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Can a supplement melt liver fat? a trial puts it to the test

NCT ID NCT07724067

Completed Disease control Sponsor: University of Bari Source: ClinicalTrials.gov ↗

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial is testing whether a special supplement containing silibin, glutathione, and vitamin E can reduce fat buildup in the liver and improve liver function in people with MASLD (a common fatty liver disease linked to metabolism). Over 42 adults, each person will take the supplement for three months and a placebo for three months, with a one-month break in between. The study uses ultrasound and a breath test to measure changes in liver fat and function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a dietary supplement containing silibin-enriched silymarin, reduced glutathione, and vitamin E, delivered using Enterosoma technology to improve absorption
What this could lead to
If effective, this supplement could offer a simple, non-drug option to reduce liver fat and improve liver function in people with MASLD.
What could go wrong
This is a small, early-stage trial with only 42 participants. The supplement may show no benefit over placebo, and results may not apply to everyone with MASLD.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fatty liver disease metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASLD (METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE)

Contacts and locations

Locations

  • University of Bari

    Bari, 70124, Italy

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