Hiatus hernia

This Italian study tests whether injecting Botulinum Toxin A (Botox) into the abdominal muscles weeks before surgery can relax them, making it easier to close large hernias. Researchers will measure changes in CT scans and see if this reduces the need for complex surgical techniq…

This study tests whether injecting platelet-rich plasma (PRP) during hiatal hernia repair can lower the chance of the hernia coming back. About 150 adults with large hiatal hernias will be randomly assigned to get either standard surgery with mesh or surgery plus PRP. The main go…

This phase 2 trial compares two numbing medications—BDE (a mix of bupivacaine, dexamethasone, and epinephrine) and Exparel—to see which one reduces pain better after hernia surgery. About 128 adults having abdominal wall reconstruction will receive one of the drugs during a nerve…

This study looks at whether playing music before or during hernia repair surgery can help lower pain after the operation. About 308 adults having surgery at Bethesda Surgery Center will take part. Researchers will measure pain scores and how much narcotic pain medicine is needed …

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study looks at how hiatal hernia repair surgery changes the flexibility of the junction between the esophagus and stomach. Researchers will use a special balloon device during surgery to measure this flexibility in 25 adults. They hope to find links between these measurement…

This study follows 200 adults who had laparoscopic repair of a large hiatal hernia with mesh and anterior fundoplication. One year after surgery, participants get a CT scan to check for hernia recurrence, and their symptoms and quality of life are assessed. The goal is to compare…

This study is a registry that will review medical records of 1,000 patients treated for benign or malignant gastrointestinal diseases between 2005 and 2030. Researchers will look at survival, symptoms like heartburn and swallowing trouble, and quality of life. The goal is to lear…

This study follows 200 patients who had minimally invasive surgery for conditions like achalasia, GERD, or hiatal hernia. Each year, patients fill out questionnaires about their symptoms and quality of life, and doctors review their medical records. The goal is to understand how …