M.d. Anderson Cancer Center

This study tests a drug called avapritinib in people with advanced solid tumors that have certain genetic changes (CKIT or PDGFRA mutations). The goal is to see if the drug can shrink or control the cancer. About 50 adults with cancers like melanoma, sarcoma, or breast, lung, or …

This study tests an investigational drug called nirogacestat in 40 adults with desmoid tumors (aggressive fibromatosis). The goal is to see if the drug is safe and how it affects the tumors. Participants receive the drug and are monitored for side effects and tumor response.

This trial tests whether combining two drugs, atezolizumab and tiragolumab, can help control bladder cancer when given before surgery to remove the bladder and tumor. It is for people with high-risk bladder cancer who cannot take standard chemotherapy. The study aims to see if th…

This early-phase trial is testing a combination of two drugs, pembrolizumab and lenvatinib, in about 15 people with advanced stomach or gastroesophageal cancer that has spread or can't be removed by surgery. Pembrolizumab helps the immune system attack cancer cells, while lenvati…

This early study tests whether adding special cells from donated cord blood to a standard drug (ruxolitinib) can better control a serious immune reaction called graft-versus-host disease (GVHD) that does not respond to steroids. The study includes 24 people aged 12 to 80 who have…

This study tests whether giving a targeted pill (sotorasib) together with standard chemotherapy before surgery can improve outcomes for people with a certain genetic type of lung cancer (KRAS G12C mutation). About 27 adults with stage IIA to IIIB non-squamous lung cancer that can…

This study tests whether giving radiation therapy before starting immunotherapy can improve outcomes for people with rare sinonasal or anorectal melanoma. About 40 adults with no distant spread will receive the combination. The main goal is to see how well the tumor responds.

This early-phase trial tests a new cell therapy for people with advanced clear cell kidney cancer that has stopped responding to standard treatments. The therapy uses donor immune cells (NK cells) that are genetically modified to better recognize and attack cancer cells while res…

This study tests the safety of a drug called olutasidenib given to people with certain blood cancers (like AML or MDS) after they have a stem cell transplant. The goal is to see if the drug can help keep the cancer from coming back. About 31 adults with an IDH1 gene mutation will…

This study tests a minimally invasive procedure called radiofrequency ablation (RFA) for people whose parathyroid cancer has come back after surgery and causes dangerously high calcium levels. About 20 adults who cannot have more surgery or prefer a non-surgical option will recei…

This study tests a combination of two drugs—blinatumomab and ponatinib—in adults with a specific, hard-to-treat leukemia (Ph-positive ALL) that has come back or not responded to prior treatment. The goal is to see if this mix can kill cancer cells more effectively. About 90 parti…

This study tests whether combining two antiviral drugs, baloxavir and oseltamivir, can treat severe flu better than oseltamivir alone in people who have had a stem cell transplant or have blood cancer. About 60 participants will receive the combination therapy. The goal is to see…

This early-phase study tests a new combination of three drugs for people with metastatic triple negative breast cancer that has spread and is no longer responding to standard treatments. The goal is to find the safest dose of two of the drugs when given together with a standard d…

This study tests whether adding venetoclax to standard chemotherapy before a stem cell transplant can help people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) live longer without their cancer coming back. About 324 adults aged 18 to 70 will receiv…

This trial tests a combination of two drugs, atezolizumab and cabozantinib, in adolescents and young adults (ages 12 and up) with osteosarcoma that has returned or spread. The goal is to see if this treatment can help control the cancer by boosting the immune system and blocking …

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and radiation before and after surgery can delay the return of high-risk soft tissue sarcoma in the arms, legs, or trunk. About 50 adults with certain aggressive sarcoma types will recei…

This study is for people with brain metastases that are considered low-risk and who are receiving systemic therapy (like targeted drugs or immunotherapy) that can reach the brain. Researchers want to see if adding precise radiation (stereotactic radiosurgery) at the right time ca…

This early-phase study tests a new drug called NBTXR3, which is activated by radiation, along with standard chemotherapy for people with esophageal adenocarcinoma. The goal is to find the safest dose and see if this combination can better control the disease. About 24 adults with…

This early-phase study tests whether tirzepatide, a weight-loss medication, can help overweight or obese men with intermediate-risk prostate cancer lose weight before prostate removal surgery. The main goal is to see if the program is safe and feasible. About 30 participants will…

This study tests a combination of drugs for people with blood cancers (like AML or MDS) that have returned or not responded to treatment. Participants must have a specific IDH1 mutation plus another mutation in a signaling pathway. The goal is to see if the drug combo is safe and…

This study tests a new treatment called KSQ-004EX for people with advanced solid tumors that have not responded to other therapies. The treatment uses a patient's own immune cells, which are modified in a lab to be stronger against cancer. The goal is to find the right dose and s…

This study tests a drug called ivonescimab in 24 people with advanced cutaneous squamous cell carcinoma that cannot be removed by surgery or has spread. The goal is to see if the drug can help control the cancer and to check for side effects. Participants will receive the drug an…

This study tests a new type of proton therapy for children with ependymoma, a brain tumor. The therapy uses special proton beams to kill tumor cells while trying to protect healthy brain tissue. About 48 children will take part to see if the treatment is safe and what side effect…

This early-stage trial is for people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose cancer came back or didn't get better after standard therapy. Researchers are testing a chemotherapy drug combo called CPX-351 to find the safest dos…

This study tests a chemotherapy-free combination of two drugs, pirtobrutinib and rituximab, in 50 adults with newly diagnosed low or intermediate risk mantle cell lymphoma (MCL). The goal is to see if this treatment can keep the cancer in remission for a long time while reducing …

This early-phase trial tests whether adding the drug lurbinectedin to two standard chemotherapy drugs (paclitaxel and bevacizumab) can better control advanced ovarian cancer that no longer responds to platinum-based treatments. About 34 adults with this type of cancer will receiv…

This study tests a combination of four drugs (cladribine, cytarabine, venetoclax, and azacitidine) to see if it can help control higher-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has not responded to standard treatments. About 60 adults age…

This study is for people with a rare adrenal gland cancer that has a high chance of coming back after surgery. It compares two treatments given after surgery: mitotane alone versus mitotane plus chemotherapy (cisplatin and etoposide). The goal is to see which approach better prev…

This early-stage study tests whether donor bone marrow stem cells can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive either standard care alone or standard care …

This early-phase study tests a new drug called HC-7366 in 18 adults with acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose and check for side effects. This is a first step to see if the drug might help control the …

This study tests whether a combination of three drugs (calaspargase pegol-mknl, decitabine, and venetoclax) can help control relapsed or treatment-resistant T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LLy) in patients aged 1 month to 21 years.…

This study tests whether combining two drugs, enasidenib and azacitidine, can help people with a specific genetic form of acute myeloid leukemia (AML) that has returned or not responded to prior treatment. About 50 adults with an IDH2 gene mutation will receive the combination to…

This study tests a new all-oral combination of three drugs (SNDX-5613, decitabine/cedazuridine, and venetoclax) in people with acute myeloid leukemia (AML) who cannot have strong chemotherapy or whose cancer has returned. The goal is to find the best dose and see if the combo can…

This study is for men with high-risk prostate cancer that hasn't spread far. It tests whether adding the drug niraparib after standard radiation and hormone therapy can keep the cancer from coming back longer. About 200 men will take part, and the study compares standard hormone …

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with relapsed or refractory multiple myeloma that has spread outside the bone marrow. About 34 adults whose cancer returned or did not respond to prior treatments wil…

This study tests whether adding the chemotherapy drug bendamustine (with or without cyclophosphamide) can prevent graft-versus-host disease (GVHD) in 25 adults with blood cancers who receive a stem cell transplant. GVHD occurs when donor cells attack the patient's body. The goal …

This study tests a new treatment for people with myeloid blood cancers that have come back or not responded to standard therapy. It uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer cells and resist tumor defenses. Up to…

This early-phase trial tests whether combining chemotherapy, radiation, and the immunotherapy drug dostarlimab is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive chemoradiation followed by chemotherapy plu…

This early-stage study is for children and young adults with acute leukemia that has come back or not responded to treatment. Researchers are testing a powerful chemotherapy regimen called hyper-CVAD combined with the targeted drug venetoclax. The main goal is to find the safest …

This study is for people with kidney cancer that has spread to a few other spots (oligometastatic). After radiation to those spots, researchers want to see if adding a year of the drug pembrolizumab can keep the cancer under control longer. About 144 participants will be enrolled…

This study tests whether infusions of stem cells from donated umbilical cord blood can help control severe pneumonia caused by COVID-19 in cancer patients. About 70 adults with moderate to critical illness will receive either stem cells plus standard care or standard care alone. …

This study tests whether combining two drugs, mosunetuzumab and zanubrutinib, can safely control marginal zone lymphoma that has returned or not responded to prior treatment. About 36 adults with stage II-IV disease who have already tried at least one therapy including a CD20 ant…

This study tests whether combining the drug enfortumab vedotin with radiation therapy can help control locally advanced bladder cancer. About 41 adults with urothelial carcinoma of the bladder will receive the treatment. The main goal is to check safety and side effects.

This early-phase study tests a new treatment called JV-213 for people with B-cell lymphoma that has come back or not responded to other treatments. JV-213 uses a patient's own immune cells, modified to attack cancer cells. The main goal is to find the safest dose and watch for si…

This study tests whether the drug ivonescimab can help control advanced clear cell kidney cancer in people who have already received at least one prior treatment, including immunotherapy. About 40 participants will receive ivonescimab and be monitored for side effects and cancer …

This early-phase study tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat advanced vulvar cancer that has spread and cannot be surgically removed. About 25 adults with stage II–IVA vulvar cancer will receive different …

This early-stage trial tests the drug talazoparib combined with one of three other drugs (palbociclib, axitinib, or crizotinib) in people with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combinations can shrink or control the cancer.…

This study looks at whether adding radiation therapy to standard immunotherapy can lower the chance of melanoma coming back in nearby lymph nodes. It involves 168 adults with high-risk melanoma that has spread to a sentinel lymph node. Participants will receive radiation to the l…

This study tests whether ultra low dose radiation, given before or after chemotherapy-free targeted therapy, can help control mantle cell lymphoma that has returned or stopped responding to treatment. About 80 adults with this type of blood cancer will receive the low-dose radiat…

This study tests a new drug called golidocitinib, given alone or with standard chemotherapy (CHOP), for people newly diagnosed with peripheral T-cell lymphoma, a rare blood cancer. The goal is to see if the drug helps control the disease safely. About 30 adults will take part at …

This early-phase study tests an inhaled form of the chemotherapy drug gemcitabine for people whose cancer has spread to the lungs from other parts of the body. The main goal is to find the highest safe dose and to watch for side effects. Up to 44 participants will take part at MD…

This study tests a combination of two drugs, azacitidine and pembrolizumab, for people whose Hodgkin's lymphoma has returned or not responded to treatment. The goal is to see if the combo can shrink tumors. The trial is for patients aged 1 and older who cannot have high-dose chem…

This study tests a two-step treatment for women whose mucinous ovarian cancer has come back. First, surgeons remove as much visible cancer as possible. Then, heated chemotherapy is pumped directly into the abdomen during the same operation. The goal is to see if this approach hel…

This study tests whether giving radiation therapy to people whose cancer has spread or grown after immunotherapy can help control the disease. About 230 adults with various cancers will receive radiation to see if it shrinks tumors or slows progression. The goal is to find a safe…

This study tests a new treatment for people with autoimmune disorders like systemic sclerosis, lupus, and lupus nephritis. It combines a special immune cell therapy (AD-PluReceptor-NK cells) with a drug called tafasitamab and chemotherapy. The goal is to find a safe dose and see …

This study tests whether giving the drug elranatamab before and after a stem cell transplant can better control high-risk multiple myeloma. About 40 adults with newly diagnosed, high-risk myeloma will receive the drug to reduce cancer cells before transplant and then as maintenan…

This study tests a drug called AMB-05X in 15 people with colorectal cancer who have completed curative treatment but still have traces of cancer DNA in their blood (ctDNA positive) with no visible tumors on scans. The goal is to see if the drug can safely eliminate these hidden c…

This study tests a new way to treat a fast-growing blood cancer called B-cell acute lymphoblastic leukemia in older adults (60+) or younger adults who cannot handle strong chemo. The treatment combines a targeted drug (blinatumomab) given as a shot under the skin with milder chem…

This early-phase study tests a wearable device that creates electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The goal is to see i…

This study tests whether a time-limited combination of three drugs (pirtobrutinib, venetoclax, and obinutuzumab) is safe and effective for people with chronic lymphocytic leukemia (CLL) or Richter transformation who have not had prior treatment. About 60 adults will participate. …

This study tests a new device that uses very short electric pulses to destroy small thyroid tumors without surgery. It includes 15 people with early-stage papillary thyroid cancer (tumors 1.5 cm or smaller). The main goal is to see if the treatment is safe and controls the cancer…

This study tests whether the drug letermovir can safely prevent the reactivation of cytomegalovirus (CMV) in people who have received a type of cell therapy called axicabtagene ciloleucel. About 36 adults who are CMV-positive and scheduled for this cell therapy will take letermov…

This early-phase study tests the safety of combining two drugs, alpelisib and pembrolizumab, in people with advanced breast cancer or melanoma that has spread. About 50 adults whose cancer has not responded to standard treatments will receive the combination to find the best dose…

This study tests whether a combination of TAS-102 and celecoxib can clear tiny amounts of cancer DNA left in the blood after standard chemotherapy in colorectal cancer patients. About 25 people who have finished their main treatment but still show cancer signals in a blood test w…

This study tests whether combining tivozanib and nivolumab can help control advanced non-clear cell kidney cancer. About 48 adults with specific types of this cancer will receive the drug combo. The goal is to see if the treatment shrinks tumors or slows disease growth while moni…

This study tests whether adding the antibiotic metronidazole to standard therapy can reduce certain bacteria linked to worse outcomes in rectal cancer. About 60 adults with locally advanced rectal cancer will receive either standard treatment alone or with metronidazole. The goal…

This study tests the drug zanzalintinib given before surgery for people with advanced thyroid cancer. The goal is to see if the drug can shrink tumors and make surgery more effective, while also checking for side effects. About 45 adults with certain types of advanced thyroid can…

This early-phase trial tests a new treatment for people with colorectal cancer who have minimal residual disease (tiny amounts of cancer left after treatment). The therapy uses specially engineered natural killer (NK) cells from donated cord blood, designed to target a protein ca…

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell non-Hodgkin lymphoma. The goal is to see if this mix can better control the cancer. About 36 adults with follicular lymphoma or diffuse large B-…

This study tests whether two drugs, venetoclax and revumenib, can control minimal residual disease (MRD) in acute myeloid leukemia (AML) patients. MRD means small numbers of cancer cells remain after initial treatment, raising the risk of relapse. The trial enrolls about 8 people…

This early-phase study tests a combination of three drugs (decitabine, lisaftoclax, and olverembatinib) in adults with advanced chronic myeloid leukemia or a related acute leukemia. The goal is to find safe and tolerable doses that can help control the disease. About 30 participa…

This study tests two drugs, azacitidine and quizartinib, in people with myelodysplastic syndromes or related blood cancers that have specific gene changes (FLT3 or CBL). The goal is to find the best dose and see if the combination can shrink or control the cancer. About 58 adults…

This study tests whether adding the drug epcoritamab to a standard chemotherapy mix (rituximab, cyclophosphamide, vincristine, prednisone) can better control newly diagnosed diffuse large B-cell lymphoma (DLBCL) in older or frail adults who cannot receive strong anthracycline che…

This study tests whether giving higher doses of radiation along with the chemotherapy drug temozolomide can better control certain aggressive brain tumors (IDH wildtype gliomas). About 40 adults with these tumors will receive the intensified treatment. The goal is to see if this …

This study tests whether a family-centered program can help Black prostate cancer survivors and their caregivers eat better, exercise more, and feel better overall. About 648 pairs of survivors and caregivers will join. The program is compared to a survivor-only group and a contr…

This early-stage trial tests whether a specially engineered virus, G207, is safe for children with cerebellar brain tumors that have come back or not responded to standard treatments. The virus is injected directly into the tumor, and a low dose of radiation is given to help the …

This study is testing whether certain breast cancer patients who respond extremely well to initial drug therapy can safely avoid surgery or radiation. It includes 120 adults with specific breast cancer types (HER2-positive, triple-negative, or ER-positive/HER2-negative). Doctors …

This early-phase study tests a new drug combination for children and young adults (ages 3–21) with acute myeloid leukemia (AML) that has returned or not responded to treatment. The goal is to find a safe dose of ziftomenib when given alongside two other drugs (venetoclax and gemt…

This study tests a mix of five drugs (fludarabine, cytarabine, filgrastim-sndz, gemtuzumab ozogamicin, and idarubicin) in 270 adults with newly diagnosed acute myeloid leukemia or high-risk myelodysplastic syndrome that have specific genetic changes. The goal is to see how well t…

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated radiation) can control Merkel cell carcinoma after surgery. About 52 adults with no signs of cancer spread will receive radiation to the tumor site and nearby lymph nodes. The goal is to see if t…

This study tests whether giving high doses of ruxolitinib and busulfan before a stem cell transplant can reduce spleen size and help the transplant work better in people with myelofibrosis. About 30 adults aged 18 to 75 with an enlarged spleen and a matched donor will take part. …

This study tests whether two drugs, fruquintinib and tislelizumab, can control leftover cancer cells in people with colorectal cancer who have completed chemotherapy but still show signs of minimal residual disease (MRD) on a blood test. About 20 adults with stable disease will r…

This study tests whether giving two drugs (acalabrutinib and obinutuzumab) in cycles can control chronic lymphocytic leukemia (CLL) and allow patients to stop treatment temporarily without the cancer coming back quickly. About 60 adults with untreated CLL who need therapy will re…

This study tests a shorter, high-dose radiation treatment (SBRT) given in just 5 sessions for people with advanced or high-risk prostate cancer. The goal is to see if it is safe and works well. About 70 participants will be enrolled.

This study tests a drug called REGN5678 in men with high-risk prostate cancer who are scheduled for prostate removal surgery. The goal is to see if the drug is safe and how it affects the cancer before surgery. About 42 men will take part, and researchers will monitor side effect…

This early-phase trial tests a new drug called nadunolimab combined with standard treatments (azacitidine, with or without venetoclax) in 40 people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The goal is to see if the combination is safe and to find the b…

This early-phase study tests a new treatment for people with advanced head and neck cancer that has spread or cannot be removed by surgery. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer cells and resist…

This early-phase trial tests a new treatment called iExosomes for people with metastatic pancreatic cancer that has a specific KRAS G12D mutation. The therapy uses tiny particles (exosomes) to deliver a molecule that silences the cancer-driving gene. The study aims to find the sa…

This study tests a combination of three drugs (azacitidine, venetoclax, and gilteritinib) in adults with FLT3-mutated acute myeloid leukemia, chronic myelomonocytic leukemia, or high-risk myelodysplastic syndrome that has returned or not responded to treatment. The goal is to fin…

This study tests a mix of medicines—including a protein from horse blood—to treat aplastic anemia and low-risk myelodysplastic syndrome (MDS). These conditions cause dangerously low blood cell counts. The treatment aims to kill overactive immune cells and stimulate white blood ce…

This study tests whether combining two therapies—axicabtagene ciloleucel (a cell therapy) and glofitamab (a drug)—can help control large B cell lymphoma that came back or didn't respond to initial treatment. About 40 adults with this aggressive blood cancer will receive the combo…

This study tests a new treatment for colorectal cancer that has spread to the lining of the abdomen. The treatment uses specially designed natural killer (NK) cells that target a protein called TROP2 on cancer cells and have a gene removed to help them work better. These cells ar…

This study is for people with a newly diagnosed, aggressive type of blood cancer called mantle cell lymphoma (MCL). Researchers want to see if adding a drug called glofitamab after initial treatment with a BTK inhibitor and rituximab can better control the disease. About 30 parti…

This early-phase trial tests a new approach for people with recurrent high-grade glioma, a fast-growing brain cancer. Researchers use stem cells to carry a modified cold virus directly to the tumor via an artery. The goal is to find the safest dose and see if the virus can shrink…

This study tests a combination of four drugs (venetoclax, cladribine, low-dose cytarabine, and azacitidine) in adults aged 50 and older with untreated acute myeloid leukemia (AML). The goal is to see if this approach can achieve complete remission. Participants will receive the d…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with this cancer will receive the drug and be monitored for side effects and cancer response. The goal is to see if the drug alone can manage t…

This study tests whether combining two targeted drugs (acalabrutinib and venetoclax) with or without an early dose of an immune-boosting antibody (obinutuzumab) can better control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that is high-risk, has return…

This study looks at whether people with stage II or III rectal cancer can safely avoid surgery by using chemotherapy and then closely watching for any tumor regrowth. About 120 participants will receive chemotherapy and then be monitored instead of having immediate surgery. The g…

This study tests whether the drug loncastuximab tesirine can help people with large B-cell lymphoma who only had a partial response after CAR T-cell therapy. About 30 adults will receive the drug to see if it can turn a partial response into a complete remission. The goal is bett…

This study is for people with stomach cancer that has spread to the lining of the abdomen. Researchers want to see if giving the chemotherapy drug paclitaxel before and after stomach removal surgery can help patients live longer and have fewer side effects. About 30 adults will t…

This study tests whether combining two drugs, CPX-351 and ivosidenib, can better control acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) in people with a specific IDH1 gene mutation. About 30 adults who are either newly diagnosed or whose cancer has retur…

This study tests a new treatment using specially engineered immune cells (TROP2 CAR-NK cells) given directly into the abdomen. It is for people with ovarian, mesonephric, or pancreatic cancer that has stopped responding to standard treatments. The main goal is to find a safe dose…

This early-stage trial tests whether specially grown donor immune cells can safely fight adenovirus infections in people with weakened immune systems, such as those with blood cancers. About 16 participants will receive cells matched to their HLA type. The main goals are to check…

This study tests whether adding a targeted drug (gemtuzumab ozogamicin) to standard therapy (tretinoin and arsenic trioxide) works better for adults with untreated acute promyelocytic leukemia. About 151 participants will receive the combination. The goal is to see if the extra d…

This study tests a chemotherapy drug called paclitaxel, given directly into the abdominal cavity, for people with appendix cancer that has spread. The goal is to find the safest dose and check for side effects. About 39 adults with advanced disease who cannot have surgery will ta…

This study tests whether using multiple treatments together (like surgery, radiation, and chemotherapy) can help people with pancreatic cancer that has spread to only a few places in the body live longer and keep the cancer from growing. About 80 adults with this type of cancer w…

This study tests whether freezing just the part of the prostate that contains cancer (focal cryotherapy) can control intermediate-risk prostate cancer. About 30 men with a single area of cancer will receive this targeted treatment. The goal is to see if this less invasive approac…

This study tests a drug called belantamab mafodotin in people with a high-risk form of smoldering multiple myeloma, an early stage of blood cancer. The goal is to find a safe dose and see if the drug can control the disease. About 30 participants will receive the drug, and resear…

This study tests a drug called emapalumab to see if it can safely help people with lymphoma whose blood cell counts stay dangerously low after CAR T-cell therapy. About 32 adults who have already received a standard CAR T-cell treatment will take part. The goal is to find out if …

This study tests whether targeted radiation can help control multiple myeloma that remains active after standard CAR-T cell therapy. About 30 adults who still have signs of disease on scans at least 30 days after CAR-T will receive radiation to up to five tumor sites. The goal is…

This early-stage trial is testing the drug pembrolizumab in people with thymoma or thymic carcinoma that cannot be surgically removed. The goal is to see how safe the drug is and whether it can help control the cancer by boosting the immune system. About 37 participants will be e…

This study tests a drug called ponatinib in people with chronic myeloid leukemia (CML) whose cancer did not respond to or who could not tolerate other targeted therapies. The goal is to see if ponatinib can control the cancer by blocking a protein that helps cancer cells grow. Ab…

This early-stage trial tests a new drug, NP-101, in about 35 adults with advanced solid tumors that have worsened after standard treatments or have no standard options. The main goal is to check the drug's safety and find the right dose. Researchers will also look for early signs…

This study tests whether a drug called dexrazoxane can protect the heart from damage caused by chemotherapy in people with certain blood cancers, such as acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). About 100 adults will receive dexrazoxane alongside…

This early-phase study tests a new drug called IACS-6274, alone or with other medicines, in people with advanced solid tumors (like melanoma, ovarian, or head and neck cancers) that have not responded to standard treatments. The main goal is to find the safest dose and understand…

This early-phase study tests a new treatment for people with advanced synovial sarcoma or myxoid/round cell liposarcoma. Participants receive donated immune cells (NK cells) that are engineered to recognize a protein called NY-ESO-1 on cancer cells, along with chemotherapy to pre…

This study tests a combination of targeted drugs and immunotherapy for people with untreated primary mediastinal large B-cell lymphoma, a rare cancer of the lymph nodes. The treatment aims to control the disease with fewer side effects than standard chemotherapy. About 31 partici…

This study looks at whether eating a diet rich in prebiotic foods (which feed good gut bacteria) can help standard immunotherapy work better in people with advanced melanoma that cannot be removed by surgery. About 75 adults starting their first immunotherapy will follow this spe…

This study tests whether adding another drug (cediranib or AZD6738) to the PARP inhibitor olaparib can shrink tumors or slow cancer growth in people with advanced BRCA-mutated breast cancer that has stopped responding to PARP inhibitors. About 60 adults with HER2-negative, BRCA-p…

This study is for adults with acute lymphoblastic leukemia (ALL), including those over 60 or unfit for standard chemo. It combines a targeted antibody-drug (inotuzumab ozogamicin) with low-intensity chemotherapy to kill cancer cells while reducing side effects. The goal is to fin…

This study is for people with esophageal or stomach cancer that has spread to 3 or fewer spots in the body. It compares standard chemotherapy alone to chemotherapy plus radiation or surgery. The goal is to see if the extra treatments help people live longer and keep the cancer fr…

This study tests a new drug, CBP-1019, combined with standard chemotherapy (FOLFOX) and possibly other drugs for people with advanced solid tumors that have stopped responding to treatment. The goal is to see if these combinations are safe and can help control the cancer. About 1…

This study tests a new drug, ADI-PEG20, combined with two chemotherapy drugs (carboplatin and cabazitaxel) in men with an aggressive form of prostate cancer that is hard to treat. The goal is to find the safest dose and see if the combination can control the disease. About 30 men…

This study tests a type of internal radiation called high-dose-rate brachytherapy for people with liver tumors that cannot be removed by surgery. The treatment uses a tiny radioactive source placed directly into the tumor to kill cancer cells while sparing nearby healthy organs. …

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink brain metastases in people with triple-negative breast cancer, non-small cell lung cancer, or other solid tumors. About 104 participants will receive the combination therapy. The main goal is to see how …

This study tests whether combining dostarlimab and LB-100 can help control ovarian clear cell carcinoma, a rare type of ovarian cancer. About 21 adults with recurrent disease will receive the treatment to check safety and effectiveness. The goal is to manage the cancer, not cure …

This phase II trial tests whether the drug ivonescimab can help control a rare and aggressive form of breast cancer called invasive lobular carcinoma that has spread and stopped responding to hormone therapy. About 29 adults with either hormone-receptor-positive or triple-negativ…

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, or multiple myeloma that have come back or not responded to standard therapy. Participants receive chemotherapy followed by specially engineered natural killer (NK) cells from a donor, designe…

This study tests a combination of three drugs (177Lu girentuximab, cabozantinib, and nivolumab) in people with advanced clear cell kidney cancer who have not had prior treatment. The goal is to see if this combination can help control the cancer. About 100 adults will take part, …

This study tests a CAR T-cell drug called brexucabtagene autoleucel in 40 adults with B-cell acute lymphocytic leukemia (ALL) that has come back or is hard to treat. Participants first receive standard chemotherapy drugs to reduce cancer, then get the CAR T-cells. The goal is to …

This early-phase trial tests a new treatment for glioblastoma, an aggressive brain cancer that has returned after standard therapy. Researchers give patients specially engineered natural killer (NK) cells from donated cord blood, modified to resist the tumor's defenses. The main …

This early study tests whether fecal microbial transplants (healthy stool from donors) are safe and can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant. The goal is to see if changing gut bacteria can improve outcomes.

This study tests whether adding a prebiotic-rich diet to standard immunotherapy (ipilimumab and nivolumab) before surgery helps melanoma patients respond better. About 35 adults with stage III or IV melanoma will follow the diet and take the drugs. The goal is to see if the diet …

This study tests whether giving belzutifan alone, pembrolizumab alone, or both together before surgery can help control advanced clear cell kidney cancer. About 10 participants will receive one of these treatments before having part or all of their kidney removed. The goal is to …

This study tests a new treatment for advanced squamous cell cancer of the nasal cavity or sinuses. It combines the immunotherapy drug pembrolizumab with chemotherapy (docetaxel and cisplatin/carboplatin) and radiation. The goal is to see if this combination shrinks tumors better …

This study tests whether ultra low doses of radiation can control skin lesions in people with mycosis fungoides, a type of lymphoma. About 50 participants will receive targeted radiation to their skin spots. The goal is to shrink or control the lesions while reducing side effects…

This study tests whether combining zanzalintinib and pembrolizumab can help control certain types of advanced soft-tissue sarcoma that have spread. About 20 adults with specific sarcoma subtypes will receive the drug combination. The main goal is to check safety and side effects,…

This study tests an oral drug called ONC201 in adults whose acute leukemia or high-risk myelodysplastic syndrome (MDS) has returned or stopped responding to standard treatments. The goal is to find the best dose and see if the drug can shrink or control the cancer. About 120 part…

This study tests a drug called ivonescimab in 45 adults whose glioblastoma has returned after standard treatment. Phase 1 finds the safest dose; Phase 2 checks if that dose can control the tumor. The goal is to manage the disease, not cure it.

This study tests a new treatment for people with certain blood cancers (like T-cell lymphoma, mantle cell lymphoma, and chronic lymphocytic leukemia) that have not responded to standard therapy or have returned. The treatment uses specially engineered immune cells from donated co…

This early-phase trial tests a combination of two drugs (REGN5678 and cemiplimab) in men with metastatic castration-resistant prostate cancer that has worsened after at least two prior treatments. The goal is to find the safest and most effective dose. About 60 participants will …

This early-phase trial tests a new treatment called attIL12-TIL for people with advanced or metastatic soft tissue and bone sarcomas. The therapy uses a patient's own tumor-fighting immune cells, modified to produce a targeted immune booster (IL12), to help shrink or control the …

This study tests whether the drug ivonescimab can help control metastatic colorectal cancer that has already been treated. About 90 adults with advanced colon or rectal cancer will receive the drug, and researchers will monitor side effects and how well the cancer responds. The g…

This early-phase trial tests a new type of high-dose radiation (HYDRA) for people with laryngeal cancer. The main goal is to find the highest safe dose and see how well it controls the tumor. About 11 adults with early to moderately advanced laryngeal cancer will take part.

This study tests a new treatment for people with multiple myeloma that has come back or not responded to standard therapies. The treatment uses immune cells from donated cord blood that are genetically modified to better recognize and attack myeloma cells. The goal is to find a s…

This study tests whether giving patients personalized natural killer (NK) cells after chemotherapy and a cord blood transplant can help kill remaining cancer cells and reduce complications. It includes 100 adults with various blood cancers like leukemia, lymphoma, or multiple mye…

This study tests two different radiation schedules given before breast cancer surgery and reconstruction. One schedule uses the standard number of doses, while the other uses fewer, larger doses. The goal is to see which schedule causes fewer side effects and works better. The st…

This study is for children whose acute myeloid leukemia (AML) has come back or not responded to treatment. It tests a combination of two oral drugs, venetoclax and ASTX727, to find the best dose and see how safe it is. About 40 children will take part. The goal is to control the …

This study tests whether low-dose sirolimus can safely improve blood cell function in adults with RUNX1 familial platelet disorder, a genetic condition that raises bleeding and leukemia risks. Six participants will receive the drug and be monitored for side effects and changes in…

This study tests a drug called tasquinimod, given alone or with another drug (ruxolitinib), to see if it can help control myelofibrosis—a serious bone marrow disorder. About 33 adults with certain types of myelofibrosis who have not responded to or cannot take standard treatments…

This study tests a combination of two drugs—CPX-351 (a stronger form of standard chemo) and quizartinib (a targeted pill)—in adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to find the best dose and see if the combo can shrink or …

This early-phase study tests a new cell therapy for people with advanced melanoma that has returned or not responded to standard immunotherapy. The treatment uses a patient's own immune cells (NK cells) that are engineered in a lab to recognize and attack a protein called PRAME f…

This study is for people with acute myeloid leukemia (AML) that has returned or not improved with standard treatments. It tests a combination of three drugs: one that blocks cancer cell growth, one that helps the body break down the first drug more slowly, and a third that target…

This study tests whether combining two oral drugs, pirtobrutinib and venetoclax, can help control mantle cell lymphoma (MCL) that has come back or not responded to prior treatments. About 30 adults with confirmed MCL will take both pills and be monitored for tumor response. The g…

This study tests whether adding the drug venetoclax to standard chemotherapy can better treat acute myeloid leukemia (AML), a fast-growing blood cancer. About 116 adults with newly diagnosed or returning AML will receive the combination. The goal is to see if the combo improves r…

This study tests whether adding the drug talazoparib to standard hormone therapy and enzalutamide can help shrink prostate cancer that has spread to lymph nodes. About 30 men will receive the combination before having their prostate removed. The goal is to see if the treatment is…

This study is for people with newly diagnosed multiple myeloma who have had a stem cell transplant. It tests whether adding belantamab mafodotin to the standard drug lenalidomide can clear remaining cancer cells (MRD-positive to MRD-negative). About 94 adults will receive this co…

This study tests whether adding venetoclax to standard ibrutinib or acalabrutinib treatment can eliminate remaining leukemia cells in patients with high-risk chronic lymphocytic leukemia (CLL). About 90 adults who have been on ibrutinib or acalabrutinib for at least a year but st…

This study tests a cream called tofacitinib 2% for people with early-stage cutaneous T-cell lymphoma (CTCL), a type of skin cancer. The goal is to see if the cream is safe and can help control the disease. About 20 adults with stage IA, IB, or IIA CTCL will take part.

This study tests whether adding isatuximab to standard lenalidomide therapy after a stem cell transplant can better control high-risk multiple myeloma. About 61 adults aged 18 to 72 with newly diagnosed high-risk myeloma will receive the drug combination as maintenance. The main …

This study tests a drug called NBTXR3 given with radiation therapy for people with locally-advanced non-small cell lung cancer who cannot have chemotherapy or surgery. The goal is to see if the combination is safe and helps control the cancer. About 40 adults will take part in th…

This study tests whether giving two drugs, cemiplimab and cetuximab, before salvage surgery can help control recurrent oral cavity squamous cell carcinoma. It involves 17 adults whose cancer has returned at least 3 months after initial treatment. The main goal is to check safety …

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can better control advanced oral cancer. It includes 29 adults with newly diagnosed stage 3-4 oral cavity squamous cell carcinoma that has a…

This study tests a drug called asciminib in 40 adults with chronic myeloid leukemia (CML) whose first treatment did not work well or caused side effects. The goal is to see if asciminib can lower the amount of leukemia cells in the blood to very low levels within 12 months. Parti…

This early-phase trial tests a combination of two drugs, gemcitabine and nab-sirolimus, in people with advanced leiomyosarcoma or soft-tissue sarcoma that has a specific genetic change (TSC1 or TSC2 mutation). The main goal is to find a safe dose and see how well the body tolerat…

This study tests whether adding an experimental drug called CTX-009 to standard chemotherapy and immunotherapy can help control advanced bile duct cancer. About 50 adults with cancer that cannot be removed by surgery or has spread will receive the combination. The main goal is to…

This study is for people with acute myeloid leukemia (AML) that has a specific genetic change called an IDH1 mutation. It tests a combination of three drugs: decitabine, venetoclax, and olutasidenib. The goal is to find a safe dose and see if the combination helps control the dis…

This study tests a drug called canakinumab in people with low- or intermediate-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The drug is an antibody that may slow cancer growth. About 76 adults will receive injections to see if it improves blood …

This study tests a treatment called Y-90 radioembolization given before liver surgery for people with colorectal cancer that has spread to the liver. The goal is to shrink tumors on the right side of the liver and help the left side grow larger so surgery can be safer and more ef…

This study is for people with stage IV cancer that has started to grow in only a few places (oligoprogression). It tests whether adding local treatments like radiation, surgery, or other procedures to all growing spots can help control the disease better than switching to a new s…

This study tests whether adding metal-detoxifying drugs to standard chemotherapy can improve outcomes for people with certain types of acute myeloid leukemia (AML). Researchers believe that lowering metal levels in the blood and bone marrow may help control the disease or make ch…

This early-stage study is testing whether adding the drug talazoparib to radiation therapy is safe and effective for people whose gynecologic cancers (like ovarian, endometrial, or cervical) have come back. The goal is to find the best dose that limits side effects while potentia…

This early-phase study tests whether adding healthy donor natural killer (NK) cells to the usual drugs azacitidine and venetoclax can better control acute myeloid leukemia (AML). About 32 adults with AML that has returned or not responded to treatment will receive the combination…

This study tests a new drug combination for people with follicular lymphoma whose cancer has returned or not responded to prior treatment. About 60 adults will receive valemetostat along with rituximab and lenalidomide. The goal is to find the safest dose and see how well the com…

This study tests whether adding olutasidenib to standard chemotherapy can better control certain blood cancers (MDS, CMML, or MPN) in people with an IDH1 gene mutation. About 45 adults with high-risk disease will receive the combination and be monitored for safety and response. T…

This study tests whether combining two drugs, tucatinib and T-DM1, can control HER2-positive solid tumors that have spread to the brain. About 30 adults with this condition will receive the treatment to see if it shrinks or stops tumor growth. The main goal is to check safety and…

This study tests whether a special imaging scan called PYLARIFY PET-CT can better detect cancer that has spread in people with pancreatic cancer, liver cancer, or breast cancer. About 36 adults will receive the scan to see if it matches standard methods. The goal is to improve ho…

This study tests a special mammogram called CESM, which uses a dye injected into a vein to make breast tissue and blood vessels show up more clearly. The goal is to see if CESM is better than standard mammography at finding the cause of nipple discharge and detecting breast cance…

This study compares synthetic mammography (a 2D image made from 3D data) to standard digital mammography for detecting breast cancer. Researchers will review medical records from 750 women to see which method is more accurate and reduces the need for extra tests. The goal is to i…

This study aims to make cervical cancer screening more accessible by offering self-collection options in safety net health systems. Researchers will work with 7,100 participants, including patients, providers, and community members, to develop education and training materials. Th…

This study is testing a new, easy-to-use HPV test that could be done right at a clinic or doctor's office, without needing a lab. Researchers want to see if this new test works as well as the standard HPV tests. The study will include 600 people with a cervix who are 21 or older.…

This study tests a new way to look at mouth lesions using special dyes and cameras. Researchers will take pictures of the lining of the mouth to see if a lesion is precancerous or cancerous. The goal is to find a non-invasive method that could help doctors decide if a biopsy is n…

This study tests a new imaging device that may help doctors see tumor tissue before taking a biopsy sample. About 150 people with suspected or confirmed cancer who need a needle biopsy of the lymph nodes, liver, or lung will take part. The goal is to see if the device is safe and…

This study looks at whether a flexible MRI coil can accurately detect aggressive prostate cancers without needing a probe inside the body. About 258 men with intermediate- or high-risk prostate cancer will get an MRI before surgery. The goal is to see if this less invasive method…

This study looks at whether a special MRI scan can help doctors predict a serious side effect called osteoradionecrosis (bone death) in people with head and neck cancer who are getting radiation therapy. About 1,400 participants will have MRI scans before, during, and after treat…

This early-phase study tests a new imaging agent called 18F-4FN for PET scans. It aims to safely detect inflammation in patients with endocrine tumors who are on immunotherapy. The agent works by reacting with high-energy molecules produced by inflammatory cells, making inflamed …

This study tests whether contrast-enhanced mammography (CEM) can find breast cancers that standard mammography might miss in women with dense breasts. About 1,000 women aged 30-75 with dense breasts will get both types of mammograms. The goal is to see if CEM improves early detec…

This early-phase study tests a special imaging agent, hyperpolarized carbon C 13 pyruvate, to see if it helps doctors diagnose glioma, a type of brain tumor, more accurately. About 13 adults with brain tumors will receive the agent before an advanced MRI scan. The goal is to impr…

This study tests if a procedure called lymphovenous bypass, done before lymph node surgery, can prevent lymphedema (arm swelling) in people with breast cancer or melanoma. The bypass creates a new path for lymph fluid to drain away from the arm. Researchers will compare swelling …

This study tests a community-based approach to help women who have not had a Pap test in over 3.5 years get screened for cervical cancer. It involves 920 women aged 25 and older in low-resource areas of Texas. The goal is to see if this strategy is safe and effective at increasin…

This study tests whether repairing the lymphatic system during lymph node removal for breast cancer can prevent lymphedema, a chronic arm swelling. About 50 women with inflammatory breast cancer will receive immediate lymphatic reconstruction. The goal is to see if this extra sur…

This study is for women with BRCA or other gene mutations that raise their risk of ovarian cancer. Instead of removing both ovaries and fallopian tubes at once, researchers are testing a two-step approach: remove the fallopian tubes first, then the ovaries years later. The goal i…

This study tests whether a special short-stitch closing method can prevent abdominal hernias better than the usual method in 140 patients having liver tumor surgery. Participants are randomly assigned to one of two closure techniques. Researchers will check for hernias using scan…

This study is testing a new educational tool designed to help people learn how to prevent liver cancer. About 40 participants from the HOPE Clinic will review the materials and share their thoughts to make sure the information is clear and helpful. The goal is to create a resourc…

This study tests whether a reward-based exercise program called TEAM Me can help children and young adults with cancer stay active during a stem cell transplant. Participants earn tokens for walking and other activities, which they can trade for prizes. The goal is to see if the …

This study tests whether a special yoga program can improve physical function, fatigue, sleep, and quality of life for people with lung or esophageal cancer who are getting radiation therapy, and also for their family caregivers. About 400 patient-caregiver pairs will take part. …

This study looks at whether a program that provides free healthy food and online cooking classes can help cancer survivors who struggle to afford food. About 80 survivors will take part. The goal is to see if the program is safe and easy to use, and if it improves their health an…

This study tests a special geriatric care program for people 65 and older who have finished treatment for early-stage breast cancer. The program includes a full health check and follow-up visits to help reduce health problems and improve quality of life. Researchers hope this app…

This study looks at whether having fewer follow-up scans after surgery for soft tissue sarcoma can help lower patients' fear of the cancer coming back. About 227 adults who finished treatment will be split into two groups: one with limited follow-up and one with intense follow-up…

This study tests four treatments (haloperidol, chlorpromazine, valproic acid, and a placebo) alongside standard non-drug care to calm agitated delirium in hospitalized cancer patients. The goal is to find which option works best to reduce distress and suffering. About 42 adults w…

This study tests whether custom 3D-printed molds can help surgeons shape breast tissue more accurately during reconstruction after mastectomy. About 160 adults having breast reconstruction with their own tissue will take part. The goal is to make the surgery more efficient and im…

This study tests a short counseling program called Focused Acceptance and Commitment Therapy (FACT) to see if it helps reduce anxiety about death in people with advanced cancer. About 70 adults whose cancer has not responded to at least one treatment will participate. The program…

This study looks at whether a computer-assisted vacuum device can safely remove blood clots from the lungs of cancer patients who have a moderate-risk pulmonary embolism. About 25 participants will be enrolled to track side effects and any improvements in quality of life. The goa…

This study aims to develop and test a yoga program designed to fit the cultural needs of cancer patients in India, Tanzania, and the United States who are undergoing stem cell transplants. Researchers will measure how the program affects depressive symptoms using a simple questio…

This study looks at whether a supervised exercise program can help people with early-stage triple negative breast cancer who are receiving immunotherapy before surgery. About 33 participants will take part. The goal is to see if the exercise is doable and if it affects immune cel…

This study aims to see if combining psychoeducational interventions (like counseling and self-help strategies) with an open-label placebo pill can better improve fatigue and quality of life in people with advanced metastatic cancer than either approach alone. About 240 adults wit…

This study looks at whether having a conversation about care goals in the emergency department can improve quality of life for people with advanced lung or gastrointestinal cancer. It involves 200 adults who have symptoms like trouble breathing or confusion. The goal is to better…

This study tests if a new nerve stimulation treatment, alone or with a steroid injection, can improve knee movement and reduce pain better than the standard steroid injection alone. It involves 45 adults with chronic knee pain, including cancer patients. The goal is to find a saf…

This study tests whether adding cryoablation (freezing cancer cells) to standard radiation therapy provides better pain relief for people with cancer that has spread to their bones. About 40 adults with advanced cancers like prostate, colorectal, or melanoma will be randomly assi…

This early-phase study tests the safety of two devices (NovoTTF-200M and 200A) in 30 patients with spinal tumors that have not responded to standard treatments like surgery or radiation. The devices use electric fields to try to control tumor growth. The main goal is to see if th…

This study tests whether giving a personalized dose of the drug apalutamide, based on how aggressive the cancer is, can reduce fatigue and other side effects in men who have had prostate surgery and are getting radiation therapy. About 120 men with detectable PSA after surgery wi…

This study tests whether an 8-week program of text messages sent to your phone can help you sit less and move more. Researchers will enroll 200 adults who sit for more than 6 hours a day and track their activity using a Fitbit. The goal is to see if simple text reminders can enco…

This study tests a mobile app that guides lung cancer patients and their caregivers through yoga exercises at home. The goal is to see if the app is safe, easy to use, and helpful during radiation treatment. About 60 patient-caregiver pairs will participate.

This study tests a program called ApricityCare that helps doctors spot and treat side effects from cancer therapy early. The goal is to see if catching problems sooner can keep patients on their treatment longer. About 425 adults with cancer who are starting systemic therapy will…

This study tests two surgical techniques, TMR and RPNI, alone or together, to reduce chronic and phantom limb pain in cancer patients who have had an amputation. About 45 adults will be randomly assigned to one of three surgery groups. The goal is to see which approach works best…

This study tests whether a shorter course of high-dose radiation (SBRT) can safely reduce symptoms in people with head and neck cancer that cannot be cured. About 108 adults whose cancer has returned or spread will receive either standard or shorter radiation. The goal is to see …

This study tests a community-based, peer-led course called BBCSI designed to improve quality of life for Black breast cancer survivors. Researchers will enroll 46 Black women who had stage 0-III breast cancer and have no signs of spread. The course focuses on social and environme…

This study is testing whether a meditation program for couples can improve the physical, emotional, and spiritual well-being of people with advanced lung cancer and their partners. About 300 couples will take part. The goal is to see if this approach is practical and helpful for …

This study tests whether nurse-delivered hypnosis before and during breast cancer surgery can lower the amount of opioid painkillers patients need after surgery. About 225 adults having breast surgery will be randomly assigned to receive hypnosis plus standard anesthesia, standar…

This study looks at whether women aged 60 and older with early-stage, low-risk breast cancer can safely skip hormone therapy after lumpectomy and just receive radiation. The goal is to see if this approach maintains good quality of life while still controlling the cancer. About 3…

This study looks at two different support programs designed to improve emotional health and quality of life for people with advanced cancer and their family caregivers. About 400 patient-caregiver pairs will take part. The goal is to see which program works better at reducing dep…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can safely reduce depression and anxiety in people with advanced cancer. About 30 adults with incurable cancers who are on maintenance therapy will receive the treatment. The…

This study tests a brief program called Positive Affect Treatment (PAT) to improve the wellbeing and quality of life of people caring for loved ones with advanced cancer. About 150 adult caregivers will take part, using phone or internet. The goal is to see if this approach helps…

This study looks at whether a special vacuum dressing (negative pressure wound therapy) helps heal the belly incision better than standard bandages in obese women having breast reconstruction surgery. About 80 participants will be randomly assigned to one of two dressing types. T…

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce breathlessness in people with cancer. About 30 participants with a chest tube that is not draining well will receive either alteplase or a placebo. The…

This study tests a virtual group therapy program that helps cancer patients explore meaning and purpose. Researchers want to see if it reduces emotional distress. The study involves 72 adults with a history of cancer who will join online sessions and fill out questionnaires.

This study tests a yoga-based lifestyle program for women with advanced ovarian cancer who will receive chemotherapy before surgery. The program aims to improve quality of life and well-being during treatment. Researchers will enroll 40 participants to see if the program is pract…

This study tests whether a yoga program designed for Black adults can help them sit less, move more, and feel better emotionally. Researchers will enroll 250 people in Houston who are not very active and sit for 6+ hours daily. Participants will be randomly assigned to the yoga p…

This study tests whether adding bright light therapy, methylphenidate, or melatonin to cognitive behavior therapy (CBT) can improve sleep and related symptoms like fatigue, anxiety, and depression in 188 adults with advanced cancer. Participants must have poor sleep for at least …

This study looks at whether a gentle exercise program is practical and helpful for people with lung cancer who are getting radiation therapy, along with their family caregivers. About 40 pairs (patient plus caregiver) will take part. The goal is to see if the program improves qua…

This early-phase study tests whether a non-invasive brain stimulation technique called rTMS can help people with impulse control disorders, specifically excessive eating. Researchers will enroll 30 adults aged 21 to 60 with a BMI over 30. The main goal is to check safety and side…

This pilot study is testing whether methylnaltrexone, a drug used for constipation, can be safely given to people with oral cavity squamous cell carcinoma for two weeks before their surgery. The main goal is to check for side effects. About 25 adults whose cancer can be removed b…

This study tests whether combining a nerve pain medication (duloxetine) with neurofeedback brain training works better than either treatment alone for chemotherapy-induced nerve damage. About 380 adults with nerve pain from cancer treatment will participate. The goal is to reduce…

This early-phase study is testing whether a minimally-invasive procedure using special light-activated nails can stabilize pelvic bone tumors and improve patients' ability to function. About 50 adults with cancer that has spread to the pelvis will receive the procedure. The main …

This study asks 200 brain cancer patients about their experience with telemedicine compared to in-person visits. Participants fill out surveys to share how they feel about the quality of care they received. The goal is to help doctors improve telemedicine for people with brain tu…

This study follows 200 people with early blood conditions (MGUS or smoldering myeloma) that sometimes turn into multiple myeloma, a blood cancer. Researchers will track age, blood protein levels, bone marrow cells, genes, and bone health to find clues that predict progression. No…

This study is following over 2,300 people with and without chronic pancreatitis to learn what causes the disease and how it progresses. Researchers will collect health information and track symptoms over time. The goal is to find better ways to treat or prevent this painful condi…

This study looks back at the medical records of up to 3000 people with chronic myelogenous leukemia (CML) who received standard tyrosine kinase inhibitor drugs (like imatinib) outside of a clinical trial. The goal is to learn how these patients respond to treatment in real-world …

This study is developing and testing a new assessment system (like the MD Anderson Symptom Inventory) to measure how cancer and its treatment affect symptoms and quality of life. Researchers will enroll 6,500 participants, including cancer patients, caregivers, and healthcare pro…

This study tests whether advanced imaging methods can tell the difference between true tumor growth and pseudoprogression (a harmless scan change that looks like growth) in people treated for brain cancer. About 25 adults who have had brain tumor treatment and now show a suspicio…

This study is testing an educational tool to help men aged 65 and older with prostate cancer decide with their doctors whether to reduce the frequency of follow-up tests like biopsies or scans. The goal is to see if the tool is easy to use and helpful for making informed choices.…

This study looks at how people's brains react to emotional triggers and whether that affects how well a treatment called rTMS (repetitive transcranial magnetic stimulation) helps them quit smoking. Researchers will enroll 100 smokers aged 21 to 60 to understand individual differe…

This study follows 430 people with stage I-IV rectal cancer to see how surgery affects their daily life and well-being. Participants fill out questionnaires about their health and preferences. No new treatments are given—the goal is simply to learn more about what life is like af…

This study looks at how things like mental health, social support, diet, and exercise affect the quality of life and health outcomes of people with melanoma. Researchers will follow up to 5,000 participants over time to see if these lifestyle factors are linked to how well patien…

This study tests a decision-making tool for women newly diagnosed with early-stage breast cancer who are considering whether to also remove the healthy breast as a preventive measure. The tool is designed to provide clear, balanced information to help patients feel more confident…

This study tracks walking and sleep habits in 240 lung cancer patients before and after surgery using a Fitbit. The goal is to see if more walking leads to fewer complications and better recovery. Participants must own a smartphone and be willing to use the Fitbit app. Results ma…

This study collects information from 250 people with lung cancer or tumors that have spread to the lungs. All participants will have a robotic bronchoscope to destroy small tumors in the outer parts of the lungs. The goal is to learn how well this procedure works and how safe it …

This study looks at whether joining a support community can improve emotional well-being and reduce feelings of isolation for people with neuroendocrine cervical cancer (NECC). About 25 participants will fill out questionnaires about their background and feelings. The goal is to …

This study looks at what breast cancer survivors and their family members know about chemicals in personal care products that might affect hormones. Researchers also want to see if there is a link between being overweight and these chemicals. About 30 people from the Acres Home c…

This study enrolls 1,200 cancer patients about to start immunotherapy drugs called immune checkpoint inhibitors. Researchers will collect blood samples and health data to identify genetic and metabolic factors that may predict who develops heart side effects. The goal is to bette…

This study looks at how tamoxifen, a common breast cancer drug, affects certain immune cells called neutrophils. It focuses on a process where these cells produce web-like structures (NETs) that may cause side effects or influence the cancer. Researchers will measure NET levels i…

This study looks at whether a blood test that catches tiny bits of tumor DNA (called cell-free DNA) can help doctors find important genetic changes in lymphoma and detect any cancer left after treatment. About 517 adults with a type of lymphoma called DLBCL will give blood sample…

This study tests a new imaging agent called [18F]4FN in PET/CT scans for people with chronic graft-versus-host disease (GVHD). The goal is to see if the agent can safely show GVHD activity in the body, especially in joints. About 16 adults with joint stiffness from GVHD will take…

This study looks at a method called 'Teaching the Teachers' to see if it helps spread guidelines for diagnosing liver cancer. About 100 radiologists from around the world will learn the guidelines and then teach them to other doctors. The goal is to see if this approach increases…

This study explores whether a blood test that measures tumor DNA (ctDNA) can help doctors decide if patients with colorectal or appendix cancer need more or less chemotherapy before surgery. About 48 adults with cancer that has spread to the lining of the abdomen will take part. …

This study looks at the financial stress that people with bone or soft tissue sarcoma face after surgery. Researchers want to understand how the cost of cancer care affects patients' quality of life. About 100 adults who can read and write English will fill out questionnaires bef…

This study tracks side effects and treatment results in 170 advanced cancer patients receiving anti-VEGF therapies. Researchers aim to see if certain side effects are linked to how well the cancer responds. The goal is to help doctors better predict treatment outcomes.

This study looks at the quality of life of people with two early blood conditions: MGUS and smoldering multiple myeloma. Researchers want to learn what symptoms and concerns are most common. About 400 adults will fill out short questionnaires at the start and then every few month…

This study aims to understand how patients recover after bladder cancer surgery (radical cystectomy). Researchers will collect information from 2,000 patients about their symptoms and recovery progress. The goal is to use this data to improve surgical care and quality of life in …

This study looks at how stress affects surgeons and professional musicians during their work. Researchers will use wearable brain monitors, saliva tests, and questionnaires to measure stress levels. The goal is to better understand occupational stress in these demanding professio…

This study is testing whether a special PET scan called 18F-FSPG can show how well chemotherapy and radiation are working in people with esophageal cancer. About 60 adults with untreated, locally advanced esophageal cancer will get the scan before and during treatment. The goal i…

This study looks at how cancer treatments can cause nerve pain. Researchers will use simple tests like heat, cold, and touch to measure pain sensitivity, and take small skin samples to see if nerve damage is involved. The goal is to better understand this type of pain, not to tre…

This study gathers information from 100 adults with blood cancers who receive standard treatments like CAR-T therapy, radiation, or both within a 90-day window. The goal is to learn which patients benefit most and how to best time and combine these therapies. Researchers will tra…

This study looks at how much of the drug Pluvicto (a type of targeted radiation) reaches tumors and organs in prostate cancer patients whose kidneys or bone marrow are not working well. About 25 people will be enrolled to check safety and side effects. The goal is to find the rig…

This study is testing whether regularly checking a heart injury marker (troponin) in the blood of cancer patients receiving immune checkpoint inhibitors can help reduce heart-related side effects. About 980 adults starting this type of immunotherapy will be monitored. The goal is…

This study follows people who have received gene transfer therapy for cancer or other conditions. Researchers want to learn about any long-term side effects or benefits over 15 years. Participants include up to 130 patients from MD Anderson Cancer Center. The goal is to build a d…

This study aims to create personalized computer walking models for people with pelvic sarcoma, a rare bone cancer. The models will help doctors plan the best surgery and rehabilitation to maximize each patient's ability to walk after treatment. About 130 adults who are scheduled …

This study aims to identify environmental, viral, behavioral, and genetic factors that influence the development and outcome of biliary tree cancers. Researchers will analyze tumor markers and genetic changes in 1,500 participants, including patients and healthy volunteers. The g…

This study looks at what helps or gets in the way of a positive hospital experience for Asian cancer patients. Researchers will survey 520 former patients and their healthcare providers at MD Anderson. The goal is to learn how to better support Asian patients during cancer care.

This study is testing whether a new type of MRI scan, using an inhaled gas called hyperpolarized xenon-129, can help doctors see and predict lung damage caused by radiation therapy in lung cancer patients. The gas is breathed in instead of injected, and it is not yet FDA approved…

This study surveys 9 radiology residents to see how comfortable they feel performing simulated blood vessel procedures after training on a special simulator. The goal is to improve hands-on training in a safe, low-risk environment before working with real patients. The study only…

This study aims to understand how rheumatic side effects—like arthritis and muscle pain—affect people who have received immune checkpoint inhibitor therapy for cancer. Researchers will interview 20 adults to learn about the severity and impact of these side effects. The goal is t…

This study aims to see if a special MRI scan can measure damage to the jaw bone and soft tissues caused by radiation therapy for head and neck cancer. Researchers will follow 300 adults receiving radiation to track how well the MRI detects injury over time. The goal is to improve…

This study is creating and testing a decision aid for people with medullary thyroid cancer and their caregivers. The tool helps patients and doctors discuss whether to start or stop new drugs, join clinical trials, or continue active monitoring. About 120 participants, including …

This study tracks memory and thinking changes in 100 adults with blood cancers who receive whole brain radiation. Researchers will test cognitive skills over time to understand the side effects of this treatment. The goal is to learn more, not to test a new therapy.

This study looks at whether having a partner to exercise with helps inactive women become more active. Researchers will compare women who get support from a partner to those who try to increase activity on their own. The goal is to see if the buddy approach leads to more moderate…

This study is for people who have had or are getting radiation therapy for head and neck cancer. Researchers want to see how different questionnaires capture the severity of side effects. The goal is to find the best way to measure symptoms, not to test a new treatment. About 300…

This study looks at why people with Li-Fraumeni syndrome (a condition that raises cancer risk) decide to take part in a future trial comparing standard genetic counseling with a more personalized approach. Researchers will ask 500 participants about their willingness to join such…

This study interviews cancer care providers, patients, and caregivers to learn what they think about receiving hospital-level care at home. The goal is to gather insights that could help design better home care programs for people with cancer. About 20 participants from MD Anders…

This study aims to learn about the symptoms and changes patients experience while receiving treatment for sinonasal or nasopharyngeal cancer. Researchers will use a questionnaire to track how severe symptoms are and how they affect daily life. The goal is to better understand pat…

This study aims to create a database of medical information from up to 2,000 people with mesonephric-like adenocarcinoma (MLA), a very rare form of uterine cancer. Researchers will collect data to better understand the disease's characteristics and behavior. No treatments or test…

This study surveys 250 lung specialists across the United States to understand how the COVID-19 pandemic changed the way they perform procedures, staff their teams, and manage patient visits. The goal is to learn from these experiences so that hospitals and clinics can better pre…

This study is testing a new screening tool called SOCS-OTS to see if it can correctly identify cancer survivors who need occupational therapy. Researchers will compare it to a standard screening measure already used at MD Anderson Cancer Center. About 80 adults who are being seen…

This study is testing whether a blood test, called a liquid biopsy, can find cancer cells and predict if endometrial cancer will return. Researchers will collect blood and tissue samples from 1,000 women with endometrial cancer before and after surgery. The goal is to see if the …

This study is creating a large collection of mammogram images, blood samples, and health information from 10,000 women getting routine screening mammograms. The goal is to build a resource that researchers can use in the future to improve early detection of breast cancer and othe…

This study uses MRI scans after radiation therapy to see if they can predict damage to healthy tissue in patients with mouth or skull base tumors. Researchers will track changes in the jawbone and other areas over time. The goal is to better understand and potentially prevent a c…

This study looks at whether CT scans can help doctors predict how well pancreatic and liver cancer patients will respond to chemotherapy. About 259 adults with these cancers will get CT scans before and during treatment. The goal is to see if changes in the tumor's blood flow on …

This study collects blood, saliva, urine, and stool samples from 1,600 children with recurrent or chronic pancreatitis. Researchers hope to find genetic markers that might predict who is at higher risk for pancreatic cancer later in life. The goal is to better understand the dise…

This study compares two types of 3D mammography (wide-angle vs. narrow-angle) to see which one makes breast masses and distortions easier to see. About 100 women getting routine screening mammograms will participate. The goal is to improve detection, not to treat any disease.

This early-stage study is testing whether the drug ulixertinib can cross the blood-brain barrier in 40 adults with recurrent gliomas (a type of brain tumor). The main goal is to see if the drug is safe and can reach the tumor. Participants will take the drug before surgery, and r…

This study looks at how cancer patients feel and manage while on long-term blood clot medication. Researchers will track quality of life, how well patients take their medicine, and healthcare costs. About 260 adults with cancer-related blood clots will participate. The goal is to…

This study is testing whether advanced scans like PET/MR, PET/CT, and whole body MRI can find leukemia that has spread outside the bone marrow in people newly diagnosed with acute myeloid leukemia (AML). About 77 participants will receive these scans to see how often this hidden …

This study is testing whether magnetic resonance spectroscopy (MRS) can safely and effectively assess lesions in the spinal cord. It will include healthy adults and patients with low-volume leptomeningeal disease (LMD) who are receiving radiation. The main goal is to see if MRS i…

This study looks at how sleep and physical activity affect the quality of life of blood cancer patients and their caregivers after a stem cell transplant. Researchers will ask both patients and caregivers to complete questionnaires about sleep, mood, fatigue, and well-being. The …

This study aims to understand how social and financial challenges impact the results of transplant and cell therapy treatments. Researchers will survey 2,000 adult patients and their caregivers at MD Anderson Cancer Center. The goal is to identify barriers to care and improve sup…

This study follows 200 people who had hemipelvectomy surgery (removing part or all of the pelvis) for bone tumors. Researchers want to learn how well patients function and feel after different types of this surgery. The goal is to find ways to improve quality of life for future p…

This study looks at how radiation therapy changes the immune cells inside breast tumors. Researchers want to see if radiation helps immune cells enter the tumor and attack cancer cells. The study will measure these changes in 20 adults with invasive breast cancer who are getting …

This study looks at how what you eat and the bacteria in your gut might cause changes in colon cells that could lead to cancer. Researchers will collect samples from 30 people having a routine colonoscopy. The goal is to understand these links better, not to test a treatment.

This study aims to describe and compare symptoms and quality of life in 100 cancer patients who also have heart failure. Participants will fill out questionnaires about their symptoms and daily functioning. No new treatments are tested; the goal is to better understand the challe…

This study looks at how chemoradiation for locally advanced lung cancer affects the heart. Researchers will track heart injury and fitness in 100 patients, using each person's risk profile to tailor treatment and potentially lower heart complications. The goal is to learn how to …

This study creates a registry of medical information and biological samples (blood, tissue, stool) from people with inflammatory or invasive breast cancer. Researchers will use this data to better understand the disease and develop improved treatments in the future. The study is …

This study looks at the best methods for tobacco quitline staff to inform heavy smokers aged 55-80 about lung cancer screening. Researchers will analyze calls, emails, and surveys from 800 participants to see what works. The goal is to increase screening rates and knowledge witho…

This study tests whether using advanced MRI (AMRI) helps doctors target brain tumor biopsies more accurately than standard methods. About 62 adults with suspected brain tumors will get both types of MRI before surgery, and researchers will compare the biopsy results. The goal is …

This study looks at how safe and helpful a procedure called portal vein stenting is for people with gastrointestinal cancer who have a narrowed portal vein. Researchers will track how long the stent keeps the vein open and how it affects patients' overall health, nutrition, and q…

This study looks at whether a simple fitness test before major cancer surgery can help predict how well a patient will recover. Researchers will measure energy use during exercise in 200 adults with abdominal or pelvic cancer. The goal is to see if this test can identify patients…

This study builds a database of 1,000 breast cancer survivors aged 50 or younger who have dense breast tissue. Participants will get routine MRI scans alongside their regular mammograms. Researchers hope to learn whether MRI helps find new cancers earlier in dense tissue, which i…

This study reviews medical records from 600 lung cancer patients who had lung surgery between 2004 and 2019. Researchers want to see if the use of robotic surgery has led to more atypical segmentectomies, a type of partial lung removal. The goal is to understand trends in surgica…

This study is for 1,000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask about symptoms before, during, and after treatment. The goal is to find markers that can predict how well a person will respond to therapies like surgery…

This study looks at how different ways of presenting medical information influence the treatment choices of people with advanced cancer. Researchers will enroll 400 adults with advanced solid tumors or aggressive lymphoma who have already tried at least two cancer therapies. The …

This study looks at why people with head and neck cancer do or don't follow through with swallowing exercises after radiation. Researchers will use blood tests to check immune proteins and questionnaires to understand patients' feelings, pain, and support. The goal is to find way…

This study looks at how often women experience posttraumatic stress disorder (PTSD) after undergoing gynecologic brachytherapy, a type of internal radiation for cancer. Researchers want to find better ways to make the removal of the treatment implants more comfortable and less di…

This study tests whether a CPAP machine (which gently pushes air into the lungs) can reduce tumor movement during lung cancer radiation therapy better than the standard deep-breath-hold technique. About 30 people receiving stereotactic body radiation therapy (SBRT) will participa…

This study looks at abnormal cells in the lungs of people who developed bronchiolitis obliterans syndrome after a stem cell or lung transplant. Researchers want to learn if these cells can help spot the disease earlier in future patients. The study involves 15 participants and us…

This study follows 100 men with low- or very low-risk prostate cancer who choose active surveillance (monitoring instead of immediate treatment). Researchers will track disease progression over 5 years using remote symptom monitoring and build a tissue and data bank to help under…

This study tests whether an abbreviated food tracking app called MySnackTracker works as well as traditional full-intake food tracking. Researchers will compare how satisfied and consistent 90 participants are with each method. The goal is to see if a simpler approach can make di…