Personalized cancer care: new trial aims to improve outcomes in biliary cancer

NCT ID NCT05615818

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether giving a targeted therapy after initial standard chemotherapy can help people with advanced biliary cancer live longer without their disease getting worse. Participants must have a tumor with a specific genetic change and stable disease after four cycles of chemo. They will be randomly assigned to receive either a matched targeted drug or continue standard care. The study aims to enroll 800 people across multiple countries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Futibatinib, Ivosidenib, Zanidatamab, Trastuzumab, Neratinib, Encorafenib, Binimetinib

What this could lead to

If successful, this could offer a more effective, personalized maintenance treatment option for people with advanced biliary cancer whose tumors have specific genetic changes.

What could go wrong

This is a large phase 3 trial, but it only includes patients whose tumors have certain genetic markers, which may limit who can benefit. The targeted therapies also have their own side effects and may not work for everyone.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

biliary tract cancer biliary tract neoplasm Biliary Tract Neoplasms distal biliary tract carcinoma gallbladder carcinoma intrahepatic cholangiocarcinoma perihilar intrahepatic cholangiocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BILIARY TRACT NEOPLASMS

Contacts and locations

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Study contacts

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Phone: •••-•••-•••• Email: •••••@•••••

Locations

APHM - CHU La Timone
NOT_YET_RECRUITING

Marseille, France

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APHP - Hopital Henri Mondor
RECRUITING

Créteil, France

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APHP - Hôpital Beaujon
RECRUITING

Paris, France

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APHP - Hôpital Cochin
RECRUITING

Paris, France

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APHP - Hôpital Paul Brousse
NOT_YET_RECRUITING

Villejuif, France

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APHP - Hôpital Saint Antoine
RECRUITING

Paris, France

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Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, United Kingdom

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Bristol Haematology and Oncology Centre
RECRUITING

Bristol, United Kingdom

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CH Cornouaille
RECRUITING

Quimper, France

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CH Valence
RECRUITING

Valence, France

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CH de Pau
RECRUITING

Pau, France

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CHRU de Nancy
RECRUITING

Vandœuvre-lès-Nancy, France

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CHU Amiens Picardie
RECRUITING

Amiens, France

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CHU Charles Nicolle
NOT_YET_RECRUITING

Rouen, France

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CHU Dupuytren
RECRUITING

Limoges, France

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CHU Estaing de Clermont Ferrand
RECRUITING

Clermont-Ferrand, France

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CHU Grenoble Alpes
NOT_YET_RECRUITING

Grenoble, France

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CHU Lille
RECRUITING

Lille, France

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CHU Nantes - Hôtel Dieu
NOT_YET_RECRUITING

Nantes, France

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CHU Poitiers
RECRUITING

Poitiers, France

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CHU Toulouse
RECRUITING

Toulouse, France

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CHU d'Angers
RECRUITING

Angers, France

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CHU de Besançon
RECRUITING

Besançon, France

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CHU de Bordeaux - Hôpital Haut-Leveque
NOT_YET_RECRUITING

Bordeaux, France

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CHU de Dijon
RECRUITING

Dijon, France

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CHU de Reims
RECRUITING

Reims, France

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Castle Hill Hospital
NOT_YET_RECRUITING

Cottingham, United Kingdom

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Centre Antoine Lacassagne
RECRUITING

Nice, France

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Centre Eugène Marquis
RECRUITING

Rennes, France

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Centre François Baclesse
RECRUITING

Caen, France

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Centre Jean Perrin
RECRUITING

Clermont-Ferrand, France

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Centre Leon Bérard
NOT_YET_RECRUITING

Lyon, France

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Centre Oscar Lambret
RECRUITING

Lille, France

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Churchill Hospital
NOT_YET_RECRUITING

Oxford, United Kingdom

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Clatterbridge Cancer Centre NHS Foundation Trust
NOT_YET_RECRUITING

Liverpool, United Kingdom

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Clinique Privée Jean Mermoz
NOT_YET_RECRUITING

Lyon, France

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Cliniques universitaires Saint-Luc
NOT_YET_RECRUITING

Brussels, Belgium

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Cliniques universitaires de Bruxelles - Hôpital Erasme ULB
NOT_YET_RECRUITING

Brussels, Belgium

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Groupe Hospitalier Diaconesses Croix Saint-Simon
NOT_YET_RECRUITING

Paris, France

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Groupe hospitalier mutaliste de Grenoble - Institut Daniel Hollard
RECRUITING

Grenoble, France

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Gustave Roussy
RECRUITING

Villejuif, France

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Guy's & St Thomas' Hospital
NOT_YET_RECRUITING

London, United Kingdom

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Hammersmith Hospital
RECRUITING

London, United Kingdom

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Hospices Civils de Lyon - Croix Rousse
RECRUITING

Lyon, France

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Hôpital Européen
RECRUITING

Marseille, France

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Hôpital Foch
RECRUITING

Suresnes, France

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Institut Curie - Saint Cloud
NOT_YET_RECRUITING

Saint-Cloud, France

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Institut Jean Godinot
RECRUITING

Reims, France

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Institut Paoli Calmettes
RECRUITING

Marseille, France

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Institut de Cancer de Montpellier
RECRUITING

Montpellier, France

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Institut de Cancerologie de l'Ouest
NOT_YET_RECRUITING

Saint-Herblain, France

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Institut de cancerologie de l'Ouest - Angers
RECRUITING

Angers, France

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Institut du Cancer Avignon Provence
RECRUITING

Avignon, France

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Institute Mutualiste Montsouris
RECRUITING

Paris, France

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Maidstone Hospital
NOT_YET_RECRUITING

Maidstone, United Kingdom

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Mount Vernon Cancer Centre
RECRUITING

Northwood, United Kingdom

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North West Anglia NHS Foundation Trust
NOT_YET_RECRUITING

Peterborough, United Kingdom

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Nottingham University Hospital
RECRUITING

Nottingham, United Kingdom

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Queen Elizabeth Hospital
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Birmingham, United Kingdom

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Royal Free Hospital
NOT_YET_RECRUITING

London, United Kingdom

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Royal Marsden Hospital
RECRUITING

London, United Kingdom

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Singleton Hospital
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Swansea, United Kingdom

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Southampton General Hospital
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Southampton, United Kingdom

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St James's Hospital
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Leeds, United Kingdom

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The Christie Hospital
NOT_YET_RECRUITING

Manchester, United Kingdom

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Universitair Ziekenhuis Antwerpen (UZA)
NOT_YET_RECRUITING

Edegem, Belgium

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Universitair Ziekenhuis Leuven
NOT_YET_RECRUITING

Leuven, Belgium

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University College London
RECRUITING

London, United Kingdom

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Weston Park Cancer Centre
NOT_YET_RECRUITING

Sheffield, United Kingdom

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