New eye drops aim to restore natural moisture in dry eyes

NCT ID NCT06544694

Completed Disease control Sponsor: Alcon Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a new eye drop called AR-15512 can improve the health of the eye surface in people with dry eye disease. 80 participants received either the new drops or artificial tears. The main goal was to see if the drops increased the number of goblet cells, which help keep the eye lubricated. The study is complete, but results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AR-15512 ophthalmic solution (also called TRYPTYR or Acoltremon)
What this could lead to: If successful, this could lead to a new eye drop that helps restore the eye's natural moisture layer, offering better relief for dry eye disease.
What could go wrong: This is a small, completed Phase 3b study focused on a specific cell count, not symptoms. The treatment may not improve how patients feel, and results may not apply to all dry eye patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dry eye syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRY EYE DISEASE

Contacts and locations

Locations

Butchertown Clinical Trials

Louisville, Kentucky, 40206, United States
CORE, Inc.

Shelby, North Carolina, 28150, United States
Oculus Research

Garner, North Carolina, 27529, United States
Wilmington Eye

Leland, North Carolina, 28451, United States

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