Can a smaller incision offer the same cancer surgery outcome?

NCT ID NCT07744087

Recruiting now Disease control Sponsor: Nanfang Hospital, Southern Medical University Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This trial compares two surgical techniques for removing tumors near the pancreas (non-pancreatic periampullary adenocarcinomas). One method uses a single small incision plus one extra port, while the other uses the conventional five-port approach. The study will enroll 232 adults who need this surgery and will measure survival rates, complications, and recovery. The goal is to see if the less invasive technique is as effective as the standard procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Modified single-incision plus one-port laparoscopic pancreaticoduodenectomy (mSILPD+1)
What this could lead to: If successful, this less invasive surgery could offer a faster recovery and similar survival outcomes compared to the standard approach, potentially becoming a preferred option for eligible patients.
What could go wrong: This is a non-inferiority trial, meaning it aims to show the new method is not worse than the standard. It may not prove superiority, and the single-incision technique could be more challenging or carry different risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

carcinoma of the ampulla of vater distal biliary tract carcinoma duodenal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPULLARY CARCINOMA DISTAL CHOLANGIOCARCINOMA DUODENAL ADENOCARCINOMA

Contacts and locations

Locations

Nanfang Hospital, Southern Medical University
RECRUITING

Guangzhou, Guangdong, 510515, China
The People's Hospital of Jianyang City
RECRUITING

Jiancheng, Sichuan, 641400, China
The Second Affiliated Hospital of Army Medical University (Xinqiao Hospital)
RECRUITING

Chongqing, Chongqing Municipality, China
West China Hospital, Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China

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