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Zapping away thyroid nodules without surgery?

NCT ID NCT07226804

Disease control Sponsor: M.D. Anderson Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a new procedure called nanosecond pulsed field ablation (nsPFA) to treat benign (non-cancerous) thyroid nodules. The goal is to see if this non-surgical treatment can shrink the nodules and improve patients' quality of life. The study will enroll 30 adults who are already scheduled to receive nsPFA as part of their standard care.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nanosecond pulsed field ablation (nsPFA)
What this could lead to
If successful, this could offer a non-surgical option to shrink benign thyroid nodules and improve symptoms.
What could go wrong
This is a small, early study with only 30 participants. It is not yet known if nsPFA is better than standard care or if it has significant side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Aug 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

MD Anderson Cancer Center

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligibility Criteria * Scheduled to undergo ultrasound guided nsPFA as standard of care * Age 18 to 80 years. * Capable of providing independent consent. * Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following: * Benign FNA X 2 or * Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or * Benign FNA X 1 and radiographic/laboratory evidence of functional nature * Nodule measuring \>2cm in greatest dimension * Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress) * No abnormal cervical lymph nodes during screening visit . Exclusion Criteria * Age \<18 * Patients considered unsuitable for nsPFA by the treating physician

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Conditions

The condition(s) this trial relates to.

benign thyroid gland neoplasm nodular goiter Thyroid Nodule

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pulsed field ablation Thyroid nodules

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.