Digestive system disorder

This study tests a hexavalent vaccine that protects against six diseases, including polio, but uses a lower dose of the inactivated polio vaccine (IPV). The goal is to see if this reduced-dose version works as well as the standard full-dose vaccine in infants. Around 1,500 health…

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This early-stage trial tested a new vaccine (CJCV2) designed to protect against Campylobacter infection, a leading cause of foodborne illness. Fifty-nine healthy adults received three different doses of the vaccine, with or without an immune-boosting adjuvant (ALFQ). The main goa…

This phase 3 study tested the 9-valent HPV vaccine (Gardasil 9) in over 1,000 Japanese males aged 16 to 26. The goal was to see if the vaccine could prevent persistent HPV infections that can lead to genital warts and anal cancers. Participants received either the vaccine or a pl…

This early-stage trial tested a new two-part vaccine designed to treat chronic hepatitis B. It involved 26 healthy adults to check safety and immune response. The vaccine uses a protein first shot followed by a booster to teach the immune system to attack the virus.

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This trial tests a temporary device called CG-100 that is placed inside the intestine during colorectal cancer surgery. The device is designed to protect the surgical connection while it heals, potentially reducing leaks and other complications. The study includes adults aged 22 …

This study tests whether a combination of ramucirumab plus FOLFIRI (a standard chemo regimen) works better than ramucirumab plus paclitaxel for people with advanced stomach or gastroesophageal junction cancer that has worsened after one prior chemo treatment. About 429 participan…

This study tested a new insulin called icodec that is injected just once a week, compared to the standard daily insulin glargine, in 429 adults with type 2 diabetes. Participants received either the weekly or daily insulin for 6 months. The goal was to see if the weekly shot cont…

This study tests whether giving a three-part treatment before surgery can improve outcomes for people with locally advanced stomach or gastroesophageal junction cancer. The treatment combines an immunotherapy drug (tislelizumab) with standard chemotherapy and a short course of ra…

This study investigates whether a structured, personalized exercise plan—tracked with a smartwatch and supported by regular phone check-ins—can help control blood sugar, blood pressure, and weight gain in pregnant women with gestational diabetes, chronic hypertension, or obesity.…

This study tests whether a secure website with educational sessions, goal-setting, and tracking tools can help survivors of several cancers (including breast, prostate, colorectal, and others) improve their diet, increase physical activity, and manage weight. Participants are age…

This trial tests an experimental antibody drug called CM-101 in adults with primary sclerosing cholangitis (PSC), a rare liver disease. The drug targets a protein called CCL24 to potentially reduce inflammation and scarring. Participants receive either CM-101 or a placebo by intr…

This Phase 3 study tests odevixibat, a daily pill, in 254 children with biliary atresia who recently had Kasai surgery. The goal is to see if the drug can prevent the need for a liver transplant or death. Children take either odevixibat or a placebo for up to 2 years, and researc…

This trial investigates whether adding antroquinonol (Hocena) to standard chemotherapy (nab-paclitaxel and gemcitabine) can safely treat people with metastatic pancreatic cancer that has not yet been treated. The study has two phases: first, finding the best dose, and second, che…

This study tests a new drug called MBX 1416 in 10 people who have low blood sugar episodes after weight loss surgery. Participants receive two injections of the drug, a low dose and a high dose, about two weeks apart. The goal is to see if the drug can raise the lowest blood suga…

This study tests whether a daily dose of Taiwanese Green Propolis, a natural bee-derived supplement, can improve blood fat levels, reduce fatigue, and enhance quality of life in people who have completed treatment for oral cavity cancer. Participants take either propolis capsules…

This study looked at whether children with cystic fibrosis (CF) who are taking CFTR modulator drugs and have regained normal pancreatic function can safely stop taking pancreatic enzyme replacement therapy (PERT). Seventeen children were followed for six months after stopping enz…

This trial compares three modern radiotherapy techniques—helical tomotherapy and two types of dynamic arc therapy (RapidArc and VMAT)—for treating prostate, cervical, and anal canal cancers that require pelvic lymph node irradiation. The goal is to determine which method is most …

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This phase 2 trial is testing whether a combination of chemotherapy (mFOLFOX6), a targeted therapy (bevacizumab), and an immunotherapy (PD-1 inhibitor) can help people with a specific type of locally advanced colorectal cancer called microsatellite stable (MSS). Unlike other colo…

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers gave them a re-induction infusion and then split them into two groups: one continued the usual shot every 8 weeks, the other got a shot every 4 weeks.…

This study tests a two-pronged chemotherapy approach for people with intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be removed by surgery. Participants receive chemotherapy directly to the liver through a surgically placed pump, plus standard chemotherap…

This study tests an experimental drug called X842 in people with severe erosive esophagitis caused by GERD (chronic acid reflux). Participants have either severe esophagus damage (grades C or D) or milder damage that hasn't healed after 8 weeks of standard treatment. The trial co…

This study tests whether giving the antibiotic vancomycin directly into the bone (intraosseous) during diabetic foot amputation works better than the standard IV method to prevent surgical site infections. It includes 40 adults with diabetes who need a below-knee amputation. Rese…

This study tested the drug larotrectinib in 215 adults with various solid cancers that have a specific change in the NTRK gene. The drug is taken orally and works by blocking the action of the altered gene. The main goal was to see how many patients had their tumors shrink or dis…

This early-phase study tested the safety of combining two drugs—pembrolizumab (an immunotherapy) and AMG386 (which targets blood vessel growth)—in 62 people with advanced solid tumors like melanoma, ovarian, renal, or colorectal cancer. The main goals were to find the safest dose…

This study tested two ways to offer HIV treatment, hepatitis C treatment, and substance use disorder medications to people who inject drugs. One group received a telehealth-enhanced program with on-demand services like mobile blood draws and counseling, while the other group got …

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This trial investigates whether eating 100 grams of curd cheese daily as part of a personalized diet for 8 weeks can improve cholesterol levels, blood sugar, and body measurements in overweight adults aged 40 to 64. Participants are randomly assigned to either a curd cheese-suppl…

This pilot study tests whether a purified green tea extract called EGCG can help prevent colon cancer from coming back after surgery. 51 patients who had their colon cancer removed took either the extract or a placebo. Researchers are checking for changes in DNA methylation, a ma…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This study tests whether psyllium fiber bars can help postmenopausal women with irritable bowel syndrome and diarrhea who experience accidental bowel leakage. Researchers will examine changes in gut bacteria and stool chemicals to see if fiber improves symptoms. The study involve…

This study tests whether the immunotherapy drug durvalumab can be safely given to people with advanced liver cancer who also have an active hepatitis B infection. All participants receive an antiviral drug (entecavir) to control the hepatitis B virus. The main goal is to see if d…

This completed trial tested whether daily omega-3 fish oil supplements can help maintain healthy blood vessels in the eyes of adults with type 1 diabetes. 82 participants took either a 1000 mg omega-3 capsule or a placebo for the study, with regular eye exams to monitor retinal c…

This study tests a combination of three immunotherapy drugs—PDS0101, M7824, and NHS-IL12—in people with advanced HPV-related cancers such as cervical, anal, and throat cancers. The goal is to see if the mix can shrink tumors or stop them from growing. Participants receive the dru…

This study compares a new drug, HRS-7535, to an existing diabetes medication, dapagliflozin, in adults with type 2 diabetes whose blood sugar is not well controlled with metformin alone. The goal is to see if HRS-7535 works better at lowering blood sugar and body weight over 32 w…

This study tests whether adding a targeted drug (Donafenib) and chemotherapy directly into the liver's blood supply can prevent liver cancer from returning after surgery. It includes adults with a single large tumor (≥5 cm) and microscopic blood vessel invasion, who are at high r…

This study tests whether a daily probiotic lysate supplement can reduce fat and stiffness in the liver of adults with non-alcoholic fatty liver disease (NAFLD). Participants take either the supplement or a placebo for three months, and doctors measure changes using MRI and ultras…

This study tests a family-based behavioral program for youth aged 6-17 with type 1 diabetes who are overweight or obese, along with an overweight parent. The program focuses on healthy meal planning, food literacy, and family habits to improve weight and diabetes control. Twenty …

This study tests a treatment plan tailored to each child's risk level for a rare liver cancer called hepatoblastoma. About 236 children will receive standard treatments like surgery and chemotherapy, plus the drug temsirolimus for high-risk cases. The goal is to see if this appro…

This pilot study tests whether dialectical behavioural therapy (DBT) — a type of talk therapy that teaches skills like mindfulness and emotion regulation — can help Indigenous youth with type 2 diabetes improve their quality of life and diabetes control. The study enrolls 20 yout…

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. One group received weekly group sessions on diet and activity, while the other got extra health information and classes. Researchers tracked weight ga…

This study compared two ways to fix a failed mitral heart valve replacement: a less invasive procedure called valve-in-valve (using a catheter to place a new valve inside the old one) versus repeat open-heart surgery. The trial included 150 adults with severe valve problems. Rese…

This study tested fecal microbiota transplantation (FMT) from different donors to treat ulcerative colitis, a type of inflammatory bowel disease. Researchers gave 102 patients a one-time colonoscopic infusion of fresh fecal bacteria from healthy donors. The goal was to see if don…

This clinical trial is testing a combination of two drugs—an immunotherapy (pembrolizumab/quavonlimab) and a targeted therapy (lenvatinib)—as a first treatment for people with advanced hepatocellular carcinoma, a type of liver cancer that cannot be removed by surgery. The study a…

This study tested whether adding Naderin (sodium nucleinate) to standard treatment could reduce complications in 75 patients with cancer, tuberculosis, or hepatitis C. The main group received Naderin plus standard therapy, while the control group received standard therapy alone. …

This study tests whether a daily capsule containing fragments of a probiotic bacterium (L. rhamnosus) can reduce liver fat and improve blood markers in adults with metabolic dysfunction-associated steatotic liver disease (MASLD). Participants take either the supplement or a place…

This trial investigates whether changing how often and when people with type 2 diabetes eat can improve weight, blood sugar, and cholesterol. Over 12 weeks, participants follow one of three eating plans: a standard 6-meal diet, a 3-meal diet, or time-restricted eating (eating all…

This trial investigates whether adding a dietary supplement called sodium nucleinate to standard FOLFOX chemotherapy helps people with metastatic colorectal cancer (cancer that has spread). Participants are randomly assigned to receive either the supplement or a placebo alongside…

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This trial investigates whether giving two immunotherapy drugs, ipilimumab and nivolumab, before liver surgery can help shrink tumors in people with liver cancer (hepatocellular carcinoma). Participants receive the drugs in the weeks leading up to their planned surgery. The study…

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study investigates whether drinking galactose before cycling can prevent low blood sugar (hypoglycemia) in people with type 1 diabetes. Fourteen participants will try four different drinks—dextrose, galactose, lactose, or a sweetened placebo—on separate days, then cycle for …

This study investigates whether giving vitamin D supplements to adults with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who also have low vitamin D levels can improve their iron status. Participants take high-dose vitamin D3 weekly for 8 weeks, then a lower…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tests whether giving patients their own stool bacteria through a temporary stoma can reduce inflammation in the unused part of the colon, a condition called diversion colitis. Sixty-six people with rectal cancer who have a temporary ileostomy will receive either a dail…

This study tests a 6-week online group program designed to help African American women with type 2 diabetes reduce diabetes-related distress and improve blood sugar control. The program combines diabetes education, motivational interviewing, and cognitive behavioral therapy, deli…

This study tested a family-focused diabetes education program delivered in Marshallese faith-based organizations. Over 300 adults with type 2 diabetes and their family members took part. The goal was to see if group education in a familiar community setting could improve blood su…

This study investigates whether a nutrition education program and omega-3 supplements can help people with non-alcoholic fatty liver disease (NAFLD) lose weight, improve liver enzymes, and lower cholesterol. Participants are randomly assigned to receive nutrition guidance, omega-…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This phase 2 trial tested whether adding an experimental drug called SRF388 to a standard two-drug regimen (atezolizumab plus bevacizumab) helps people with advanced liver cancer that hasn't been treated before. The study enrolled 30 adults whose cancer could not be surgically re…

This early-phase trial tested an experimental drug called BW-20507 in 32 people. First, healthy volunteers received a single dose to check safety. Then, people with chronic hepatitis B received multiple doses to see how the drug behaves in the body and whether it fights the virus…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This completed Phase 2 study tested whether a combination of two experimental drugs, K-877-ER and CSG452, can improve liver health in adults with nonalcoholic steatohepatitis (NASH) and liver fibrosis. The 228 participants received either the combination or a placebo. The main go…

This study tested a 12-week program where nurses provided diabetes education and support through video calls to 128 adults with type 2 diabetes in Thailand. Participants had uncontrolled diabetes and owned a smartphone. The program included an initial in-person session followed b…

This study tested whether giving adults with type 2 diabetes and food insecurity a small weekly incentive ($10.50 per household member) to buy healthy foods could improve their blood sugar control. 597 participants were randomly assigned to receive either the food incentive plus …

This trial tests whether giving intravenous thiamine (vitamin B1) alongside standard treatment helps people with diabetic ketoacidosis recover faster. Diabetic ketoacidosis is a serious condition where the blood becomes too acidic. The study includes adults hospitalized with this…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This phase 2 trial tested a combination of two drugs—paclitaxel (given intravenously and directly into the abdomen) and oral nilotinib—in 21 adults with cancers that had spread to the lining of the abdomen and could not be surgically removed. The goal was to see if the treatment …

This phase 2 trial tests whether OSE-127, an antibody that blocks a key immune signal, can reduce disease activity in people with moderate to severe ulcerative colitis who have not responded to or cannot tolerate previous treatments. Participants are randomly assigned to receive …

This study tested an updated version of the Control-IQ system, which automatically adjusts insulin delivery for people with type 1 diabetes. Sixty-six adults and adolescents used the new software along with a continuous glucose monitor for several weeks. The main goal was to see …

This large phase III trial studied whether adding the targeted drug cetuximab to standard chemotherapy after surgery helps prevent cancer from coming back in patients with stage III colon cancer. Over 3,300 patients took part, and the study focused on those with a specific geneti…

This study tested whether using two advanced drugs together (either two biologics or one biologic plus a small molecule) is safe and effective for people with inflammatory bowel disease (IBD) who haven't gotten better on standard treatments. Researchers followed 117 patients in C…

This study tested an experimental drug called HSK31679 in 186 Chinese adults with non-alcoholic steatohepatitis (NASH), a serious liver condition. Participants took either 80 mg, 160 mg, or a placebo daily for 52 weeks. The goal was to see if the drug could improve liver damage a…

This study tests the long-term safety of maralixibat, an oral medication, in children with progressive familial intrahepatic cholestasis (PFIC), a rare liver disease that causes intense itching. Participants who completed a prior study will receive maralixibat twice daily. Resear…

This study tested whether giving extra support to Black adults who don't lose weight early in a diabetes prevention program helps them lose more weight. Over 400 participants joined a 12-week program at churches or community centers. Those not losing weight early got extra phone …

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tested whether giving a mix of immunotherapy drugs (tislelizumab and IL-2) plus chemotherapy before surgery could shrink tumors more effectively in people with locally advanced rectal cancer. The trial involved 130 adults whose cancers had not spread but were hard to t…

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This study tested whether adding the chemotherapy drug doxorubicin to the targeted therapy sorafenib helps people with advanced liver cancer live longer. Over 350 patients received either sorafenib alone or sorafenib plus doxorubicin. The main goal was to compare overall survival…

This completed trial tested whether a daily EPA (an omega-3 fatty acid) supplement could help preserve muscle mass and reduce inflammation in 18 people with advanced liver cancer that could not be surgically removed. Participants took either the EPA supplement or a placebo for 12…

This study tested whether low doses of the hormone drug danazol can slow the shortening of telomeres—the protective caps on DNA—in people with telomere diseases. These conditions can cause bone marrow failure, lung scarring, and liver damage. Eighteen participants took danazol fo…

This early-stage trial tested a new drug, LY3849891, in 115 people with fatty liver disease who carry a specific gene variant (PNPLA3 I148M). The main goal was to check safety and how the body processes the drug. Researchers also looked at changes in liver fat and inflammation us…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study tested a combination of three drugs—camrelizumab, apatinib, and chemotherapy (gemcitabine plus cisplatin)—in 49 people with advanced biliary tract cancer that could not be removed by surgery. The goal was to see if the combo is safe and how well it shrinks tumors. Resu…

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Twenty adults with end-stage heart failure on the transplant waiting list will receive these hearts and take antiviral medication to prevent infection. The goal …

This trial tests whether a family-centered diabetes education program helps people with type 2 diabetes manage their blood sugar better than standard education. About 1,100 adults with type 2 diabetes and their family members take part. Participants are randomly assigned to eithe…

This study tested a mobile health tool called REACH-Español, which sends interactive text messages to help Latino adults with type 2 diabetes remember and take their medications. The trial included 70 participants who were at least 18 years old, identified as Latino or Hispanic, …

This trial compares two types of surgery for pancreatic cancer in the body or tail of the pancreas: minimally invasive (laparoscopic or robot-assisted) versus traditional open surgery. The goal is to see if the less invasive approach can remove the tumor just as completely. Adult…

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This trial compares two types of oral nutritional supplements given to colorectal cancer patients before surgery. One group receives standard high-protein drinks, while the other gets immunonutrition drinks enriched with arginine, nucleotides, vitamin D, and omega-3 fatty acids. …

This study looked at adding the drug pazopanib to standard radiation or chemoradiation before surgery for patients with certain soft tissue sarcomas. The goal was to see if the combination is safe and helps shrink tumors more effectively. About 140 adults and children with newly …

This trial tests whether a nurse-led education program, based on the Health Belief Model, can improve treatment adherence in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis) who are receiving anti-TNF therapy. The program aims to address patients' co…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This study tested whether personalized dietary advice helps people with early-stage type 2 diabetes control their blood sugar better than standard advice or usual care. About 255 participants were split into three groups: personalized diet, standardized diet, or usual care. Resea…

This completed study looked at whether adding an immune-boosting drug called thymalfasin to standard chemoradiotherapy and a PD-1 inhibitor could help shrink advanced rectal tumors before surgery. Researchers studied 47 patients with stage II/III mid-low rectal cancer. The main g…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This Phase II trial tested a combination of chemotherapy drugs (FOLFIRINOX) plus the blood pressure drug losartan, followed by proton radiation, in 50 people with locally advanced pancreatic cancer. The goal was to see if this approach could shrink tumors enough to allow complete…

This early-phase trial tested a new approach for advanced liver cancer that has not responded to standard treatments. Researchers took participants' own immune cells, modified them in a lab to target a protein called AFP found on cancer cells, and infused them back after a short …

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to other treatments. The cancer must be a specific type called MMR-proficient. The trial involves 18 par…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This early-phase trial tested a new drug called RO7496353 combined with an immunotherapy (atezolizumab) and sometimes chemotherapy in 102 people with advanced lung, stomach, or pancreatic cancer. The main goal was to check safety and side effects. Researchers also looked at how t…

This study tested whether taking tempeh powder (a source of isoflavones) and vitamin D3 daily for 8 weeks could improve vitamin D levels, reduce inflammation, and boost quality of life in people with inflammatory bowel disease (IBD). Fifty adults with ulcerative colitis or Crohn'…

This trial tests a smartphone app called Tappt that uses smart tags to help people with hepatitis C stick to their daily oral medication. Participants scan tags each time they take a dose, and the app tracks adherence. The study compares their results to historical data from simi…

This study tested whether a combination of two drugs (atezolizumab and bevacizumab) can prevent liver cancer from returning in people who had surgery or ablation to remove their tumor. About 668 participants at high risk of recurrence were randomly assigned to receive the drug co…

This trial tested a new treatment called EGFR BATs for people with advanced pancreatic cancer. The treatment uses a patient's own immune cells, armed with a special antibody, to target cancer cells. The study included 22 participants who had already received chemotherapy. The goa…

This trial tests whether a program of exercise, nutrition advice, and psychological support—started four weeks before surgery and continued afterward—can reduce complications in people having colon cancer surgery. Participants are adults over 40 with non-metastatic colon cancer w…

This phase 2 trial tested a modified virus called JX-594 (Pexa-Vec) in 30 people with liver cancer that could not be surgically removed. The virus was injected directly into the liver tumors to see if it could stop the cancer from growing. Researchers measured how many patients h…

This early-stage study tested a new treatment called MB310 in 29 adults with mild-to-moderate ulcerative colitis. The main goal was to see if it is safe and how well it takes hold in the body. Participants received either MB310 or a placebo, and researchers monitored side effects…

This study tested whether a smartphone app that lets people log their blood sugar readings at home can improve diabetes control. One hundred adults with poorly controlled type 2 diabetes used the app or continued usual care for 3 months. Researchers measured changes in HbA1c, a k…

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested a new insulin called icodec that is injected just once a week, compared to standard daily insulin shots, in over 1,000 adults with type 2 diabetes who had never used insulin before. The goal was to see if the weekly shot controls blood sugar just as well as dail…

This early study tested whether a sterile bacterial chemical called lipopolysaccharide (LPS) can be safely injected into abdominal tumors during laparoscopic surgery. Twelve adults with advanced digestive tract tumors received one injection into a tumor, and researchers checked f…

This study tested a new drug called BLI5100 in 1250 adults with erosive esophagitis, a condition where stomach acid damages the esophagus. Participants took either BLI5100 or a standard PPI (proton pump inhibitor) daily for up to 8 weeks to see if it healed the damage, then for 2…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This completed Phase 2 trial tested whether the drug pentoxifylline can help people with jaundice caused by liver or bile duct problems. 45 adults took 400 mg of pentoxifylline twice daily for 3 months, alongside standard care. Researchers measured changes in antioxidant levels, …

This completed Phase 2 trial tested whether N-acetylcysteine (NAC), a common antioxidant supplement, can help people with jaundice caused by liver or bile duct issues. 44 adults took NAC twice daily for 3 months alongside standard care. Researchers measured changes in antioxidant…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested whether adding prazosin, a drug usually used for high blood pressure, to standard hepatitis C treatment could reduce liver scarring. 112 adults with chronic hepatitis C (genotype 1 or 4) and severe liver fibrosis took part. Researchers measured changes in liver …

This completed phase 2 trial tested whether the drug cediranib, given with chemotherapy, is safe for women with advanced ovarian cancer who are at risk of bowel obstruction. 30 participants received the combination. The study focused on whether the treatment caused serious bowel …

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This study tested whether an educational mobile game could help children aged 7 to 14 with type 1 diabetes better manage their blood sugar. 76 children played the game alongside their usual care. Researchers measured changes in HbA1c (a long-term blood sugar marker) and how satis…

This small, completed phase II study tested the safety of combining two drugs—atezolizumab (an immunotherapy) and bevacizumab (a blood vessel blocker)—in 6 people with advanced liver cancer who also had moderate cirrhosis (Child-Pugh B7 or B8). The goal was to see if this treatme…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This study looked at 715 patients with very large liver cancers (over 10 cm) to see if giving a combination of local treatments (like chemo directly into the liver) and body-wide treatments (targeted drugs and immunotherapy) before surgery helps them live longer. Patients were di…

This study looked at 410 patients with a bile duct infection (cholangitis) who had a procedure to drain the bile duct. It compared giving antibiotics for just 1 day versus the usual 4 to 7 days. The goal was to see if the shorter course is just as good at curing the infection, wh…

This study tested two experimental drugs (AK104 and AK117) together, sometimes with chemotherapy, in 128 people with advanced solid tumors. The goal was to see if the combination is safe and can shrink tumors. It focused on patients with stomach, esophageal, or other advanced can…

This phase 3 trial tested whether a combination of two drugs, regorafenib and nivolumab, helps people with advanced gastro-oesophageal cancer live longer than standard chemotherapy. The study included 462 adults whose cancer had stopped responding to prior treatments. The goal wa…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study tested a new way to reconnect the stomach and small intestine after removing the lower part of the stomach in people with advanced stomach cancer. The goal was to see if the new stapling method was safe and worked well. One hundred patients took part, and the researche…

This early-stage study tested a new treatment approach for adults with chronic hepatitis B or D. Twenty participants received two medications in sequence: P1101 (a type of interferon) followed by an anti-PD1 drug. The main goal was to check safety and tolerability, while also loo…

This phase 2 trial tested whether adding an immunotherapy drug called botensilimab to standard chemotherapy could help people with metastatic pancreatic cancer who had already progressed on a common chemo regimen (FOLFIRINOX). The study enrolled 81 participants and compared the c…

This early-phase trial tested a new approach for people with advanced head and neck cancer that has come back or spread. It combined specially trained natural killer (NK) immune cells with drugs that help the immune system attack cancer. The study enrolled 11 participants to chec…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested whether using a continuous glucose monitor (CGM) helps adults with type 2 diabetes control their blood sugar better than traditional finger-prick testing. About 600 participants from two community health centers in China wore a CGM device for three 2-week period…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This study tested a combination of two drugs, cadonilimab and regorafenib, in 36 adults with advanced liver cancer that had worsened after standard treatments. The goal was to see if the combo could slow cancer growth and how safe it was. Results may help develop better options f…

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested the drug mirikizumab in 172 adults with moderate-to-severe ulcerative colitis who still had bowel urgency despite other treatments. The main goal was to see if the drug reduces the sudden, urgent need to use the bathroom. Participants were followed for 36 weeks …

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This Phase 3 study tested a new drug called IBI362 (mazdutide) against the well-known semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. Participants received weekly injections for 32 weeks, with some continuing for an extra 24 weeks. The main goal was to s…

This study tested a combination of three drugs—Grazoprevir/Elbasvir, Sofosbuvir, and Ribavirin—in 26 adults with hepatitis C genotype 1 or 4 who had not been cured by previous treatments. The goal was to see if 16 or 24 weeks of this therapy could clear the virus. The main measur…

This study tested whether adding a virus-based immunotherapy (Pexa-Vec) to the standard drug sorafenib helps people with advanced liver cancer live longer. About 459 adults with advanced liver cancer who had not received prior treatment took part. The approach uses a modified vir…

This early-phase trial tested a new type of vaccine made from a patient's own immune cells (dendritic cells) that are engineered to target a protein called WT1 found in many cancers. Ten people with advanced esophageal, pancreatic, ovarian, or liver cancer received six vaccines o…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested whether using a negative pressure wound therapy device (a special vacuum bandage) for a longer time after surgery could lower the chance of wound infections in people with gastrointestinal cancer. About 290 patients took part. The goal was to see if this approac…

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This phase 2 trial tested personalized immunotherapy combinations for advanced gastric cancer that had worsened after initial chemotherapy. Researchers matched treatments to tumor genetics: patients with certain genetic features received atezolizumab plus ipatasertib, while other…

This study tested whether a seaweed-derived supplement called Aquamin® can reduce gut permeability (often called 'leaky gut') in people with ulcerative colitis, irritable bowel syndrome with diarrhea, and healthy volunteers. Thirty-five adults took Aquamin capsules for 90 days. R…

This study tested a new closed-loop system that automatically delivers both insulin and pramlintide to manage blood sugar in 33 adults with type 1 diabetes. Pramlintide slows digestion to prevent blood sugar spikes after meals. The system was compared to insulin alone. Researcher…

This study looked at how safe a new once-weekly insulin (insulin icodec) is during exercise and long periods without food in 30 adults with type 2 diabetes. Participants first took a daily insulin for a week, then switched to the weekly insulin for up to 14 weeks. The goal was to…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This early-phase study tested whether adding indomethacin, a common anti-inflammatory drug, to standard platinum-based chemotherapy is safe for people with colorectal, esophageal, or ovarian cancers. The 13 participants received escalating doses of indomethacin alongside their ch…

This study tested a new drug called MK-1200 in 13 people with advanced solid tumors, including stomach, esophageal, bile duct, and pancreatic cancers. The goal was to find safe doses and see if the drug could shrink tumors. The study is complete, but results are not yet available…

This study tested a drug called seladelpar in 96 adults with primary biliary cholangitis (PBC), a rare liver disease. Participants had not responded well or could not tolerate the standard treatment. The goal was to see if seladelpar could lower a key liver enzyme (alkaline phosp…

This completed phase 4 trial tested whether adding SB Flavon (a blend of flavonoids, vitamin C, and L-arginine) to standard Tenofovir therapy can reverse advanced liver scarring (cirrhosis) and prevent liver cancer in 134 people with chronic hepatitis B. The study measured liver …

This phase 2 trial tested a combination of radiation, a targeted drug (olaparib), and an immunotherapy (pembrolizumab) in 9 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if this approach could shrink tumors that were not dir…

This study tests a new medicine called SHR-3167 against a standard insulin (insulin glargine) for people with type 2 diabetes. About 275 adults who are not on insulin yet, but take metformin (alone or with another diabetes drug), will receive either SHR-3167 or insulin glargine. …

This study tested whether a new form of interferon (IFN alfa-2b XL) combined with ribavirin works better and causes fewer side effects than the standard treatment for chronic hepatitis C (genotypes 1 or 4). 84 adults who had not been treated before or had not responded to previou…

This phase 2 study tested a combination of two drugs, pembrolizumab and ramucirumab, in 26 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if the combo could shrink tumors or slow the disease. Participants received both drugs …

Liver cirrhosis often causes muscle weakness and frailty, even in stable patients. This study tested whether a personalized diet with extra calories and protein, along with nutrition counseling, could improve muscle strength and quality of life. About 70 adults with stable cirrho…

This study tested two different approaches to help people recently released from jail or prison get connected to care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatme…

This study tested a new once-weekly injection called IcoSema, which combines two diabetes drugs (insulin icodec and semaglutide), against daily insulin glargine in 485 adults with type 2 diabetes whose blood sugar was not well controlled on oral medications. The goal was to see i…

This study tested a new drug called VR-AD-1005 for treating severe diarrhea caused by cholera. The drug aims to reduce fluid loss and the need for antibiotics, which could help fight antibiotic resistance. 150 adults with cholera took part, and researchers measured stool output a…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This study tested a combination of two drugs (atezolizumab and bevacizumab) given before surgery to people with liver cancer. The goal was to see how well the drugs shrink the tumor and how they affect the immune system. 40 participants were enrolled, and researchers also studied…

This study tested whether community health workers (trained members of the community) can help people with type 2 diabetes and food insecurity use a program that provides free fruits and vegetables. 104 Hispanic adults on Medicaid in Connecticut took part. The goal was to see if …

This phase III trial tested whether adding trastuzumab (Herceptin) to standard chemotherapy and radiation helps people with HER2-positive esophageal cancer. 203 patients were randomly assigned to get chemo and radiation with or without trastuzumab. The study measured how long pat…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tests a new, less invasive way to measure stomach acid using a small wireless capsule (SmartPill) that patients swallow. It compares the capsule's accuracy to the standard method, which involves a tube placed through the nose into the stomach. The study includes health…

This study tests a computer program called NIMIT-AI that analyzes routine blood test results over multiple doctor visits to detect liver scarring in people with fatty liver disease (MASLD). Unlike the current standard method (FIB-4), which often misses cases and fails with incomp…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study uses machine learning to tell apart diabetic kidney disease from other kidney diseases in people with type 2 diabetes. Researchers analyzed data from over 2,200 patients across 14 medical centers to build a model that uses routine clinical and lab information. The goal…

This study tested whether a special ultrasound technique (D-CEUS) can predict how well rectal cancer responds to chemotherapy and radiation. The goal is to identify good responders who might avoid major surgery and instead have a less invasive procedure. Only 2 people took part, …

This study tested whether a bedside ultrasound (POCUS) can accurately detect or rule out bowel obstruction in 150 adults with abdominal pain. Doctors performed the ultrasound after a physical exam, then compared results to a CT scan. The goal is to see if this quick, radiation-fr…

This study tests whether a software called ColoMaia II can help doctors find abnormal growths (polyps) in the colon during a routine colonoscopy. About 600 adults aged 40 to 80 having a screening or diagnostic colonoscopy will be randomly assigned to have the procedure with or wi…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tests whether a device called Fibroscan can diagnose fatty liver disease (steatosis) without needing a biopsy. Researchers will measure liver stiffness and viscosity in 72 people, including healthy volunteers and patients with confirmed fatty liver. Results will be com…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study looked at whether measuring a protein called calprotectin in the blood can help diagnose acute appendicitis. Researchers compared 74 patients with abdominal pain, some with confirmed appendicitis and others with non-specific pain. They measured calprotectin levels and …

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested whether a PET scan using a tracer called 18F-FAZA can measure low oxygen levels (hypoxia) in pancreatic cancer. Hypoxia can affect how the cancer grows and responds to treatment. 48 adults with pancreatic cancer received the scan, and researchers also collected …

This study looked at 639 adults with cirrhosis to see if a blood test called mSEPT9 can detect liver cancer (hepatocellular carcinoma) better than the current standard test (AFP). Participants gave an extra blood sample during routine care, and researchers compared how well each …

This completed Phase 3 trial tested a special PET-CT scan using a radioactive tracer called gallium-68 DOTATOC to find neuroendocrine tumors in the stomach, intestines, and pancreas. 69 adults with confirmed or suspected tumors received the scan. The goal was to see how accuratel…

This study tested whether a thermal camera could detect intestinal inflammation in 43 children with Crohn disease. The camera measures heat patterns on the belly, which may reflect underlying inflammation. Researchers compared these readings to standard stool tests and symptom sc…

This study looked at whether a 1-hour glucose test (using 50 grams of sugar) can accurately diagnose gestational diabetes, so pregnant women might not need the longer 3-hour test. Researchers analyzed results from 351 women with singleton pregnancies who had already completed bot…

This study tested a new rapid blood test (LumiraDx HbA1c) to see how well it measures blood sugar control in people with diabetes. Researchers compared it to a standard lab method in 177 adults. The goal was to see if the quick test is accurate enough for routine diabetes monitor…

This study tested whether a low-dose CT scan, enhanced with deep learning image reconstruction, can diagnose acute abdominal conditions as accurately as a standard CT scan. 246 adults with abdominal pain received both scans, and the low-dose version used less than 30% of the usua…

This study looked at how well a special biopsy method called EUS-FNB can diagnose hard-to-reach tumors in the abdomen, such as those near the bile duct or small intestine. Researchers reviewed data from 131 patients who had this procedure over 10 years. The goal was to see if thi…

This study tested a phone-based health coaching program for pregnant women with a higher body mass index. The goal was to help them gain a healthy amount of weight during pregnancy and prevent problems like gestational diabetes and later obesity in both mothers and children. Over…

This trial investigates whether a low-level diode laser can prevent or reduce severe mouth sores (mucositis) caused by radiation and chemotherapy in people with advanced head and neck cancer. Participants receive either real laser therapy or a non-functional placebo laser during …

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tests whether giving general practitioners a list of patients who have not completed colorectal cancer screening encourages those patients to get screened. Over 48,000 patients aged 50-74 are involved, and their doctors either receive the list or do not. The goal is to…

This study looked at two different exercise programs in 24 adults with prediabetes (higher than normal blood sugar but not yet diabetes). One group did short bursts of intense exercise (HIIT), the other did steady moderate exercise. Researchers measured changes in blood sugar, ch…

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This study tested whether a Mediterranean-style diet could help prevent episodes of diverticulitis, a painful digestive condition. 71 adults who had recently recovered from a diverticulitis attack were randomly assigned to follow either a Mediterranean diet or standard high-fiber…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested whether personalized reminders (like texts or emails) could encourage more people to return their at-home stool test kits for colon cancer screening. Over 2,100 adults aged 45 to 75 who had not yet returned their kit took part. The goal was to see if these gentl…

This trial compares two approaches to a nerve block (TAP block) for pain after colorectal cancer surgery. One group receives the standard numbing drug bupivacaine, while the other gets bupivacaine plus dexmedetomidine, a drug that may extend pain relief. The study measures pain s…

This study tests whether a mild electrical pulse to the ear (taVNS) can change how the brain and stomach interact in people with chronic indigestion or gastroparesis. Researchers will use brain scans and stomach electrical readings to see if the stimulation helps. The goal is to …

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study tests whether preserving the cystic artery during laparoscopic gallbladder removal can reduce complications like bleeding. Two hundred patients with symptomatic gallstones will be split into two groups: one where the artery is preserved and one where it is clipped or b…

This study tests whether a self-help app called MyDiaMate can reduce diabetes distress in adults with type 1 diabetes. Researchers are enrolling 660 participants across the Netherlands, UK, Spain, and Germany. The app aims to support mental health alongside usual care.

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…

This trial investigates whether inhaling a 50/50 mix of nitrous oxide (laughing gas) and oxygen can reduce pain when a nasogastric tube is placed in children aged 3 months to 3 years. The study includes children with mild to moderate dehydration from conditions like gastroenterit…

This study tests whether a 9-week relaxation response mind-body program can improve quality of life and reduce symptoms in people with irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). Participants attend weekly group sessions that include breathing exercises, m…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This study looked at whether giving fewer antibiotics after appendicitis surgery could lower the risk of antibiotic side effects without compromising patient safety. Over 650 adults who had surgery for simple or complicated appendicitis took part. The goal was to find the right b…

This trial compares two minimally invasive surgical techniques for removing the lower part of the stomach in people with gastric cancer: laparoscopy-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG). The goal is to see which approach leads to b…

This study tests whether acupuncture using tiny, semi-permanent needles can prevent diarrhea caused by the chemotherapy drug irinotecan in children with solid tumors. About 22 children will receive the acupuncture during their second round of chemo, and researchers will measure p…

This study tests whether a chair-based yoga program is practical and acceptable for people with functional dyspepsia or gastroparesis—conditions that cause nausea, vomiting, and stomach pain. Ten adults will attend two one-hour yoga sessions and practice at home. Researchers will…

This study tested custom-made insoles for people with diabetic foot to see if they improve balance and walking. Twenty-five participants aged 40 to 65 with early-stage diabetic foot issues were included. The insoles were designed using pressure measurements to offload high-pressu…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tested whether a remote nutrition coaching program is practical and well-liked by people with pancreatic cancer who are undergoing chemotherapy. Forty participants were asked to complete online food questionnaires and attend coaching sessions over 12 weeks. The goal wa…

This study tested a 21-step enhanced recovery protocol for children aged 10-18 undergoing elective gastrointestinal surgery. The protocol included things like shorter fasting times, early eating and moving, and less use of opioids. The goal was to see if it could shorten hospital…

This study tested whether a personalized home exercise program (walking three times a week and strength training with elastic bands twice a week) could improve fitness and strength in 30 adults waiting for a liver transplant. The goal was to see if better fitness before surgery c…

This study tested whether putting special elastic tape on the belly can help relieve severe pain, bloating, and nausea in people with advanced cancer who have bowel blockage and fluid buildup. 38 adults whose symptoms didn't improve after standard treatments were randomly assigne…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This study tests whether giving IV lidocaine during paraesophageal hernia surgery can reduce pain and speed recovery. About 50 adults having elective laparoscopic hernia repair will receive either lidocaine or a placebo alongside standard pain management. Researchers will measure…

This study tested whether a nerve block called the external oblique intercostal plane block can reduce pain after liver transplant surgery. Sixty-four adult patients received either the block or a sham procedure after surgery. Researchers measured how much morphine patients neede…

This study tested two types of radiation therapy for nasopharyngeal cancer (a cancer in the upper throat). One group received standard photon radiation plus carbon ion therapy, and the other received proton radiation plus carbon ion therapy. The main goal was to see which approac…

This study tested whether cognitive behavioral therapy (CBT) can reduce symptoms of gastroparesis, a condition where the stomach empties slowly, causing nausea, bloating, and pain. Twenty-seven adults with idiopathic gastroparesis received CBT sessions and were assessed before an…

This study looked at whether adding the drug nefopam to standard pain relief (morphine and paracetamol) can reduce the amount of morphine needed after major colon surgery. 80 adults having planned surgery for colon cancer or diverticulosis took part. The main goal was to measure …

This study looked at whether it's safe to stop changing wound dressings after gastrointestinal cancer surgery. Over 1,100 adults were randomly assigned to either have their wound dressing removed after 48 hours and left uncovered, or to receive routine dressing changes every two …

This study tested a group telehealth program called TREAT-ED for young adults aged 18-26 with type 1 diabetes. The program used video sessions led by a diabetes educator to teach self-management skills. The goal was to see if this approach could improve participation in diabetes …

This study explores whether practicing tai chi, a gentle mind-body exercise, can reduce symptoms of irritable bowel syndrome with constipation (IBS-C). Adults aged 18 to 70 with IBS-C will take part in tai chi sessions and report their symptom severity and satisfaction. The goal …

This study looked at whether starting feeding through a tube soon after esophageal cancer surgery can lower infection rates and help the gut work again. 70 adults who had their esophagus removed took part. The goal was to see if early feeding reduces complications like leaks and …

This study tested whether using warm, humidified carbon dioxide gas during low-pressure laparoscopic colorectal surgery reduces pain 24 hours after the procedure. 148 adults having surgery for colon or rectal tumors (benign or malignant) took part. One group received warm, moist …

This completed phase 1 study tested whether a weekly injection of retatrutide helps people with type 2 diabetes recover faster from low blood sugar (hypoglycemia). 80 participants on metformin and diet/exercise received either retatrutide or a placebo for 16 weeks. Researchers me…

This study tested a drug called M701, given directly into the belly, combined with standard cancer therapy, for people with malignant ascites (fluid buildup) from stomach, colon, or ovarian cancer. The goal was to see if M701 could delay the need for fluid drainage and improve su…

This study tested whether PepZinGI, a zinc-L-carnosine supplement, can reduce heartburn triggered by food. Fifty adults with frequent heartburn completed two one-week treatment periods (PepZinGI and placebo) remotely, using wearable devices and surveys to track symptoms and sleep…

This study tested whether a daily probiotic capsule containing two bacterial strains could reduce gastrointestinal symptoms like bloating, gas, and cramps in adults with lactose intolerance and methanogenic intestinal overgrowth. Twenty-two adults took either the probiotic or a p…

This study investigates whether laughter yoga can lower stress and improve quality of life for pregnant women diagnosed with gestational diabetes. Participants will practice laughter yoga sessions that combine breathing exercises, clapping, and playful activities. The trial measu…

This study tested whether Phycocare, a supplement made from spirulina, can reduce nerve damage caused by the chemotherapy drug oxaliplatin in people with metastatic gastrointestinal cancers. 73 participants took either Phycocare or a placebo daily for 9 months. The goal was to se…

This study tested whether a structured recovery plan (ERAS) could reduce infections and speed up recovery compared to standard care in 102 adults who had emergency abdominal surgery for a blocked or perforated bowel. Participants were randomly assigned to receive either the ERAS …

This study tested whether a daily probiotic called Weizmannia coagulans BC99 can improve symptoms of chronic constipation in adults. One hundred participants took either the probiotic or a placebo for a period, and researchers measured changes in stool consistency and gut bacteri…

This study tested two local anesthesia techniques—intraseptal and periodontal ligament—in 120 adults with controlled type 2 diabetes who needed a tooth pulled. The goal was to see which method numbs better and how it affects blood pressure and heart rate. Results help dentists ch…

This study compared two devices used during a procedure called ERCP to remove stones from the pancreatic duct in people with chronic pancreatitis. One group used a basket first, the other a balloon first. The goal was to see which tool cleared more stones. A total of 104 adults w…

This study looked at whether placing a bridge device during loop ileostomy creation reduces complications like infections or stoma problems. 166 adults having elective colorectal surgery took part. The goal was to see if the device improves outcomes or just adds difficulty to car…

This study tests whether cognitive behavioral therapy (CBT) can reduce anxiety and depression in people with inflammatory bowel disease (Crohn's disease or ulcerative colitis). Participants receive either psychologist-led or self-administered CBT over 8 weeks. The goal is to see …

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This trial investigates whether drinking coffee after pancreatic surgery can help the bowel start working again sooner. About 200 adults who had open pancreatic surgery will receive either regular coffee, decaf coffee, or water twice a day. The main goal is to see how quickly the…

This study compared two different surgical knives used during a procedure called POEM, which treats swallowing disorders by cutting throat muscles. 104 adults were randomly assigned to receive either a standard monopolar knife or a newer bipolar knife (Speedboat-RS2). The goal wa…

This study compared two methods of pain control after open stomach surgery: a nerve block (rectus sheath block) using bupivacaine versus standard epidural pain relief. Sixty adults scheduled for elective open gastrectomy were randomly assigned to one of the two groups. The resear…

Many colorectal cancer survivors lose muscle mass and strength after chemotherapy. This study tested whether adding creatine supplements to a 10-week resistance training program could help. Twenty-seven survivors participated, comparing those who took creatine with those who only…

This study tested whether a dietary supplement containing digestive enzymes (Galactol®) could reduce bloating after meals in people with irritable bowel syndrome (IBS). 300 adults were randomly assigned to take the enzyme supplement plus a low-FODMAP diet, or just the diet alone,…

This study looked at whether a swaddle blanket with a gentle abdominal band can reduce acid reflux, breathing pauses, heart rate drops, and low oxygen levels in premature infants. About 50 babies in the NICU were observed to see if the blanket helped. The goal was to find a simpl…

This study tested whether a numbing injection into the abdominal wall muscles (called a TAP block) can reduce pain for people with acute appendicitis waiting for emergency surgery. 105 adults in the emergency department received the block, and researchers measured how much pain m…

This study tested a drug called MT-7117 in 165 adults and adolescents (ages 12-75) with erythropoietic protoporphyria (EPP) or X-linked protoporphyria (XLP), conditions that cause severe pain from sunlight exposure. The goal was to see if the drug could delay the first symptoms o…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This study tested a web app called PrehabPal designed to help frail adults aged 65 and older prepare for colon cancer surgery. The app creates a personalized prehabilitation program and offers coaching. Researchers compared it to standard written instructions in 132 participants …

This study tested whether naldemedine, a drug already used for opioid-induced constipation, can also prevent nausea and vomiting when cancer patients start strong painkillers. 120 adults with cancer who were beginning opioid therapy took either naldemedine or a placebo for up to …

This study tested a small, disposable device that gently stimulates nerves in the ear to see if it could reduce the amount of strong painkillers (opioids) needed after open abdominal or pelvic surgery. 286 adults who had surgery for cancer or a liver transplant took part. The goa…

This study tested whether a self-regulation hypnotic intervention could help reduce pain and anxiety during brachytherapy for rectal cancer. Fifty-two adults were randomly assigned to receive either hypnosis training or standard care with pain and anxiety medication. Researchers …

This study looked at whether emergency gallbladder removal (laparoscopic cholecystectomy) can be performed as an outpatient procedure, meaning patients go home the same day. Researchers measured patient satisfaction using a simple scale. The study enrolled 25 adults with acute ch…

This study investigates whether PET-CT scans can accurately measure the radiation dose delivered by radioactive spheres during a liver cancer treatment called radioembolization. Researchers will compare scans taken before and after the procedure in patients with liver tumors. The…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This trial tests whether presenting a cancer screening appointment as a pre-selected default option (opt-out) makes people at high risk for lung or stomach cancer more likely to accept it, compared to a standard opt-in approach. Participants complete an online questionnaire and d…

This study follows adults in Zambia who have both HIV and chronic hepatitis B to track liver health over up to 10 years. Researchers aim to understand how current HIV treatments affect hepatitis B and liver damage, and to identify factors that lead to serious outcomes like liver …

This completed Phase 1 study looked at 27 people with and without pulmonary hypertension to learn more about how blood vessel problems contribute to the disease. Researchers used heart catheterization, imaging, and blood tests to find biomarkers and understand disease mechanisms.…

This study tests how well a dummy patch pump (with no electronics or medicine) sticks to the skin of 175 adults with insulin-requiring diabetes. The goal is to see if the adhesive can stay on for 5 to 7 days in different body locations. The results will help design a future comme…

This study investigates whether women who have completed breast cancer treatment have a higher chance of developing colorectal polyps or colon cancer. Researchers will perform screening colonoscopies in 216 asymptomatic breast cancer survivors and check for abnormal growths. The …

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

This study compares two simple educational tools—a written PDF and an audio podcast—to see which helps people with inflammatory bowel disease (IBD) learn more about their condition. Participants fill out questionnaires at the start and after three months to measure knowledge, sat…

This study followed 1,771 adults and children who received blood transfusions to check how safe the blood supply is. Researchers tested patients' blood for viruses like HIV and hepatitis before and after transfusion, and stored samples for future testing. The goal was to keep blo…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This study looked at whether having a special consultation with a radiotherapy technician (called a manipulator) helps cancer patients feel more informed about their treatment. Researchers enrolled 308 adults with various cancers who were getting radiation therapy. They compared …

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study investigates whether certain genetic differences make children with nephroblastoma (kidney cancer) or acute lymphoblastic leukemia (blood cancer) more likely to develop a serious liver condition called hepatic veno-occlusive disease (VOD) during chemotherapy. Researche…

This study investigates whether exercising in the morning versus the afternoon changes how the body handles blood sugar and burns fat in people with type 1 diabetes. Twelve adults with type 1 diabetes will do one hour of moderate exercise at 9 AM and another session at 4 PM on se…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study looked at whether using a physical activity screener, along with exercise coaching and self-monitoring, could help breast and colon cancer survivors become more active and spend less time sitting. Twenty survivors who had finished their main cancer treatment at least t…

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study enrolled 800 adults undergoing upper endoscopy to find risk factors and blood markers that could help diagnose and monitor eosinophilic esophagitis (EoE), a chronic allergic condition of the esophagus. Researchers compared people with and without EoE, collecting blood,…

This study tested whether a weekly electronic survey could help identify cancer treatment delays and racial differences. About 100 adults with newly diagnosed breast or colorectal cancer who hadn't started treatment yet filled out a short survey each week for 8 weeks. The goal wa…

This completed Phase 1 study looked at how the drug tirabrutinib is processed in people with mild, moderate, or severe liver impairment compared to healthy volunteers. Forty participants took a single oral dose, and researchers measured drug levels and safety. The goal was to und…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study investigates whether having an empty bladder reduces movement of the mesorectum (tissue around the rectum) during radiotherapy for rectal cancer. About 50 adults with rectal cancer receive planning CT scans and weekly CBCT scans under both empty and full bladder condit…

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study reviewed medical records of 148 adults admitted to the ICU with severe acute pancreatitis. The goal was to find risk factors for infected pancreatic necrosis, a serious complication that raises the risk of death. By identifying these factors, doctors hope to diagnose a…

This study looked at how a protein called IL-22 binding protein (IL-22BP) affects gut healing in people with Crohn's disease or ulcerative colitis. Researchers compared samples from 52 patients and healthy volunteers to understand how IL-22BP is regulated during disease flares. T…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This study looked at how chemotherapy affects the gut microbiome in 40 people with non-Hodgkin's lymphoma. Researchers collected stool samples to analyze changes in gut bacteria after treatment. The goal was to better understand why chemotherapy causes digestive problems like dia…

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study reviewed medical records of 320 children with biliary atresia, a rare liver disease, treated at hospitals in the northeastern U.S. between 2012 and 2021. The goal was to find which factors lead to better outcomes, such as avoiding liver transplant or clearing jaundice.…

This study looked at 153 people having liver cancer surgery to see if the type of anesthesia they received affected their recovery and immune response. Researchers compared different anesthesia methods and measured blood markers related to inflammation and immune cell activity. P…

This completed trial tested whether an AI system called Easy-ICD helps clinical coders assign ICD-10 codes to medical notes more quickly and accurately. Fifteen healthcare professionals coded 20 clinical notes both with and without the AI tool. The goal was to see if AI can reduc…

This completed study looked at a new antibody called anti-SIRPα as a potential immunotherapy for liver cancer. Researchers used blood and tissue samples from 30 liver cancer patients to see how the antibody affects immune cells. The goal was to understand whether blocking the SIR…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This study looked at 30 adults with Alpha-Gal syndrome, a condition where eating red meat causes allergic reactions. Participants ate cooked ground pork with or without a sugar called alpha-gal, then researchers checked for allergic reactions, gut symptoms, and changes in immune …

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This completed study surveyed over 2,500 appendicitis patients to understand their satisfaction and regret after choosing either surgery or antibiotics. Researchers aim to use this information to design decision-support tools that help future patients make choices aligned with th…

This completed study looked at how well Danish hospitals followed official guidelines for managing blood sugar in people with diabetes who had major, non-cardiac surgery. Researchers reviewed records from over 13,000 patients treated between 2017 and 2023. They focused on whether…

This completed study at Northwestern University brought together 35 patients, caregivers, and healthcare providers to discuss how to improve the identification and management of high blood sugar (hyperglycemia) and diabetes during hospital stays and when moving between care setti…

This study tested whether an online diabetes self-management program could help newly diagnosed adults with type 2 diabetes learn about their condition and improve health measures. 123 participants were split into online education, face-to-face education, or a no-education contro…

This completed study looked at 3000 patients having liver surgery to see if considering both medical and social factors could reduce how long they stay in the hospital. Researchers tracked things like complications and readmissions. The goal is to find ways to improve recovery an…

This study tests whether a lifestyle program held at senior centers can help older adults (age 60+) with type 2 diabetes improve their physical function and quality of life. About 20 participants will take part in the program, which includes education and activity sessions. The m…

This study looks at how being physically fit changes the bacteria in your gut. Researchers will compare the gut microbes of 30 healthy men, from inactive to elite athletes, by testing their exercise capacity and analyzing stool samples. The goal is to find connections between fit…

This study looked at 805 blood donors who tested positive for hepatitis C virus (HCV) to learn how the virus spreads and affects health over time. Researchers collected blood samples and health information to track infection and liver disease. The goal was to better understand HC…

This study tests whether a special capsule, called SIMBA, can safely collect fluid from the small intestine in people with liver cirrhosis. Participants swallow two capsules, which are later recovered from stool. Researchers will analyze the fluid to compare gut bacteria and meta…

This study creates a registry of adults with pancreatic exocrine insufficiency (PEI), a condition where the pancreas does not produce enough enzymes to digest food properly. Researchers at eight specialist centers across Europe will track how doctors prescribe pancreatic enzyme r…

This study checks if Fitbit devices can accurately measure heart rate, breathing, oxygen levels, sleep, and activity in patients admitted to a general medicine ward. About 100 adults will wear a Fitbit alongside standard monitors to see how well the wearable matches medical-grade…

This study looked at 294 women with deep endometriosis affecting the rectum. Researchers compared how patients felt after conservative surgery versus more radical bowel removal. The goal was to see which approach leads to fewer bowel and bladder problems and to find factors that …

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study tested whether people with chronic hepatitis B who had been on antiviral drugs for at least 4 years could safely stop treatment. Fifteen adults were monitored with monthly blood tests for 6 months after stopping, then every 3 months. The goal was to see if the virus st…

This study looked at liver fibrosis (scarring) in 127 HIV patients who had high liver enzymes while on antiretroviral therapy. Participants underwent tests like liver biopsy, ultrasound, and CT scans to measure liver damage. The goal was to understand how common and severe liver …

This study looked at whether it's possible to create a group of people with hepatitis C in Hai Phong, Vietnam, for future research. 300 adults with active hepatitis C took part. The goal was to see how many patients could be enrolled and how much information could be collected, n…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This study investigates whether gut microorganisms and their byproducts play a role in triggering severe flare-ups of ulcerative colitis. Researchers will compare patients hospitalized with severe colitis to those with milder symptoms, analyzing stool and blood samples over three…

This study looks at whether a narrowed inferior mesenteric artery (IMA) — seen on routine CT scans — is linked to a higher chance of anastomotic leakage after rectal cancer surgery. Anastomotic leakage is a serious complication where the surgical connection leaks. The study will …

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This study looked at how well a combination of nivolumab (an immunotherapy drug) and chemotherapy works for people with advanced or recurrent stomach cancer who haven't had treatment before. It involved 500 patients in Japan and tracked things like how long the cancer stayed unde…

This study developed a risk assessment scale to identify hospitalized patients likely to develop constipation. Researchers enrolled 516 adults staying at least 4 days in the hospital. The goal is to catch high-risk individuals early and start prevention measures.

This study checked how well two continuous glucose monitors (Dexcom G6 and FreeStyle Libre) work when oxygen levels are low. Thirty people with type 1 or type 2 diabetes took part. Researchers compared sensor readings to blood tests during controlled low-oxygen conditions to see …

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study looked at how the body processes a single dose of the drug etavopivat in people with mild, moderate, or severe liver disease compared to those with healthy livers. 48 adults took part. The goal was to understand how liver function affects drug levels and safety, which …

This early-phase trial tested the safety and tolerability of a drug called X842 in 39 healthy adults. Participants received either single or multiple doses of X842 to see how the body handles it and what side effects may occur. The study is complete and does not aim to treat any …

This study checked how many organ transplant recipients in the U.S. have antibodies to the hepatitis E virus, which can become chronic in people with weakened immune systems. Researchers enrolled 447 adults who had a liver, kidney, or small bowel transplant or were on a waiting l…

This study looked at 100 patients who had sleeve gastrectomy for severe obesity. Researchers checked how many developed Barrett's esophagus, a condition that can lead to esophageal cancer, five or more years after surgery. They also examined whether routine endoscopy (a camera te…

This study looked at 117 people with gastro-enteropancreatic neuroendocrine tumors (GEP-NETs) who received a type of radiation therapy called PRRT in German clinics. Researchers collected information on patient characteristics, treatment timing, and how PRRT was given in everyday…

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This study looked at how the drug ITF2357 is handled by the body in people with chronic liver disease compared to healthy volunteers. 24 adults received a single 50 mg dose by mouth. The goal was to measure drug levels and check safety, not to treat the liver condition.

This study follows up on 370 mothers and their children who were part of a larger trial testing metformin for gestational diabetes. Researchers want to see if taking metformin during pregnancy reduces the risk of diabetes, obesity, and heart problems in mothers up to 10 years lat…

This study looked at 180 people with liver cancer (hepatocellular carcinoma) who also had cirrhosis caused by either fatty liver disease or alcohol use. Researchers compared immune cells and gut bacteria in the liver to understand why cancer develops. The goal was to gather knowl…

This study looked at colon tissue samples from 200 people with irritable bowel syndrome (IBS) to understand why their gut barrier may be leaky. Researchers tested whether substances released by mast cells (a type of immune cell) can damage the gut lining and nerves. The goal is t…

This study investigates how differences in cell membrane voltage, caused by varying physical pressures inside a tumor, help colorectal cancer resist chemotherapy and evade the immune system. Using advanced lab models and tissue samples from 11 patients, researchers found that cel…

This completed study looked at how often hospitalized patients with cirrhosis experience pain. Researchers asked 30 patients about their pain, its location, intensity, and whether it was chronic. The goal was to highlight an often-overlooked issue and encourage better pain care f…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looks at how certain genetic changes (mutations) in the hepatitis B virus (HBV) affect the amount of virus in the blood of people with chronic infection. Researchers analyzed blood samples from 92 patients not on antiviral treatment. They found that specific mutations …

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study looked at how well people with self-reported fiber sensitivity tolerate different doses of soluble fiber. 141 adults took fiber or a placebo for 7 days, and researchers measured digestive symptoms and dropout rates. The goal was to find a dose that causes minimal disco…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study looked at whether the amount of three types of bacteria in stool samples is linked to gallbladder cancer risk. Researchers compared 230 South American patients with gallstones, some who had gallbladder cancer and some who did not. The goal was to confirm earlier findin…

This study followed 110 people with anal cancer to see if PET/CT scans can help doctors monitor the disease after initial treatment. Researchers tracked how long patients stayed cancer-free and measured metabolic activity in tumors. The goal is to find better ways to detect relap…

This study analyzed health records from nearly 195,000 people in Denmark, Sweden, and Norway to see if semaglutide (the drug in Ozempic and Rybelsus) is linked to a higher risk of pancreatic cancer. Researchers compared new users of semaglutide to new users of other diabetes medi…

This study looked at 98 adults with cirrhosis who were hospitalized for sudden worsening of their liver condition. Researchers measured different forms of iron in the blood to see how they relate to short-term death risk. The goal was to better understand iron's role in liver fai…

This study looks at whether placing a tube through the nose into the stomach (nasogastric tube) before surgery helps prevent breathing complications in infants with hypertrophic pyloric stenosis. The condition causes a blockage in the stomach outlet, leading to forceful vomiting.…

This study looked at 58 patients scheduled for pancreatic surgery due to suspected cancer. Researchers collected blood samples before and after surgery to measure immune function and inflammation. They then tracked complications like low blood pressure and infections. The goal wa…

This study followed 326 adults in Zambia with chronic hepatitis B for up to 5 years. Researchers tracked how the virus behaves, how many patients need treatment, and how many develop serious liver problems like cirrhosis or liver cancer. The goal was to better understand the dise…

This study looked back at the medical records of 27 patients with alcoholic hepatitis or sudden liver failure who received a treatment called MARS (a type of dialysis that cleans the blood). The goal was to see if MARS helped them survive without needing a liver transplant. Resea…

This study reviewed medical records of 500 adults treated for benign or malignant pancreatic and stomach diseases from 2005 onward. Researchers looked at overall survival after various treatments. The goal was to understand real-world outcomes, not to test a new drug or procedure…

This completed study looked at over 4.7 million trauma patients in the U.S. to see if those with liver cirrhosis have higher death rates and more infections. Researchers compared patients with and without cirrhosis using hospital records from 2010 to 2018. The goal was to better …

This study investigates whether analyzing bowel sounds with a computer can help measure disease activity in children with Crohn's disease. Researchers will record bowel sounds and compare them to a standard disease activity score. The goal is to find a noninvasive, painless way t…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study analyzed data from 500 Crohn's disease patients to create a tool that uses routine blood tests to predict the risk of needing intestinal surgery. The goal is to help doctors move from reacting to problems to preventing them. The model is still in early development and …

This study looked at health insurance records of over 75,000 people with cirrhosis in France to see if doctors follow guidelines for early liver cancer screening. The goal was to find out how often screening is done correctly and what factors might lead to missed or delayed diagn…

This study tested whether a special fiber supplement changes intestinal gas production over 36 hours in 29 adults. Participants included lean healthy people and those with insulin resistance or prediabetes who were overweight. Researchers measured gas levels, energy use, and gut …

This completed study observed 40 people with type 2 diabetes to find blood markers that could identify those at risk for a serious liver condition called NASH. Researchers measured liver stiffness and calculated scores like FIB-4 and ELF to see which patients might have liver sca…

This study looked at a new method to measure pressure in the liver's blood vessels during an endoscopic ultrasound. Researchers tested it in 100 adults with liver disease to see if it is safe and works well. The goal was to gather information, not to treat the disease.

This early-stage study tested different oral versions of the drug AZD5004 in 65 healthy adults. The goal was to see how the body absorbs and processes each version, and whether taking it with food changes those effects. The study is complete, but results are not yet available.

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This study looked at whether a new blood test called EPISPOT can predict how well chemotherapy works in people with metastatic colorectal cancer. Researchers measured circulating tumor cells in 168 patients before and during treatment. The goal was to see if early changes in thes…

This study followed 300 adults with functional dyspepsia (chronic stomach discomfort) who were taking standard medications like acid reducers or antidepressants. The goal was to see which factors—such as anxiety or sleep problems—might predict whether symptoms improve after 6 mon…

This study followed 250 chronic hepatitis B patients over age 30 who had detectable virus but normal liver enzyme levels (ALT). All had never received antiviral treatment before. Researchers measured how many became virus-negative after 48 weeks of antiviral therapy, and how many…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study tested whether a defined mixture of live gut bacteria from a healthy donor (MET-4) is safe and can be detected in patients with advanced oropharyngeal cancer receiving standard chemoradiation. Thirty participants took the bacteria by mouth daily for up to four weeks. T…

This completed study looked at how common celiac disease is in Spain and what factors might influence it. Researchers tested nearly 5,000 people of all ages across five regions using blood tests and biopsies. They aimed to understand why earlier studies found different rates in c…

This study looked at 120 South American patients with gallstones to confirm if certain bacteria in stool are linked to gallbladder cancer risk. Researchers measured three types of gut bacteria using advanced DNA sequencing. The goal was to validate earlier findings that these bac…

This completed study followed over 1,000 children with newly diagnosed type 1 diabetes and their healthy siblings for up to three years. Researchers collected genetic information, measured diabetes-related antibodies, and asked about environmental exposures. The goal was to build…

This study surveyed 231 adults with Lynch syndrome, an inherited condition that raises bowel cancer risk. Researchers wanted to find out how many people follow the UK recommendation of a colonoscopy every two years, and what makes it harder or easier to keep up with these check-u…

This study analyzed health records from nearly 75,000 people with type 2 diabetes in Hungary to see if different diabetes medications are linked to cancer risk. Researchers compared various drugs, including metformin, and adjusted for age, gender, and other health factors. The go…

This study looked at how repeatable and reproducible ADC maps are for measuring head and neck cancer in 58 adults. Participants had MRI scans using a standard method to see if results were consistent across different machines and sessions. The goal was to improve the reliability …

This study looked at how a diabetes medicine called ertugliflozin affects fat tissue around the heart. Researchers took fat samples from 61 adults with type 2 diabetes and heart disease during heart surgery. They tested the fat in a lab to see if the drug improved how the fat cel…

This study looked at 60 people having stomach cancer surgery to see if adding an epidural to general anesthesia changes how much muscle relaxant is needed and how fast it wears off. Half got general anesthesia alone, half got general anesthesia plus a thoracic epidural. Researche…

This study tested whether an educational video and action plan, called 'Prepare for Your Diabetes Care,' could help older adults (75+) with type 2 diabetes reduce their risk of dangerously low blood sugar. Over 12 months, 669 participants were randomly assigned to receive the int…

This completed study collected blood or saliva samples from 213 people with rare liver diseases to extract and store their DNA. The goal was to create a genetic resource that scientists can use in future studies to explore the causes, biomarkers, and genetic factors of these cond…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This study looked at how a new insulin (NNC0363-1063) interacts with a non-glucose carbohydrate (a type of sweetener) in 36 adults with type 1 diabetes. Participants received fixed doses of the insulin and different amounts of the carbohydrate in random order over 4 tests. The go…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at how a single dose of MY008211A tablets moves through the body in people with different levels of liver function. 24 adults (some with liver problems, some without) took part. The goal was to understand safety and how the liver affects drug levels, not to trea…

This study looked at 10 people with liver cancer (HCC) who were getting a standard treatment called chemoembolization (c-TACE). The goal was to see if mixing the chemotherapy drug doxorubicin with salt water or a contrast dye changes how the drug spreads inside the tumor. Researc…

This study looked at two faster ways to test for hepatitis C in people who recently injected drugs and visit needle exchange programs. One method uses a fingerstick test with results in about an hour, and the other uses a dried blood spot sent to a lab. The goal was to see if the…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at the safety of Bevacizumab-Pfizer Biosimilar, a drug used to treat colorectal cancer, by analyzing medical records from 1,000 patients in Japan. Researchers focused on side effects like bleeding, high blood pressure, and kidney problems. The goal was to unders…