Could these eye drops replace reading glasses? new trial tests a daily drop for aging eyes
NCT ID NCT06542497
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed Phase 3 trial tested whether phentolamine eye drops (Nyxol) can improve near vision in people with presbyopia, the age-related loss of ability to focus on close objects. 569 adults aged 45 to 64 used the drops or a placebo once daily for 8 days. The main goal was to see if more people in the treatment group could read three lines better on a near-vision chart without losing distance vision, measured 12 hours after the last dose.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- phentolamine ophthalmic solution 0.75% (Nyxol)
- What this could lead to
- If it works, this could offer a daily eye drop to temporarily improve near vision for people with presbyopia, reducing the need for reading glasses.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet public. The effect may be modest or not work for everyone, and side effects like eye redness or headache are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advancing Vision Research
Goodlettsville, Tennessee, 37072, United States
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Arizona Eye Center
Chandler, Arizona, 85224, United States
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Athens Eye Care
Athens, Ohio, 45701, United States
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Bergstrom Eye
Fargo, North Dakota, 58103, United States
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Bowden Eye & Associates
Jacksonville, Florida, 32256, United States
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Carrot Eye Center
Mesa, Arizona, 85202, United States
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Durrie Vision
Overland Park, Kansas, 66210, United States
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Empire Eye & Laser Center
Bakersfield, California, 93309, United States
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Eye Doctors of Arizona
Phoenix, Arizona, 85028, United States
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Eye Institute of Utah
Salt Lake City, Utah, 84107, United States
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Eye Research Foundation
Newport Beach, California, 92663, United States
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Fraser Eye Care Center
Fraser, Michigan, 48026, United States
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Global Research Management, Inc.
Glendale, California, 91204, United States
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Gordon Schanzlin New Vision Institute
La Jolla, California, 92307, United States
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Heart of America Eye Care, P.A.
Shawnee Mission, Kansas, 66204, United States
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Kannarr Eye Care
Pittsburg, Kansas, 66762, United States
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Lake Travis Eye and Laser Center/ Revolution Research
Lakeway, Texas, 78738, United States
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Levenson Eye
Jacksonville, Florida, 32204, United States
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LoBue Laser and Eye Medical Center, Inc.
Murrieta, California, 92562, United States
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MRB Eye Care Consultants, LLC
Scottsdale, Arizona, 85260, United States
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Mid Florida Eye Center
Mt. Dora, Florida, 32757, United States
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Moyes Eye Center
Kansas City, Missouri, 64154, United States
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Oculus Research , Inc.
Garner, North Carolina, 27529, United States
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Optometry Group
Memphis, Tennessee, 38111, United States
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Parkhurst NuVision
San Antonio, Texas, 78229, United States
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Price Vision Group
Indianapolis, Indiana, 46260, United States
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Red River Research Partners
Fargo, North Dakota, 58103, United States
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Red River Research Partners
Richardson, Texas, 75080, United States
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Rochester Ophthalmological Group
Rochester, New York, 14618, United States
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Sabal Eye Care/dba Omega Vision Center
Longwood, Florida, 32779, United States
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Segal Drug Trials, Inc.
Delray Beach, Florida, 33484, United States
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Shettle Eye Research
Largo, Florida, 33773, United States
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South Florida Glaucoma
Delray Beach, Florida, 33484, United States
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The Eye Care Institute
Louisville, Kentucky, 40206, United States
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Total Eye Care
Memphis, Tennessee, 38119, United States
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Virdi Eye Clinic
Rock Island, Illinois, 61201, United States
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West Bay Eye Associates
Warwick, Rhode Island, 02888, United States
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Whitsett Vision Group
Houston, Texas, 77055, United States
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Wolstan and Goldberg Eye Associates
Torrance, California, 90505, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new contact lens sharpen both near and far vision for aging eyes?
- A tiny corneal pocket may restore Close-Up vision — no glasses needed
- Laser eye surgery may offer a One-Time fix for reading glasses — a trial puts it to the test
- Eye drops may offer a new way to read without glasses — a trial puts them to the test
- Tiny corneal lens holds up after 4 years for near vision
- Could a micro implant replace reading glasses?