Can a blood injection stop hernias from returning?

NCT ID NCT05023174

Ongoing Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting platelet-rich plasma (PRP) during hiatal hernia repair can lower the chance of the hernia coming back. About 150 adults with large hiatal hernias will be randomly assigned to get either standard surgery with mesh or surgery plus PRP. The main goal is to see if PRP reduces hernia recurrence one year after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich plasma (PRP)
What this could lead to: If it works, this could reduce the chance of a hiatal hernia coming back after surgery, improving long-term outcomes for people with GERD.
What could go wrong: This is a small pilot study, so results may not be definitive. PRP is generally safe, but its effectiveness for this use is unproven, and the trial is not yet complete.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal reflux disease hiatus hernia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIATAL HERNIA LARGE REFLUX, GASTROESOPHAGEAL

Contacts and locations

Locations

Hoag Hospital

Newport Beach, California, 92663, United States
Keck Hospital of USC

Los Angeles, California, 90033, United States

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