Blood test may spot returning colorectal cancer earlier
NCT ID NCT04739072
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing if a simple blood test can find tiny bits of tumor DNA left after treatment, which might help doctors know if colorectal cancer will return sooner than current methods. About 1,000 people with colorectal cancer who have finished or are about to start treatment will give blood samples over time. The goal is to see if these DNA signals can predict recurrence and improve follow-up care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 1,000 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2019
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with colorectal cancer at MD Anderson Cancer Center.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 18 years. 2. Histological/cytological confirmation of colorectal adenocarcinoma. 3. Patients with any stage colorectal adenocarcinoma deemed potentially eligible for curative intent treatment. Patients with stages II-IV colorectal cancer post-R0 resection may also be enrolled onto the protocol any time before or up to 3 months post-surgery and prior to initiating adjuvant therapy. 4. Ability to understand and the willingness to sign a written informed consent document. 5. Willing to pursue standard of care surveillance post completion of curative therapies. 6. Willing to provide blood samples for correlative research. Exclusion Criteria: 1. Known active malignancies other than colorectal adenocarcinoma that may interfere with detection and / or interpretation of circulating plasma markers. Patients with known clonal hematopoiesis of indeterminate potential are eligible. 2. Co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Banner - MD Anderson Cancer Center
TERMINATEDGilbert, Arizona, 85234, United States
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Baptist- MD Anderson Cancer Center
TERMINATEDJacksonville, Florida, 32207, United States
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Baylor Scott & White Research Institute
TERMINATEDTemple, Texas, 76508, United States
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Cooper Hospital UNIV MED CTR.
TERMINATEDCamden, New Jersey, 08103, United States
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Houston Methodist Cancer Center
TERMINATEDHouston, Texas, 77030, United States
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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St. Luke's Cancer Institute
TERMINATEDBoise, Idaho, 83712, United States
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The Queen's Medical Center
TERMINATEDHonolulu, Hawaii, 96813, United States
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UT Health San Antonio MD Anderson Cancer Center
TERMINATEDSan Antonio, Texas, 78229, United States
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UT Southwestern/Simmons Cancer Center-Dallas
TERMINATEDDallas, Texas, 75390, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Experimental drug put to the test against Hard-to-Treat GI cancers
- Can berry compounds tame inflammation during colorectal cancer care?
- Can a vaccine stop GI cancers from returning?
- Blood test guides immunotherapy for hidden cancer cells
- Can blocking a cancer cell survival protein open a new path for colorectal cancer?
- Can blocking a DNA repair protein make immunotherapy work better against colorectal cancer?