M.d. Anderson Cancer Center

This early-phase study is testing a personalized peptide vaccine for people with advanced pancreatic or colorectal cancer that has spread. The vaccine is made from each patient's own tumor cells and blood, aiming to help the immune system attack the cancer. The main goals are to …

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, and multiple myeloma that have returned or not responded to treatment. Participants receive chemotherapy followed by specially engineered natural killer (NK) cells from donated cord blood. The…

This phase II trial is testing a combination of two drugs—CPX-351 (a liposomal chemotherapy) and venetoclax (a targeted therapy)—in people with acute myeloid leukemia that has come back, not responded to treatment, or is newly diagnosed. The study aims to see if this combo can he…

This study tests whether radiofrequency ablation (using heat to destroy tumors) can safely lower high calcium levels in 20 adults with recurrent parathyroid cancer who cannot have surgery. Participants will have one to five neck tumors treated. The goal is to control the disease …

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This trial is testing a high-precision liver ablation technique that combines stereotactic guidance, CT imaging during liver angiography, and computer software to ensure complete tumor coverage. Up to 50 patients with colorectal liver metastases will be enrolled to see if this ap…

This early-stage study is testing the safety of two devices (NovoTTF-200M and NovoTTF-200A) that deliver electric fields to treat spinal tumors that have not responded to standard treatments like surgery or radiation. About 30 participants will receive the treatment, either alone…

This phase 2 trial tests a combination of drugs—horse anti-thymocyte globulin, cyclosporine, methylprednisolone, and a white blood cell booster—in 140 adults with aplastic anemia or low-risk myelodysplastic syndrome. The goal is to improve blood cell counts by killing overactive …

This early study tests whether adding special cells from donated umbilical cord blood (called mesenchymal stromal cells) to the drug ruxolitinib can help control severe graft-versus-host disease (GVHD) that hasn't improved with steroids. GVHD is a serious complication where donor…

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderate…

This phase 2 trial tests whether adding focused radiation (stereotactic radiosurgery) after initial drug therapy can better control brain metastases that have spread from other cancers. About 316 adults with low-risk brain metastases will receive standard cancer drugs first, then…

This phase 2 trial is testing a drug called zanidatamab in 20 people with early-stage, low-risk HER2-positive breast cancer. The drug is given intravenously, along with hormone therapy pills (letrozole or tamoxifen). The main goal is to see if the cancer disappears completely by …

This early-stage trial is testing a drug called tasquinimod, either alone or with the standard drug ruxolitinib, in 33 people with myelofibrosis (a type of bone marrow cancer). The goal is to see if the combination is safe and can help control the disease, especially in patients …

This early-phase trial is testing whether a combination of three drugs—adagrasib, cetuximab, and cemiplimab—can help control metastatic colorectal cancer that has a specific genetic change called KRAS G12C. The study will enroll 31 people whose cancer has not responded to at leas…

This early-phase trial tests whether giving specially engineered natural killer (NK) cells from donated cord blood, along with standard chemotherapy, is safe for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. The NK cells are designed to recognize and att…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a low dose of radiation to help th…

This study tests whether combining two drugs, blinatumomab and asciminib, can control Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It includes 40 adults who are not suitable for intensive chemotherapy. The goal is to check safety and how well the combi…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This study is testing whether giving radiation therapy along with immunotherapy before surgery can help people with rare sinonasal or anorectal melanoma. About 40 participants will receive combination immunotherapy (like ipilimumab with nivolumab) followed by radiation, then surg…

This early-phase trial is testing whether combining an immunotherapy drug (nivolumab) with chemotherapy (fluorouracil) and an immune stimulant (interferon alpha 2b) can safely shrink or control fibrolamellar liver cancer that cannot be removed by surgery. The study will enroll 15…

This phase 2 trial tests whether pravastatin (a cholesterol drug) or a combination of pentoxifylline and vitamin E can prevent lymphedema and fibrosis (swelling and scarring) caused by radiation therapy in head and neck cancer patients. About 295 adults with oropharyngeal cancer …

This early-phase trial tests whether combining two immune-boosting drugs, atezolizumab and tiragolumab, can help control bladder cancer when given before surgery to remove the bladder and tumor. It includes 10 adults with muscle-invasive bladder cancer who cannot take the standar…

This Phase 2 trial is testing a drug called ivonescimab for people with advanced clear cell renal cell carcinoma (a type of kidney cancer) that has already been treated. The study aims to see if ivonescimab can help control the cancer and to check for side effects. About 40 parti…

This study is for people with certain types of breast cancer (HER2-positive or triple-negative) who have a complete response to initial drug therapy. It tests whether they can safely skip surgery and only receive radiation, or skip radiation if surgery shows no cancer left. For a…

This phase 2 trial tests an optimized cord blood transplant for 35 patients with high-risk blood cancers (like leukemia) who relapsed after their first stem cell transplant. Participants receive chemotherapy followed by a cord blood infusion, plus drugs to prevent rejection. The …

This study tracks 150 gastrointestinal cancer patients with a narrowed portal vein who receive a stent to keep the vein open. Researchers will monitor how long the stent stays clear, changes in liver function, nutrition, bleeding risk, and quality of life. The goal is to see if s…

This phase 2 trial tests two drugs, tucatinib and T-DM1, in 30 people with HER2-positive solid tumors that have spread to the brain. The goal is to see if the combination can help control the cancer. Participants will receive both drugs and be monitored for side effects and tumor…

This Phase 3 trial tests whether giving apalutamide (a hormone therapy) in a personalized way can reduce fatigue and other side effects in men with prostate cancer who have detectable PSA after prostate removal. About 120 men will receive either standard therapy or a tailored apa…

This early-phase trial is testing a combination of two oral drugs—venetoclax and decitabine/cedazuridine—in children and teens whose acute myeloid leukemia (AML) has returned or not responded to prior treatment. The study aims to find the safest dose and check for early signs tha…

This early-stage trial tests whether specially grown donor T cells can safely treat adenovirus infections in people with weakened immune systems, such as cancer patients. The cells are designed to target and kill the virus. The study will check for side effects and see if the inf…

This phase 2 trial is testing whether a combination of three drugs—acalabrutinib, venetoclax, and obinutuzumab—can better control chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) that has come back or is resistant to treatment. About 168 adults with high-ri…

This phase 2 trial is testing whether adding the drug glofitamab after an initial treatment with acalabrutinib (or zanubrutinib) and rituximab can better control high-risk mantle cell lymphoma (MCL) in people who have not been treated before. The study will enroll 30 participants…

This early-stage trial is testing a combination of two oral drugs, ziftomenib and quizartinib, for adults with relapsed or hard-to-treat acute myeloid leukemia (AML) that has certain genetic markers. The study will enroll 44 participants to check safety and find the best dose. Th…

This early-phase trial tests a combination of two drugs—REGN5678 and cemiplimab—in 60 men with metastatic castration-resistant prostate cancer that has progressed after at least two prior treatments. The goal is to find the safest dose and see if the drugs can help control the ca…

This clinical trial is testing whether adding the drug venetoclax to standard chemotherapy before a stem cell transplant can improve outcomes for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study will enroll 324 participants and aims …

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can shrink advanced squamous cell cancers of the nasal cavity and sinuses better than chemotherapy alone. About 35 adults with newly diagnosed, untreated stage II to IVb disease …

This phase 2 trial tests the drug zanzalintinib given before surgery in 45 people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors, making surgery more effective. Researchers will also monitor safety and side effects.

This phase II trial tests whether giving patients personalized natural killer (NK) cells after chemotherapy and a cord blood transplant can help prevent their blood cancer from returning. The study includes 100 people with various blood cancers like leukemia, lymphoma, and myelom…

This early-phase trial is testing whether combining two drugs, naxitamab and sacituzumab govitecan, is safe and effective for people with metastatic triple-negative breast cancer. The study aims to find the best dose and check for side effects in 31 adults whose cancer has spread…

This phase 2 trial tests whether adding metal detoxification drugs (DMSA and Ca-EDTA) to standard therapy can improve outcomes for adults with intermediate- to high-risk acute myeloid leukemia (AML). Researchers believe lowering metal levels in blood and bone marrow may help cont…

This early-phase trial tests whether adding natural killer (NK) cells from a healthy donor to the standard drugs azacitidine and venetoclax can help control acute myeloid leukemia (AML). About 32 adults with relapsed or hard-to-treat AML will receive the combination. The main goa…

This phase 2 trial tests whether giving two drugs, cemiplimab and cetuximab, before salvage surgery can help control recurrent oral cavity squamous cell carcinoma. The study will enroll 17 adults whose cancer has returned at least 3 months after prior treatment. Researchers will …

This study tests a combination of four drugs (venetoclax, cladribine, low-dose cytarabine, and azacitidine) in adults aged 50 and older with untreated acute myeloid leukemia (AML). The goal is to see if this approach can achieve complete remission and improve survival. Participan…

This early-phase trial tests the safety and best dose of a drug called ulixertinib when given with cetuximab and/or encorafenib. It is for people with advanced colorectal cancer that has spread and who have already tried treatments targeting EGFR or BRAF. The goal is to find a do…

This study tests whether combining two antiviral drugs (baloxavir and oseltamivir) can shorten or reduce the severity of influenza in people who have had a stem cell transplant or have blood cancer. About 60 participants will receive the drug combination or standard care. The goa…

This study tests whether combining the drug enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. About 41 adults with urothelial carcinoma of the bladder are being enrolled. The main goal is to check safety and side effects.

This early-stage trial tests the safety of a new drug, NP-101, in about 35 adults with advanced solid tumors that have stopped responding to standard treatments. The study aims to find the right dose and check for side effects. It is not expected to cure the cancer, but may help …

This early-phase study tests a combination of two drugs, pembrolizumab and lenvatinib, in about 15 people with advanced stomach or gastroesophageal cancer that has spread or can't be surgically removed. Pembrolizumab helps the immune system attack cancer cells, while lenvatinib b…

This study tests whether combining two drugs, niraparib and dostarlimab, can control advanced cancers that have spread to the brain. It includes 120 adults with certain cancer types like BRCA-mutated or lung cancers. The goal is to see if the treatment shrinks or stabilizes brain…

This early-stage study tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive standard heart failure care alone or with st…

This early-phase study tests a new treatment called JV-213 for adults with B-cell lymphoma that has come back or not responded to other treatments. JV-213 uses the patient's own immune cells, modified to attack cancer cells. The main goal is to find the safest dose and monitor si…

This study tests a new treatment using cord blood-derived NK cells that are genetically engineered to recognize and attack multiple myeloma cells. It is for patients whose cancer has returned or not responded to standard therapies. The goal is to find a safe dose and see if these…

This study tests whether a blood test that detects tiny bits of tumor DNA (ctDNA) after liver surgery can help doctors decide who needs more chemotherapy. About 120 adults with colorectal cancer that spread to the liver will have their ctDNA levels checked after surgery. Those wi…

This study tests a new treatment using specially engineered immune cells (TROP2 CAR-NK) delivered directly into the abdomen. It is for people with ovarian cancer that no longer responds to platinum chemotherapy, as well as certain rare ovarian and pancreatic cancers. The goal is …

This study looks at whether adding radiation to the liver can improve outcomes for people with advanced intrahepatic cholangiocarcinoma, a type of bile duct cancer that has spread. About 60 adults with at least one liver tumor 3 cm or larger will receive either standard therapy a…

This study provides compassionate access to a device that selects CD34+ cells (special blood-forming cells) for patients whose stem cell transplant did not work well. The goal is to improve graft function and monitor for graft-versus-host disease. Up to 200 participants will rece…

This study looks at whether eating a diet rich in prebiotic foods (like fiber) can improve how well the first immunotherapy treatment works in people with advanced melanoma that cannot be removed by surgery. About 75 adults will eat a special diet while starting standard immunoth…

This study tests a combination of two drugs, azacitidine and enasidenib, in people with a high-risk blood cancer called myelodysplastic syndrome (MDS) that has a specific genetic change (IDH2 mutation). The goal is to see if the drugs can stop cancer growth and improve outcomes. …

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain tumors in people with breast cancer, lung cancer, or other solid tumors that have spread to the brain. About 87 participants will receive the combination therapy. The goal is to see how well the tr…

This early-phase study tests a combination of two drugs, alpelisib and pembrolizumab, in people with metastatic breast cancer or melanoma that has spread. The main goal is to find a safe dose and watch for side effects. About 50 adults whose cancer has worsened after standard tre…

This early-stage trial is testing the drug talazoparib together with radiation therapy for people whose gynecologic cancer (ovarian, endometrial, cervical, or related cancers) has come back. The main goal is to find the safest dose and see how well the combination works at shrink…

This early-phase study tests a new drug called IACS-6274, given alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers) that haven't responded to standard treatments. The main goal is to find the safest dose and under…

This early-stage study tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat advanced vulvar cancer that has spread and cannot be surgically removed. About 25 adults with stage II-IVA vulvar cancer will take part. The mai…

This study tests a combination of ultra-low-dose radiation to the whole skin and a drug called brentuximab vedotin for people with mycosis fungoides, a rare type of skin lymphoma. The treatment is given every three months for a year. The goal is to see if this approach can better…

This study tests whether very low doses of radiation can control skin lesions in people with mycosis fungoides, a type of lymphoma. About 50 adults with at least one skin lesion will receive targeted radiation. The goal is to shrink or control the treated lesions while reducing s…

This study is for people with certain blood cancers (like acute myeloid leukemia) that have a specific genetic change called a FLT3 mutation. The cancers have either come back or not responded to prior treatment. The trial tests a combination of three drugs—azacitidine, venetocla…

This study is for people with stage IV cancer that has started to grow in only a few new spots (oligoprogression). Researchers want to see if treating those spots directly with radiation, surgery, or other local methods can help control the disease better than just switching to a…

This phase 2 trial is testing whether the drug sacituzumab govitecan can help control salivary gland cancer that has come back or spread to other parts of the body. About 30 adults with this rare cancer will receive the drug through an IV. The study is currently recruiting at MD …

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy (carboplatin and paclitaxel) can improve outcomes for people with stage 1 triple-negative breast cancer. The study will enroll 28 participants at MD Anderson Canc…

This early-phase trial is testing whether people with stage II-III rectal cancer can safely avoid surgery by first receiving chemotherapy and then being closely monitored. The goal is to see if the rectum can be preserved without harming survival. Around 120 participants will be …

This early-phase trial is testing whether the immunotherapy drug nivolumab can be safely given both into a vein and directly into the fluid around the spinal cord for people with melanoma or lung cancer that has spread to the lining of the brain. About 75 participants will receiv…

This phase 2 trial is testing whether combining two immunotherapy drugs, nivolumab and relatlimab, can help control melanoma that has spread to the brain. About 30 adults with active brain metastases will receive the drugs by IV. Researchers will monitor side effects and how well…

This phase 2 trial tests whether combining surgery to remove visible tumor with heated chemotherapy delivered directly into the abdomen can help women whose mucinous ovarian cancer has returned. About 30 participants will receive this intensive treatment. The goal is to see how l…

This phase 2 trial tests whether adding cediranib or ceralasertib to olaparib can overcome resistance in BRCA-mutated advanced breast cancer. About 60 participants with HER2-negative, BRCA-positive tumors that have progressed on prior therapy will receive one of the two drug comb…

This phase II trial tests whether the drug loncastuximab tesirine (Lonca) can help control large B-cell lymphoma in patients who had only a partial response after CAR T-cell therapy. About 30 adults with relapsed or refractory lymphoma will receive Lonca intravenously. The main g…

This early-phase trial is testing a new combination of three drugs—cyclophosphamide, axatilimab, and retifanlimab—in people with metastatic triple negative breast cancer that has stopped responding to standard treatments. The goal is to find the safest and most effective doses. T…

This phase 2 trial tests whether a CAR T-cell therapy called obecabtagene autoleucel (obe-cel) can help control high-risk B-cell acute lymphoblastic leukemia (ALL) after initial treatment. The study enrolls 30 adults with newly diagnosed high-risk ALL who are in first remission. …

This study tests whether a mask that pushes air into the lungs (non-invasive ventilation) can reduce the need for a breathing tube in cancer patients with respiratory failure. About 256 participants will be randomly assigned to receive either the mask or standard high-flow oxygen…

This phase II trial is testing two oral drugs, binimetinib and encorafenib, in 35 adults with advanced melanoma that has spread to the brain. The drugs block enzymes that help cancer cells grow. The study aims to see if this combination can control the disease and improve surviva…

This phase II trial tests whether combining two drugs—azacitidine and pembrolizumab—can help people with Hodgkin's lymphoma that has come back or stopped responding to treatment. About 24 participants will receive both drugs by IV. The main goal is to see how many patients respon…

This phase 1 trial tests an oral chemotherapy drug (decitabine) alone or combined with other targeted drugs to prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. About 125 adults whose AML is under control but who are not ready for a s…

This phase 2 trial is testing whether adding isatuximab to lenalidomide after a stem cell transplant can better control high-risk multiple myeloma. About 61 adults aged 18 to 72 will receive the drug combination. The main goal is to check safety and side effects.

This early-stage trial tests the drug talazoparib together with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combinations can help control tumor growth. Ab…

This phase 2 trial tests whether the drug belzutifan can control metastatic clear cell renal cell carcinoma in people who are currently just being watched (active surveillance). Researchers will compare belzutifan to continued observation in 78 adults with slow-growing disease wh…

This early-stage trial is testing whether two drugs that lower metal levels in the body can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) respond better to chemotherapy. The study will enroll 58 adults and aims to find the safest dose and check f…

This study tests whether adding chemotherapy (cisplatin and etoposide) to standard mitotane therapy works better than mitotane alone after surgery for adrenal cancer that is likely to come back. About 240 adults with stage I-III adrenal cancer at high risk of recurrence will be r…

This study tests a combination of three drugs—ivosidenib, venetoclax, and azacitidine—in people with blood cancers like acute myeloid leukemia (AML) that have a specific IDH1 mutation. The goal is to see if the combo is safe and works better than current treatments. About 96 adul…

This study is testing a combination of oral medications for acute myeloid leukemia (AML) that has returned or not responded to treatment. The drugs include decitabine/cedazuridine, venetoclax, and either ivosidenib or enasidenib. The goal is to see if this combination is safe and…

This study tests whether adding a prebiotic-rich diet to standard immunotherapy before surgery can improve immune response in people with melanoma. About 35 adults with resectable melanoma will receive prebiotic snack packs and diet counseling alongside their usual treatment. The…

This phase III trial tests whether giving focused radiation before surgery is better than after surgery for people with cancer that has spread to the brain. About 180 participants will be randomly assigned to one of the two timing schedules. The main goal is to see which approach…

This phase 2 trial is testing a combination of four chemotherapy drugs—cladribine, idarubicin, cytarabine, and venetoclax—in people with acute myeloid leukemia, high-risk myelodysplastic syndrome, or blast-phase chronic myeloid leukemia. The goal is to see if this mix can kill ca…

This study follows 50 people who choose radiofrequency ablation (RFA) instead of surgery for benign thyroid nodules, indeterminate nodules, or low-risk papillary thyroid cancer. Researchers track how well the treatment works over time and how it affects quality of life. Participa…

This phase 2 trial is testing a drug called ivonescimab in 24 people with advanced cutaneous squamous cell carcinoma (a type of skin cancer) or castration-resistant prostate cancer. The goal is to see if the drug can help control the cancer and to check for side effects. Particip…

This phase 2 study is testing whether adding talazoparib to standard hormone therapy and enzalutamide can help men with prostate cancer that has spread to lymph nodes. About 30 participants will take the drug combination before having their prostate removed. The goal is to see if…

This study tests a new treatment using immune cells (NK cells) from donated cord blood that are engineered to target a protein called CD5 found on certain cancer cells. The treatment is given after chemotherapy to prepare the body, and the goal is to see if it is safe and effecti…

This phase 2 study tests asciminib, a daily pill, in 40 adults with chronic myeloid leukemia whose first treatment with a TKI drug didn't work or caused side effects. Participants take asciminib for up to 2 years. The main goal is to see how many achieve a major molecular respons…

This study tests whether adding a drug called NBTXR3 to radiation and immunotherapy can help control advanced solid tumors that have spread to the lung or liver. About 40 adults with incurable metastatic cancer will receive the combination to see if it shrinks tumors and how safe…

This study tests a new drug called valemetostat combined with two standard treatments (rituximab and lenalidomide) for adults with follicular lymphoma that has returned or not responded to prior therapy. The goal is to find a safe dose and see how well the combination works. Abou…

This study tests whether adding belantamab mafodotin to lenalidomide after a stem cell transplant can turn residual myeloma cells undetectable in patients with newly diagnosed multiple myeloma. About 94 adults who have already had a transplant will receive the combination therapy…

This study tests whether the drug asciminib can help control chronic myeloid leukemia (CML) in people who were recently diagnosed. About 50 adults will take the drug, and researchers will watch for side effects and how well it works. The goal is to manage the disease, not cure it…

This study tests an oral drug called larotrectinib in people aged 16 and older whose advanced solid tumors have too many copies of the NTRK gene. The drug blocks enzymes that help cancer cells grow. Researchers will measure how many patients' tumors shrink or disappear.

This early-phase trial is testing whether combining two drugs—atezolizumab (an immunotherapy) and cabozantinib (a targeted therapy)—can safely shrink tumors and improve outcomes for adults with glioblastoma that has returned after standard treatment. The study involves about 6 pa…

This study looks at whether stem cell transplant patients can safely stop taking a medicine called letermovir earlier if their immune system shows a strong response to CMV. About 105 participants will be monitored to see if this approach reduces infections and side effects compar…

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 25 participants will receive the drug after transplant, along with s…

This study tests an experimental drug called puxitatug samrotecan (AZD8205) in 28 adults with an aggressive form of adenoid cystic carcinoma (ACC-I) that has spread or cannot be removed by surgery. The goal is to see if the drug is safe and effective against this rare cancer. Par…

This study tests two drugs, atezolizumab and cabozantinib, in 40 adolescents and young adults (ages 12 and up) with osteosarcoma that has come back or spread. Atezolizumab helps the immune system attack cancer cells, while cabozantinib blocks enzymes that help tumors grow. The go…

This study tests a drug called AMB-05X in 15 people with colorectal cancer who have completed curative treatment but still have traces of cancer DNA in their blood (ctDNA-positive) with no visible tumors on scans. The goal is to see if the drug can safely control or eliminate the…

This study is for adults with high-risk soft tissue sarcoma that can be removed by surgery. It tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy, radiation, and surgery can delay the cancer from coming back. About 50 participants will receive the …

This study is for people with a high-risk form of smoldering multiple myeloma, an early stage of blood cancer. The purpose is to test a drug called belantamab mafodotin to find the safest dose and see if it can control the disease. About 30 participants will receive the drug, and…

This study tests a chemotherapy drug called paclitaxel, given directly into the abdominal cavity, for people with appendix cancer that has spread. The goal is to find a safe dose and see if it helps control the disease. About 39 adults with advanced appendix cancer that cannot be…

This study tests a new treatment that uses specially designed immune cells (AD-PluReceptor-NK cells) combined with a drug called tafasitamab and chemotherapy to control autoimmune diseases like systemic sclerosis, lupus, and lupus nephritis. The study has three parts: first check…

This early-stage trial is testing a chemotherapy drug called CPX-351 in people with high-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) that came back or didn't respond to standard treatment. The goal is to find the best dose that is safe and to se…

This study tests whether adding the drug niraparib to standard hormone therapy after radiation helps control high-risk prostate cancer that hasn't spread far. About 200 men will receive either hormone therapy alone or hormone therapy plus niraparib. The goal is to see if the comb…

This study tests whether two drugs, fruquintinib and tislelizumab, can control leftover cancer cells in people with colorectal cancer who have completed chemotherapy but still show signs of minimal residual disease (MRD) on a blood test. About 20 adults with stable disease will r…

This study tests a drug called ivonescimab in people with a rare breast cancer (invasive lobular carcinoma) that has spread and stopped responding to hormone therapy. The goal is to see if the drug can help control the cancer. About 29 adults will take part, and researchers will …

This study tests whether adding the antibiotic metronidazole to standard cancer therapy can reduce levels of harmful bacteria (F. nucleatum) in the gut of people with rectal cancer. About 60 adults with locally advanced rectal cancer will receive either standard therapy alone or …

This study tests whether alternating two different drug combinations can help control higher-risk myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). About 60 adults who have not responded to or relapsed after standard treatment will receive cladribine, low…

This study tests whether adding celecoxib to TAS-102 can clear tiny amounts of cancer DNA (ctDNA) in the blood of colorectal cancer patients who have finished standard chemotherapy. About 25 adults with stage II-IV colorectal cancer and no visible tumors on scans will take TAS-10…

This study compares two surgical approaches for people with advanced ovarian, fallopian tube, or primary peritoneal cancer who have received chemotherapy before surgery. One group will have minimally invasive surgery (small incisions) and the other will have standard open surgery…

This early-phase study tests a combination of four drugs (venetoclax, dexamethasone, bortezomib, and daratumumab) for teens and young adults aged 12 to 30 whose T-cell acute lymphoblastic leukemia or lymphoma has returned or not responded to prior treatment. The main goal is to c…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma brain tumor has returned after standard treatment. Phase 1 finds the safest dose, and Phase 2 checks if that dose can control the tumor. The goal is to manage the disease, not cure it.

This early-phase trial tests a new treatment made from specially engineered cord blood cells (TROP2-CAR-NK cells) in adults with advanced solid tumors that have not responded to standard therapies. The main goal is to find a safe dose and monitor side effects. Up to 54 participan…

This study tests whether the drug ubamatamab, alone or with cemiplimab, can help control rare cancers like renal medullary carcinoma and epithelioid sarcoma. About 40 adults with advanced or metastatic disease will receive the treatment to check safety and effectiveness. The goal…

This study is for people with a specific type of lung cancer (non-squamous non-small cell) that has a KRAS G12C mutation and can be removed with surgery. It tests whether giving a targeted drug (sotorasib) plus standard chemotherapy before surgery can shrink the tumor more than c…

This study tests a new treatment using specially engineered immune cells (called CAR-NK cells) from donated cord blood, given alongside chemotherapy, for people with advanced kidney cancer, mesothelioma, or bone cancer. The goal is to find a safe dose and see if it helps control …

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell non-Hodgkin lymphoma. The goal is to see if this mix can shrink tumors or stop the cancer from growing. About 36 adults who have already tried o…

This study tests a CAR T-cell drug called brexucabtagene autoleucel in 40 adults with B-cell acute lymphocytic leukemia that has come back or is hard to treat. Participants first receive standard chemotherapy drugs to reduce cancer, then get the CAR T-cells. The goal is to see if…

This study tests a new all-oral combination of three drugs (SNDX-5613, decitabine/cedazuridine, and venetoclax) for people with acute myeloid leukemia (AML) or related leukemia. The goal is to find the best dose and see if it helps control the disease. It is for newly diagnosed p…

This study tests whether giving high-dose ruxolitinib and busulfan before a stem cell transplant can reduce spleen size and help the transplant work better in people with myelofibrosis. About 30 adults aged 18 to 75 with an enlarged spleen and a matched donor will take part. The …

This study tests a new treatment plan for people with a rare and aggressive blood cancer called BPDCN. The plan combines two targeted drugs (tagraxofusp and venetoclax) with standard chemotherapy to kill cancer cells. The goal is to see if this combination can control the disease…

This study tests whether the chemotherapy drug paclitaxel, given before and after stomach removal surgery, can improve outcomes for people with gastric cancer that has spread to the lining of the abdomen. About 30 adults with this condition will receive the drug and be monitored …

This study tests an investigational drug called nirogacestat in about 40 adults with desmoid tumors (a type of non-cancerous growth). The main goal is to check the drug's safety and side effects. Researchers will also see how the tumor responds to treatment.

This early-phase study tests a new treatment for advanced clear cell kidney cancer that has stopped responding to standard therapies. The treatment uses donor immune cells (NK cells) that are genetically modified to better recognize and attack cancer cells while resisting the tum…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This early-phase trial tests whether combining chemotherapy with radiation, followed by a maintenance drug called dostarlimab, is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive the treatment and be monito…

This study tests a two-step treatment for hairy cell leukemia, a rare blood cancer. First, patients receive chemotherapy (cladribine) to kill cancer cells, then an immunotherapy drug (rituximab) to help the immune system attack any remaining cells. The goal is to see if adding ri…

This study looks at whether targeted radiation can help control multiple myeloma that is still active after CAR-T cell therapy. About 30 adults whose cancer did not fully respond to CAR-T will receive radiation to up to five tumor sites. The goal is to see if this approach improv…

This study tests whether combining three drugs—pemigatinib, atezolizumab, and bevacizumab—can help control advanced bile duct cancer that has a specific genetic change (FGFR2 fusion). About 25 adults whose cancer has not responded to other treatments will take part. The main goal…

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or stopped responding to prior treatment. About 36 adults with stage II–IV disease will receive the combination. The goal is to see how well t…

This early-phase study tests a combination of two drugs (BMS-986504 and olaparib) in adults with advanced solid tumors that have lost a gene called MTAP. The main goal is to find safe doses and understand side effects. About 36 people will take part, and the study is currently re…

This study tests whether the drug olverembatinib can control newly diagnosed chronic myeloid leukemia (CML) in its early phase. About 50 adults will take the drug alone and be monitored for side effects and how well the cancer responds. The goal is to find a treatment that keeps …

This study tests a new drug, SAR445877, in people with advanced non-small cell lung cancer that has stopped responding to immunotherapy. The goal is to see if the drug can help control the cancer. About 29 adults will take part, and researchers will monitor safety and side effect…

This study tests whether having a partner to exercise with helps inactive women become more physically active. Researchers will enroll 500 women aged 18-65 who are not currently active enough. Participants will either receive a standard individual program or a partner-based progr…

This study tests a combination of two drugs, enasidenib and azacitidine, in about 50 adults with a type of leukemia (AML) that has come back or not responded to prior treatment. Participants must have a specific gene mutation (IDH2). The goal is to see if the combo can shrink or …

This study tests a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be surgically removed. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby healthy tissue. …

This study tests whether adding venetoclax to ongoing ibrutinib or acalabrutinib treatment can eliminate remaining leukemia cells in people with high-risk chronic lymphocytic leukemia (CLL). Participants must have been on their current therapy for at least 12 months and still hav…

This study tests whether giving belzutifan alone, pembrolizumab alone, or both together before kidney surgery can help control advanced clear cell kidney cancer. About 10 people with locally advanced disease will receive the drugs before partial or total kidney removal. The main …

This study tests whether adding local treatments like surgery or radiation to the immunotherapy drug durvalumab can help control stage III non-small cell lung cancer that has started to grow again after chemoradiation and durvalumab. About 51 adults will receive this combination.…

This study tests whether adding local treatments (like radiation or surgery) to the targeted drug lorlatinib helps control advanced ALK-positive non-small cell lung cancer better than lorlatinib alone. About 30 people with this specific type of lung cancer will take lorlatinib fo…

This study tests whether combining two chemotherapy drugs (tretinoin and arsenic trioxide) with a targeted therapy (gemtuzumab ozogamicin) works better than the two drugs alone for adults with a specific type of leukemia called acute promyelocytic leukemia. About 151 newly diagno…

This early-phase trial tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. It combines specially engineered natural killer (NK) cells, given both into a vein and directly into the belly, with the drug cetuximab. The goal is to find the safest…

This study tests whether adding 1 year of pembrolizumab (an immunotherapy drug) after radiation therapy can better control kidney cancer that has spread to a few spots. About 144 people with this type of cancer will take part. The main goal is to see if the combination is safe an…

This study looks at whether giving radiation to the lymph nodes after surgery can lower the chance of melanoma returning in people who are already receiving immunotherapy. About 168 adults with high-risk melanoma that has spread to a sentinel lymph node will take part. The goal i…

This study tests whether a combination of three drugs—calaspargase pegol-mknl, decitabine, and venetoclax—can help control relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LLy) in patients aged 1 month to 21 years. T…

This early-phase study tests a new drug called NBTXR3, which is injected into the tumor and activated by radiation therapy, alongside standard chemotherapy. The goal is to find the safest dose and see if it helps control esophageal cancer. About 24 adults with stage II or III eso…

This study tests whether combining two drugs, dostarlimab and LB-100, can help control ovarian clear cell carcinoma, a rare and aggressive cancer. About 21 adults with recurrent disease will receive the treatment. The main goal is to check safety and side effects, while also seei…

This early-phase study tests a new type of high-dose radiation (HYDRA) for people with laryngeal cancer. The main goal is to find the highest safe dose and check for side effects. About 11 adults with early to moderately advanced laryngeal cancer will take part. The study is run …

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in people with acute myeloid leukemia (AML). MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 par…

This early-phase study tests a new treatment called JV-394 for people with T/NK cell lymphoma that has come back or not responded to standard therapy. JV-394 uses the patient's own immune cells, which are modified in a lab to better recognize and attack cancer cells. The main goa…

This early-phase study is testing whether a new drug called SAR445877, when added to standard chemotherapy and a targeted therapy, is safe for people with advanced colorectal cancer that hasn't spread widely yet. About 41 adults will take part. The main goal is to find any side e…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML) that is newly diagnosed or has come back. About 116 adults with AML or high-risk MDS will receive the combination. The goal is to see if the combo improves r…

This study tests whether adding the investigational drug NKTR-255 to the standard immunotherapy durvalumab can help restore immune cells after chemoradiation in people with advanced non-small cell lung cancer. About 39 adults will receive the combination and be followed for overa…

This early-phase trial tests a new combination treatment for people with colorectal cancer who have minimal residual disease (MRD) — tiny amounts of cancer left after standard therapy. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, desi…

This early-phase trial aims to find a safe dose of gemcitabine combined with nab-sirolimus for people with advanced leiomyosarcoma or soft-tissue sarcoma that has specific TSC1 or TSC2 gene changes. About 18 participants will receive the drug combination to see how well it is tol…

This study tests a drug called ivonescimab in 90 adults with metastatic colorectal cancer that has already been treated. The goal is to see if the drug can help control the cancer. Participants will receive the drug and be monitored for side effects.

This early-phase trial tests whether adding the drug lurbinectedin to two standard chemotherapy drugs (paclitaxel and bevacizumab) can better control platinum-resistant ovarian cancer. About 34 adults with advanced ovarian, fallopian tube, or peritoneal cancer will receive the co…

This study tests whether adding ASTX727 to the standard drug dasatinib can better control chronic myeloid leukemia (CML) in newly diagnosed patients. About 70 adults with a specific genetic marker (Philadelphia chromosome) will receive both pills. The goal is to see if the combin…

This study tests a combination of drugs for people whose blood cancer (like AML or MDS) has come back or not responded to treatment. Participants must have specific gene changes (IDH1 and another signaling mutation). The goal is to see if the combination is safe and tolerable. Ab…

This early-phase study tests a new combination treatment for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, given through a belly infusion and a vein,…

This study tests if adding medication can treat or prevent lymphedema and fibrosis (tissue hardening and swelling) caused by radiation therapy in head and neck cancer survivors. About 250 participants who finished radiation at least 6 months ago and have moderate-to-severe side e…

This study tests whether a chemotherapy-free combination of pirtobrutinib and rituximab can help people with low or intermediate risk mantle cell lymphoma achieve long-term remission. About 50 adults who have not yet been treated for MCL will receive the two drugs. The main goal …

This study tests a new way to give radiation therapy for advanced prostate cancer. Instead of many sessions, patients get just 5 high-dose treatments. The goal is to see if this shorter approach is safe and works well. About 70 people with high-risk prostate cancer will take part…

This study is testing a new treatment approach for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). It combines standard chemotherapy with two targeted immunotherapy drugs, blinatumomab and inotuzumab ozogamicin, to see if this mix works better…

This study tests whether adding the drug BMS-986504 to standard chemotherapy can help control pancreatic cancer in people with a specific genetic change (MTAP deletion). About 60 adults with this type of pancreatic cancer will receive the combination before and after surgery or w…

This early-phase trial tests a new treatment called attIL12-TIL for people with advanced or metastatic soft tissue and bone sarcoma. The therapy uses a patient's own tumor-fighting immune cells, modified to better target and attack cancer. The study first finds a safe dose, then …

This early-phase study tests a chemotherapy drug (gemcitabine) given as a mist to breathe in. It is for people whose solid tumors have spread to the lungs and who have no standard treatment options. The main goal is to find the safest dose and watch for side effects. Up to 44 par…

This study tests if a very low dose of radiation (4 Gy) can control marginal zone lymphoma, a slow-growing blood cancer. Participants first get the low dose, and if the tumor shrinks enough, they may avoid higher doses. The goal is to reduce side effects while still controlling t…

This early-phase study tests a new treatment for people with advanced pancreatic cancer that has spread and has a specific mutation called KRAS G12D. The treatment uses tiny particles called exosomes to deliver a molecule that blocks the mutated gene. The goal is to find the best…

This study tests the safety of a drug called olutasidenib given after a stem cell transplant to people with certain blood cancers (like AML or MDS) that have an IDH1 mutation. About 31 participants will take the drug as maintenance therapy to try to keep the cancer from coming ba…

This study is for people with acute myeloid leukemia (AML) that has a specific genetic change called IDH1. It tests a combination of three drugs: decitabine, venetoclax, and olutasidenib. The goal is to find a safe dose and see how well the drugs work together. About 78 adults wi…

This study tests whether inhaling a drug called tranexamic acid can help cancer patients who have severe lung bleeding and are on a breathing machine. The goal is to see if it lowers the chance of death within 28 days compared to standard care. About 60 adults with blood cancers …

This study tests a new treatment for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to recognize and attack cancer cells…

This study tests whether the drug letermovir can prevent the reactivation of cytomegalovirus (CMV) in people who have received a type of cell therapy called axicabtagene ciloleucel. About 36 adults who are CMV-positive and scheduled for this cell therapy will take letermovir. The…

This study tests whether a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) can help people with kidney cancer that has spread to the brain. The goal is to see if the treatment can keep brain tumors from growing. The study involves 20 adults who have not had t…

This early-phase study tests a combination of two chemotherapy drugs (hyper-CVAD and venetoclax) in 22 children and young adults whose acute leukemia has returned or not responded to standard treatment. The main goal is to find a safe dose and monitor side effects. Participants m…

This study tests a combination of three drugs (177Lu girentuximab, cabozantinib, and nivolumab) in people with advanced clear cell kidney cancer who have not had prior treatment. The goal is to see if the combination can control the cancer and to check for side effects. About 100…

This early-phase trial tests a new drug called nadunolimab combined with standard treatments (azacitidine, with or without venetoclax) in 40 adults with high-risk myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to see if the combination is safe and to …

This study tests if injecting the cancer drug nivolumab directly into high-risk precancerous mouth lesions can stop them from turning into cancer. About 45 adults with these lesions will receive either the drug or a placebo injection. The goal is to see if the treatment is safe a…

This early-phase study tests a new treatment for advanced head and neck cancer that has stopped responding to standard therapies. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer cells and resist the tumor…

This study combines a targeted antibody-drug (inotuzumab ozogamicin) with low-intensity chemotherapy to treat adults with acute lymphoblastic leukemia (ALL). The goal is to find the best dose and see if the combination improves survival and remission rates. Participants include o…

This study tests a cream called tofacitinib for people with early-stage cutaneous T-cell lymphoma (CTCL), a rare skin cancer. The cream is applied to the skin to see if it can safely control the disease. About 20 adults with stage IA, IB, or IIA CTCL will take part.

This study tests whether giving standard chemotherapy (doxorubicin and trabectedin) after surgery can help people with early-stage uterine leiomyosarcoma stay cancer-free longer. About 48 participants who had their tumor fully removed will receive the treatment. The goal is to se…

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or …

This study tests a drug called NBTXR3 given with radiation therapy for people with locally-advanced non-small cell lung cancer who cannot have chemotherapy or surgery. The goal is to see if the combination is safe and helps control the cancer. About 40 adults with stage I to III …

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can control mantle cell lymphoma (MCL) in patients whose cancer has come back or hasn't responded to prior treatments. About 30 adults with confirmed MCL will take these pills to see how many achieve…

This study tests a drug called olutasidenib in people with certain early blood conditions (CCUS, lower-risk MDS, or CMML) that have a specific IDH1 gene change. The goal is to see if the drug can control the disease and is safe. About 15 participants will take the drug and be mon…

This early-phase study tests a combination of three drugs (decitabine, lisaftoclax, and olverembatinib) in 30 adults with advanced chronic myeloid leukemia or a related acute leukemia. The goal is to find safe doses and see if the combo can control the disease in people who have …

This phase 3 trial tests whether a multi-disciplinary treatment plan can help people with pancreatic cancer that has spread to only a few other places in the body live longer without the disease getting worse. About 80 adults with this condition will receive either standard care …

This study combines three chemotherapy drugs (cladribine, idarubicin, cytarabine) with a targeted drug (quizartinib) to treat acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). It includes up to 80 adults who are newly diagnosed or whose cancer has returne…

This early-phase study tests the safety of an engineered virus called M032 in 20 children and adults with diffuse midline glioma, a rare and aggressive brain tumor. Participants receive the virus directly into the tumor after completing standard radiation therapy. The goal is to …

This study tests adding an experimental drug called CTX-009 to standard chemotherapy (gemcitabine and cisplatin) plus an immunotherapy (durvalumab) as a first treatment for people with advanced bile duct cancer that cannot be removed by surgery. The goal is to see if this combina…

This study tests a drug called REGN5678 in men with high-risk prostate cancer who will later have their prostate removed. The goal is to check the drug's safety and how it affects the cancer before surgery. About 42 men will take part in this early-phase trial at MD Anderson Canc…

This study tests whether two drugs, zanzalintinib and pembrolizumab, can help control advanced soft-tissue sarcoma that has spread. About 20 adults with specific sarcoma types will receive the combination. The main goal is to check safety and see if the treatment slows tumor grow…

This study tests a combination of two drugs, CPX-351 and ivosidenib, in about 30 adults with a specific genetic form of acute myeloid leukemia or high-risk myelodysplastic syndrome. The goal is to see if the combo can shrink or control the cancer. Participants must have the IDH1 …

This early-phase study tests a new three-drug combination for children and young adults (ages 2–21) with acute leukemia that has returned or not responded to treatment. The goal is to find the safest dose of ziftomenib when given with venetoclax and azacitidine. Only patients wit…

This study tests whether adding a third drug (relatlimab) to a standard two-drug combination (nivolumab and ipilimumab) works better for advanced kidney cancer that hasn't been treated before. About 15 adults with stage IV clear cell kidney cancer will receive either the three-dr…

This early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to find …

This study tests whether a combination of three drugs (avutometinib, defactinib, and cetuximab) can help control advanced colorectal cancer that no longer responds to standard anti-EGFR therapy. About 33 adults with unresectable, anti-EGFR-refractory cancer will receive the drugs…

This study compares two drug combinations to prevent graft-versus-host disease (GVHD) in people aged 65 and older with certain blood cancers who receive a stem cell transplant. Participants will receive either cyclophosphamide, sirolimus, and MMF or cyclophosphamide, sirolimus, a…

This study tests a combination of targeted drugs and immunotherapy for people with untreated primary mediastinal large B-cell lymphoma (PMBL), a rare type of blood cancer. The treatment uses brentuximab vedotin (which delivers a toxin directly to cancer cells) and nivolumab (whic…

This study tests a new treatment for people with myeloid blood cancers (like leukemia) that have come back or not responded to standard therapy. The treatment uses specially engineered immune cells from donated cord blood, designed to better target and kill cancer cells while res…

This study tests a drug called ponatinib in 50 adults with chronic myeloid leukemia (CML) whose cancer did not respond to or they could not tolerate other targeted therapies. The goal is to see if ponatinib can control the disease by blocking a protein that helps cancer cells gro…

This study tests a drug called emapalumab to see if it can safely help people whose blood cell counts stay dangerously low after CAR T-cell therapy for certain lymphomas. About 32 adults who have already received standard CAR T-cell therapy will take part. The goal is to find out…

This study tests whether fecal microbiota transplantation (FMT) can reduce gut-related side effects from antibiotics in 40 adults with B-cell lymphoma who are receiving standard CAR-T cell therapy. Participants will receive FMT alongside their cancer treatment to see if it improv…

This study tests a drug called revumenib in people with certain types of leukemia that have high levels of HOX genes. The goal is to see if the drug can help control the cancer. About 40 people aged 12 and older with leukemia that has come back or not responded to treatment can j…

This study tests if the drug elranatamab, given before and after a stem cell transplant, can better control high-risk multiple myeloma. About 40 adults with newly diagnosed, high-risk disease will receive the drug to reduce cancer cells before transplant and then as maintenance t…

This early-phase trial tests a new treatment called Attil12-T cell therapy for people with advanced soft tissue or bone sarcoma that has spread or cannot be removed. The therapy uses a patient's own immune cells, modified to target and attack the tumor. The main goals are to find…

This early-phase study tests a drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. Researchers will also watch for any signs that the drug helps contr…

This early-phase trial tests a new approach for people with recurrent high-grade glioma, an aggressive brain cancer. Researchers use a modified cold virus (DNX-2401) loaded into stem cells and injected into an artery to target and attack tumor cells. The main goals are to find th…

This study tests whether adding radiation therapy to a CAR T-cell drug (axicabtagene ciloleucel) can safely treat follicular lymphoma that has come back or not responded to at least two prior treatments. About 20 adults will receive the combination and be monitored for side effec…

This early-phase trial tests the safety and effectiveness of pembrolizumab, an immunotherapy drug, in people with thymoma or thymic carcinoma that cannot be surgically removed. The drug helps the immune system attack cancer cells. About 37 adults with advanced thymus gland cancer…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (cisplatin and gemcitabine) before and after surgery can improve long-term results for people with a type of bile duct cancer called intrahepatic cholangiocarcinoma. About 24 adults with…

This study tests a combination of chemotherapy drugs (mini-Hyper-CVD) plus three targeted drugs (rituximab, inotuzumab ozogamicin, and blinatumomab) in children and young adults whose B-cell acute lymphocytic leukemia has come back or not responded to treatment. The goal is to se…

This study tests a combination of five drugs for people newly diagnosed with a specific type of acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to see how well the treatment kills cancer cells and what side effects occur. About 270 participan…

This early-phase study tests whether adding a new drug (HC-7366) to standard immunotherapy (nivolumab with or without ipilimumab) can help control advanced clear cell kidney cancer. About 35 adults with stage IV disease will participate. The main goal is to check safety and side …

This study tests a new drug called golidocitinib, given alone or with standard chemotherapy (CHOP), for people newly diagnosed with peripheral T-cell lymphoma, a rare blood cancer. The goal is to see if the drug helps control the disease safely. About 30 adults will take part at …

This study tests a drug called canakinumab in people with low- or intermediate-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The drug is a lab-made antibody that may help slow cancer growth and improve blood cell counts. About 76 adults will rece…

This study tests a shorter, higher-dose radiation schedule (hypofractionated) for people with Merkel cell carcinoma, a rare skin cancer. About 52 participants who have had surgery but no distant spread will receive radiation to the tumor site and nearby lymph nodes. The goal is t…

This study tests whether a combination of three drugs—pirtobrutinib, venetoclax, and obinutuzumab—can control relapsed chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). About 40 adults who have had prior treatment will receive this time-limited therapy. The …

This study tests a combination of three drugs (ASTX727, venetoclax, and gilteritinib) for people with acute myeloid leukemia or high-risk myelodysplastic syndrome that has a specific gene change called FLT3. The goal is to find the best dose and see how well the drugs work togeth…

This early-phase study tests a new drug called CBP-1019 combined with standard chemotherapy or other targeted therapies in people with advanced solid tumors that have stopped responding to treatment. The goal is to find the safest dose and see if the combination can shrink tumors…

This early-phase study tests a new type of cell therapy for people with advanced melanoma that has not responded to standard treatments. The therapy uses a patient's own immune cells (NK cells) that are engineered in the lab to recognize and attack a protein called PRAME found on…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This study is testing a combination of six chemotherapy drugs in people whose acute lymphoblastic leukemia, lymphoblastic lymphoma, or related blood cancers have returned or stopped responding to treatment. The goal is to see how well this drug cocktail works and what side effect…

This study tests a new device that uses very short electric pulses to destroy small thyroid tumors without cutting the skin. It is for people with early-stage papillary thyroid cancer that has not spread. The goal is to see if this treatment is safe and can control the disease.

This study tests a drug called brentuximab vedotin for people with a rare type of chest cancer (CD30+ mesothelioma) that cannot be removed with surgery. The drug works like a smart bomb, targeting a specific marker on cancer cells to stop them from growing. About 55 adults will t…

This study tests whether matching smoking cessation treatments—like nicotine patches, counseling, or medications—to a person's unique traits can help them quit. About 2,010 smokers who want to quit will receive personalized care. The goal is to find better ways to help people sto…

This study tests a combination of two drugs, blinatumomab and ponatinib, along with standard chemotherapy, in people with a specific type of acute lymphoblastic leukemia (ALL) that has a genetic change called the Philadelphia chromosome. The goal is to see if this mix can better …

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer places in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery to the main tumor and those spots. The goal is to see if adding local treatment helps peo…

This study tests whether adding a second cream (calcipotriene) to the standard treatment (fluorouracil) works better for people with multiple actinic keratoses—rough, scaly patches caused by sun damage that can turn into skin cancer. About 30 adults will apply one of the two crea…

This study tests a new treatment called KSQ-004EX for people with advanced solid tumors that have not responded to standard therapies. The treatment uses a patient's own immune cells (tumor infiltrating lymphocytes) that are genetically modified to be more powerful against cancer…

This study tests whether a combination of three drugs—cladribine, low-dose cytarabine, and decitabine—can help control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) in people aged 60 and older. Participants receive the drugs in cycles to stop cancer cel…

This study is for people with breast cancer who need a mastectomy (breast removal) followed by immediate breast reconstruction using their own tissue. It compares two ways of giving radiation before surgery: the standard longer course versus a shorter course with fewer, higher do…

This early-phase study tests a new drug combination (ziftomenib, venetoclax, and gemtuzumab) in children and young adults aged 3 to 21 with acute myeloid leukemia that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. Th…

This study tests an oral drug called ONC201 in 120 adults whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink or control the cancer. ONC201 w…

This study tests a new combination of three drugs (eribulin, irinotecan, and temozolomide) in children and young adults up to age 25 whose solid tumors have come back or not responded to treatment. The main goal is to find the safest dose of eribulin when given with the other two…

This study tests whether two drugs, tivozanib and nivolumab, can control advanced non-clear cell kidney cancer. About 48 adults with this rare cancer type will receive the combination. The goal is to see if the treatment is safe and helps keep the disease from growing.

This study tests whether a family-centered program can help Black prostate cancer survivors and their caregivers eat better, be more active, and feel better overall. About 648 survivor-caregiver pairs will join, with some receiving the family program, some the survivor-only progr…

This study tests a drug called zanzalintinib in people with advanced bone sarcomas that cannot be removed by surgery or have spread. About 70 adults with osteosarcoma, Ewing sarcoma, chondrosarcoma, or other bone sarcomas will take the drug to see if it can shrink or control the …

This early-stage trial tests a new drug called Peposertib combined with radiation and chemotherapy for people with a fast-growing brain cancer (glioblastoma). The goal is to find the best dose and see if the drug can reach the brain to help kill tumor cells. About 29 adults with …

This study tests whether adding the drug epcoritamab to a standard, gentler chemotherapy mix (R-miniCVP) can help control newly diagnosed diffuse large B-cell lymphoma in older or frail adults who cannot tolerate stronger chemo. About 40 participants will receive the combination …

This early-stage trial tests genetically engineered natural killer (NK) cells in 25 people with recurrent glioblastoma, an aggressive brain cancer. The cells are designed to resist the tumor's defenses. The main goal is to find a safe dose and check for side effects, while also w…

This study is for people with colorectal cancer that has spread to the liver and cannot be removed right away because the healthy part of the liver is too small. Doctors will use a treatment called Y-90 radioembolization to deliver radiation directly to the tumor side of the live…

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with multiple myeloma that has come back or not responded to treatment and has spread outside the bone. About 34 adults will receive the combination. The goal is to s…

This study tests a drug called luspatercept in 40 adults with lower-risk myelodysplastic syndromes (MDS), a bone marrow condition that often requires frequent blood transfusions. The goal is to see if luspatercept can reduce the number of transfusions needed. Participants will re…

This early-stage trial tests a precise type of proton radiation for children with ependymoma, a brain tumor. The therapy is designed to kill cancer cells while reducing damage to healthy brain tissue. About 48 children will take part to see if the treatment is safe and what side …

This study tests whether freezing only the part of the prostate that contains cancer (focal cryotherapy) can control intermediate-risk prostate cancer. About 30 men with a single area of cancer will receive this targeted treatment. The goal is to reduce side effects while keeping…

This study tests whether a combination of three drugs—pembrolizumab, bevacizumab, and low-dose cyclophosphamide—can help control high-grade ovarian cancer that remains after standard frontline therapy. About 20 women with minimal residual disease will receive the treatment to see…

This study tests a new drug called axatilimab, alone and with the standard drug ruxolitinib, for people with myelofibrosis (MF) or chronic myelomonocytic leukemia (CMML). The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who hav…

This study tests whether giving two powerful cell therapies together can control large B cell lymphoma that has returned or not responded to first treatment. About 40 adults will receive the drugs axicabtagene ciloleucel and glofitamab. The goal is to manage the disease, not to c…

This study tests a new drug combination for men with an aggressive type of prostate cancer. The goal is to find the best dose of ADI-PEG20 when given with two standard chemotherapy drugs. About 30 men will take part to see if the combo is safe and tolerable.

This study tests a combination of three drugs (quizartinib, decitabine, and venetoclax) in people with acute myeloid leukemia or high-risk myelodysplastic syndrome that is new or has returned. The goal is to find the best dose and see how well the drugs work together to stop canc…

This study tests a combination of two chemotherapy drugs (CPX-351) plus a targeted drug (quizartinib) in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to find the best dose and see if the combo helps control the cancer. About 52…

This study is for people with multiple myeloma that has come back or stopped responding to other treatments. The trial has two parts: first, finding the best dose of a drug called belumosudil mesylate, and second, testing that dose alone or with dexamethasone to see if it can con…

This study tests a powerful mix of chemotherapy drugs, including nelarabine, for people with untreated T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. About 160 participants will receive the treatment to see how well it controls the cancer and what side effects occ…

This study tests whether a time-limited combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) is safe and effective for people with untreated chronic lymphocytic leukemia (CLL) or Richter transformation (RT). About 60 adults with good organ function and perform…

This study tests whether a special type of immune cell (ONC-PluReceptor NK cells) given with two antibody drugs (epcoritamab and tafasitamab) can control B-cell Non-Hodgkin lymphoma that has come back or not responded to prior treatments. About 30 adults aged 18-80 who have alrea…

This early-phase study tests a new drug called rezatapopt combined with azacitidine in 24 adults with acute myeloid leukemia or myelodysplastic syndrome that has a specific TP53Y220C mutation and has not responded to standard treatment. The main goal is to check safety and side e…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests whether magnetic resonance elastography (MRE), a special MRI that measures tissue stiffness, can tell the difference between radiation necrosis (scarring from radiation) and recurrent glioma (tumor regrowth) in people who have already been treated for brain cance…

This study tests a handheld device called the MasSpec Pen to see if it can quickly tell the difference between tumors and healthy tissue during surgery. About 60 people with neurofibromas or MPNST will take part. The goal is to help surgeons remove all the tumor while saving as m…

This study is testing whether a special dye and camera system can help doctors see pre-cancerous or cancerous spots in the mouth without needing a biopsy. Researchers will apply a fluorescent dye called proflavine to the mouth and use two types of cameras to take detailed images.…

This study is testing whether contrast-enhanced mammography (CEM) can find breast cancers better than standard mammography in women with dense breasts. Dense breast tissue can hide tumors on regular mammograms. The trial will enroll 1,000 women aged 30-75 with dense breasts to co…

This early-phase study tests whether a special PET scan using a radioactive tracer called 18F-AraG can find tumors in people with esophageal cancer and predict how well they respond to chemoradiation. About 60 adults with untreated, locally advanced esophageal cancer will receive…

This pilot study tests a new MRI technique using a special dye called hyperpolarized 13-C-pyruvate to better see inside pancreatic cysts. The goal is to tell harmless cysts from those that could turn into cancer. Twenty adults with pancreatic cysts who are already scheduled for s…

This study tests whether a special MRI scan (DCE-MRI) can detect early signs of bone damage caused by radiation therapy in head and neck cancer patients. Researchers will scan 1,400 participants before, during, and after radiation to see if the MRI can predict osteoradionecrosis,…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see if the synthetic method works as well or better, with the added benefit of lower rad…

This study is testing a new radioactive tracer called [18F]FTT, which is used with PET/CT scans to find tumor cells in people with solid cancers like ovarian, fallopian tube, or breast cancer. The goal is to see if this tracer can better detect cancer activity compared to standar…

This study is testing a new type of MRI scan (without a probe in the rectum) to see if it can accurately find aggressive prostate cancers in men with intermediate or high-risk disease. About 258 men who are planning to have their prostate removed will get this MRI first. The goal…

This study tests whether advanced scans (PET/MR, PET/CT, and whole-body MR) can find leukemia that has spread outside the bone marrow in people newly diagnosed with acute myeloid leukemia (AML). About 77 participants will receive these scans to see how well they detect hidden dis…

This study compares two types of breast imaging—molecular breast imaging (MBI) and magnetic resonance imaging (MRI)—to see how well each finds or rules out breast cancer in women at high risk. About 300 women will take part. The goal is to find out if MBI works as well as MRI, wh…

This study aims to see if combining the standard CA-125 blood test with other tumor markers can help detect ovarian cancer earlier in women who are at low risk. Researchers will track changes in these markers over time in 8,000 postmenopausal women aged 50-75 who have at least on…

This study is testing a new, easy-to-use HPV test that could be done at a doctor's office without special lab equipment. Researchers want to see if this new test works as well as the standard HPV test. About 600 people with a cervix, aged 21 or older, will take part. If successfu…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests a special type of mammogram called CESM, which uses a dye injected into a vein to make breast tissue and blood vessels clearer. The goal is to see if CESM is better than standard mammograms at finding the cause of nipple discharge and detecting breast cancer. Abo…

This study tests a new imaging device that may help doctors see tumor tissue before taking a needle biopsy. About 150 people with suspected or confirmed cancer will take part. The goal is to see if the device is safe and can make biopsies more precise.

This study tests a new imaging device called the Active Biopsy Guidance System to help doctors decide when and where to take tissue samples (biopsies) from mouth lesions. About 90 adults with suspicious mouth spots or a history of oral cancer will participate. The goal is to see …

This early-phase study tests a special imaging agent called hyperpolarized pyruvate to see if it can help doctors better diagnose glioma, a type of brain tumor. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to improve how tumors…

This study aims to find better ways to screen and diagnose cervical cancer in Mozambique. Researchers will test a rapid HPV test and a special imaging system in about 678 women aged 25-49 who have had abnormal screening results. The goal is to see if these new methods are as accu…

This study tests whether a special PET-CT scan using PYLARIFY (piflufolastat F18) can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will get the scan, and doctors will compare the results to standard methods…

This study is testing a mixed meal test to better diagnose a specific type of diabetes (type 3c) that occurs in people with pancreatic cancer or chronic pancreatitis. Researchers will enroll 775 adults aged 30 to 84 who have new-onset diabetes and one of these pancreatic conditio…

This study looks at whether doing a lymphovenous bypass procedure at the same time as lymph node removal surgery can prevent lymphedema (chronic leg swelling). Twenty adults having groin lymph node surgery will get the bypass and be followed for 2 years. The main goal is to see i…

This trial tests whether a different way of closing the abdominal wall during liver tumor surgery can lower the chance of developing an incisional hernia. 140 patients will be randomly assigned to receive either the new 'short stitch' method or the traditional closure. Researcher…

This study tests whether naproxen or aspirin can increase immune cells in the colon to prevent cancer in people with Lynch syndrome, a genetic condition that raises cancer risk. About 40 participants will take one of these drugs or a placebo for a short time. Researchers will mea…

This study is creating a shared decision-making tool to help women and their doctors talk about using a levonorgestrel IUD to prevent endometrial cancer. Researchers will survey 270 women, both with and without the condition, to understand their preferences. The goal is to make i…

This study tests if repairing the lymphatic system during breast cancer surgery can prevent lymphedema, a painful arm swelling. 50 women with breast cancer will receive this reconstruction. The goal is to see if this approach reduces the risk of developing lymphedema.

This study tests whether doing a lymphovenous bypass during lymph node surgery can prevent lymphedema (arm swelling) in people with breast cancer or melanoma. The bypass creates a new path for fluid to drain away from the arm. Researchers will compare swelling rates in 252 partic…

This study looks at whether removing the fallopian tubes first and delaying the removal of the ovaries is as safe as removing both at once for preventing ovarian cancer. It involves 100 premenopausal women with BRCA or other high-risk gene mutations. The goal is to see if the two…

This study tracks how nerve pain from chemotherapy develops in breast cancer patients. It also tests a brain-stimulating device called a closed-loop brain-computer interface to see if it can prevent that pain. About 45 participants will be observed or receive the experimental sti…

This study tests whether the drug canakinumab can prevent lung cancer in 50 people who have suspicious lung nodules that haven't gone away. Participants receive the drug and are monitored for nodule shrinkage and cancer development. The goal is to see if this approach can stop lu…

This study tests a community-based approach to make cervical cancer screening easier for women who haven't had a Pap test in over 3.5 years. It involves 920 women in low-resource areas of Texas. The goal is to see if this strategy is safe and works well.

This phase 2 trial tests whether custom 3D-printed oral stents can reduce mouth blisters and sores in head and neck cancer patients receiving radiation. About 119 adults will be randomly assigned to standard radiation with or without a personalized stent that covers teeth and gum…

This phase 3 trial is testing domperidone, a drug that helps the stomach empty food, in 200 people with chronic digestive disorders like gastroparesis, severe heartburn, or dyspepsia. Participants have already tried standard treatments without success. The study measures whether …

This study tests the ApricityCare program, which helps people with metastatic cancer and their doctors spot treatment side effects early. The goal is to manage these side effects quickly so patients can stay on their cancer therapy longer. About 425 adults starting systemic cance…

This study tests whether peripheral nerve stimulation (PNS) can reduce pain from chemotherapy-induced peripheral neuropathy (CIPN). Ten people with chronic leg pain after chemo will receive PNS via thin needles inserted near nerves. Researchers will track safety and pain relief o…

This study tests a web-based program called Project Prepare for head and neck cancer patients getting radiation. The program aims to help patients stick with swallowing exercises and coping strategies to reduce long-term side effects. About 300 patients will use the website and r…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors who feel depressed or anxious. Twenty adults who have finished cancer treatment and have no brain tumors will receive a single dose of psiloc…

This study tests two supportive care programs—meditation and discussion sessions—for people with advanced (stage IV) cancer and their family caregivers. Researchers want to see if these programs can reduce depressive symptoms and improve quality of life. About 400 patient-caregiv…

This study tests a program called Focused Acceptance and Commitment Therapy (FACT) for advanced cancer patients who feel anxious about death. 70 participants will attend four weekly 35-45 minute sessions to learn coping skills. The goal is to see if FACT is safe, acceptable, and …

This study looks at two ways to treat malignant pleural effusion, a buildup of fluid in the lungs caused by cancer. One uses a small tube (indwelling pleural catheter) to drain fluid; the other adds the antibiotic doxycycline to help seal the lung. Researchers want to see if addi…

This study is testing whether a yoga program designed to fit different cultures can help cancer patients feel better during a stem cell transplant. About 60 adults in India, Tanzania, and the United States will take part in up to 12 yoga sessions before and after their transplant…

This study looks at whether a food farmacy (free healthy food) plus online cooking classes can help cancer survivors who struggle to afford food. About 80 survivors will take part. The goal is to see if the program is safe, easy to use, and helps improve their diet and well-being…

This study tests whether adding a freezing procedure called cryoablation to standard radiation therapy can better relieve pain from cancer that has spread to the bones. About 40 adults with certain cancers (like prostate, kidney, or melanoma) that have spread to the bone will be …

This study tests a newer, more precise radiation method called SBRT against standard radiation to see which better relieves pain from cancer that has spread to the bones. About 220 adults with solid tumors or multiple myeloma and pain at the treatment site will take part. The goa…

This study is for people with cancer that has spread to the pelvic bone, causing pain or weakness. Doctors are testing a new, less invasive surgery that uses special light-activated nails to stabilize the bone. The goal is to see if patients can move better and have less pain wit…

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study looks at whether having fewer follow-up scans after surgery for soft tissue sarcoma can lower patients' fear of cancer coming back. About 227 adults who finished treatment will be split into two groups: one with limited follow-up and one with intense follow-up. Researc…

This study looks at whether a digital art activity can help cancer patients better express their distress, symptoms, and experiences. Researchers will enroll 60 adult cancer patients who are currently receiving treatment. Participants will use a digital tablet to create art and t…

This study tests a community-based course called BBCSI, led by trained peers, to see if it helps Black breast cancer survivors feel better day-to-day. About 46 women with early-stage breast cancer will take part. The goal is to improve quality of life, not to treat the cancer its…

This study tests whether certain medications can help calm agitated delirium in cancer patients in the hospital. Delirium causes confusion, restlessness, and distress. The trial compares three drugs (haloperidol, chlorpromazine, and valproic acid) against a placebo, all given thr…

This study explores whether a couple-based meditation program can improve quality of life for people with stage IV lung cancer and their romantic partners. Researchers will enroll 300 couples to attend meditation sessions and complete questionnaires about their health, mood, and …

This study tests whether a drug called dexrazoxane can protect the heart from damage caused by chemotherapy in people with certain blood cancers, such as acute myeloid leukemia and high-risk myelodysplastic syndrome. About 100 participants will receive dexrazoxane alongside stand…

This study tests whether adding bright light therapy, a stimulant (methylphenidate), or melatonin to cognitive behavior therapy can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants will receive one of these …

This study tests whether using a special MRI scanner combined with a radiation machine (MR-LINAC) during spinal radiation therapy can improve treatment results and quality of life. About 40 adults with cancer that has spread to the spine will receive stereotactic radiosurgery whi…

This study tests a new way to give radiation to people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to see if giving a slightly higher dose of radiation to the tumor while protecting the spinal cord is safe. About 60 adults with this co…

This study looks at whether giving only radiation after lumpectomy is safe and effective for women aged 60 and older with early-stage, low-risk breast cancer. The goal is to see if skipping hormone therapy can improve quality of life while still controlling the cancer. About 300 …

This study is testing a program called TEAM Me that uses stickers and rewards to encourage young cancer patients (ages 6-29) to walk and exercise while they recover from a stem cell transplant. The goal is to see if this approach can improve their physical fitness, activity level…

This study aims to find out if combining counseling and education with an open-label placebo (a pill that patients know has no active drug) can improve quality of life for people with advanced cancer who suffer from fatigue. About 240 adults with metastatic cancer and significant…

This early-phase study tests whether a noninvasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30 to receive personalized, accelerated rTMS s…

This study looks at whether it's safe and preferred to go home the same day after a partial thyroid removal (lobectomy) instead of staying overnight in the hospital. Researchers will track side effects, patient satisfaction, and costs. About 224 adults having this surgery will ta…

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in people with cancer-related pleural effusion that is not draining well. About 30 participants will receive either alteplase or a …

This study looks at whether expressive writing can help cancer survivors cope with stress, especially during events like the COVID-19 pandemic. About 414 adults who had cancer in the last 3 years will write about their experiences online. The goal is to see if this simple activit…

This study tests if the drug ustekinumab can control diarrhea and colon inflammation caused by immune checkpoint inhibitors in cancer patients. Ten adults with solid tumors who have moderate to severe symptoms will receive ustekinumab and be monitored for side effects and symptom…

This study tests if a nerve stimulation device, used with or without a steroid injection, can improve knee movement and reduce pain better than a steroid injection alone. About 45 adults with long-term knee pain will be randomly assigned to one of three groups. The goal is to fin…

This early-phase study tests whether a weight-loss drug called tirzepatide can help overweight or obese men with intermediate-risk prostate cancer lose weight before their prostate removal surgery. The study will enroll 30 participants and focus on safety and how well the program…

This study tests a tele-exercise program called RISE-YA to see if it can reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants must be 6 months to 5 years past treatment and currently get little exercise. The goal is to improve ene…

This study tests whether listening to live or recorded music before neurosurgery can lower stress, improve mood, and reduce pain. Researchers will measure changes in vital signs, stress hormones, and how patients feel using questionnaires. The goal is to find a simple, drug-free …

This study looks at whether using a longer IV catheter, placed with ultrasound guidance, can reduce the chance of failure in cancer patients who need IV access in the emergency department. About 400 adults with difficult veins who are expected to stay in the hospital for more tha…

This study tests a new spiritual care program called PEACE for people with advanced cancer. It involves chaplains and doctors working together to help patients explore how their faith affects their medical choices. The goal is to see if this approach is practical and helpful for …

This study tests a mobile app that guides lung cancer patients and their family caregivers through yoga exercises at home. The goal is to see if the app is safe, easy to use, and helpful during radiation treatment. About 60 patient-caregiver pairs will participate.

This study explores whether a virtual, group-based expressive writing program can improve quality of life for survivors of adolescent and young adult cancer. Researchers will enroll 30 survivors aged 18-39 who were diagnosed between 1 and 5 years ago. Participants will complete f…

This study tests whether a virtual group therapy program, called Meaning-Centered Psychotherapy, can help people with cancer feel better emotionally. Researchers want to see if talking about meaning and purpose in a group setting reduces distress and improves quality of life. The…

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, as well as for their family caregivers. About 400 patient-caregiver pairs will take part…

This study is testing a new treatment called nanosecond pulsed field ablation (nsPFA) for people with benign (non-cancerous) thyroid nodules. The procedure uses short electrical pulses to shrink the nodule and improve symptoms. Researchers will follow 30 participants aged 18 to 8…

This study looks at whether a special vacuum dressing (negative pressure wound therapy) can help heal the belly incision better than standard bandages in obese women having breast reconstruction surgery. About 80 participants will be randomly assigned to receive either the vacuum…

This early-phase study tests whether a cream made from capsaicin (the compound that makes chili peppers hot) can reduce nerve pain in the feet and legs caused by chemotherapy. About 20 adults who finished chemo within the last year and have had pain for over 3 months will apply t…

This study looks at two surgical techniques, TMR and RPNI, used alone or together to reduce long-term pain in the remaining limb and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three groups to see which appr…

This study tests whether a custom-made video, showing symptoms and side effects based on each patient's own brain scan, can lower anxiety for people with brain tumors and their caregivers during radiation treatment. About 117 patients with newly diagnosed glioma and their caregiv…

This study tests a parenting support program for 120 parents with advanced cancer and their spouses. The program aims to reduce parenting worries, improve family communication about cancer, and boost emotional wellbeing. Participants must have a child aged 4-16 living at home and…

This study tests whether a drug called methylnaltrexone is safe for people with head and neck cancer when taken for two weeks before their surgery. The drug is already used for constipation, but researchers want to see if it can be given safely in this setting. About 25 adults wi…

This study looks at whether a simple exercise program is practical and helpful for people with non-small cell lung cancer who are getting radiation therapy, along with their family caregivers. About 40 pairs (patient and caregiver) will take part. The goal is to see if exercising…

This study tests whether olanzapine, a medication typically used for mental health conditions, can help lower opioid cravings and misuse in adults with cancer who are on long-term opioid therapy for pain. About 87 participants will receive either olanzapine or a placebo to see if…

This study tests a short program designed to improve the emotional wellbeing and quality of life of people caring for a loved one with advanced cancer. Researchers will enroll 150 adult caregivers who live with a patient with stage IV cancer. Participants will learn skills to inc…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. About 192 people who finished cancer treatment in the last 5 years will take part. They will write and report how they feel, and researchers will track an…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests a special yoga program for women with advanced ovarian cancer who will receive chemotherapy before surgery. The program aims to improve quality of life and overall well-being. Researchers want to see if it is practical and helpful for patients.

This study tests whether a shorter course of high-precision radiation (SBRT) can safely reduce symptoms in people with head and neck cancer that cannot be cured. About 108 adults whose cancer has returned or spread will receive either standard or shorter radiation. The goal is to…

This study aims to improve breast reconstruction after mastectomy by using custom 3D-printed molds to shape tissue into a natural breast form. Researchers will enroll 160 adults scheduled for flap-based reconstruction. The goal is to make surgery more efficient and reduce complic…

This study looks at whether having a conversation about care goals in the emergency room can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who have symptoms like trouble breathing or confusion. The goal is to better suppo…

This study tests whether a CPAP device (a mask that gently blows air into the lungs) can reduce tumor movement during radiation therapy for lung cancer. About 30 people will be enrolled to compare CPAP with a standard breath-holding technique. The goal is to see if CPAP helps kee…

This study compares symptoms, especially appetite, in patients who have one of two types of minimally invasive stomach cancer surgery: removing only the upper part of the stomach or the whole stomach. Researchers will track how patients feel using a simple questionnaire. The goal…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in 30 adults with advanced cancer who are on long-term treatment. Participants will receive the drug in a controlled setting and be m…

This study tests whether combining a nerve pain medication (duloxetine) with neurofeedback brain training can better reduce chemotherapy-related nerve pain than either treatment alone. About 380 adults with nerve damage from cancer treatment will participate. The goal is to impro…

This study tests whether an accelerated recovery program can safely shorten hospital stays for 36 adults undergoing minimally invasive liver surgery. Participants must have a tumor suitable for a specific type of liver resection, no cirrhosis, and live within 50 miles of the medi…

This study looks at whether a supervised exercise program can help people with early-stage triple negative breast cancer who are receiving immunotherapy before surgery. About 33 participants will take part in aerobic exercise sessions. The goal is to see if the program is practic…

This study looks at whether nerve transfer surgery can improve facial movement and quality of life for cancer patients who have facial paralysis after treatment. About 40 adults who are scheduled for this surgery will take part. Researchers will track side effects and measure cha…

This study tests a physical activity program designed for cancer survivors and their caregivers. About 164 adults who have finished cancer treatment (except hormone therapy or maintenance chemo) will take part. The goal is to see if the program improves physical function and redu…

This study tests a personalized treatment plan called SPOT-ON that combines oxygen therapy with other supportive care to reduce shortness of breath in cancer patients. The trial will enroll 150 adults hospitalized with cancer who have significant breathing difficulty. The goal is…

This early-stage study tests whether a precise radiation dose to the pituitary gland (hypophysectomy) can safely reduce severe cancer pain that hasn't responded to standard treatments like opioids. About 40 adults with advanced cancer and hard-to-control pain will receive this on…

This pilot study at MD Anderson Cancer Center looks at how diet and the microbiome (gut bacteria) might cause changes in colon cells that could lead to colorectal cancer. Researchers will compare vegetarians and non-vegetarians undergoing screening colonoscopies. They will analyz…

This study looks at how lifestyle factors like diet, exercise, mental health, and social support relate to quality of life and outcomes in people with melanoma. Researchers will survey up to 5,000 participants over time. The goal is to gather information that could guide future s…

This study is creating a registry of blood, tissue, and stool samples from up to 1,200 people with inflammatory breast cancer. Researchers will use these samples and medical records to better understand the disease. The goal is to support future studies that could lead to improve…

This study tests a special brain-mapping grid placed during surgery to better identify areas that control movement and speech. Researchers will compare this method with standard techniques in 75 adults with brain tumors. The goal is to see if the new grid helps surgeons avoid dam…

This study uses a large registry of 2030 people with medullary thyroid cancer to track how the disease develops and spreads. Researchers will collect medical records, genetic data, and patient surveys to better understand the cancer's natural history. The goal is to improve how a…

This study is testing whether a special MRI scan can accurately detect and track damage to the mouth and jaw caused by radiation therapy for head and neck cancer. Researchers will enroll 300 adults who are scheduled for radiation, and give them additional MRI scans before and aft…

This study is a registry that collects information from 200 people with stage III or IV inflammatory breast cancer (IBC). Participants fill out a quality-of-life questionnaire and provide blood samples for MRD testing. The goal is to gather data on how MRD test results relate to …

This pilot study at MD Anderson Cancer Center is testing whether changes in pupil size and reactivity can predict neurological side effects in 100 adults with lymphoma who receive CAR-T cell therapy. Participants will have their pupils scanned with a handheld device for less than…

This study tests a decision-making tool for women newly diagnosed with breast cancer who are considering whether to have the healthy breast removed preventively (contralateral prophylactic mastectomy). The tool is designed to provide clear, balanced information. Researchers will …

This study asks 500 people with Li-Fraumeni syndrome (or their parents) to fill out a questionnaire about why they would or would not join a future trial comparing standard genetic counseling to a personalized version. The goal is to understand what factors influence their decisi…

This study is collecting tissue and blood samples, along with questionnaires, from 1,500 people with biliary tree cancers and healthy volunteers. Researchers hope to identify risk factors and genetic changes that influence how these cancers develop and respond to treatment. The g…

This study is testing an educational tool designed for people with melanoma who also have an autoimmune disease and are considering treatment with immune checkpoint inhibitors. Researchers want to see if the tool is easy to use and helpful for both patients and healthcare provide…

This study enrolls 75 lung cancer patients under age 50 to see if a dedicated care program improves their experience and outcomes. Participants fill out surveys over five years about their needs, satisfaction, and the impact of peer support. The goal is to learn what helps younge…

This study is testing whether checking troponin levels in the blood before each dose of immune checkpoint therapy can help catch heart problems early. 980 cancer patients will either get regular troponin monitoring or standard care. The goal is to see if this approach lowers hear…

This study is developing and testing an educational tool to help men aged 65 and older with prostate cancer decide with their doctors whether to reduce the frequency of follow-up tests like biopsies. The tool is being tested with 45 participants, including patients, caregivers, a…

This study is gathering feedback from adults who have completed a weight loss program to improve a dietary mobile application. Researchers will hold focus groups and interviews with about 39 participants to learn what features and messages they find helpful. The goal is to make t…

This study looks at how radiation therapy changes immune cells inside breast cancer tumors. Researchers want to see if radiation helps immune cells enter the tumor to fight cancer. The study involves 36 adults with invasive breast cancer who will receive radiation and have tumor …

This study looks at why people with head and neck cancer follow (or don't follow) swallowing exercises after radiation. Researchers will use blood tests and questionnaires to see if immune system proteins or feelings about the disease affect exercise habits. The goal is to find w…

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. It focuses on a process where neutrophils release web-like traps that may cause side effects. Researchers will study blood samples from 290 women with ER+ breast cance…

This study looks at how walking and sleeping habits affect recovery after lung cancer surgery. Researchers will give some patients a Fitbit to track their steps and sleep, and see if those who walk more have fewer complications. The goal is to learn how to improve recovery and qu…

This study aims to create personalized computer models of how patients walk to help doctors plan the best surgery and rehabilitation for pelvic sarcoma. Each patient's tumor is unique, making surgery challenging. The models may predict the best surgical methods to maximize walkin…

This study uses a 10-minute questionnaire to learn how the COVID-19 pandemic impacted the quality of life, mental health, finances, and social connections of people with melanoma. Researchers will also look at what factors, like social support, helped people cope. About 1,152 par…

This study looks at whether a remote training program called Project ECHO can improve the quality of palliative care for advanced cancer patients and their caregivers in underserved areas of Kenya, Nigeria, Ghana, South Africa, India, and Ethiopia. Researchers will measure change…

This study looks at the quality of life of people with two early blood conditions: MGUS and smoldering myeloma. Researchers will ask 400 participants to fill out short questionnaires about their symptoms and concerns. The goal is to learn what matters most to patients, not to tes…

This study looks at whether CT scans can help doctors predict how well chemotherapy will work for people with pancreatic or liver cancer. About 259 adults with these cancers will get CT scans before and during treatment. The goal is to see if changes in the scan can tell if the t…

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track heart injury and fitness in 100 patients to see if tailoring radiation based on individual risk can reduce heart problems. The goal is to learn how to better protect …

This study is testing whether a special MRI scan using an inhaled gas (xenon-129) can help doctors see and predict lung damage caused by radiation therapy for lung cancer. About 70 people, including healthy volunteers and lung cancer patients receiving radiation, will take part. …

This study observes adults with advanced thyroid cancer who are receiving standard treatments in real-world settings, not in clinical trials. Researchers aim to understand barriers to accessing care and how well patients tolerate and respond to available medications. About 459 pa…

This study is creating a database of medical information from 2,000 people with mesonephric-like adenocarcinoma (MLA), a very rare type of uterine cancer. Researchers hope to learn more about how MLA behaves and what makes it different from other cancers. No treatments or tests a…

This study looks at how people with both cancer and heart failure feel day-to-day. Researchers will ask 100 participants about their symptoms and quality of life using simple questionnaires. No new treatments are tested—the goal is to better understand the challenges these patien…

This study follows 200 people who had or will have a hemipelvectomy (removal of part of the pelvis and leg) for pelvic tumors. Researchers want to learn how different types of this surgery affect daily function and quality of life over time. The goal is to help doctors improve ca…

This study looks at the financial stress that patients with bone or soft tissue sarcoma face after surgery. Researchers will ask 100 adults to fill out questionnaires about the costs of their cancer care and how that affects their quality of life. No new treatments are being test…

This study creates and tests a decision aid for people with medullary thyroid cancer and their caregivers. The tool helps them discuss with their doctors whether to start or stop drugs, join clinical trials, or continue active monitoring. About 120 participants, including patient…

This study looks at how the COVID-19 pandemic impacted out-of-pocket costs, lost wages, and unemployment for 600 breast cancer patients undergoing surgery. Participants will fill out questionnaires about their financial experiences. The goal is to understand the financial toxicit…

This study will adapt educational materials about medullary thyroid cancer to be more culturally appropriate and easier to understand for Spanish-speaking Hispanic or Latino patients. Researchers will interview 40 participants, including patients and caregivers, to gather feedbac…

This study is creating a decision aid called TA-DA to help people with advanced cancer talk with their doctors about whether to try more treatments after several have already failed. The tool is designed to support shared decision-making. Researchers will test it with 155 patient…

This study is testing a new questionnaire called the SOCS-OTS to see if it can correctly identify cancer survivors who need occupational therapy. Researchers at MD Anderson will compare it to a standard screening tool in 80 adults. The goal is to make sure the new tool works well…

This study looks at how self-collection for HPV testing can help more people get screened for cervical cancer, especially in safety net health systems. Researchers will interview healthcare providers, staff, and patients to understand attitudes and develop training materials. The…

This study reviews medical charts of up to 3,000 chronic myelogenous leukemia (CML) patients who received standard tyrosine kinase inhibitors like imatinib outside of a clinical trial. Researchers want to understand real-world treatment patterns, responses, side effects, and preg…

This study at MD Anderson Cancer Center is testing whether an advanced MRI scan can help doctors more accurately target brain tumor biopsies. About 62 adults with suspected brain tumors will get an advanced MRI before their standard surgery. Researchers will compare the imaging r…

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance instead of immediate treatment. Researchers will use questionnaires, exams, biopsies, and MRIs every 6 months to 2-3 years to monitor disease progression over 5 years. The goal is…

This study looks at how the way medical information is presented influences treatment choices for people with advanced cancer. About 400 participants will fill out questionnaires and review made-up case scenarios. The goal is to learn how to better communicate health options to e…

This study is creating a large database of how patients recover after bladder cancer surgery (radical cystectomy). Researchers at MD Anderson and other centers will collect information from patients and doctors about symptoms and recovery. The goal is to understand what helps peo…

This study aims to find women in Texas who are at risk for hereditary breast, ovarian, and colorectal cancers but have limited access to healthcare. Researchers will use mobile mammography units to offer genetic testing and counseling on the spot. Up to 1,000 women will provide a…

This study looks at how sleep and physical activity change for blood cancer patients and their caregivers after a stem cell transplant. Researchers will use a Fitbit to monitor activity, sleep, and heart rate, and ask participants to complete questionnaires about their quality of…

This study surveys 9 radiology residents to see how comfortable they feel performing simulated blood vessel procedures after training on a special simulator. The goal is to improve hands-on training in a safe environment, which may lead to safer patient care in the future. Partic…

This study is testing a new computer program that helps doctors see which parts of the brain control important functions like language and movement. The goal is to help surgeons plan brain tumor removal more safely. About 1,720 adults with brain tumors who need surgery will take …

This study follows 100 people who were diagnosed with mycosis fungoides or lymphomatoid papulosis before age 20. Researchers will check their health status and ask about long-term outcomes. The goal is to understand how these rare skin conditions affect patients over time, not to…

This study looks at how the COVID-19 pandemic impacted the emotional, financial, physical, and social well-being of adolescent and young adult (AYA) cancer patients and survivors. Researchers will survey 600 participants to measure COVID-related distress and changes in health beh…

This study tests whether a special type of MRI, called hyperpolarized MRI, can predict how well thyroid and head/neck cancers respond to radiation or drug therapy before surgery. About 42 participants will get this imaging scan before and after starting treatment. The goal is to …

This study is testing if a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer will return sooner than current methods. About 1,000 people with colorectal cancer who have finished or are about to start treatme…

This study aims to help Black individuals and their families in Houston learn about their risk for hereditary cancers like breast and colorectal cancer. Researchers will use a simple questionnaire and remote genetic counseling to connect people with testing. The goal is to make g…

This study is creating a registry of 750 people with a rare and aggressive form of cervical cancer called neuroendocrine carcinoma. Researchers will collect information from medical records to learn more about the disease, how it is treated, and what happens to patients over time…

This study watches 40 adults with colorectal cancer who have no visible tumors but still have cancer DNA in their blood (minimal residual disease). Researchers will see how well biomarker-directed therapy, chosen by their own doctor, works to clear that DNA. The goal is to learn …

This study looks at whether joining a support group can improve emotional well-being and reduce feelings of isolation for people with a rare cervical cancer called NECC. About 40 adults with NECC will take part. Researchers will use surveys to measure changes in how participants …

This study looks at tissue samples from people with parathyroid tumors to better tell apart benign growths from cancer and to find genetic changes that could be targeted by new drugs. Researchers will test the samples for specific markers and genes. The goal is to reduce misdiagn…

This study is testing whether having additional MRI scans during radiation and chemotherapy can help doctors see how a high-grade glioma (a type of brain tumor) is changing. The goal is to use that information to adjust the treatment plan for each patient. About 80 adults with th…

This study looks at a method called 'Teaching the Teachers' to help spread liver cancer diagnosis guidelines. Experts learn the guidelines first, then teach other radiologists around the world. The goal is to see if this approach increases how often the guidelines are used. About…

This observational study follows 200 people with early blood conditions (MGUS or smoldering myeloma) that sometimes turn into multiple myeloma. Researchers will track age, blood protein levels, bone marrow cells, genes, and bone health to find patterns that predict progression. N…

This study is testing whether a special PET scan (18F-FSPG) and a blood test for tumor DNA can help doctors better guide treatment for liver cancer. About 60 people with hepatocellular carcinoma will receive standard Y90 radioembolization therapy. The goal is to see if these test…

This study looks at whether crushing belumosudil tablets affects how the drug is absorbed in people with chronic graft-versus-host disease (cGVHD). Eight adults who have had a stem cell transplant will take the drug as a whole tablet and later as a crushed tablet in water. The go…

This study looks at how cancer treatments can cause nerve pain. Researchers will use simple tests, like checking how you feel heat, cold, and touch, along with small skin samples, to understand why this pain happens. The goal is to find better ways to measure and eventually treat…

This study gathers information from 125 people with von Hippel-Lindau (vHL) disease to learn more about how the condition progresses and how it affects daily life. Participants provide data on their disease status, treatments, surgeries, and quality of life. No experimental treat…

This very early study looks at whether it is safe to collect blood stem cells from people with RUNX1 familial platelet disorder, a rare condition that raises the risk of bleeding and leukemia. Only 4 adults will take part to see how well the collection process works and what side…

This study looks at whether measuring a patient's energy reserve (fitness) before major cancer surgery can help predict how well they recover. Researchers will use a special exercise test to measure gas exchange and see if it relates to complications after surgery. The goal is to…

This study looks at abnormal cells in the lungs of 15 people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to understand these cells better so doctors can spot the disease earlier in future patients. Participants will have …

This study tests whether a simpler food tracking app, MySnackTracker, works as well as traditional full-intake diet logging. Researchers will compare how satisfied people are and how well they stick with each method. About 90 adults who already take part in certain cancer researc…

This study looks at what breast cancer survivors and their family members know about chemicals in personal care products that might affect hormones. Researchers also want to see if there is a link between being overweight and these chemicals. The study involves filling out questi…

This study looks at how well healthcare providers and family caregivers agree on the level of discomfort in advanced cancer patients who have hypoactive delirium (a state of reduced awareness and responsiveness). Researchers will survey both groups to compare their perceptions. T…

This study aims to understand why some people respond better to a brain stimulation treatment (rTMS) for smoking. Researchers will measure brain activity in 100 smokers aged 21-60 to see if emotional triggers affect treatment success. The goal is to personalize future therapies f…

This study aims to learn about the symptoms and changes patients experience while receiving treatment for sinonasal or nasopharyngeal cancer. Researchers will use a questionnaire to track how severe symptoms are over time. The goal is to better understand what patients go through…

This study looks at how a person's ancestry and financial situation influence their choice of bone marrow donor cells and whether they receive a genetically matched transplant. Researchers will follow 1,200 adults who are candidates for allogeneic transplantation. The goal is to …

This study looks at a rare cervical cancer called clear cell carcinoma. Researchers will test tumor samples from 70 patients to learn more about its genetic and protein features. The goal is to better understand this disease, not to test a new treatment.

This study aims to create and test an educational tool that teaches people how to prevent liver cancer. About 40 adults who have not been diagnosed with liver cancer will review the materials and share their thoughts. The goal is to make sure the information is clear, helpful, an…

This study tests tumor tissue from up to 12,000 cancer patients to find gene changes (mutations). The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to help future patient…

This study gathers medical information and tumor samples from 2,000 people with low-grade ovarian or peritoneal tumors. The goal is to create a detailed database that helps researchers understand these rare cancers better and develop improved treatments in the future. Participant…

This study collects blood, stool, and saliva samples from 150 people with non-small cell lung cancer who are getting chemotherapy, radiation, and immunotherapy. The goal is to find early signs of lung inflammation (pneumonitis), a common side effect. Researchers hope this will he…

This study tests whether a screening tool can improve how well patients with advanced lung cancer understand their illness. About 100 adults recently diagnosed with stage IV lung cancer will either use the tool or receive usual care. The goal is to help patients make informed dec…

This study reviews medical records from 600 lung cancer patients who had surgery between 2004 and 2019. The goal is to see if the use of robotic surgery has led to more atypical segmentectomies (removing part of a lung lobe). Researchers want to understand how robotic methods com…

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung cancer, or g…

This study follows 260 cancer patients who are on long-term blood-thinner medication for blood clots (VTE). Researchers will track how well patients take their medicine, their quality of life, and healthcare costs. The goal is to learn about patient experiences, not to test a new…

This study tests advanced imaging methods to tell the difference between true tumor growth and pseudoprogression (a harmless scan change after treatment) in people with brain cancer. About 25 adults who have had brain tumor treatment and show a new suspicious finding on scans wil…

This study is for adults about to start immune checkpoint inhibitor therapy for cancer. Researchers want to understand why some patients develop heart problems from this treatment. They will analyze blood samples and genetic factors from 1200 participants to find clues that could…

This study looks at how radiation treatment for esophageal cancer affects the body's ability to respond to the pneumonia vaccine. Researchers will measure antibody levels in 80 patients before and after vaccination. The goal is to understand if radiation-induced low white blood c…

This study looks at whether regular MRI scans after radiation therapy can help predict damage to healthy tissue in patients with mouth or skull base cancers. Researchers will track changes in MRI images over time to see if they can spot early signs of a condition called osteoradi…

This study gathers information on side effects from proton therapy in 5,000 adults with various cancers. Researchers will collect details on treatment plans and any short- or long-term side effects. The goal is to better predict who might have side effects and improve future care…

This study looks at how much of the radioactive drug Pluvicto reaches tumors and organs in patients whose kidneys or bone marrow are not working well. About 25 people will be enrolled to check for side effects and safety. The goal is to better understand dosing in these patients,…

This study builds a database of 1000 breast cancer survivors aged 50 or younger who have dense breast tissue. Researchers will track their MRI scans over time to see if MRI helps find new cancers that mammograms might miss. No new treatments are tested; the goal is to gather info…

This study aims to understand why people with hereditary colorectal cancer syndromes have different symptoms and outcomes. Researchers will compare patients and their family members to see how genes affect the disease. The goal is to learn more, not to test a new treatment.

This study looks at occupational stress in surgeons and musicians by using wearable brain monitors, saliva tests, and questionnaires. Researchers want to understand how these demanding jobs affect the body and mind. The study involves 20 adults and is run by MD Anderson Cancer Ce…

This study tracks memory and thinking changes in 100 adults with blood cancers who receive whole brain radiation. Researchers will test cognitive skills like recall and attention over time. The goal is to better understand the mental side effects of this treatment, not to change …

This study is testing a new imaging agent called 18F-4FN for PET/CT scans in 16 adults with chronic graft-versus-host disease (GVHD) affecting their joints. The goal is to see if the scan is safe and can help doctors see disease activity better. Participants must be at least 18 a…

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource for future research on breast cancer and women's health. Participants provide a blood sampl…

This study collects extra tissue and fluid from routine lung procedures that would otherwise be thrown away. Researchers will use these samples to better understand lung complications in cancer patients. Up to 12,000 adults undergoing pulmonary procedures at the Cardiopulmonary C…

This study is testing whether wearing a fitness tracker (like a Fitbit) can give doctors a better picture of how active cancer patients are, and whether that activity level relates to how well they are doing overall. About 590 people with various cancers will wear activity monito…

This study follows people who have already received gene transfer therapy for cancer or other conditions. The goal is to monitor long-term safety and any side effects over up to 15 years. No new treatment is given; participants provide health updates and occasional blood samples.…

This study is testing a new questionnaire system to see how well it measures common cancer symptoms and how those symptoms affect quality of life. Researchers will ask about 6,500 cancer patients, caregivers, and doctors to fill out surveys. The goal is to create a better way to …

This early-stage trial is testing whether the drug ulixertinib can cross the blood-brain barrier in people with recurrent brain tumors called gliomas. About 40 adults will take the drug before surgery to see how much reaches the tumor and how safe it is. The goal is to learn if t…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…

This study looks at the best ways to teach heavy smokers about lung cancer screening using tobacco quitlines. Researchers will work with 800 participants, including quitline staff and smokers aged 55-80 with a heavy smoking history. The goal is to see what methods work best to sh…

This study aims to help heavy smokers aged 55 to 80 make informed decisions about lung cancer screening. Researchers are updating a decision aid and testing it with 620 participants. The goal is to improve understanding and support better choices, not to treat or prevent disease.

This study aims to create a shared decision-making tool for Spanish-speaking women with advanced ovarian cancer. The tool will help them and their doctors discuss and choose maintenance therapy after chemotherapy. About 70 patients will test the tool to see if it reduces regret a…

This study uses a special type of MRI (called hyperpolarized 129-Xenon MRI) to look at lung function in adults who have had a bone marrow transplant and developed lung problems. Researchers want to see if this scan can measure how well the lungs are working and predict if the con…

This study is testing whether giving nutrition through a feeding tube after a stem cell transplant is safe and practical. It involves 40 children and young adults aged 2 to 25. The goal is to see if this method works better than standard care.

This study aims to understand how rheumatic side effects (like arthritis) from cancer immunotherapy affect patients' daily lives. Researchers will interview 20 adults who have experienced these side effects to learn about their severity and impact. The goal is to improve future c…

This study is testing a decision aid to help people decide whether to get screened for lung cancer. The tool is designed for patients in a safety-net healthcare system. Researchers will enroll 360 current or former smokers aged 50-80 to see if the aid is safe and helpful.

This study gathers blood, saliva, urine, and stool from up to 1,600 children with recurrent or chronic pancreatitis. Researchers look for genetic markers that might increase the risk of pancreatic cancer later in life. No treatment is given—the goal is simply to learn more about …

This study gathers information from 100 adults with blood cancers who receive CAR-T therapy and/or radiation as part of their standard care. The goal is to learn how these treatments work together, including side effects and how long the benefits last. By collecting this data, do…

This study looks at whether a tool called DIGEST helps doctors better measure swallowing problems in cancer patients. Researchers will work with 85 hospitals and clinics to see if they start using this tool regularly. The goal is to improve how swallowing issues are tracked and t…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This study explores whether magnetic resonance spectroscopy (MRS) can be used to safely evaluate spinal cord lesions. Researchers will test the technique in healthy volunteers and patients with leptomeningeal disease who are receiving radiation. The main goal is to see if MRS is …

This study tests a rice-sized device that is temporarily placed inside a sarcoma tumor. The device releases tiny amounts of up to 10 different drugs to see which ones damage the tumor tissue. The goal is to find the most effective drug for each patient without exposing the whole …

This study looks at whether a blood test that finds tiny bits of tumor DNA (called cfDNA) can help doctors see if lymphoma is still present after treatment. About 517 adults with diffuse large B-cell lymphoma will give blood samples before and after therapy. The goal is to see if…

This study follows 430 people with stage I-IV rectal cancer to see how surgery affects their daily life and well-being. Participants fill out questionnaires about their health and preferences. The goal is to learn more about what life is like after treatment, not to test a new dr…

This study looks at how the COVID-19 pandemic impacted the mental health of 20,000 employees at MD Anderson Cancer Center. Researchers are using surveys to measure stress and emotional well-being during and after the pandemic. The goal is to understand what factors put workers at…

This study is for adults with certain advanced solid tumors (non-small cell lung cancer, colorectal cancer, or ovarian cancer). Researchers want to find biological markers that show how the experimental drug SAR444881 works, alone or with cemiplimab. About 40 participants will re…

This study aims to understand what helps or hinders a positive experience for Asian patients being treated for cancer at MD Anderson. Researchers will survey former patients and healthcare providers to identify key factors. The goal is to use these insights to improve care and su…

This study collects information on side effects and how well the cancer responds in 170 advanced cancer patients receiving anti-VEGF therapy. The goal is to see if certain side effects are linked to better or worse treatment outcomes. No new treatment is being tested; this is an …

This study brings together a panel of prostate cancer experts to agree on the most important pieces of information that should be included in medical reports. The goal is to create a standard way of reporting key data in electronic health records, which could help doctors better …

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after gynecologic brachytherapy, a type of internal radiation. Researchers want to find better ways to keep patients comfortable and reduce psychological distress when the treatment applicat…

This study aims to learn how patients rate their symptoms during or after radiation therapy using different questionnaires. Researchers want to see if different rating scales give similar or different results. The study involves 300 adults with head and neck cancer who are curren…

This study compares two types of 3D mammography (digital breast tomosynthesis) to see which one makes breast masses and distortions easier to see. About 100 women getting standard screening mammograms will participate. The goal is to improve detection, not to treat any disease.

This study is testing whether a blood test, called a liquid biopsy, can find cancer cells and predict if endometrial cancer will return. Researchers will collect blood and tissue samples from 1,000 women with endometrial cancer before and after treatment. The goal is to see if th…

This study aims to understand how social and financial challenges influence the results of transplant and cell therapy treatments. Researchers will follow 2,000 adult patients at MD Anderson Cancer Center and ask them about their social circumstances. The goal is to identify barr…

This study watches children aged 2 to 12 who are getting radiation therapy for cancer. Researchers want to see how their anxiety changes over time. The goal is to learn more about their emotional needs, not to test a new treatment.

This study surveys 250 U.S. lung specialists to learn how the COVID-19 pandemic changed their procedures, staffing, and clinic operations. The goal is to help pulmonary programs improve and guide future research for better pandemic preparedness. Participants are pulmonologists wh…

This study explores whether a simple blood test that measures tumor DNA (ctDNA) can help doctors decide if patients with colorectal or appendix cancer need stronger or weaker chemotherapy before surgery. About 48 adults with cancer that has spread to the abdomen will take part. T…

This study is a registry that gathers information from 250 people with lung cancer or cancer that has spread to the lungs. Participants will have their tumors treated with a robotic scope inserted through the mouth to burn the tumor. The goal is to learn how well this procedure w…

This study is testing whether a specially designed video game can help young people (ages 15-39) who have had a stem cell transplant for leukemia or lymphoma improve their health habits. Researchers will gather feedback from 40 participants to see if the game is easy and enjoyabl…

This study is following over 2,300 people across the US to better understand chronic pancreatitis, a painful long-term condition of the pancreas. Researchers will track participants' symptoms and disease changes over time to identify what causes the disease and how it progresses.…

This study is testing a special type of MRI scan to see if it can better measure how colorectal cancer liver tumors respond to chemotherapy. About 70 people with liver metastases that have not been treated yet will get the scan before and after chemo. The goal is to improve how d…

This study interviews cancer care providers, patients, and caregivers to learn their thoughts and feelings about receiving hospital-level care at home. The goal is to understand what people know and believe about home hospital care, so that future programs can be designed to bett…