Could a nasal spray soothe dry eyes?
NCT ID NCT05514041
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Varenicline nasal spray (OC-01)
What this could lead to
If it works, this could offer a new way to improve tear film quality and reduce dry eye discomfort quickly after use.
What could go wrong
This is a small, early-phase trial with only 50 participants. Results may not apply to everyone, and the effect may be short-lived or no better than placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Stephenson Eye Associates
Venice, Florida, 34285, United States