Radiation before surgery may boost chemo for Stomach-Esophagus cancer

NCT ID NCT04375605

Completed Disease control Sponsor: Universitätsmedizin Mannheim Source: ClinicalTrials.gov ↗

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether adding radiation to chemotherapy before surgery helps people with a certain type of stomach-esophagus cancer live longer without the disease returning. About 342 adults with locally advanced but potentially removable cancer will receive either chemotherapy alone or chemotherapy plus radiation before surgery. The study aims to see which approach better prevents cancer progression or recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FLOT chemotherapy (5-fluorouracil, calcium folinate, oxaliplatin, docetaxel) plus radiation
What this could lead to: If adding radiation to chemotherapy before surgery improves outcomes, this could become a new standard treatment for this type of cancer.
What could go wrong: This is an early-stage comparison; adding radiation may increase side effects without clear benefit. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTROESOPHAGEAL JUNCTION ADENOCARCINOMA

Contacts and locations

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Locations

Unversity Hospital Mannheim

Mannheim, 68167, Germany

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