Could a nasal spray soothe dry eyes?
NCT ID NCT05514041
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a nasal spray containing varenicline (OC-01) can improve tear film quality and reduce dryness in people with dry eye disease. Fifty adults used either the active spray or a placebo. Researchers measured tear film changes and symptom scores shortly after use.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Varenicline nasal spray (OC-01)
- What this could lead to
- If it works, this could offer a new way to improve tear film quality and reduce dry eye discomfort quickly after use.
- What could go wrong
- This is a small, early-phase trial with only 50 participants. Results may not apply to everyone, and the effect may be short-lived or no better than placebo.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Stephenson Eye Associates
Venice, Florida, 34285, United States
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