M.d. Anderson Cancer Center

This early-stage trial tests a DNA vaccine made from patients' own cancer cells to treat lymphoplasmacytic lymphoma, a rare blood cancer. The goal is to find the safest dose and see if the vaccine can boost the immune system to attack cancer cells. Nine participants with early, s…

This study tests whether adding a drug called ribociclib to two existing drugs (everolimus and letrozole) works better for people with advanced or recurrent endometrial cancer. About 90 participants will be randomly assigned to one of two treatment groups. The goal is to see if t…

This early-phase study tests several new drug combinations in people with advanced solid tumors (cancers that have spread) that no longer respond to standard treatments. The main goal is to find the safest dose and see if the drugs can shrink tumors or slow their growth. About 35…

This early-phase study tested a combination of three drugs (daratumumab, ixazomib, and dexamethasone) in 21 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The goal was to find the safest dose and check for side effects. Researchers hope thi…

This early-phase study tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in 65 people with advanced prostate, bladder, or kidney cancer that has spread. The main goals are to find the safest dose and check side effects. Researchers hope this combination can he…

This early-phase study tests a combination of four drugs (ensartinib, carboplatin, pemetrexed, and bevacizumab) in people with advanced ALK-positive non-small cell lung cancer that has spread or returned. The goal is to find the best dose and check for side effects. About 12 part…

This early-phase study is testing the safety and best dose of the chemotherapy drug paclitaxel when given directly into the abdomen (intraperitoneal) for people with advanced stomach or gastroesophageal cancer that has spread to the lining of the abdomen. The study includes about…

This study tests whether combining zanubrutinib (a BTK inhibitor) with rituximab (an antibody) can help people with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma achieve a lasting remission after stopping treatment. About 60 participants will rec…

This study tests a drug called adavosertib, given alone or with olaparib, in about 96 women with ovarian, fallopian tube, or peritoneal cancer that came back after PARP inhibitor treatment. The goal is to see if these drugs can shrink tumors or stop them from growing. Participant…

This study tests pegloticase, a drug used for gout, in 10 cancer patients with high uric acid from tumor lysis syndrome. The goal is to quickly lower uric acid and protect kidney function. Participants receive one infusion, and researchers track uric acid levels and kidney health…

This study tests whether giving two drugs (atezolizumab and bevacizumab) before surgery can help prevent liver cancer from coming back. The drugs work by boosting the immune system to attack cancer and blocking blood supply to tumors. 16 adults with removable liver cancer took pa…

This early-phase trial tests a new drug called tegavivint, combined with decitabine, in 9 adults with leukemia that has come back or not responded to standard treatments. The goal is to find the safest dose and see if the combination can control the disease. Participants must hav…

This early-phase trial tests a new drug, adagrasib, combined with two existing cancer drugs (cetuximab and irinotecan) in 24 people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effects…

This early-phase trial tests whether adding special 'veto' cells to a stem cell transplant can help donor cells grow in the patient's body without causing severe graft-versus-host disease. It includes 16 people aged 12-75 with various blood cancers or bone marrow failure. The vet…

This study tests two drugs, regorafenib and lorigerlimab, in people with high-risk colorectal cancer who have tiny traces of cancer DNA in their blood after finishing standard treatments. The goal is to see if this combination can safely clear those hidden cancer cells. The trial…

This study tests a combination of three drugs (pemetrexed, etrumadenant, and zimberelimab) in 10 adults with advanced bladder cancer that has a specific genetic change called MTAP deficiency. All participants had already received immunotherapy. The goal is to see if the triplet t…

This study looks at whether giving the drug sunitinib before surgery can help control metastatic kidney cancer. About 50 people with kidney cancer that has spread will receive sunitinib, then have surgery to remove the kidney tumor. Researchers will track how long the cancer stay…

This study was designed to test the safety and effectiveness of combining two drugs (TTI-101 and pembrolizumab) for people with head and neck cancer that had spread or come back. It planned to enroll adults whose cancer could not be cured with standard treatments. However, the st…

This study tests a drug called vibecotamab in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who still have small amounts of disease after standard treatments. The drug works by helping the immune system find and attack cancer cells. The main goal is t…

This study tests a drug called brentuximab vedotin in 79 people with three types of skin lymphoma that have a specific marker (CD30). The goal is to see if the drug can shrink or control the cancer. Participants receive the drug through an IV every three weeks, and researchers tr…

This study tests whether adding an experimental drug (GSK2636771) to an approved immunotherapy (pembrolizumab) can help control metastatic melanoma that has not responded to prior treatment. It is for patients whose tumors have a specific genetic change called PTEN loss. Up to 41…

This study tested a combination of two drugs, pemetrexed and avelumab, in 18 people with a rare, advanced form of bladder cancer that lacks a protein called MTAP. The goal was to see if the drugs could shrink or control the cancer. Pemetrexed blocks enzymes that cancer cells need…

This study tests whether specially trained white blood cells from a donor can treat a stubborn CMV infection in people who have had a stem cell transplant. About 49 participants will receive these donor cells to see if the infection clears. The goal is to control the virus withou…

This study tests a drug called talazoparib in people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, especially in tumors with changes in the BRCA genes or related DNA repair genes. The go…

This early-phase study tests a new way to fight advanced melanoma. Doctors take a patient's own immune cells (T-cells), modify them in a lab to resist a tumor-blocking signal (TGF-beta), and return them to the body along with a drug (IL-2) that boosts their activity. The goal is …

This study looks at whether people with early HER2-positive or triple-negative breast cancer who had a complete response to initial treatment (no cancer found after surgery) and have no cancer DNA in their blood can safely receive less post-surgery therapy. The goal is to maintai…

This study tests whether adding telotristat ethyl to standard therapy can help control carcinoid syndrome and prevent heart damage in people with advanced neuroendocrine tumors that have spread. About 79 adults who are already on stable somatostatin analog therapy will take part.…

This early-phase trial tests a new treatment for advanced bile duct cancer that has spread. It combines a special type of radiation (given in fewer, stronger doses) with an immunotherapy drug called bintrafusp alfa, which helps the immune system fight cancer. The study includes a…

This study tests a specific timing of chemotherapy drugs (busulfan, fludarabine, and cyclophosphamide) before and after a donor stem cell transplant in 204 people with various blood cancers. The goal is to reduce the risk of the transplant failing or causing severe side effects l…

This study looks at whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive either olaparib or observation after chemo. The goal is to see if olaparib delays cancer progression.

This study is for adults newly diagnosed with a challenging form of acute myeloid leukemia (AML) that is either related to a prior blood disorder or caused by previous cancer treatment. The trial tests a combination of three drugs—azacitidine, venetoclax, and pevonedistat—to find…

This study tests a combination of targeted drugs and chemotherapy in 51 young adults newly diagnosed with mantle cell lymphoma, a rare blood cancer. The goal is to see if starting with ibrutinib and rituximab, then adding venetoclax and chemo, can shrink tumors completely. Partic…

This study tests two drugs, venetoclax and acalabrutinib, given together to people with mantle cell lymphoma that came back or didn't respond to prior therapy. The goal is to see if the combination can shrink or eliminate cancer. 32 adults with this specific blood cancer are part…

This study looks at whether varenicline (a pill) or the nicotine patch works better for smokers based on how sensitive they are to rewards. About 204 adults who smoke at least 5 cigarettes a day will get behavioral counseling plus one of the treatments. The goal is to see who sta…

This study tests a combination of four drugs (ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab) as the first treatment for people with chronic lymphocytic leukemia (CLL) who have a specific genetic feature (mutated IGHV) and no deletion in chromosome 17. The goal is to …

This study tests a radioactive drug, 177Lu-PSMA-617, in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bone marrow, causing low blood cell counts. The goal is to see if the drug is safe and how it affects the cancer. About 40 ad…

This study tests a combination of two targeted drugs (encorafenib and cetuximab) plus an immunotherapy (nivolumab) in people with a specific type of advanced colorectal cancer that has a BRAF mutation and is microsatellite stable. The goal is to find the best dose and see if the …

This study tests a drug called ibrutinib in 20 people with a slow-growing form of mantle cell lymphoma that hasn't been treated before. The drug works by blocking certain enzymes that cancer cells need to grow. The goal is to see if it can keep the cancer from getting worse, whil…

This study tests a combination of three drugs (ixazomib, gemcitabine, and doxorubicin) in people with bladder cancer that has spread or cannot be removed by surgery. The first part finds the safest doses, and the second part checks if the treatment shrinks tumors. About 57 adults…

This study compares two medications, infliximab and vedolizumab, to treat colitis (colon inflammation) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer are participating. The goal …

This early-phase study tests whether adding a new drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe for people with advanced pancreatic cancer. The study includes 19 adults whose cancer has spread. The main goal is to check for side effects and s…

This study tests whether the immunotherapy drug BALSTILIMAB can clear HPV virus from the blood of 20 people who have been treated for HPV-positive oropharyngeal cancer but still have signs of the virus. The goal is to see if clearing the virus leads to better long-term cancer con…

This early-stage study tests a drug called NBTXR3, which boosts the effects of radiation on cancer cells, in people with non-small cell lung cancer that has returned and cannot be surgically removed. About 34 participants will receive the drug injected into the tumor followed by …

This study looks at whether combining chemotherapy with surgery to remove lung tumors works better than either treatment alone for people with colorectal cancer that has spread to the lungs. About 40 participants will be grouped by risk level and receive different treatments. The…

This early-phase study tests a new treatment for adults with metastatic melanoma that has not responded to standard immunotherapy. Researchers take immune cells from the patient's tumor, engineer them to produce a protein (IL15) to help them survive and fight better, and give the…

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants with progressive or recurrent disease were enrolled. The goal was to see if the tumors shrank or stopped growing, and to chec…

This study tests two drugs—pembrolizumab (an immunotherapy that helps the immune system attack cancer) and romidepsin (which blocks enzymes cancer cells need to grow)—in people with a rare type of blood cancer (peripheral T-cell lymphoma) that has returned or not responded to pri…

This early-phase trial tests the safety and best dose of a three-drug combination (dasatinib, temsirolimus, and cyclophosphamide) in children and young adults (ages 1 to 21) with advanced solid tumors that have come back or not responded to standard treatments. The goal is to fin…

This study tests a drug called 177Lu rhPSMA-10.1, which delivers radiation directly to prostate cancer cells. It is given alone or with hormone therapy to men with high-risk prostate cancer before they have surgery to remove the prostate. The goal is to see if the treatment is sa…

This study tests a new drug, seclidemstat, combined with a standard treatment (azacitidine) for people with myelodysplastic syndromes or chronic myelomonocytic leukemia. The goal is to find the best dose and see if the combination can shrink or control the cancer. About 24 adults…

This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) and radiation before surgery can help shrink tumors in patients with two rare types of sarcoma. About 32 adults with these sarcomas that can be surgically removed will receive treatment and…

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in 46 people with advanced or inoperable adenocarcinoma of the bladder or urachus. The goal was to see how many patients' tumors shrank or disappeared. The treatment aims to …

This study tests whether the drug Avastin (bevacizumab) can help control ovarian, fallopian tube, or primary peritoneal cancer that is still present after initial treatment and found during a second-look surgery. About 35 adults with advanced cancer who completed standard chemoth…

This study tests whether taking apalutamide for 6 months before prostate removal surgery can lower the chance that patients will need radiation therapy afterward. It includes 45 men with intermediate-risk prostate cancer. The goal is to see if the drug reduces signs of aggressive…

This study tests a new drug combination (ALX148, rituximab, and lenalidomide) in people with B-cell non-Hodgkin lymphoma that has not responded to prior treatment. The goal is to find the best dose and see if the combo can shrink or control the cancer. About 47 adults with variou…

This study tests whether proton beam therapy, sometimes combined with standard radiation, can control skull base chondrosarcoma—a rare tumor near the brain. Fifteen participants who had surgery will receive this precise radiation to prevent the cancer from coming back. Researcher…

This study tests whether giving a fecal microbiota transplant (healthy bacteria from stool) along with re-starting immunotherapy (pembrolizumab or nivolumab) can help shrink tumors in people with advanced colorectal cancer that did not respond to immunotherapy alone. The trial in…

This study compares two radiation treatments for people whose cancer has spread to the brain (but not from melanoma). One method, stereotactic radiosurgery, targets only the tumors with a strong dose. The other, whole brain radiation, treats the entire brain with lower doses over…

This early-phase trial studies the safety and best way to give the immunotherapy drug pembrolizumab after radiation therapy for patients with malignant pleural mesothelioma, a rare lung cancer. About 24 participants will receive the combination to see if it helps control the dise…

This study tests a combination of two drugs, ibrutinib and rituximab, in people with mantle cell lymphoma that has returned or not responded to treatment, as well as in older adults newly diagnosed with the disease. The goal is to see if the combo can shrink or control the cancer…

This study tests a new treatment called KSQ-001EX for people with advanced solid tumors, including melanoma, lung, and head/neck cancers. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are modified in a lab to better fight cancer. The main g…

This study looks at whether adding local treatments like surgery or radiation to a combination of two immunotherapy drugs (nivolumab and ipilimumab) helps people with stage IV non-small cell lung cancer live longer. About 339 participants will receive the immunotherapy drugs alon…

This early-phase study tests a combination of the drug neratinib with either everolimus, palbociclib, or trametinib in people with advanced solid tumors that have not responded to standard treatments. The tumors must have specific gene changes (EGFR, HER2, HER3, HER4, or KRAS). T…

This study tests a shorter, more intense course of proton beam radiation for men with early-stage prostate cancer that hasn't spread. The goal is to see if this approach can effectively control the cancer while reducing long-term side effects like bowel problems. About 241 men wi…

This early-phase study tests whether injecting the cancer drug nivolumab directly into high-risk mouth lesions can shrink or control them. About 18 adults with biopsy-proven oral premalignant lesions will receive the injections. The goal is to see if this approach is safe and eff…

This early-phase study tests a new drug (valemetostat) combined with a targeted therapy (trastuzumab deruxtecan) in people with HER2 low, ultra-low, or null metastatic breast cancer. The main goal is to find a safe dose and see if the combination can shrink tumors. About 17 adult…

This study tests a combination of two drugs, venetoclax and azacitidine, in about 34 people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has returned or not responded to prior treatment. The goal is to find the best dose and see how…

This study tests a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including breast, digestive, female/male genital, and thyroid cancers). The first phase finds the safest dose, and the second phase checks if that dose can he…

This study tests whether adding hydroxychloroquine (a malaria drug) to standard chemotherapy can help control osteosarcoma that has returned or stopped responding to treatment. About 31 participants will receive the combination to find the best dose and see if it slows tumor grow…

This study tests the drug vemurafenib in 24 people with advanced papillary thyroid cancer. The drug blocks a gene mutation that fuels cancer growth, aiming to shrink tumors before surgery. Researchers will measure changes in tumor size and biomarkers in blood and tissue to see ho…

This early-phase study tests whether a combination of two drugs (acalabrutinib and rituximab) followed by a special cell therapy (brexucabtagene autoleucel) can help control high-risk mantle cell lymphoma in people who have not yet been treated. About 22 participants will receive…

This study tests a two-step treatment plan for people with multiple myeloma that has come back or stopped responding to therapy. First, patients receive a combination of daratumumab, bortezomib, and dexamethasone, then switch to daratumumab, ixazomib, and dexamethasone. The goal …

This study tests a drug called cetuximab in people with advanced or metastatic chordoma, a rare type of bone cancer. The goal is to see if the drug can shrink tumors or stop them from growing. About 29 adults with chordoma that cannot be removed by surgery or has spread will rece…

This study tests a drug called inotuzumab ozogamicin in 40 adults with B-cell acute lymphoblastic leukemia who are in remission but still have tiny amounts of cancer cells (minimal residual disease). The drug works like a guided missile, attaching to a marker on cancer cells and …

This study tests whether proton beam therapy, sometimes combined with standard radiation, can control skull base chordoma—a rare tumor near the brain. Nineteen participants who had surgery to remove most of the tumor will receive this targeted radiation. Researchers will monitor …

This study tests whether adding sunitinib to standard hormone therapy can shrink or control high-risk prostate cancer before surgery to remove the prostate. About 64 participants will receive the drug combination for a short time before their planned prostatectomy. The main goal …

This study tests two drug combinations for people with inflammatory breast cancer that has come back or spread. One group gets three drugs (atezolizumab, cobimetinib, eribulin) and the other gets two (atezolizumab and eribulin). The goal is to see if these combos shrink tumors. A…

This study tests a combination of three drugs (decitabine, venetoclax, and ponatinib) in 20 people with a rare, aggressive leukemia called Philadelphia chromosome-positive acute myeloid leukemia or chronic myelogenous leukemia in blast phase. The goal is to see if the drugs can s…

This study tested whether adding the targeted drug Tarceva to two standard chemotherapy drugs (cisplatin and docetaxel) could shrink tumors in people with head and neck cancer that had spread or come back. 50 participants received the combination. The main goal was to see how man…

This study was designed to test a combination of two drugs (regorafenib and lorigerlimab) in people whose rectal cancer had come back or continued growing after standard treatment. The goal was to see if the combination was safe and could control the cancer. However, the trial wa…

This study tests whether giving patients their own specially grown immune cells (T cells) along with high-dose IL-2 can fight metastatic melanoma. Some patients also receive a dendritic cell vaccine to help the T cells last longer. The trial includes several groups to explore dif…

This study looks at whether adding the drug cidofovir to standard care can better control bladder bleeding caused by BK virus in people who have had a stem cell transplant. About 27 participants will be randomly assigned to receive either cidofovir plus standard care or standard …

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy can help people with aggressive thyroid cancers (anaplastic or poorly differentiated) live longer. About 50 adults with advanced or inoperable disease will receive different drug combinat…

This study tests two different three-drug combinations in people with advanced melanoma (skin cancer that has spread or can't be removed). The drugs include an immunotherapy (nivolumab) plus targeted therapies that block cancer growth signals. The goal is to see if these combinat…

This early-phase study tests a combination of three drugs—bortezomib, gemcitabine, and doxorubicin—in people with advanced urothelial cancer or other solid tumors that cannot be removed by surgery. The main goal is to find the safest dose of the two chemotherapy drugs when given …

This study tests whether adding an experimental drug (DKN-01) to an existing immunotherapy (pembrolizumab) can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer are taking part. The mai…

This early-phase study tests the safety and best dose of two drugs, ceritinib and everolimus, given together to adults with advanced solid tumors or a type of lung cancer called ALK-positive NSCLC. The goal is to see if the combination can stop tumor growth by blocking key enzyme…

This early-phase study tested two immunotherapy drugs (ipilimumab and nivolumab) combined with radiation in 21 people with stage II or III non-small cell lung cancer that could not be removed by surgery. The goal was to see if the combination is safe and helps shrink tumors. Part…

This study tests whether giving the drug selpercatinib before surgery can shrink thyroid cancers that have a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will take selpercatinib for a short time before their operation. The go…

This study tests two drug combinations (olaparib plus either vistusertib or capivasertib) in people with endometrial, triple-negative breast, ovarian, or related cancers that returned after prior treatment. The main goal is to find the safest dose and understand side effects. Abo…

This early-phase trial tests whether elotuzumab can help control myelofibrosis, a rare bone marrow cancer. The study includes 15 adults with a specific genetic mutation (JAK2) whose disease is at intermediate or higher risk. The main goal is to see if the drug improves blood cell…

This study tests a three-drug combination (abiraterone, prednisone, and apalutamide) in 60 men with prostate cancer that has spread but hasn't yet been treated with hormone therapy. The goal is to see how long the treatment can control the cancer. Participants must have high-risk…

This early-phase trial tests a shorter course of chemoradiotherapy (2 weeks instead of 5) followed by standard chemotherapy before surgery for stomach cancer. The goal is to see if this approach is safe and helps control the disease. About 25 adults with resectable gastric cancer…

This study tests a combination of two drugs, atezolizumab and bevacizumab, in people with rare solid tumors that are hard to treat. The goal is to see if the drugs can shrink or control the cancer by boosting the immune system and blocking blood supply to tumors. About 133 adults…

This study tests a new combination of chemotherapy drugs (venetoclax, busulfan, cladribine, and fludarabine) given before a donor stem cell transplant in people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to kill cancer cells and make room for…

This study tests whether combining two or three drugs can shrink or control melanoma that has spread to the brain. It involves 29 adults with untreated brain metastases. The drugs work by blocking tumor growth and helping the immune system attack cancer cells. The goal is to see …

This study compares proton beam therapy (a newer, more targeted radiation) to standard intensity-modulated radiation therapy (IMRT) for people with esophageal cancer. Both are given with chemotherapy. The goal is to see if proton therapy is as effective at controlling the cancer …

This study tests whether an ultra low dose of radiation (4 Gy) can safely control slow-growing B-cell lymphoma or mantle cell lymphoma that has spread to the eye socket. About 50 adults with stage I to IV disease will receive this targeted radiation. The goal is to shrink or stop…

This early-phase trial tests the drug olaparib in 15 people with newly diagnosed BRCA-mutant ovarian, fallopian tube, or peritoneal cancer. Participants take olaparib for two cycles before their planned surgery to see if it can shrink tumors safely. The goal is to find out if thi…

This study was designed to test a combination of two drugs (ASTX727 and ASTX029) in adults with certain genetic mutations (RAS pathway) in myelodysplastic syndromes or related blood cancers. The goal was to find a safe dose and see if it could control the disease. However, the st…

This early-phase study tested two immunotherapy drugs, durvalumab and tremelimumab, given before surgery to patients with aggressive bladder cancer who cannot receive standard chemotherapy. The main goal was to check safety and side effects. Researchers also looked at how the dru…

This study was designed to test a combination of two drugs (regorafenib and lorigerlimab) given before surgery to people with a certain type of colorectal cancer that had spread only to the lungs. The goal was to see if the treatment was safe and could help shrink tumors. However…

This study tests a shorter course of radiation given only to the part of the breast where cancer was removed, for women with early-stage breast cancer. The goal is to see if this approach causes fewer side effects and maintains good cosmetic results compared to standard whole-bre…

This study tests a drug called isatuximab, given alone or with lenalidomide, in 61 people with high risk smoldering multiple myeloma. The goal is to see if the treatment can shrink or control the cancer cells before they turn into active myeloma. Participants receive the drugs in…

This study compares two treatments for lung tumors: microwave ablation (using heat to kill cancer cells) and surgical wedge resection (removing a small piece of lung). It includes 74 adults with non-small cell lung cancer, sarcoma, or colorectal cancer that has spread to the lung…

This study tests two drugs—niraparib and dostarlimab—together in people with small cell lung cancer or other high-grade neuroendocrine cancers that have already been treated. Niraparib blocks a repair process in cancer cells, while dostarlimab helps the immune system attack them.…

This study tests an inhaled form of a natural immune protein (IL-2) to treat cancers that have spread to the lungs, such as melanoma, kidney cancer, and sarcoma. About 70 adults will receive the drug through a nebulizer to see what dose is safe and whether it can shrink lung tumo…

This study tests whether a hormone-releasing IUD (Mirena) alone or combined with the drug everolimus can control or shrink early-stage endometrial cancer or its precancerous condition. About 102 women with complex atypical hyperplasia or low-grade endometrial cancer will receive …

This study tests whether a very low dose of radiation (4 Gy) can effectively treat gastric MALT lymphoma, a type of stomach cancer. About 25 adults with stage I to IV disease will receive this ultra low-dose therapy. The goal is to shrink tumors and control the disease while redu…

This study tests whether a program of diet, exercise, stress management, and social support can improve outcomes for women with stage II or III breast cancer undergoing radiation therapy. About 110 participants will be randomly assigned to the lifestyle program or usual care. Res…

This study tests whether giving a personalized dose of radiation (Y-90) to liver cancer patients can shrink tumors better than standard dosing. The approach uses individual patient scans to plan the exact amount of radiation needed. The trial includes 42 adults with advanced live…

This study tests a drug called acalabrutinib in people with mantle cell lymphoma who had to stop taking ibrutinib because of bad side effects. The goal is to see if acalabrutinib can shrink or control the cancer without causing the same problems. About 9 participants are being tr…

This study tests adding the targeted drug sorafenib to standard chemotherapy before a donor stem cell transplant in people with acute myeloid leukemia (AML) that has returned or not responded to treatment. The goal is to find the safest dose and see if it helps patients live long…

This early-stage trial tests whether tranexamic acid (TXA) can reduce blood loss in patients with pelvic tumors undergoing hemipelvectomy, a surgery that removes part of the pelvis. About 80 adults and children will receive TXA or a placebo during surgery. The goal is to see if T…

This study tests different combinations of approved drugs in 196 men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see which mix works best to control the cancer and improve survival. Participants receive standard hormone-…

This study tests whether giving personalized, targeted drugs to people with acute myeloid leukemia (AML) can prevent the cancer from returning early. It is for patients who show signs of remaining cancer cells after initial treatment. The approach uses genetic testing to match ea…

This study tests a combination of two drugs—SX-682 and nivolumab—in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder to treat. The go…

This study looks at whether a precise type of radiation, called stereotactic radiosurgery, can prevent brain tumors from coming back after surgery. About 132 people with up to 3 brain metastases will either receive this radiation or be watched closely. The goal is to see if the r…

This study tests whether using MRI scans to plan radiation therapy can safely lower the dose for people with low-risk HPV-positive throat cancer. The goal is to keep the cancer under control while reducing swallowing problems and the need for feeding tubes. About 90 adults with e…

This early-phase study tests a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus a special type of radiation (RadScopal) in people with advanced solid tumors that have spread. The main goal is to check safety and side effects. Only 7 participants are enro…

This study tests whether adding an immunotherapy drug (nivolumab) to precise, high-dose radiation (SABR) can better prevent lung cancer from coming back or spreading, compared to radiation alone. About 140 adults with early-stage non-small cell lung cancer or a single recurrence …

This early-stage trial tests a new treatment called IVS-3001, which uses a patient's own immune cells (CAR-T cells) that are modified to recognize and attack a protein called HLA-G found on some solid tumors. The study includes 31 adults with advanced solid tumors that have not r…

This study compares radiation therapy alone to radiation combined with rituximab (a drug that helps the immune system attack cancer) in people with early-stage (I or II) follicular lymphoma. The goal is to see if adding rituximab keeps the cancer from growing or coming back longe…

This study tested a treatment that combines two chemotherapy drugs (cisplatin and docetaxel) with an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this approach could control the cancer and allow patients to keep t…

This study tests a combination of three chemotherapy drugs (docetaxel, cisplatin, and fluorouracil) as a first treatment for people with advanced nasal cavity or sinus cancer that hasn't spread to other parts of the body. The goal is to shrink tumors enough to avoid or reduce the…

This study tests a combination of three drugs (acalabrutinib, lenalidomide, and rituximab) in 60 people with untreated stage III-IV follicular lymphoma. The goal is to see if the combination can shrink or eliminate tumors and keep the disease under control. Participants must have…

This study tests a powerful chemotherapy regimen (Hyper-CVAD) combined with the targeted drug ponatinib in people with a specific type of acute lymphoblastic leukemia (ALL) that has a genetic change called the Philadelphia chromosome. The goal is to see if this combination can ke…

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer schedule for men with prostate cancer who have had surgery. About 186 men will take part. The goal is to see if the shorter treatment causes fewer side effec…

This study aimed to see if the drug glofitamab could stop large B-cell lymphoma from coming back in patients who were in remission but still had tiny traces of cancer (minimal residual disease). The trial was withdrawn before enrolling any participants, so no results are availabl…

This study tests whether combining two drugs, dasatinib and venetoclax, can better control early chronic phase chronic myeloid leukemia (CML). About 155 adults with newly diagnosed CML (within 12 months) who have had little or no prior treatment are participating. The goal is to …

This study tests whether adding targeted radiation to standard drug therapy can better control cancer that has spread to a few places in the body (oligometastatic disease). About 380 adults with solid tumors and up to 5 metastatic spots will be randomly assigned to receive either…

This study tests whether adding elotuzumab to standard lenalidomide maintenance therapy can help keep multiple myeloma from returning after a stem cell transplant. About 113 people who recently had a transplant using their own stem cells will receive the drug combination. The goa…

This study tests a combination of two drugs, acalabrutinib and rituximab, in people aged 65 and older with newly diagnosed mantle cell lymphoma. The goal is to see if the combo can control the cancer while causing fewer severe side effects. About 53 participants will receive the …

This study tests whether giving a mix of targeted drugs before and with standard chemotherapy can better control a fast-growing lymphoma called DLBCL. About 62 adults with newly diagnosed disease will receive the combination. The goal is to see if more patients achieve complete r…

This study tests whether using home devices to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study tests whether the drug regorafenib can help control gastrointestinal stromal tumors (GIST) that have specific gene changes (KIT exon 17, 18, or 14, or SDHB deficiency) and have stopped responding to the first treatment, imatinib. About 3 adults with advanced GIST will …

This study tests a combination of chemotherapy (gemcitabine, nab-paclitaxel) and two immunotherapy drugs (durvalumab, oleclumab) given before surgery to people with pancreatic cancer that can be removed. The goal is to shrink the tumor and improve the body's immune response. Abou…

This study tests a combination of drugs (olaparib, durvalumab, carboplatin, etoposide) and radiation for people with extensive-stage small cell lung cancer that hasn't been treated yet. The goal is to see if this mix is safe and works better than standard care. About 63 adults wi…

This study tests whether special imaging devices can better detect pre-cancerous or cancerous changes in the mouth compared to a standard visual exam. About 63 adults with suspicious mouth lesions or a history of oral cancer will be followed over time. The goal is to see if these…

This study compares two imaging methods—CT urography and IV urography—to see how well they show bladder and urinary tract tumors. About 133 people with bladder cancer will get both scans as part of their routine care. The goal is to find out if the newer CT scan alone is good eno…

This study compares two types of scans—PET/MR and CECT—to see which one better finds ovarian cancer tumors in the belly. About 21 women with known or suspected ovarian cancer will get both scans before surgery. The goal is to help doctors decide if tumors can be fully removed and…

This study is testing whether a special MRI contrast drug, called hyperpolarized 13-C pyruvate, can help doctors see how aggressive ovarian cancer is. The trial involves 30 people at high risk for ovarian cancer, such as those with a family history. The main goal is to check the …

This study tests a new radioactive tracer called [18F]FluorThanatrace to improve PET/CT scans in 36 people with breast cancer. The tracer may help detect an enzyme linked to cancer growth. Participants will have the tracer injected before their standard biopsy or surgery.

This study tests a new 3D MRI technique to improve how doctors see prostate cancer, without needing a special coil inside the body. About 33 men with untreated, intermediate- or high-risk prostate cancer will be scanned before surgery. The goal is to see if the new method gives c…

This study tests whether shining special lights in the mouth can help find early signs of oral cancer. About 338 people at higher risk for mouth cancer (like those with leukoplakia, Fanconi anemia, or heavy tobacco use) will have their mouth tissues examined with fluorescence ima…

This study looks at whether a special type of CT scan, called dual energy CT, can find carcinoid tumors in the digestive system better than a regular CT scan. About 71 people with signs of carcinoid tumors or known tumors will get this scan during their routine check-up. The goal…

This study aimed to see if a shorter, less expensive MRI scan (using only two types of images) could find prostate cancer as well as the standard longer scan. It was designed for men with prostate cancer who were planning surgery. However, the study was withdrawn before any parti…

This study compares MRI and CT scans to see which better detects thymoma, a rare chest tumor. About 40 adults with new or returning thymoma will get both scans before surgery. The goal is to find out if MRI can replace CT for more accurate staging.

This study tests whether a modified MRI scan (called Dixon sequencing) can produce clearer images of prostate cancer than the standard MRI. Researchers will compare the two methods in 65 men who have prostate cancer and are scheduled for surgery. The goal is to see if the new tec…

This study looks at whether a special MRI contrast called hyperpolarized 13-C pyruvate can help doctors see prostate tumors more clearly than standard MRI. About 130 men with prostate cancer will get this contrast before their MRI. The goal is to improve how well doctors can find…

This study tests a special mammogram that uses a dye injected into the blood to make breast tissue and blood vessels clearer. The goal is to see if this method finds cancer better than standard mammograms in women with suspicious breast changes. About 100 women aged 25-85 who nee…

This early-phase trial studies a special PET-CT scan called FAZA that measures oxygen levels in solid tumors. About 25 adults with breast, colorectal, or pancreatic cancer will get two scans to see if the results are consistent. The goal is to help doctors plan more effective tre…

This study looks at three approaches for women with BRCA gene mutations who are at high risk for ovarian cancer: regular screening, removing both ovaries and fallopian tubes at once, or removing only the fallopian tubes first and the ovaries later. The goal is to see if delaying …

This study looks at how to increase HPV vaccination among young adults aged 18-26 in Texas. Researchers will test different methods to encourage college students to start and complete the vaccine series. The goal is to prevent HPV infections and related cancers.

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and potentially lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize tr…

This study looks at whether eating canned, pre-cooked beans can improve the balance of healthy bacteria in the gut and lower the effects of obesity on colorectal cancer risk. It involves up to 80 adults who are overweight or obese and have had colorectal cancer or precancerous po…

This study tests whether giving whole brain radiation to people with small cell bladder cancer (a rare and aggressive type) can lower the chance of cancer spreading to the brain. Participants had already responded well to chemotherapy. The goal is to see if this preventive radiat…

This study tests a program called Tu Salud Si Cuenta designed to help Latino families eat more fruits and vegetables and get more physical activity. About 80 adults will receive six monthly home visits from a community health worker who will teach them skills like goal-setting an…

This study tests whether acupuncture can prevent dry mouth in people receiving radiation for head and neck cancer. About 435 participants will be assigned to one of two acupuncture approaches. The goal is to see which method better protects saliva production and improves quality …

This study looks at whether a diet and exercise program can reduce breast cancer risk in normal-weight postmenopausal women who have excess body fat. About 40 women will take part in supervised sessions with a trainer and health coaching. The goal is to see if lowering body fat a…

This study tests whether a comprehensive lifestyle program—including diet advice, physical activity, stress management, mindfulness, sleep tips, and counseling—can help prevent breast cancer in premenopausal women at higher risk. About 60 women with a BMI of 25 or higher and low …

This study tests a program called Tu Salud Si Cuenta! that helps Latino families adopt healthier habits like eating more fruits and vegetables and being more physically active. Around 600 participants join with a family member. The goal is to see if the program leads to lasting h…

This study tests different programs to help people at high risk for cancer—such as those with BRCA or Lynch syndrome, or cancer survivors—increase their physical activity and eat healthier. The goal is to see which approach works best for reducing cancer risk. About 337 participa…

This study tests high-dose steroids (prednisone or methylprednisolone) to see if they can improve symptoms of nerve damage that can occur years after radiation treatment for head and neck cancer. The trial involves 35 adult survivors of oropharyngeal cancer who have specific nerv…

This early-stage trial tests whether a liver cancer treatment called Y90 radioembolization can be safely done in a single session instead of the usual two days. The study involves 12 patients with liver cancer that has spread. The goal is to see if this faster approach reduces tr…

This study tests a procedure called cordotomy for people with advanced cancer who have severe, one-sided pain below the shoulder that hasn't been helped by other treatments. Using CT scans as a guide, a doctor places a needle in the spinal cord to reduce pain. The goal is to see …

This study looks at whether adding lorazepam (a sedative) to haloperidol (a standard antipsychotic) can better reduce delirium—sudden confusion and agitation—in people with advanced cancer. About 90 patients in a palliative care unit will receive either haloperidol alone or halop…

This study tests a behavioral program that combines mood management with smoking cessation support for pregnant women who are depressed and smoke. About 26 participants will receive the program during pregnancy and after birth. The goal is to help them quit smoking and stay smoke…

This study tested whether neurofeedback training can help reduce pain caused by radiation therapy in people with head and neck cancer. Neurofeedback uses brain wave measurements to teach patients how to change their brain activity and possibly lower pain. The study involved 17 pa…

This study tests whether a non-invasive magnetic brain stimulation technique (nrTMS) can improve motor function recovery in brain tumor patients after surgery. About 32 participants who have motor weakness due to their tumor or surgery will receive nrTMS alongside standard rehabi…

This study looks at whether draining fluid from the chest every day helps people with advanced cancer breathe better compared to draining it only three times a week. About 257 adults with cancer-related fluid buildup around the lungs will take part. The goal is to see which sched…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce cancer-related fatigue in people with advanced cancer. About 90 participants will be randomly assigned to high or low dose dexamethasone along with exercis…

This study is testing a smartphone app designed to help people reduce or quit smoking. Participants use the app along with nicotine patches. The goal is to see if the app is easy to use and helpful. About 56 adults who smoke at least 10 cigarettes a day will take part.

This study tests whether combining exercise, supportive counseling, and a stimulant drug (methylphenidate) can reduce severe fatigue in prostate cancer patients receiving radiation and hormone therapy. 175 participants will be assigned different combinations of these treatments. …

This study looks at whether adding acupuncture to standard care can reduce pain and the need for strong painkillers after open surgery for colorectal or pancreatic cancer. About 70 patients will either get acupuncture or usual care. The goal is to see if acupuncture helps people …

This study tests whether the drug Jakafi (ruxolitinib) can reduce severe fatigue in people with chronic lymphocytic leukemia (CLL). Ten participants who have CLL but do not yet need standard treatment will take Jakafi and report their fatigue levels. The goal is to see if blockin…

This study tests an exercise program designed for Hispanic women who have had breast cancer. Researchers want to find the best ways to help these survivors become more active. The study includes 53 participants and measures changes in exercise habits and energy levels.

This study aims to find a fast and effective way to identify depression in women with ovarian, peritoneal, or fallopian tube cancer. It compares a special intervention program with enhanced standard care to see which better improves quality of life. About 409 women on active canc…

This study compares two different methods for prescribing opioid pain medication to people recovering from abdominal cancer surgery. The goal is to find which approach provides better pain control with fewer side effects. About 170 adults having certain types of abdominal surgery…

This study tested whether ginseng can reduce fatigue and improve mood in 165 adults with advanced cancer. Participants took ginseng or a placebo for 29 days. The goal was to see if ginseng helps people feel less tired and more energetic during cancer treatment.

This study tests whether fast-acting opioids (fentanyl or morphine) can reduce shortness of breath during physical activity in 150 cancer patients who already take strong painkillers. Participants will take the drug or a placebo before a walking test, and their breathing difficul…

This study looks at whether adding a technology-based symptom monitoring program to regular palliative care (in-person and remote visits) can improve quality of life for 119 adults with advanced solid tumors who are also in phase 1 immunotherapy trials. Participants use the progr…

This study tests whether regular exercise and behavioral skills training can improve physical fitness and quality of life in people with pancreatic cancer who are receiving chemotherapy or radiation before surgery. About 128 participants will take part at MD Anderson. The main go…

This study is testing a mindfulness program that has been adapted for Latino cancer patients and their family caregivers. The goal is to see if this program can help reduce stress and anxiety and improve mental well-being. About 68 patient-caregiver pairs will take part, and rese…

This study compares a 3-week radiation schedule to the standard 5-week schedule for breast cancer patients who need radiation to the lymph nodes. The goal is to see if the shorter treatment works just as well to prevent cancer from coming back, while causing less arm swelling and…

This study looks at how cancer patients view using marijuana products (THC or CBD) along with opioids for pain relief. Researchers will survey 200 patients in Texas and Arizona to understand their preferences and symptom control. The goal is to learn if adding marijuana helps pat…

This study tests a new type of counseling called Acceptance and Commitment Therapy (ACT) to help people with certain cancers quit smoking. About 51 participants who have or had head and neck, lung, breast, gastrointestinal, or genitourinary cancer and smoke at least one cigarette…

This study tests whether a special type of talk therapy (CBASP) combined with standard smoking cessation help works better than health education plus standard smoking help for depressed smokers. About 91 adults with current major depression or dysthymia who smoke at least 5 cigar…

This study tests if a technique called neuromodulation can reduce pain caused by chemotherapy. About 24 people with nerve damage from specific chemo drugs will receive the treatment. The goal is to see if it's safe and helps with pain and sensation.

This study tests whether neurofeedback training, a non-invasive therapy that uses brain wave monitoring, can help people with chemotherapy-induced peripheral neuropathy (nerve pain, numbness, or tingling) feel better. About 91 adults who have had chemotherapy and still have nerve…

This pilot study tests whether smartphone apps can help current smokers quit. Researchers will track how well participants use the app, changes in mood and activity, and whether they stop smoking. The study involves 24 adults who smoke daily and have some history of depression.

This study looks at whether exercising the muscles used for coughing and swallowing can reduce the risk of pneumonia in people who had radiation for head and neck cancer. About 175 survivors will participate. The goal is to see if stronger cough muscles help prevent food or liqui…

This study tests a mobile lifestyle program for 30 women with breast cancer who have unhealthy habits. The program offers coaching on diet, exercise, stress management, mindfulness, sleep, and social support. The goal is to see if the program is practical and helps improve qualit…

This study tests an online program designed to improve social well-being and emotional support for women with non-small cell lung cancer. About 70 women currently receiving treatment will practice mindfulness, compassion, and emotional processing techniques. The goal is to see if…

This study is testing a supportive care program designed specifically for Black patients with advanced cancer. The program uses meditation and mind-body techniques adapted to be culturally relevant. Researchers will first gather input from patients and caregivers, then run a smal…

This study looks at whether a single large dose of radiation is better than three smaller doses for treating cancer that has spread to the spine. About 80 adults with spine metastases will be randomly assigned to one of the two radiation schedules. The goal is to see which approa…

This study tests whether a pulmonary rehabilitation program can improve lung function enough to make lung cancer patients eligible for surgery. Researchers will enroll 75 patients who were initially deemed unable to have surgery due to poor lung health. The goal is to see if reha…

This study looks at whether one session of radiation therapy can improve symptoms like pain and bleeding in women with advanced gynecologic cancer that has spread. The goal is to see if a single treatment works as well as the standard multiple sessions for improving quality of li…

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms like fatigue and distress in cancer patients undergoing radiation therapy and their partners. About 600 patients with lung, head and neck, or esophageal cancer, along…

This study tests whether a supervised exercise program done at home via video can help people with pancreatic cancer get stronger while they receive chemotherapy before surgery. About 58 participants will follow the program and be monitored for safety and side effects. The goal i…

This study compares two pain relief methods—thoracic epidural analgesia and a four-quadrant abdominal wall block—in 101 people having open liver surgery for cancer. The goal is to see which approach leads to a shorter hospital stay and better pain control after surgery. Participa…

This study tests whether a drug called anamorelin, along with physical activity and nutritional counseling, can reduce severe fatigue in people with advanced solid tumors that cannot be cured. About 129 participants will receive the combination and report their fatigue levels ove…

This study looks at whether cognitive behavioral therapy (CBT) can help people with acute myeloid leukemia or lymphoma who feel very tired from their cancer or treatment. About 48 patients will learn new ways to think and act to better cope with fatigue, anxiety, and depression. …

This study looks at whether exercise and weight management can help reduce fatigue in people who have had chronic lymphocytic leukemia (CLL). About 30 adults aged 18-85 with CLL will take part. Participants will be randomly assigned to start the program right away or after a wait…

This study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week during their treatment. The goal is to see if…

This study tests whether a non-invasive technique called neurofeedback can help people with chemotherapy-induced nerve pain learn to change their own brain waves to feel less pain. About 80 participants will be divided into two groups to compare the effects. The goal is to see if…

This study compares two numbing medicines, EXPAREL and lidocaine, to see which one provides better pain relief for patients with malignant pleural neoplasm (a type of lung cancer) undergoing a procedure called pleuroscopy with biopsy and chest tube placement. About 80 adults will…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce chronic pain in women who had breast cancer surgery. About 111 women with stage I-III breast cancer who have pain lasting at least 3 months after treatment will be randomly …

This study tests whether combining talk therapy, a stimulant, melatonin, and light therapy can improve sleep in cancer patients. About 68 adults with cancer and poor sleep are taking part. The goal is to reduce fatigue and improve quality of life.

This study looks at whether hypnosis can help women with early-stage breast cancer relax during surgery and reduce the need for general anesthesia. About 50 women will try hypnosedation, a technique that uses words and images to keep them calm and awake while numb. The goal is to…

This study looks at whether weighted blankets can improve sleep in adults with blood cancers. Twenty participants will use the blankets, and researchers will monitor safety and any side effects. The goal is to see if this simple, drug-free approach can help patients rest better.

This study is for people with a type of throat cancer (oropharyngeal) that is only on one side of the neck. Normally, radiation is given to both sides, which can cause more side effects. The researchers want to see if giving radiation only to the side with cancer is safe and redu…

This study tests a training program for family members caring for someone with a high-grade glioma. The goal is to see if the training helps reduce caregiver stress and improves the patient's symptoms and quality of life. About 124 pairs of caregivers and patients will take part.

This study looks at whether a drug called anamorelin can help improve appetite and stop weight loss in people with advanced non-small cell lung cancer who have lost their appetite and weight. About 25 participants will take either the drug or a placebo daily and share their exper…

This study looks at whether massage therapy can reduce nerve problems caused by chemotherapy, such as pain, numbness, and tingling. About 90 people who had breast or digestive system cancer and finished chemo at least 6 months ago will receive massage sessions. The goal is to see…

This study compares two relaxation programs (including stretching and relaxation techniques) to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. About 681 women with early-stage breast cancer will participate. Some wi…

This study tests whether a meditation-based mind-body program can improve quality of life for adolescents and young adults (ages 18-39) recently diagnosed with lymphoma. Participants learn meditation techniques to help lower distress, anxiety, and depressive symptoms. The goal is…

This study looks at whether teaching cancer survivors who have heart failure about exercise and diet can help them change their lifestyle. About 85 people with mild to moderate heart failure that got worse after chemotherapy will take part. The goal is to see if they can stick wi…

This study looks at whether watching an online genetics video, with or without phone counseling, can help reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have at least one ovary. R…

This early-phase study looks at whether special imaging scans (DCE-MRI and MBI) can predict how well chemotherapy works in people with triple negative breast cancer. About 96 participants will get these scans before, during, and after chemo to see if the images can tell who is re…

This study looks at whether giving patients with advanced cancer and their caregivers a special information sheet helps them communicate better with their doctors. About 207 patients and their caregivers are taking part. The goal is to see if these materials make it easier for pa…

This study looks at how women aged 65 and older with early-stage breast cancer decide whether to have chemotherapy before or after surgery. Researchers will interview patients and doctors to understand what information they need. The goal is to create a tool that helps patients a…

This study looks at whether improving sleep can help overweight or obese African American adults who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is p…

This study tests whether special software can help doctors more accurately destroy liver tumors with heat (ablation). About 107 people with up to 3 liver tumors will be in the study. Half will get the standard visual check, and half will get the software-assisted check to see if …

This pilot study explores whether adding physical activity to a quit-smoking program helps African American adults stop smoking. Researchers will enroll 45 participants to test if the approach is feasible and acceptable. The goal is to gather information for a larger future study…

This study looks at how cancer patients feel about receiving hospital-level care at home through the Care and Monitoring at Home program at MD Anderson. Researchers will use surveys to understand patients' quality of life and experiences. The goal is to learn how to improve this …

This study is creating a web-based program to help people with hereditary cancer-causing mutations share their genetic test results with family members. The goal is to increase awareness among at-risk relatives so they can take steps to prevent cancer. The program is designed for…

This study tracks 130 adults who have had their voice box removed (total laryngectomy) to see how often they use a ProvoxLife heat-moisture exchanger (HME), a device that warms and moistens air as they breathe through a hole in their neck. Researchers want to learn what personal …

This study looks at whether a group education program can help women with BRCA 1 or 2 gene changes, especially those from underserved or minority groups, follow recommended cancer screening and risk-reducing procedures. About 30 women will take part. The goal is to see if this ap…

This study looks at whether patient navigators (health coaches) can help more people with obesity sign up for and stick with weight management programs. About 171 participants who are obese and referred by a doctor will be split into two groups: one gets a navigator, the other do…

This early-phase study uses special PET and MRI scans to measure oxygen levels, metabolism, and blood supply in high-grade glioma and cervical cancer tumors. About 20 adults with newly diagnosed or recurrent tumors will undergo imaging before treatment. The goal is to understand …

This study looks at how different treatments for recurrent rectal cancer impact patients' quality of life and well-being. About 116 people with rectal cancer that has come back in the pelvis will answer surveys every 6 months. The goal is to understand the connection between trea…

This study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these "circulating tumor elements" can tell us how the cancer responds to standard treatment. They will also compare results from cancer patients …

This study follows women with gynecologic cancers who have had a pelvic exenteration—a surgery removing the lower colon, rectum, and bladder. Researchers track complications, quality of life, and survival to learn which surgical methods work best. The goal is to improve recovery …

This study looks at the symptoms people with oropharyngeal (throat) cancer have after finishing radiation or chemoradiation therapy. Researchers will ask 77 patients to rate their symptoms to learn which ones matter most. The goal is to create better care plans for recovery after…

This study was designed to test new nano-sized painkillers on nerve cells taken from people having surgery for spinal tumors. The goal was to learn how these cells respond to pain signals and treatments, which could help develop safer pain medicines. However, the study was withdr…

This study looks at whether molecular testing and lymph node mapping can help predict the risk of endometrial cancer returning in patients with low-risk cancer. About 518 people with early-stage, low-grade endometrial cancer will be followed for two years after surgery. The goal …

This study looks at why some people who had surgery for cancer are afraid to take the opioid pain medicine their doctor prescribed. Researchers will talk to 50 adults after they leave the hospital to learn about their fears and concerns. The goal is to better understand these bar…

This study looks at whether the bacteria in your gut and what you eat can change how well your body responds to the flu vaccine. Researchers will collect stool samples, blood samples, and diet information from 74 MD Anderson employees. The goal is to understand, not to treat—so n…

This study asks cancer patients and their caregivers about their preference for waiting in an exam room versus a waiting room at a supportive care center. The goal is to understand what makes them more comfortable. About 406 people will answer a questionnaire to share their opini…

This study tests whether reminder messages can encourage adults aged 40 to 80 who smoke or have smoked to get screened for lung cancer. Participants will receive reminders and then fill out a questionnaire about how acceptable they find them. The goal is to see if these messages …

This study looks at whether a genetic test on tumor samples can predict if HER2-negative breast cancer will respond to chemotherapy or hormone therapy. About 1,100 people with early-stage breast cancer are taking part. The goal is to see if this testing can help doctors choose th…

This early-phase study looks at how the drug adavosertib changes the DNA of advanced ovarian, fallopian tube, or peritoneal cancer in 38 patients before they have surgery. The goal is to understand how the drug affects tumor cells, not to cure or control the disease directly. Res…

This study looked at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to learn about people's experiences, such as exposure to the virus, isolation, and financial or social disrupti…

This study gathers medical information from 450 people with head and neck cancer who received or will receive proton therapy. Researchers will analyze this data to learn about treatment outcomes and side effects. The goal is to help doctors improve proton therapy for future patie…

This study surveys 100 cancer patients at a pain management clinic to learn how they use cannabis and CBD, how often, and why. The goal is to understand their habits and where they get information, not to test a treatment. Results will help doctors better support patients using t…

This study aimed to understand why women might want to receive their screening mammogram results immediately during the same visit. Researchers planned to survey female patients aged 30 and older scheduled for a mammogram at MD Anderson centers. The study was withdrawn before enr…

This study looks at what parents think about the risks of using opioids for pain in children with cancer. Researchers want to understand why some parents give less pain medicine than prescribed or stop it early, even when their child is in pain. About 110 parents of children with…

This study looks at whether a non-invasive brain-mapping technique called nTMS can help doctors plan radiation more safely for people with brain tumors near the motor cortex—the area that controls movement. About 22 adults who already had radiation for brain tumors will be scanne…

This study looks at how people recently diagnosed with cancer cope with the financial burden of their illness. Researchers will survey 625 English- or Spanish-speaking adults to understand what social, behavioral, and knowledge factors are linked to financial toxicity. The goal i…

This study is building a database of health information from people with MEN1 or MEN2, rare genetic conditions that cause tumors in hormone-making glands. Researchers will collect data through questionnaires from up to 1,500 participants, including patients at MD Anderson Cancer …

This study looks at whether giving breast cancer patients a 3D printed model of their breast helps them feel more confident about their surgery choices. About 20 women will either get the 3D model or standard scans. Researchers will then compare how clear and confident each group…

This study looks at whether a type of breast scan called molecular breast imaging (MBI) can predict how well breast cancer responds to chemotherapy given before surgery. About 96 women with invasive breast cancer will get MBI scans before, during, and after chemo. The goal is to …

This study looks at whether using electronic tools (like a tablet) to check mental function is practical for patients about to have liver surgery. About 100 English-speaking adults at MD Anderson Cancer Center will try both a digital brain test and a traditional paper test. The g…

This study looks at whether additional MRI scans and blood biomarker tests can help predict how head and neck tumors change during radiation therapy. Researchers will track tumor growth and blood markers in up to 80 cancer patients and 20 healthy volunteers. The goal is to better…

This study looks at whether men with intermediate-risk prostate cancer can follow a Mediterranean diet before their surgery. The goal is to see if changing what they eat is practical and well-tolerated. Researchers hope to learn how diet might influence health outcomes in these p…

This study tests a decision-aid website that helps women with cancer understand their options for preserving fertility before starting treatment. The goal is to see if the website reduces confusion and helps women make choices that match their values. The study includes 130 women…

This study looks at whether a special website and a genetic counselor can help more family members of people with hereditary cancer get tested for cancer genes. About 205 adults who have a known cancer gene mutation and their close relatives will take part. The goal is to see if …

This study looks at small molecules called microRNAs in the blood of 150 people with sepsis, a severe bloodstream infection. Researchers want to see if changes in these molecules can help predict who will survive or how the body reacts. The goal is to better understand sepsis, no…

This study looks at how the COVID-19 pandemic impacted the well-being of cancer patients who also have nerve pain (neuropathy). Researchers are surveying 274 people who took part in earlier studies to understand their quality of life and stress during the pandemic. They also want…

This study looks at how a person's genes and lifestyle choices, like smoking, affect their risk of getting bladder cancer. Researchers are comparing over 6,000 people with and without bladder cancer to find these links. The goal is to better understand who is at higher risk, not …

This study looks at whether special nutrition checkups can help find malnutrition in older cancer patients. Researchers want to see if poor nutrition is linked to a higher risk of death within 6 months to a year. The goal is to improve how doctors spot and address malnutrition in…

This study looks at whether short educational videos can help people with inherited cancer gene mutations understand their condition better. About 43 adults who carry a BRCA or other cancer-related gene mutation will watch the videos and then answer questions to measure their kno…

This study looks at whether having naturally low testosterone levels might increase the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks to see if there is a cause-and-effect link. No treatments or medications are given—this is a…

This study looks at how often cancer patients in a supportive care clinic experience cachexia (unintentional weight loss and loss of appetite) and the emotional toll it takes on both patients and their primary caregivers. Researchers will track weight changes and use questionnair…

This study looks at whether eating a high-fiber diet can improve the bacteria in your gut and help your body respond better to the flu vaccine. About 31 adults will follow a special diet before getting their flu shot. Researchers will check if the diet is easy to follow and if it…

This study checks if a special scale (bioelectrical impedance) can accurately measure muscle and fat loss in 50 head and neck cancer patients getting radiation therapy. The goal is to see if this simple tool can replace CT scans for tracking body changes, helping doctors decide w…

This study aims to create an educational guide to help people understand and decide about Multi-Cancer Early Detection (MCED) blood tests. About 150 adults without a cancer history will take part. The goal is to support informed decision-making, not to test the blood test itself.

This study looks at how day-to-day stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their feelings and activities throughout the day. The goal is to u…

This study looks at whether a commercial genetic test, called the Molecular Functional Portrait, can quickly provide useful information for treating lymphoma. About 111 adults with a type of lymphoma called diffuse large B-cell lymphoma will take part. The main goal is to see if …

This study compares two breathing strategies used during robotic bronchoscopy (a lung biopsy procedure) to see which one better prevents atelectasis (partial lung collapse). About 62 adults with suspicious lung nodules will take part. The goal is to find the safer, more effective…

This early-phase study tests whether adding zoledronic acid to standard chemotherapy and a targeted therapy can help women with ovarian cancer that has stopped responding to platinum-based treatment. The main goal is to see how the drug combo affects immune cells called macrophag…

This study looks at whether a lifestyle program can help African American prostate cancer survivors and their partners improve quality of life, diet, and physical activity. About 6 survivors with early-stage prostate cancer and their spouses or romantic partners will take part. T…

This study looks at how a single dose of antibiotics given before melanoma surgery changes the bacteria in your gut. Researchers want to see if these changes might affect how well the body responds to surgery. The trial involves 20 adults with early-stage melanoma who are having …

This study uses EEG (brain wave testing) to find out if patients in their final days of life who appear unresponsive can still hear or feel. Researchers will measure brain activity when sounds or words are played. The goal is to help families and doctors better understand what dy…

This study tests whether a less invasive ultrasound-guided needle biopsy can accurately tell if breast cancer has been completely eliminated by chemotherapy, compared to standard surgery. About 43 women with aggressive breast cancer types (triple negative or HER2-positive) who ha…