Personalized cancer care: new trial aims to improve outcomes in biliary cancer

NCT ID NCT05615818

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether giving a targeted therapy after initial standard chemotherapy can help people with advanced biliary cancer live longer without their disease getting worse. Participants must have a tumor with a specific genetic change and stable disease after four cycles of chemo. They will be randomly assigned to receive either a matched targeted drug or continue standard care. The study aims to enroll 800 people across multiple countries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Futibatinib, Ivosidenib, Zanidatamab, Trastuzumab, Neratinib, Encorafenib, Binimetinib
What this could lead to: If successful, this could offer a more effective, personalized maintenance treatment option for people with advanced biliary cancer whose tumors have specific genetic changes.
What could go wrong: This is a large phase 3 trial, but it only includes patients whose tumors have certain genetic markers, which may limit who can benefit. The targeted therapies also have their own side effects and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer biliary tract neoplasm Biliary Tract Neoplasms distal biliary tract carcinoma gallbladder carcinoma intrahepatic cholangiocarcinoma perihilar intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT NEOPLASMS

Contacts and locations

Locations

APHM - CHU La Timone
NOT_YET_RECRUITING

Marseille, France
APHP - Hopital Henri Mondor
RECRUITING

Créteil, France
APHP - Hôpital Beaujon
RECRUITING

Paris, France
APHP - Hôpital Cochin
RECRUITING

Paris, France
APHP - Hôpital Paul Brousse
NOT_YET_RECRUITING

Villejuif, France
APHP - Hôpital Saint Antoine
RECRUITING

Paris, France
Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, United Kingdom
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, United Kingdom
CH Cornouaille
RECRUITING

Quimper, France
CH Valence
RECRUITING

Valence, France
CH de Pau
RECRUITING

Pau, France
CHRU de Nancy
RECRUITING

Vandœuvre-lès-Nancy, France
CHU Amiens Picardie
RECRUITING

Amiens, France
CHU Charles Nicolle
NOT_YET_RECRUITING

Rouen, France
CHU Dupuytren
RECRUITING

Limoges, France
CHU Estaing de Clermont Ferrand
RECRUITING

Clermont-Ferrand, France
CHU Grenoble Alpes
NOT_YET_RECRUITING

Grenoble, France
CHU Lille
RECRUITING

Lille, France
CHU Nantes - Hôtel Dieu
NOT_YET_RECRUITING

Nantes, France
CHU Poitiers
RECRUITING

Poitiers, France
CHU Toulouse
RECRUITING

Toulouse, France
CHU d'Angers
RECRUITING

Angers, France
CHU de Besançon
RECRUITING

Besançon, France
CHU de Bordeaux - Hôpital Haut-Leveque
NOT_YET_RECRUITING

Bordeaux, France
CHU de Dijon
RECRUITING

Dijon, France
CHU de Reims
RECRUITING

Reims, France
Castle Hill Hospital
NOT_YET_RECRUITING

Cottingham, United Kingdom
Centre Antoine Lacassagne
RECRUITING

Nice, France
Centre Eugène Marquis
RECRUITING

Rennes, France
Centre François Baclesse
RECRUITING

Caen, France
Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France
Centre Leon Bérard
NOT_YET_RECRUITING

Lyon, France
Centre Oscar Lambret
RECRUITING

Lille, France
Churchill Hospital
NOT_YET_RECRUITING

Oxford, United Kingdom
Clatterbridge Cancer Centre NHS Foundation Trust
NOT_YET_RECRUITING

Liverpool, United Kingdom
Clinique Privée Jean Mermoz
NOT_YET_RECRUITING

Lyon, France
Cliniques universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, Belgium
Cliniques universitaires de Bruxelles - Hôpital Erasme ULB
NOT_YET_RECRUITING

Brussels, Belgium
Groupe Hospitalier Diaconesses Croix Saint-Simon
NOT_YET_RECRUITING

Paris, France
Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard
RECRUITING

Grenoble, France
Gustave Roussy
RECRUITING

Villejuif, France
Guy's & St Thomas' Hospital
NOT_YET_RECRUITING

London, United Kingdom
Hammersmith Hospital
RECRUITING

London, United Kingdom
Hospices Civils de Lyon - Croix Rousse
RECRUITING

Lyon, France
Hôpital Européen
RECRUITING

Marseille, France
Hôpital Foch
RECRUITING

Suresnes, France
Institut Curie - Saint Cloud
NOT_YET_RECRUITING

Saint-Cloud, France
Institut Jean Godinot
RECRUITING

Reims, France
Institut Paoli Calmettes
RECRUITING

Marseille, France
Institut de Cancer de Montpellier
RECRUITING

Montpellier, France
Institut de Cancerologie de l'Ouest
NOT_YET_RECRUITING

Saint-Herblain, France
Institut de cancerologie de l'Ouest - Angers
RECRUITING

Angers, France
Institut du Cancer Avignon Provence
RECRUITING

Avignon, France
Institute Mutualiste Montsouris
RECRUITING

Paris, France
Maidstone Hospital
NOT_YET_RECRUITING

Maidstone, United Kingdom
Mount Vernon Cancer Centre
RECRUITING

Northwood, United Kingdom
North West Anglia NHS Foundation Trust
NOT_YET_RECRUITING

Peterborough, United Kingdom
Nottingham University Hospital
RECRUITING

Nottingham, United Kingdom
Queen Elizabeth Hospital
RECRUITING

Birmingham, United Kingdom
Royal Free Hospital
NOT_YET_RECRUITING

London, United Kingdom
Royal Marsden Hospital
RECRUITING

London, United Kingdom
Singleton Hospital
NOT_YET_RECRUITING

Swansea, United Kingdom
Southampton General Hospital
NOT_YET_RECRUITING

Southampton, United Kingdom
St James's Hospital
NOT_YET_RECRUITING

Leeds, United Kingdom
The Christie Hospital
NOT_YET_RECRUITING

Manchester, United Kingdom
Universitair Ziekenhuis Antwerpen (UZA)
NOT_YET_RECRUITING

Edegem, Belgium
Universitair Ziekenhuis Leuven
NOT_YET_RECRUITING

Leuven, Belgium
University College London
RECRUITING

London, United Kingdom
Weston Park Cancer Centre
NOT_YET_RECRUITING

Sheffield, United Kingdom

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