drops (0.01%, 0.04%, and 0.1%) in 219 children with high myopia (severe nearsightedness). The goal was to see which dose best slows the worsening of vision and eye growth over two years. Children received one drop in each eye every night, and researchers tracked changes in prescription and eye length, as well as side effects and how well children tolerated the treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: atropine eye drops
What this could lead to: If successful, this could offer a simple, nightly eye drop treatment to slow worsening nearsightedness in children, reducing future eye health risks.
What could go wrong: This is a completed study, but results may not apply to all children. Side effects like light sensitivity or blurred near vision are possible with higher doses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

degenerative myopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH MYOPIA

Contacts and locations

Locations

Shanghai Eye Disease Prevention & Treatment Center

Shanghai, Shanghai Municipality, 200040, China
Shanghai General Hospital

Shanghai, China
Shanghai Ninth People's Hospital

Shanghai, China

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