New anesthesia combo could slash opioid use after hernia surgery
NCT ID NCT05953428
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a special anesthesia plan using dexmedetomidine and ketamine could reduce the need for opioid painkillers after laparoscopic hiatal hernia repair. Fifty adults having elective surgery were randomly assigned to receive either the opioid-sparing protocol or standard opioid-based anesthesia. The goal was to see if the new approach lowers opioid use at discharge and during recovery, while also tracking pain scores, nausea, and hospital costs.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Opioid Sparing Anesthesia Protocol (dexmedetomidine and ketamine)
What this could lead to
If successful, this could offer a way to manage pain after hiatal hernia surgery with fewer opioids, reducing the risk of addiction and side effects.
What could go wrong
This is a small, early-phase study with only 50 participants, so results may not apply to everyone. The non-opioid drugs also have their own side effects.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Endeavor Health
Evanston, Illinois, 60201, United States