Hiatus hernia

This study is testing a new robotic system that uses just one small incision to perform surgeries on the liver, pancreas, stomach, and esophagus. The goal is to see if this single-port approach is safe and works well for these complex operations. The study will enroll 35 adults w…

This study tests a new device called ECLIPSIUM that uses a dissolvable material to hold mesh in place during hernia surgery. The goal is to see if it reduces the chance of the hernia coming back compared to current methods. About 240 adults with small to medium-sized hernias will…

This study looks at a fetal surgery called FETO for babies with a severe diaphragmatic hernia, where organs move into the chest. The surgery places a balloon in the baby's windpipe to help the lungs grow, then removes it before birth. Researchers will compare 40 babies who get FE…

This study is tracking 245 hernia patients who receive the GORE ENFORM biomaterial mesh during surgery. The mesh is absorbable and used to reinforce the repair. Researchers will monitor hernia recurrence, infections, and other complications for up to two years. The goal is to see…

This study looks at how well a special mesh called OviTex works for fixing hiatal hernias. About 173 adults having robotic or laparoscopic hernia repair will be followed for 24 months to see if the hernia returns or if there are complications. The goal is to improve long-term out…

This study tests whether using Ovitex mesh during robotic surgery can reduce the chance of a large hiatal hernia coming back. About 100 adults with large or paraesophageal hernias will receive the mesh-reinforced repair. Researchers will track hernia recurrence and any mesh-relat…

This study looks at a new surgical method called PoRSHA for repairing large or recurrent paraesophageal hernias. The technique uses a flap made from the patient's own abdominal lining to reinforce the diaphragm opening, aiming to reduce hernia recurrence. About 100 adults with he…

This study tests whether a home-based program of exercise, weight loss, and health optimization before ventral hernia surgery can lower the chance of complications. 130 adults with hernias 4-8 cm wide will be randomly assigned to either the prehabilitation program or standard car…

This study compares a new nerve-sparing surgery (TLSA) to the standard surgery for people with hiatal hernia and GERD. The goal is to see if the new approach improves quality of life by avoiding damage to a key nerve. About 143 adults will take part in this randomized trial.

This study looks at whether using a biosynthetic mesh during robotic anti-reflux surgery can lower the chance that a hiatal hernia returns. About 200 adults with GERD who are already scheduled for surgery will be randomly assigned to receive either the standard repair or repair w…

This study compares two surgical techniques to repair a type of hiatal hernia (paraesophageal hernia) that often comes back. Researchers want to see if using a special mesh (Ovitex) is better than using sutures alone to prevent the hernia from returning within two years. About 16…

This study tests whether a one-time Botox injection into the side abdominal muscles, given 3-7 weeks before surgery, helps surgeons fully close large ventral hernias. About 188 adults will be randomly assigned to receive Botox or a placebo, and neither they nor their doctors will…

This study aims to collect medical data and biological samples (blood, urine, stool, and tissue) from up to 4,000 adults with known or suspected gastrointestinal diseases. Participants receive standard medical care at the NIH, and any extra samples or leftover tissue from procedu…

This study is collecting medical history, blood, and tissue samples from 7,000 people with esophageal disorders like GERD or Barrett's esophagus. Researchers hope to find genetic or protein markers that signal a higher risk of developing esophageal cancer. The goal is to enable e…

This study looks at whether removing the hernia sac during surgery for a paraesophageal hernia (a type of hiatal hernia) reduces tension on the repair, which might lower the chance of the hernia coming back. About 42 adults aged 18-80 having hernia repair will be enrolled. Resear…