Can a One-Two punch of heat and drainage tame inoperable bile duct cancer?
NCT ID NCT05563870
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This trial is testing a personalized treatment for people with inoperable perihilar cholangiocarcinoma, a type of bile duct cancer. The approach combines radiofrequency ablation — using heat to destroy tumor tissue — with complete drainage of bile ducts, guided by both endoscopy and radiology. The goal is to see if this protocol is feasible, safe, and effective at controlling local disease and improving outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiofrequency ablation via endoscopy and radiology guidance
- What this could lead to
- If successful, this approach could offer a new way to control local tumor growth and improve survival in patients with inoperable bile duct cancer.
- What could go wrong
- This is a small, early-phase trial with only 26 participants. The procedure carries risks such as infection, bleeding, or pancreatitis, and it is unclear if it will improve overall survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gastroenterology Department, Colentina Hospital
Bucharest, 020125, Romania
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Liver transplant offers new hope for incurable bile duct cancer