M.d. Anderson Cancer Center

This study looks at how well a pneumonia vaccine (PCV20) works in people who have recovered from B-cell lymphoma and were treated with anti-CD20 therapy. Researchers want to see if a single dose or a boosted dose is safer and more effective at preventing pneumococcal infections. …

This study tests whether the Gardasil 9 vaccine can help stem cell transplant patients build immunity against HPV. About 48 adults who had a stem cell transplant for blood cancer will receive the vaccine. Researchers will measure antibody levels to see if the vaccine works in the…

This study aimed to find a safe dose of a custom-made mRNA vaccine for people with a rare skin cancer called cutaneous angiosarcoma. The vaccine was designed to train the immune system to attack the cancer. However, the trial was withdrawn before any participants were enrolled.

This study tests a combination of two drugs—tagraxofusp and decitabine—in people with chronic myelomonocytic leukemia or high-risk myelodysplastic syndromes. Tagraxofusp is a targeted therapy that delivers a toxin to cancer cells, while decitabine is a chemotherapy drug. The tria…

This early-stage trial tests a new antibody drug called Hu8F4 in 72 people with advanced blood cancers like leukemia and myelodysplastic syndrome. The goal is to find the safest dose and see if it can slow or stop cancer growth. Researchers will also track how long patients live …

This phase II trial tests two different three-drug combinations in people with advanced BRAF-mutated melanoma that has spread or can't be removed surgically. One group gets nivolumab (immunotherapy) plus trametinib and dabrafenib (targeted drugs); the other gets nivolumab plus en…

This early-phase trial tests a combination of drugs—mTOR inhibitors (sirolimus, everolimus, or temsirolimus) and vorinostat—in people with advanced cancer that has not responded to standard treatments. The main goal is to find the safest dose and check for side effects. Up to 249…

This study tests whether giving a personalized dose of Yttrium-90 radiation to liver cancer patients can better shrink tumors while protecting healthy liver tissue. About 42 adults with advanced liver cancer that cannot be removed by surgery will receive a custom treatment plan b…

This study tests an inhaled form of interleukin-2 (IL-2), a protein that helps the immune system fight cancer. It is for people whose cancer has spread to the lungs from melanoma, sarcoma, or kidney cancer. The goal is to find the best dose and see if it can shrink lung tumors wi…

This phase 2 trial tests whether adding venetoclax to a specific chemotherapy regimen before a donor stem cell transplant can improve outcomes for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study enrolls 116 adults aged 18-70 who have a matche…

This study is testing a combination of three drugs—ALX148, rituximab, and lenalidomide—in people with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The goal is to find the best dose and see if the combination can shrink or control the cancer. About…

This Phase II trial tests whether proton beam therapy, sometimes combined with photon radiation, can control skull base chordoma after surgery. Nineteen participants received daily radiation for 35-39 treatments. Researchers are tracking how long it takes for the tumor to come ba…

This phase 2 trial tests a combination of two immunotherapy drugs (nivolumab and ipilimumab) plus a chemotherapy drug (azacitidine) in 99 people with myelodysplastic syndromes (MDS), a type of blood cancer. The goal is to see if the combination improves response rates, especially…

This study was designed to test whether adding an experimental drug called TTI-101 to the immunotherapy pembrolizumab (Keytruda) is safe and effective for people with head and neck cancer that has returned or spread. The trial was withdrawn before enrolling any participants, so n…

This study is testing a combination of drugs and radiation for people with extensive-stage small cell lung cancer (ES-SCLC) who haven't been treated yet. The drugs include olaparib (which blocks cancer cells from repairing themselves), durvalumab (which helps the immune system at…

This early-phase trial tests whether combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy is safe and effective for patients with stage II or III non-small cell lung cancer that cannot be surgically removed. The goal is to see if this chemo-free app…

This small pilot study tests whether giving a fecal microbiota transplant (FMT) along with re-introducing anti-PD-1 immunotherapy (pembrolizumab or nivolumab) can help colorectal cancer patients whose tumors did not respond to immunotherapy alone. The trial enrolls 15 adults with…

This phase II trial is testing a combination of targeted drugs (ibrutinib, rituximab, venetoclax) plus chemotherapy in 51 newly diagnosed young adults with mantle cell lymphoma. The goal is to see if this approach can achieve a complete response—meaning no signs of cancer—after t…

This early-phase trial is testing whether adding an experimental drug called Q702 to two standard leukemia drugs (azacitidine and venetoclax) is safe for people with relapsed or refractory acute myeloid leukemia (AML). About 17 adults whose leukemia has not responded to or has re…

This phase 2 trial tests whether adding an experimental vaccine called PDS0101 to standard chemoradiation is safe and helps control advanced cervical cancer. The vaccine is designed to train the immune system to recognize and attack HPV-infected cancer cells. About 22 adults with…

This phase 2 trial tests a treatment called LN-145, made from a patient's own immune cells taken from their tumor. These cells are grown in a lab and then given back to the patient to attack the cancer. The study includes people with ovarian cancer, triple-negative breast cancer,…

This phase II trial tests whether combining an immunotherapy (atezolizumab), a targeted therapy (cobimetinib), and a chemotherapy (eribulin) can shrink tumors in people with inflammatory breast cancer that has returned or spread. About 37 participants will receive either the trip…

This phase 2 trial tests whether combining two immunotherapy drugs, atezolizumab and tiragolumab, can help control cancers of unknown primary (CUP) — cancers that have spread but whose origin cannot be found. The study includes 4 adults whose cancer has not responded to or cannot…

This study tests whether adding tocilizumab (a drug used for arthritis) to standard immunotherapy can reduce severe side effects in people with advanced melanoma, lung cancer, or bladder cancer. About 35 participants will receive all three drugs. The goal is to see if the combina…

This phase 2 trial tests whether white blood cells from donors who have been exposed to CMV can treat persistent CMV infections in patients who have had a stem cell transplant. The study includes 49 participants with CMV that has not improved with standard therapy. The goal is to…

This study tests whether combining two drugs, azacitidine and quizartinib, can help people with myelodysplastic syndromes or related blood cancers that have specific genetic changes (FLT3 or CBL mutations). The trial involves 30 adults and aims to find the best dose and see how w…

This phase II trial is testing whether combining two oral drugs, venetoclax and acalabrutinib, can help people with mantle cell lymphoma that has come back or not responded to prior treatment. The study includes 32 participants and aims to see how many achieve a complete response…

This phase II trial is testing a type of radiation called proton beam therapy for women with early-stage breast cancer (stage 0 to II). The goal is to see if this targeted approach can kill cancer cells while causing less damage to normal tissue, leading to fewer side effects and…

This study tests whether a special fluorescent dye and imaging system can help surgeons see and remove all cancer during breast-conserving surgery. The goal is to reduce the chance that cancer cells are left behind, which often requires a second operation. About 175 women with br…

This Phase 2 trial tests bortezomib (Velcade) and rituximab (Rituxan) as an initial treatment for Waldenstrom's macroglobulinemia, a rare blood cancer. The goal is to control the disease and collect stem cells for a possible future transplant. The study involves 46 participants a…

This study tests the safety and effectiveness of combining the immunotherapy drug avelumab with other treatments (utomilumab, ivuxolimab, or radiation) in 173 people with advanced cancers that have not responded to standard therapies. The goal is to find tolerable doses and see i…

This early-phase trial is testing whether adding an experimental drug called IM156 to standard chemotherapy (gemcitabine and nab-paclitaxel) is safe and tolerable for people with advanced pancreatic cancer. The study involves 19 participants and primarily looks at side effects. I…

This study tests whether combining three drugs—ipilimumab, nivolumab, and ciforadenant—can better control advanced kidney cancer that has spread. About 50 adults with clear cell renal cell carcinoma who have not had prior treatment will receive the combo. The main goal is to see …

This early-phase trial tests whether adding special immune cells called veto cells to a stem cell transplant can help donor cells grow in the patient without causing severe graft-versus-host disease (GVHD). The study includes 16 people with various blood cancers or bone marrow fa…

This early-phase trial tests whether giving patients with advanced melanoma immune cells that have been genetically modified to resist tumor-suppressing signals can help fight the cancer. The modified T-cells are given along with high-dose Interleukin-2, a drug that boosts immune…

This study tests whether a home-based weight loss program, with or without resistance training, is practical for endometrial cancer survivors. Fifteen participants will follow a guided exercise and diet plan for 6 months. Researchers will check if people stick with the program an…

This study tests a type of radiation called hypofractionated partial breast irradiation for women with early-stage breast cancer. Instead of treating the whole breast, it targets only the area where the cancer was removed, using higher doses over fewer sessions. The goal is to se…

This phase II trial tests inotuzumab ozogamicin, a drug that targets and kills leukemia cells carrying a specific marker (CD22). It enrolls 40 adults with B-cell acute lymphoblastic leukemia who are in remission but still have minimal residual disease (MRD) — tiny amounts of canc…

This early-phase trial is testing whether giving two immunotherapy drugs (durvalumab and tremelimumab) before surgery can help patients with aggressive bladder cancer who cannot take standard chemotherapy. The study involves 54 participants and primarily looks at safety and how t…

This phase 2 trial tests a combination of two targeted drugs (brentuximab vedotin and pembrolizumab) plus standard chemotherapy (doxorubicin and dacarbazine) in 25 people with untreated advanced Hodgkin lymphoma. The goal is to see if this approach is safe and effective. Particip…

This early-phase trial tested the drug pembrolizumab in 20 adults with a slow-growing form of multiple myeloma that has a higher risk of becoming active cancer. The goal was to see if the drug could shrink or control the cancer and delay its progression. Pembrolizumab helps the b…

This study tests whether giving immunotherapy drugs (nivolumab with or without ipilimumab) and radiation before surgery can help shrink tumors in people with two rare types of sarcoma. About 32 adults with these cancers that can be surgically removed will receive the treatment an…

This study tests a combination of two chemotherapy drugs (gemcitabine and docetaxel) plus hydroxychloroquine, a drug usually used for malaria, in people whose osteosarcoma (a type of bone cancer) has returned or stopped responding to standard treatment. The goal is to find the sa…

This study tests whether two immunotherapy drugs, nivolumab and relatlimab, can shrink or control a rare and aggressive kidney cancer called renal medullary carcinoma (RMC). The trial includes 30 adults whose cancer has spread or cannot be removed by surgery. The goal is to see h…

This trial tests whether giving targeted drugs based on a patient's specific genetic mutations can prevent early relapse in acute myeloid leukemia (AML). It involves a small number of participants and focuses on safety and side effects. The goal is to tailor treatment to each per…

This early-phase trial tests a new drug that targets a specific gene (EphA2) to slow tumor growth in people with advanced solid tumors that have spread or returned. About 49 participants will receive the drug to find the safest dose and check for side effects. The goal is to cont…

This early-phase trial tests the safety and potential benefits of the drug AL101 given before standard surgery in 14 people with a rare salivary gland cancer called adenoid cystic carcinoma that has a specific genetic change (NOTCH activation). The goal is to see if AL101 can hel…

This early-phase study tests whether a single, precise session of radiation (spine stereotactic radiosurgery) can safely treat spinal cord compression caused by cancer that has spread to the spine. The study includes 43 adults with inoperable tumors pressing on the spinal cord. R…

This study tests whether giving a mix of targeted drugs (rituximab, lenalidomide, acalabrutinib, tafasitamab) before and with standard chemotherapy can better control a fast-growing type of lymphoma called DLBCL. About 62 adults with newly diagnosed disease will participate. The …

This phase 2 trial studies whether combining chemotherapy with surgery to remove lung tumors works better than either treatment alone for patients with colorectal cancer that has spread only to the lungs. About 40 participants will be grouped by risk level to see if the combinati…

This study tests whether adding an immunotherapy drug (nivolumab) to precise, high-dose radiation therapy helps prevent lung cancer from coming back in people with early-stage non-small cell lung cancer. About 140 participants will receive either radiation alone or radiation plus…

This study tests a drug called talazoparib in 150 people with advanced cancers that have not responded to standard treatments. The drug works by blocking an enzyme that helps cancer cells survive, specifically targeting tumors with changes in BRCA or related genes. The goal is to…

This study tests a two-drug combination (ibrutinib and rituximab) in people with mantle cell lymphoma that has returned or not responded to treatment, or in older adults newly diagnosed. The goal is to shrink or control the cancer. About 113 participants will receive the drugs to…

This study tests whether a personalized, behavior-based program can help people with early liver disease (fatty liver or scarring) manage their condition better than standard care. About 49 adults with risk factors like obesity or diabetes are taking part. The goal is to see if t…

This study looks at whether varenicline (a prescription drug) or nicotine patches help people quit smoking more effectively, depending on their natural levels of emotion and attention. About 204 smokers aged 18-75 who smoke at least 5 cigarettes daily will receive behavioral coun…

This early-phase study tests whether injecting the immunotherapy drug nivolumab directly into high-risk oral precancerous lesions is safe and can shrink or control them. About 18 adults with visible, untreated mouth lesions will receive the injections. The goal is to see if this …

This study tests a three-drug combination (sorafenib, carboplatin, and paclitaxel) in 48 people with head and neck cancer that has spread or returned. The goal is to see how well the treatment shrinks tumors and delays cancer growth. Participants must have a confirmed diagnosis a…

This study tests a combination of two targeted drugs (encorafenib and cetuximab) plus an immunotherapy (nivolumab) in people with a specific type of advanced colorectal cancer (BRAF V600E mutation) that is stable (MSS) and has spread or can't be removed by surgery. The goal is to…

This early-phase trial tests whether a shorter course (2 weeks instead of 5) of chemoradiotherapy before standard chemotherapy and surgery is safe and effective for people with resectable stomach cancer. About 25 participants will receive the shortened radiation combined with che…

This study tests whether using MRI scans to guide the placement of internal radiation (brachytherapy) can improve treatment for women with advanced HPV-related cervical or vaginal cancer. About 26 participants will receive standard chemoradiation plus MRI-guided brachytherapy. Th…

This study looks at whether combining a nightly fasting period with the diabetes drug metformin can slow the growth of early-stage breast cancer. About 120 women with hormone-sensitive breast cancer or a pre-cancerous condition called DCIS will follow a fasting schedule and take …

This early-stage trial tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose of momelotinib when given with gilteritini…

This study tests whether focused, high-dose radiation (SBRT) can control kidney cancer that has spread to a few spots in the body. The goal is to see if this approach can delay or avoid the need for strong drugs (systemic therapy). About 123 people with metastatic kidney cancer w…

This study tests whether combining two drugs, obinutuzumab and CC-99282, can control follicular lymphoma in people with a high tumor burden who have not had prior treatment. About 33 adults with stage II–IV disease will receive the combination and be monitored for side effects an…

This study tested a combination of four chemotherapy drugs (5-FU, leucovorin, gemcitabine, and cisplatin) in 46 people with advanced bladder cancer that had spread or could not be removed by surgery. The goal was to see how many patients' tumors shrank or disappeared. The treatme…

This study tests whether low-dose sirolimus can safely improve blood cell function in adults with RUNX1 familial platelet disorder, a genetic condition that raises bleeding and leukemia risks. Six participants receive the drug and are monitored for side effects and changes in blo…

This early-phase trial tests a portable device that creates electric fields to stop cancer cells from growing, combined with chemotherapy and a targeted drug, in people whose cancer has spread to the liver and hasn't responded to standard treatments. The main goal is to check saf…

This study looks at how well surgery works for people with kidney cancer that has spread to other parts of the body. About 86 patients will have the cancer removed by a surgeon. The goal is to see if this surgery helps them live longer without the cancer coming back.

This study tested a combination of three chemotherapy drugs (docetaxel, cisplatin, and fluorouracil) in 31 people with advanced nasal cavity or sinus cancer that had not been treated before. The goal was to shrink tumors and control the disease, while also tracking side effects a…

This study aimed to see if the drug glofitamab could prevent large B-cell lymphoma from returning in patients who had traces of cancer after standard treatment. It was designed for adults who had completed first-line therapy and still had minimal residual disease. However, the tr…

This study tests whether adding cryoablation—a procedure that freezes and kills cancer cells—can improve the effectiveness of standard immunotherapy in people with metastatic cancer. Fifteen participants will receive both treatments, and researchers will measure how many patients…

This phase 2 trial is studying whether giving the drug sunitinib before surgery to remove a kidney can help control metastatic renal cell carcinoma. About 50 patients with kidney cancer that has spread will take sunitinib for 28 days, then have the affected kidney removed. Resear…

This early-phase trial tests the safety and best dose of the chemotherapy drug paclitaxel when given directly into the abdomen (intraperitoneal) for people with advanced stomach or gastroesophageal junction cancer that has spread to the lining of the abdomen. About 27 participant…

This phase 2 trial is testing whether adding local treatments like surgery or high-dose radiation to standard chemotherapy or hormone therapy can help breast cancer patients whose disease has spread to 1–3 bones. The goal is to see if this combination keeps the cancer from progre…

This study compares two chemotherapy combinations for people with advanced head and neck cancer that hasn't been treated yet. One group gets paclitaxel, carboplatin, and cetuximab weekly; the other gets cetuximab, docetaxel, cisplatin, and fluorouracil in cycles. The goal is to s…

This phase 2 trial is testing a drug called XmAb20717 in people with advanced rare cancers, including mesothelioma, lymphoma, and small cell lung cancer. The goal is to see if the drug can shrink tumors and is safe. The trial is currently suspended, so results are not yet availab…

This early-phase trial is testing whether adding the immunotherapy drug pembrolizumab to standard chemoradiotherapy can help control gastroesophageal cancer that cannot be removed by surgery. The study includes 16 participants and primarily looks at safety and whether the cancer …

This study aimed to find a safe dose of revumenib when given with standard chemotherapy drugs for children and young adults with acute leukemia. It was designed for patients with certain genetic markers. However, the trial was withdrawn before any participants were enrolled, so n…

This study looks at whether adding Juice Plus+ supplements to the diet helps ovarian cancer patients who are in remission. About 75 participants will either take the supplements plus get dietary counseling, or receive counseling alone. Researchers will measure changes in blood ma…

This phase 2 trial is testing a drug called blinatumomab, given as a shot under the skin, together with a milder chemotherapy regimen for people aged 60 and older (or younger adults who are too frail for standard chemo) with a type of blood cancer called B-cell acute lymphoblasti…

This study tests whether combining two treatments—thermal ablation (using heat to destroy tumor cells) and stereotactic radiosurgery (precise, high-dose radiation)—can better control cancer that has spread to the spine and is pressing on the spinal cord. About 60 adults with vari…

This phase 2 trial tests a combination of three drugs—pemetrexed, etrumadenant, and zimberelimab—in 10 people with advanced bladder cancer that has a specific genetic change (MTAP deficiency) and has already been treated with immunotherapy. The goal is to see if the triple therap…

This phase 2 trial is testing whether cetuximab, a targeted antibody drug, can shrink tumors in people with advanced or metastatic chordoma, a rare type of bone cancer. About 29 adults with inoperable or spread chordoma will receive cetuximab intravenously. The main goal is to se…

This study tests whether a type of counseling called behavioral activation therapy, combined with nicotine patches, helps people quit smoking. It focuses on smokers who have low reward sensitivity—meaning they don't get as much pleasure from rewards. The study compares this appro…

This phase II trial is testing whether adding elotuzumab to standard lenalidomide maintenance therapy can help keep multiple myeloma from returning after a stem cell transplant. About 113 patients who have already had a transplant using their own stem cells will receive the combi…

This phase 2 trial is testing whether a combination of four drugs—BMS-986340, nivolumab, trifluridine/tipiracil, and bevacizumab—can help control advanced colorectal cancer that has not responded to standard treatments. The study is for people with a specific type called microsat…

This phase II trial tests whether radiation therapy can help control cancer that has spread or grown after immunotherapy. About 230 patients with metastatic or lymphoid cancers will receive targeted radiation to see if it stabilizes the disease or shrinks tumors. The study also m…

This study tests a combination of two drugs—venetoclax and ASTX727—in people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't been treated before. The goal is to find the safest dose and see if the combo can shrink or control the…

This pilot study tests whether adding physical activity to standard smoking cessation tools (nicotine patch and counseling) helps African American adults quit smoking. The study enrolls 45 daily smokers who are motivated to quit. The main goal is to see if the approach is feasibl…

This phase 2 trial is testing whether adding the drug sunitinib to standard hormone therapy can shrink or control high-risk prostate cancer before the prostate is removed. About 64 men with localized but aggressive prostate cancer will receive sunitinib pills plus a hormone block…

This study tests a combination of two drugs—pembrolizumab (an immunotherapy) and trametinib (a targeted therapy)—in people with advanced non-small cell lung cancer that has come back or spread. The goal is to see if the combination is safe and can shrink or control tumors. Partic…

This phase 2 trial is testing whether proton beam therapy, a precise form of radiation, can control skull base chondrosarcoma after surgery. Fifteen participants who have had maximal surgical removal of their tumor will receive daily proton treatments for about 7 weeks. The study…

This early-phase trial is testing a combination of two immunotherapy drugs (tiragolumab and atezolizumab) plus a special type of radiation (RadScopal) in 7 people with advanced solid tumors that have not responded to standard treatments. The main goal is to check safety and side …

This phase II trial is testing a shorter course of proton beam radiation for men with early-stage prostate cancer that hasn't spread. The goal is to see if this approach can kill cancer cells effectively while causing fewer bowel and urinary side effects than standard radiation. …

This study tests a combination of two drugs, selumetinib and olaparib, in people with advanced or recurrent solid tumors (including breast, digestive, and reproductive organ cancers). The first phase finds the safest dose, and the second phase checks if that dose helps control th…

This phase II trial tests a combination of three drugs—acalabrutinib, lenalidomide, and rituximab—in 60 people with untreated follicular lymphoma that has spread. The goal is to see if this chemo-free mix can make the cancer disappear completely. Participants take the drugs by mo…

This early-stage trial is testing the safety and best dose of a three-drug combination—daratumumab, ixazomib, and dexamethasone—in 21 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. The goal is to find a dose that limits side effects while e…

This study planned to test two drugs, regorafenib and lorigerlimab, given before surgery to people with colorectal cancer that had spread only to their lungs. The goal was to see if the combination was safe and could help shrink tumors. However, the trial was withdrawn before any…

This study planned to test two drugs—regorafenib (a pill) and lorigerlimab (given by IV)—in people whose rectal cancer had come back or grown after standard treatment. The goal was to see if the combination was safe and effective. However, the trial was withdrawn before enrolling…

This study tests whether the drug ixabepilone can help people with HER2-negative breast cancer who still have significant cancer after standard chemotherapy. About 116 participants will either receive ixabepilone or standard care. The goal is to see if ixabepilone improves outcom…

This early-phase study tests a combination of two drugs, ceritinib and everolimus, in people with advanced solid tumors or a specific type of lung cancer (ALK-positive NSCLC) that has stopped responding to standard treatments. The main goal is to find the safest dose and see if t…

This study tests whether two immunotherapy drugs, oleclumab and durvalumab, can help people with sarcoma that has come back, spread, or stopped responding to treatment. About 75 adults and teens with three sarcoma types (angiosarcoma, dedifferentiated liposarcoma, or osteosarcoma…

This study tests a two-step treatment for men with aggressive prostate cancer that has spread. First, patients receive chemotherapy plus an immunotherapy drug. Then, they take a maintenance pill (niraparib) with or without more immunotherapy. The goal is to see if this approach c…

This study explores whether a blood test that detects tumor DNA (ctDNA) can help doctors choose the right treatment for people with advanced colorectal cancer that has not responded to prior therapies. About 100 participants will receive either standard treatment or treatment gui…

This study tests whether the immunotherapy drug nivolumab can help control cancer in 16 people with advanced solid tumors that have spread or can't be removed by surgery. Participants must have a specific genetic change (ARID1A mutation) and a protein marker (CXCL13) in their tum…

This study tests whether adding local treatments like surgery or radiation to a combination of two immunotherapy drugs (nivolumab and ipilimumab) helps people with stage IV non-small cell lung cancer live longer compared to immunotherapy alone. About 339 participants who have not…

This study tests whether adding telotristat ethyl to standard therapy can help control carcinoid syndrome and prevent heart damage in people with advanced neuroendocrine tumors. About 79 adults with metastatic disease who are already on stable somatostatin analog therapy will tak…

This study is testing whether adding two immunotherapy drugs (atezolizumab and tiragolumab) to standard chemotherapy before surgery can help control esophageal or gastroesophageal cancer. About 43 adults with stage II or III cancer will receive the drug combination, then undergo …

This study tests whether the drug regorafenib can help control gastrointestinal stromal tumors (GIST) that have specific gene changes (KIT exon 17, 18, or 14, or SDHB deficiency) after imatinib stops working. It includes adults with measurable, unresectable tumors. The main goal …

This early-stage trial tests a drug called tegavivint, combined with decitabine, in adults with leukemia that has come back or stopped responding to standard treatments. The goal is to find the safest dose and see if the combination can control the disease. Only 9 participants ar…

This study tests a combination of three drugs—pirtobrutinib, rituximab, and venetoclax—in 50 adults with previously untreated mantle cell lymphoma. The goal is to see how many patients achieve a complete response (no cancer detected) after the treatment period. Researchers will a…

This study tests whether a very low dose of radiation (4 Gy) can effectively treat gastric MALT lymphoma, a type of stomach cancer. About 25 adults with stage I to IV disease will receive this ultra low-dose therapy. The goal is to kill tumor cells and shrink tumors while causing…

This study tests whether infusions of cord blood stem cells can help people with moderate to critical COVID-19 pneumonia. About 65 adults with COVID-19-related lung distress will receive either stem cells plus standard care or standard care alone. The goal is to see if the stem c…

This early-stage study tests a drug called NBTXR3, which makes cancer cells more sensitive to radiation, combined with a second round of radiation for people whose non-small cell lung cancer has returned and cannot be surgically removed. The main goal is to find the safest dose a…

This study tests whether a pulmonary rehabilitation program can improve lung function enough to make lung cancer patients eligible for surgery. Researchers will enroll 75 patients who were initially deemed unable to have surgery due to poor lung health. The goal is to see if reha…

This study tests whether the drug MGD019 can help control advanced cervical cancer that has spread or come back. About 47 people with untreated, advanced cervical cancer will receive this immunotherapy. The goal is to see if it improves survival and helps manage the disease.

This study compares two treatments for lung lesions in people with non-small cell lung cancer, sarcoma, or colorectal cancer that has spread. One treatment uses microwaves to heat and kill tumor cells, while the other is a surgery to remove a small piece of lung. Researchers want…

This study tests whether combining zanubrutinib (a BTK inhibitor) with rituximab (an antibody) can help control chronic lymphocytic leukemia or small lymphocytic lymphoma in people who have not had treatment before. About 60 participants will receive the combination, and research…

This study tests whether combining evolocumab (a cholesterol drug) with nivolumab (an immunotherapy) can help control metastatic renal cell carcinoma that hasn't responded to prior treatments. Ten adults with clear-cell kidney cancer are enrolled. The main goal is to check safety…

This study tests two different drug treatments in people with advanced kidney cancer that has spread and continued to grow despite prior immunotherapy. About 90 participants will receive either a combination of lenvatinib and everolimus or cabozantinib alone. The goal is to see w…

This study tests the drug vemurafenib in 24 people with advanced papillary thyroid cancer that has a BRAF gene mutation. The drug aims to block this mutation to shrink tumors before surgery. Researchers will measure changes in tumor size and biomarkers in blood and tissue over 56…

This study tests two drugs, lenvatinib and everolimus, together in people with advanced carcinoid tumors that cannot be removed by surgery. The goal is to see if the combination can shrink tumors or slow their growth. The trial includes 36 adults with measurable disease, and rese…

This study tests whether the drug isatuximab, given alone or with lenalidomide, can control or shrink the signs of smoldering multiple myeloma in people at high risk of developing active disease. About 61 participants receive the treatment to see if it delays progression and impr…

This study compares two medications, infliximab and vedolizumab, to treat colitis (colon inflammation) caused by immune checkpoint inhibitor therapy in cancer patients. About 47 adults with genitourinary cancer, melanoma, or non-small cell lung cancer are participating. The goal …

This study tests whether combining venetoclax with ASTX727 can help control acute myeloid leukemia (AML) in two groups: patients whose cancer returned or didn't respond to prior treatment, and older adults newly diagnosed who cannot handle strong chemotherapy. The drugs work toge…

This study tests a special bacteria (Clostridium novyi-NT) injected directly into tumors, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors that haven't responded to standard treatments. The bacteria are designed to break down tumor cells f…

This study tests a combination of three drugs (atezolizumab, obinutuzumab, and venetoclax) in 50 adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or Richter syndrome that has returned or not responded to prior treatment. The goal is to see if the combination …

This early-phase study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy can help control advanced ovarian, fallopian tube, or primary peritoneal cancer. About 18 people with stage III or IV cancer will receive the combination. The main goal is to me…

This study was designed for people with HPV-positive oropharyngeal cancer who still had signs of the virus in their blood after completing standard treatment. Researchers planned to give an immunotherapy drug called BALSTILIMAB to see if it could clear the virus and improve long-…

This study tests whether adding the drug itacitinib to standard care can prevent graft-versus-host disease (GVHD) in 31 adults with blood disorders who receive a donor stem cell transplant. GVHD occurs when donor cells attack the patient's body. The approach aims to reduce this r…

This study looks at two types of programs—one focused on parents alone and another involving the whole family—to see which works better at reducing obesity risk in African American families. About 120 parent-child pairs will take part. The goal is to find ways to lower obesity an…

This study tests whether giving the immunotherapy drug cemiplimab before surgery can shrink tumors in people with head and neck skin cancer that can be removed. About 44 adults with stage II to IV cancer will receive cemiplimab, then have surgery. The goal is to see if the drug h…

This study tests whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with bladder cancer that has spread to nearby lymph nodes. About 60 participants will receive either chemo alone or chemo plus durvalumab, followed by maintenance durvalumab fo…

This study tested whether adding a special type of talk therapy (CBASP) to standard smoking cessation treatment helps depressed smokers quit and feel better. About 91 adults with depression who smoked at least 5 cigarettes a day took part. The goal was to see if the combined appr…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy helps people with advanced anaplastic or poorly differentiated thyroid cancer live longer. About 50 adults with cancer that cannot be removed by surgery or has spread will receive differe…

This study was designed to test whether adding olutasidenib to standard chemotherapy could help control certain blood cancers (MDS, CMML, and MPN) in people with an IDH1 mutation. The trial was withdrawn before enrolling any participants, so no results are available. The goal was…

This study tests whether two drugs, fulvestrant and abemaciclib, can help control low-grade serous ovarian cancer in women with advanced disease. About 18 participants who are not good candidates for surgery will receive the drugs before any other treatment. The goal is to see if…

This study tests a treatment that uses a patient's own immune cells (T-cells) to fight advanced melanoma. Some participants also receive a dendritic cell vaccine to boost the immune response. The goal is to see if the T-cells last longer and work better against the cancer. The tr…

This study tests a drug called acalabrutinib in people with mantle cell lymphoma who had to stop taking ibrutinib because of bad side effects. The goal is to see if acalabrutinib can shrink or control the cancer without causing the same problems. About 9 participants will receive…

This study tests a combination of two drugs, avelumab and M6620, in people with advanced solid tumors that have spread or can't be removed by surgery. The tumors must have a specific DNA repair defect. The goal is to find the safest dose and see if the combination can help contro…

This early-phase study tests whether giving acalabrutinib and rituximab followed by a special cell therapy (brexucabtagene autoleucel) can help control high-risk mantle cell lymphoma in people who have not yet been treated. About 22 participants will receive the combination to se…

This study tests whether combining two drugs, atezolizumab and bevacizumab, can shrink or control rare solid tumors. About 133 adults with cancers like appendix, anal, cervical, or mesothelioma will receive the drugs intravenously. The goal is to see if this immunotherapy approac…

This study looks at whether a hormonal intrauterine device (IUD) alone or combined with the drug everolimus can treat precancerous changes or very early-stage endometrial cancer. About 100 women with these conditions will receive the IUD, and some will also take everolimus if the…

This early-phase trial tests a combination of three drugs (dasatinib, temsirolimus, and cyclophosphamide) in children and young adults with advanced solid tumors that have come back or not responded to standard treatment. The main goals are to find the safest dose and understand …

This study tests whether adding rituximab to ibrutinib works better than ibrutinib alone for patients with chronic lymphocytic leukemia (CLL) that has returned after previous treatment. About 66 adults with relapsed CLL or related blood cancers will receive either ibrutinib alone…

This was a planned early-stage study to test the safety of a new drug called MT-0169 in people with certain types of acute leukemia that had come back or not responded to treatment. The study was withdrawn before any participants were enrolled, so no results are available.

This study tests whether giving two drugs—acalabrutinib and obinutuzumab—in cycles can control chronic lymphocytic leukemia (CLL) and allow patients to stop treatment for periods of time. About 60 adults with untreated CLL who need therapy will receive the combination. The goal i…

This study tests a combination of three drugs (cetuximab, LY3214996, and abemaciclib) in people with advanced colorectal cancer that has spread and no longer responds to standard therapy. The goal is to see if the combination can shrink tumors and improve survival. About 46 adult…

This study tests whether giving radiation therapy before surgery can shrink tumors in people with hormone receptor-positive, HER2-negative breast cancer. The goal is to make the tumor smaller so less healthy tissue needs to be removed during surgery. About 25 adults with residual…

This study looks at whether using focused radiation (stereotactic radiosurgery) only on the brain tumors, instead of the whole brain, can help preserve thinking and memory in people with small cell lung cancer that has spread to the brain. About 55 participants will receive this …

This early-phase study tests whether giving immunotherapy drugs (nivolumab alone or with bevacizumab or ipilimumab) before surgery is safe for people with advanced kidney cancer that has spread. About 104 participants will receive one of these treatments before their tumor is rem…

This study tests a combination of two chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in about 50 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment, or with high-risk myelodysplastic syndrome (MDS). The goal is to see if the combo is …

This early-stage trial tests a new treatment called IVS-3001, which uses a patient's own immune cells (T cells) engineered to recognize and attack a protein called HLA-G found on certain solid tumors. The study includes 31 adults with advanced cancers that have not responded to s…

This study tests whether a combination of two chemotherapy drugs, azacitidine and venetoclax, can help keep acute myeloid leukemia (AML) in remission and prevent it from returning. About 50 adults whose AML is in remission after initial treatment and who are not ready for a stem …

This study tests whether the drug bevacizumab (Avastin) can help control ovarian, fallopian tube, or primary peritoneal cancer that is still present after initial treatment and found during a second-look surgery. The trial enrolled 35 adults with advanced-stage cancer who had alr…

This study compares proton beam therapy (a newer, more targeted radiation) to standard intensity-modulated radiation therapy (IMRT) for people with esophageal cancer. Both are given along with chemotherapy. The goal is to see if proton therapy can control the cancer just as well …

This study tested whether a combination of three drugs—everolimus, letrozole, and metformin—can help control advanced or recurrent endometrial cancer. The 62 participants had cancer that came back or spread and had limited prior treatments. The goal was to see how many patients h…

This study tests a drug called adavosertib, given alone or with olaparib, in women with ovarian, fallopian tube, or peritoneal cancer that has returned and stopped responding to PARP inhibitors. The goal is to see if these drugs can shrink tumors or stop them from growing. About …

This study tests whether giving two drugs—sacituzumab govitecan and pembrolizumab—before surgery can help control early-stage triple-negative breast cancer that did not respond well to initial chemotherapy and immunotherapy. About 27 adults with this specific type of breast cance…

This study compares radiation therapy alone versus radiation plus rituximab (a drug that helps the immune system attack cancer) for patients with early-stage (I or II) low-grade follicular lymphoma. The goal is to see if the combination keeps the cancer from progressing longer. A…

This early-phase trial tests several new drug combinations in people with advanced solid tumors (like stomach, ovarian, or liver cancer) that have spread and stopped responding to standard treatments. The goal is to find the safest dose and see if the drugs can help control the c…

This study looks at whether patient navigators (health coaches) can help more obese adults sign up for and attend weight management programs. About 171 participants will be assigned to either get navigator support or standard care. The goal is to see if this approach increases pr…

This study tests a combination of two chemotherapy drugs and two immunotherapy drugs given before surgery to people with pancreatic cancer that can be removed. The goal is to shrink the tumor and help the immune system fight the cancer, potentially improving outcomes. The trial i…

This early-phase study tests whether combining two drugs, amivantamab and tepotinib, can help control non-small cell lung cancer that has changes in the MET gene. The study includes about 3 adults with advanced lung cancer that cannot be removed by surgery. Researchers will monit…

This early-phase study tests a DNA vaccine made from patients' own cancer cells to help their immune system attack lymphoplasmacytic lymphoma, a rare blood cancer. Nine participants with asymptomatic disease will receive the vaccine to find the safest dose and see if it boosts ca…

This study tests if tranexamic acid, a drug that helps blood clots stay stable, can reduce bleeding in patients having hemipelvectomy surgery for pelvic tumors. About 80 adults and children with pelvic tumors will take part. The goal is to see if the drug lowers the amount of blo…

This early-phase study tests a drug called palbociclib, given alone or with other medicines, in people whose leukemia has returned or stopped responding to standard treatments. The main goal is to find the safest dose and understand side effects. About 32 adults with acute myeloi…

This study tests a combination of targeted therapy (ibrutinib) and immunotherapy (rituximab) followed by strong chemotherapy in young patients with newly diagnosed mantle cell lymphoma, an aggressive blood cancer. The goal is to see if this approach improves response rates while …

This study tested whether a combination of two drugs, letrozole and everolimus, can help control advanced or recurrent endometrial cancer. 42 participants whose cancer had returned or worsened despite prior treatment were enrolled. The goal was to see if the tumors shrank or stop…

This early-stage trial tests a new drug (DS3201) combined with an immunotherapy (ipilimumab) in adults with advanced prostate, bladder, or kidney cancer that has spread. The goal is to find the safest dose and see if the combination can help control the disease. About 65 particip…

This study tests two drug combinations (olaparib plus either vistusertib or capivasertib) in people with recurrent endometrial, triple-negative breast, ovarian, or related cancers. The goal is to find the safest dose and see if the drugs can control tumor growth. About 159 partic…

This study tests whether adding targeted radiation to standard drug therapy can better control cancer that has spread to 1 to 5 spots in the body. About 380 adults with solid tumors will be randomly assigned to receive either standard therapy alone or standard therapy plus radiat…

This early-phase study tested a new drug called UGN-201 in 10 people with bladder cancer who were scheduled to have their bladder removed. The main goal was to check the drug's safety and see if it caused any serious side effects or surgery delays. Researchers also looked for sig…

This study compares two FDA-approved drugs, cabozantinib and sunitinib, in people with a rare type of advanced kidney cancer called variant histology renal cell carcinoma. The goal is to see which drug is safer and more effective at slowing cancer growth. About 32 to 84 participa…

This early trial tests combining the targeted drug brigatinib with local treatments like surgery or radiation for people with advanced ALK-positive non-small cell lung cancer. The goal is to see if this approach is safe and helps control the cancer longer. About 35 participants w…

This study tests whether adding the immunotherapy drug pembrolizumab to standard hormone therapy can help prevent recurrence in people with a rare, aggressive type of breast cancer called inflammatory breast cancer. Participants had hormone receptor-positive cancer that did not f…

This study tested whether adding the targeted drug Tarceva to two standard chemotherapy drugs (cisplatin and docetaxel) could shrink tumors in people with head and neck cancer that had spread or come back. 50 adults with this advanced cancer took part. The goal was to see how wel…

This early-phase study tests a drug called neratinib combined with one of three other drugs (everolimus, palbociclib, or trametinib) in people with advanced solid tumors that have not responded to standard treatments. The study focuses on tumors with specific gene changes (EGFR, …

This study tests whether giving a higher radiation dose directly to the tumor, while keeping the standard dose to surrounding healthy tissue, can improve outcomes for people with stage II to IIIB non-small cell lung cancer. About 146 participants will receive either photon (IMRT)…

This study tests two drugs, panitumumab and trametinib, in people with stage IV colorectal cancer that no longer responds to standard treatments. The goal is to see if these drugs can shrink tumors or slow cancer growth. About 59 participants will receive either panitumumab alone…

This study tests whether a very low dose of radiation (4 Gy) can control slow-growing B-cell lymphoma in the eye socket. About 50 adults with stage I-IV indolent lymphoma or mantle cell lymphoma will receive this targeted treatment. The goal is to shrink or stop the cancer while …

This study tests a powerful mix of chemotherapy drugs plus a targeted pill (ponatinib) for people with a fast-growing leukemia called Philadelphia chromosome-positive ALL. The goal is to see if this combination can stop the cancer from coming back. About 88 adults with newly diag…

This study aimed to see if the drug TTI-101 could slow tumor growth in people with HPV-negative head and neck cancer before they had surgery. It was designed for patients with stage II to IV cancer that could be removed. However, the trial was withdrawn before enrolling any parti…

This early study tests whether elotuzumab can help people with a specific type of myelofibrosis, a serious bone marrow disorder. The drug targets a protein on cancer cells to try to improve blood counts, shrink an enlarged spleen, and ease symptoms. The trial includes 15 adults w…

This study looks at whether a Mediterranean diet is safe and doable for 25 Hispanic or Black men with prostate cancer who get care at LBJ Hospital in Houston. The goal is to see if this diet can help manage the disease. Participants will follow the diet and be checked for side ef…

This study tests a new drug, SX-682, alone and with the immunotherapy nivolumab, in people with a specific type of advanced colorectal cancer that has spread or cannot be removed. The cancer must have a RAS mutation and be microsatellite stable (MSS), which often makes it harder …

This early-phase study tests a new treatment called OBX-115, which uses a patient's own tumor-fighting immune cells that have been modified to include a protein (IL15) to help them survive longer. These cells are given along with a drug called acetazolamide to adults with advance…

This study was designed to test a radioactive drug (177Lu-PSMA-617) in men with advanced prostate cancer that has spread to the bone marrow and caused low blood cell counts. The goal was to see if the treatment was safe and how it affected the cancer. However, the study was withd…

This study tested a combination of two chemotherapy drugs (cisplatin and docetaxel) plus an immunotherapy drug (pembrolizumab) in 28 patients with stage II or III laryngeal cancer. The goal was to see if this drug-only approach could control the cancer and avoid the need for surg…

This study looks at whether adding surgery or radiation to the targeted drug osimertinib helps people with advanced EGFR-mutant non-small cell lung cancer live longer without their cancer growing. About 173 participants will receive either osimertinib alone or osimertinib plus lo…

This study tests a specific timing of chemotherapy drugs (busulfan and fludarabine) before a donor stem cell transplant, followed by cyclophosphamide after the transplant, to treat high-risk blood cancers like leukemia and lymphoma. The goal is to reduce the chance of the transpl…

This study looks at whether a very low dose of radiation, given before or after drug therapy, can help control mantle cell lymphoma that has returned or stopped responding to treatment. About 51 adults with this type of cancer will receive ultra low dose radiation, which aims to …

This study tests whether adding ribociclib to the standard combination of everolimus and letrozole can better control advanced or recurrent endometrial cancer. About 90 participants will receive either two or three drugs to see which approach improves tumor shrinkage or stability…

This study looks at whether a focused, one-time radiation treatment called stereotactic radiosurgery (SRS) can control melanoma tumors that have spread to more than three spots in the brain while also protecting memory and thinking skills. About 49 adults with advanced melanoma a…

This study tests a combination of four drugs (ibrutinib, fludarabine, cyclophosphamide, and obinutuzumab) as the first treatment for people with chronic lymphocytic leukemia (CLL) who have a specific genetic marker (mutated IGHV gene). The goal is to see if this combo can achieve…

This early-phase trial tests a new approach for people with advanced bile duct cancer that has spread. It combines a special type of radiation (given in fewer, stronger doses) with an immunotherapy drug called bintrafusp alfa, which helps the immune system fight cancer. The goal …

This study tests a combination of two drugs, venetoclax and decitabine, in 20 adults with acute myeloid leukemia that has returned or not responded to prior treatment. The goal is to see if the combination can shrink or control the cancer. Participants will take the drugs by mout…

This study tests whether using MRI scans to plan radiation doses can control HPV-positive throat cancer as well as standard treatment, while reducing severe swallowing side effects. About 90 adults with early-stage cancer will receive radiation doses adjusted based on MRI images.…

This early-phase study aims to find the highest safe dose of a chemotherapy combination (gemcitabine and doxorubicin) when given with the targeted drug bortezomib. It includes up to 80 adults with advanced urothelial cancer or other solid tumors that cannot be removed by surgery.…

This study compares two types of radiation therapy for people with stage III-IVB oropharyngeal (throat) cancer. One uses protons (IMPT) and the other uses standard X-rays (IMRT). The goal is to see if proton therapy causes fewer severe side effects while still controlling the can…

This study tested the drug pembrolizumab in 71 people with advanced inflammatory or triple-negative breast cancer that had spread or returned. Participants had already responded to chemotherapy. The goal was to see if pembrolizumab could keep the cancer from growing for at least …

This study tests two drugs, regorafenib and lorigerlimab, in people with high-risk colorectal cancer who have tiny amounts of cancer DNA in their blood after finishing standard treatments. The goal is to see if this combination can safely clear those leftover cancer cells. The tr…

This study tests whether a precise type of radiation called stereotactic radiosurgery, given after surgery to remove brain tumors, can prevent the tumors from coming back. About 132 patients with up to 3 brain metastases will be randomly assigned to receive either the radiation o…

This study is for people with advanced non-small cell lung cancer that has spread to the brain. It tests whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to radiation therapy can better control the cancer. The goal is to find the safest and most effective…

This early-phase study tests whether combining two drugs, DKN-01 and pembrolizumab, can help control advanced or recurrent endometrial cancer that cannot be cured with surgery or radiation. Eight adult women with this type of cancer will receive the combination. The main goals ar…

This study tests a combination of two drugs, pemetrexed and avelumab, in people with a specific type of advanced bladder cancer that lacks a protein called MTAP. The goal is to see if this treatment can shrink or control the cancer. About 18 participants who have already tried ch…

This study tests whether taking selpercatinib before surgery can shrink thyroid tumors that have a specific genetic change (RET alteration). About 30 people with advanced or recurrent thyroid cancer will receive the drug before their operation. The goal is to make surgery more ef…

This study was designed to test a new combination of two drugs (ASTX727 and ASTX029) for people with certain types of blood cancers (MDS or MDS/MPN) that have a specific gene mutation (RAS). The goal was to find a safe dose and see if the combination could control the disease. Ho…

This study tested a combination of two targeted drugs, venetoclax and ibrutinib, in 234 people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Some participants had already tried other treatments, while others had high-risk features and had not been t…

This study tests a new way to treat adults with a specific type of leukemia (Ph+ ALL) that has come back or not responded to treatment. The approach combines low-intensity chemotherapy with two targeted drugs, ponatinib and blinatumomab, to kill cancer cells and boost the immune …

This early-phase study tests whether combining two drugs—sarilumab (Kevzara) and cemiplimab—can safely control non-small cell lung cancer with specific gene changes (EGFR or LKB1/STK11 mutations). About 56 adults with advanced disease will receive the combination. The main goal i…

This study tests the safety of adding an experimental drug (MPDL3280A) to standard chemotherapy and radiation for people with non-small cell lung cancer that cannot be removed by surgery. About 52 participants will receive the combination therapy at MD Anderson Cancer Center. The…

This study tests a combination of two drugs—pembrolizumab (an immunotherapy) and romidepsin (a targeted therapy)—in people with a rare type of blood cancer called peripheral T-cell lymphoma that has returned or not responded to prior treatment. The goal is to see if the combo is …

This study tests whether a shorter, higher-dose radiation schedule (hypofractionated) works as well as the standard longer course for men with prostate cancer who have had their prostate removed. About 186 men will be randomly assigned to one of the two radiation plans. The main …

This early-phase study tests a new drug combination for people with advanced ALK-positive non-small cell lung cancer. The goal is to find the best dose of ensartinib when given with standard chemotherapy and a targeted antibody. About 12 participants will receive the treatment to…

This early-phase study tests a drug called NBTXR3, which is activated by radiation, in people with pancreatic cancer that is locally advanced or borderline resectable. The goal is to find a safe dose and see if it helps control the disease. About 24 adults will receive the drug i…

This study tests whether the drug olaparib can help control aggressive variant prostate cancer when given after initial chemotherapy. About 96 men will receive cabazitaxel, carboplatin, and prednisone first, then either olaparib or observation. The goal is to see if olaparib exte…

This study tests a shorter, higher-dose radiation treatment given before surgery for soft tissue sarcoma of the arm, leg, or trunk. The goal is to see if this approach reduces wound complications after surgery while still controlling the cancer. About 122 adults with resectable s…

This study tests two drugs together for people with small cell lung cancer or other high-grade neuroendocrine cancers that have already been treated. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the immune system attack the tumor. The goal is to …

This study tested a drug called pembrolizumab in 157 people with rare cancers that had spread or couldn't be removed. The drug works by helping the body's immune system attack the cancer. The main goal was to see how many patients were alive and their cancer hadn't grown after 27…

This study tests a two-part treatment plan for people with multiple myeloma that has come back or is not responding to therapy. First, patients receive daratumumab, bortezomib, and dexamethasone, then switch to daratumumab, ixazomib, and dexamethasone. The goal is to see if this …

This early-phase study tests a new drug (valemetostat) combined with a standard targeted therapy (trastuzumab deruxtecan) in people with metastatic breast cancer that has low, ultra-low, or no HER2 protein. The goal is to find a safe dose and see if the combination shrinks tumors…

This study tests whether combining rituximab and pembrolizumab (with or without lenalidomide) can shrink tumors in people with follicular lymphoma or diffuse large B-cell lymphoma that has returned after prior treatment. About 53 adults whose cancer came back after at least one p…

This study tested two targeted drugs, dabrafenib and trametinib, given before and after surgery in 58 people with stage III melanoma that has a BRAF gene mutation. The goal was to shrink tumors before surgery and kill any remaining cancer cells afterward. The approach aims to imp…

This study tests whether giving two drugs (atezolizumab and bevacizumab) before surgery can help prevent liver cancer from coming back. Sixteen adults with liver cancer that can be surgically removed will receive the drug combination. The goal is to see if the treatment can shrin…

This study tests whether two drugs, venetoclax and azacitidine, can help prevent leukemia from returning in 100 adults who have already had a stem cell transplant. Participants have high-risk acute myeloid leukemia (AML) or related blood cancers and are in remission after transpl…

This study tests a combination of two drugs, dasatinib and venetoclax, in people with early chronic phase chronic myeloid leukemia (CML). The goal is to see if the combination can better control the disease by blocking enzymes that help cancer cells grow. About 155 participants w…

This study tests whether giving two immunotherapy drugs (nivolumab and ipilimumab) along with chemotherapy and radiation before surgery can help treat stomach cancer that can be surgically removed. The trial includes 32 adults with early-stage stomach or gastroesophageal junction…

This study tests whether a one-time procedure called brachytherapy, where tiny radioactive seeds are placed directly into the prostate, can control intermediate risk prostate cancer without needing additional treatments. Three hundred men with specific tumor features (Gleason sco…

This early-phase trial tests whether transferring healthy gut bacteria from donor stool can help control pancreatic cancer. Ten patients scheduled for tumor-removal surgery will receive the transplant to see if it is safe and affects the disease. The study is currently suspended.

This study tests whether combining two or three drugs can shrink or control melanoma that has spread to the brain. About 29 adults with untreated brain metastases will receive bevacizumab and atezolizumab, with or without cobimetinib. The goal is to see if these combinations are …

This study is for people whose head and neck cancer has returned after previous radiation and who cannot have surgery. It compares two radiation techniques: a high-precision, short-course method (stereotactic body radiation therapy) and a standard longer-course method (intensity …

This study tests whether giving radiation and chemotherapy at the same time can better control stage I or II nasal NK cell lymphoma. About 26 newly diagnosed adults are receiving this combination to see if it improves how long the disease stays away. The goal is to manage the can…

This study tests a new combination of three drugs (azacitidine, venetoclax, and pevonedistat) in adults with a difficult-to-treat form of acute myeloid leukemia (AML). The goal is to find the best dose and see how well the drugs work together to control the cancer. About 40 parti…

This study looks at whether a program that focuses on parents and families can help African American families lose weight. Obesity often runs in families, so the program uses parents as the main leaders for change. The goal is to see if this approach can help families manage thei…

This study aimed to find safe doses of two experimental drugs (lisaftoclax and pelcitoclax) combined with standard FLAG chemotherapy for adults with T-cell acute lymphoblastic leukemia that returned or didn't respond to treatment. The trial was withdrawn before enrolling any part…

This study tests a new drug, seclidemstat, combined with a standard drug, azacitidine, for people with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The goal is to find the best dose and see if the combination can shrink or control the cancer. About 2…

This study tests whether adding abiraterone and prednisone to standard hormone therapy works better than hormone therapy alone for men whose prostate cancer has come back after surgery or radiation. About 310 men will receive either hormone therapy or hormone therapy plus abirate…

This study tests whether giving two immunotherapy drugs (tiragolumab and atezolizumab) before and after standard surgery and chemoradiation can help control advanced oral cancer. It includes 29 adults with newly diagnosed, stage 3-4 oral cavity squamous cell carcinoma that has a …

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This study tests a drug called AK104 (Cadonilimab) in 18 adults with a rare, aggressive cervical cancer that has returned or spread after standard chemotherapy. The goal is to see if the drug can stop the cancer from growing for at least 6 months. Participants receive the drug al…

This study looks at 180 people with kidney cancer that has spread. It compares six different ways to give two drugs (everolimus, bevacizumab, or pazopanib) one after the other. The goal is to see which sequence works best and is safest for controlling the cancer.

This study tests a combination of two drugs, lenvatinib and pembrolizumab, in 25 people with advanced anaplastic thyroid cancer that cannot be removed by surgery or has spread. Lenvatinib blocks enzymes that help cancer cells grow, while pembrolizumab helps the immune system atta…

This study tests whether the drug cemiplimab can control a specific type of colon cancer (dMMR) without needing surgery. About 50 adults with early-stage colon cancer that has not spread will receive the drug. The main goal is to see if the treatment is safe and effective at cont…

This study aimed to see if the drug ASTX727, alone or with donor immune cells, could help control blood cancers in people who already had a stem cell transplant. It was designed for adults aged 18-75 with certain high-risk blood cancers. However, the study was withdrawn before en…

This early-phase trial tested the drug olaparib in 15 people with newly diagnosed BRCA-mutant ovarian, fallopian tube, or peritoneal cancer before they had surgery. The goal was to see if taking olaparib for two cycles could shrink tumors or stop them from growing. Olaparib works…

This study tests whether adding the drug panitumumab to standard chemotherapy helps shrink tumors more effectively in people with a rare and aggressive type of breast cancer called triple-negative inflammatory breast cancer. About 42 participants will receive chemotherapy before …

This study tests whether adding an experimental drug (GSK2636771) to an approved immunotherapy (pembrolizumab) can help control metastatic melanoma in patients whose tumors have lost a gene called PTEN. Up to 41 adults with advanced melanoma that hasn't responded to prior treatme…

This study tests whether a diet rich in prebiotic foods can help the immune system better fight advanced melanoma that no longer responds to standard immunotherapy. Four adults with stage III or IV melanoma will eat a prebiotic-enriched diet while receiving a combination of two i…

This study tests whether adding the drug ixazomib to standard chemotherapy (gemcitabine and doxorubicin) can shrink tumors or stop them from growing in people with a rare and aggressive kidney cancer called renal medullary carcinoma. About 30 patients with advanced or spreading d…

This early-phase study tests whether combining two drugs, pembrolizumab and lenvatinib, can help control advanced pancreatic cancer that has not responded to prior treatment. Fifteen adults with metastatic pancreatic cancer will receive the combination. The goal is to see if the …

This early-phase study tests whether a new treatment called KSQ-001EX is safe for people with advanced solid tumors like melanoma, lung cancer, or head and neck cancer. The treatment uses a patient's own immune cells (tumor-infiltrating lymphocytes) that are genetically modified …

This early-stage trial tests a new drug called adagrasib combined with two existing cancer drugs (cetuximab and irinotecan) in people with advanced colorectal cancer that has a specific genetic change called KRAS G12C. The main goal is to find a safe dose and check for side effec…

This study tests different combinations of approved drugs in 196 men with advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see which combinations work best to extend life and control the cancer. Participants receive standard hormo…

This study tests a combination of two drugs, acalabrutinib and rituximab, in people aged 65 and older with newly diagnosed mantle cell lymphoma who haven't had treatment yet. Acalabrutinib blocks enzymes that help cancer grow, while rituximab targets and kills cancer cells. The g…

This study tests whether a personalized cell therapy called liso-cel can stop large B-cell lymphoma from returning in patients who still have traces of cancer DNA after initial treatment. About 50 adults who are in remission but test positive for lymphoma DNA will receive their o…

This study tests whether giving three drugs (pembrolizumab, dabrafenib, and trametinib) before surgery can help people with a rare and aggressive thyroid cancer called anaplastic thyroid cancer that has a specific gene change (BRAF V600E). The goal is to shrink the tumor enough s…

This study tests a drug called ibrutinib in 20 people with a slow-growing type of lymphoma that hasn't been treated yet. The goal is to see if the drug can stop the cancer from getting worse by blocking certain enzymes cancer cells need to grow. Participants must have no symptoms…

This early-phase trial is testing two drugs, niraparib and copanlisib, together in people whose endometrial, ovarian, or related cancers have returned. The main goal is to find the safest dose and understand side effects. About 31 adults with specific cancer types are taking part…

This early-phase study tests the safety and best dose of combining two drugs (bevacizumab and temsirolimus) with one of three other cancer drugs for people with advanced cancer that hasn't responded to standard treatments. About 278 participants will receive one of the combinatio…

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia or small lymphocytic lymphoma. About 120 adults who either haven't been treated or have had prior therapy will receive the drug combination. The goal is to shrink or slow c…

This study tests adding the targeted drug sorafenib to standard chemotherapy (busulfan and fludarabine) before a donor stem cell transplant in adults with acute myeloid leukemia that has returned or not responded to treatment. The goal is to find the safest dose of sorafenib and …

This study tests a combination of three drugs—ixazomib, gemcitabine, and doxorubicin—in people with advanced bladder cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combo can shrink tumors. About 57 adults will take part …

This study is for people with early HER2-positive or triple-negative breast cancer whose tumors completely disappeared after initial treatment before surgery. Researchers want to see if giving less therapy after surgery can still keep the cancer away while reducing side effects. …

This study tests a combination of three drugs (abiraterone, prednisone, and apalutamide) in 60 men whose prostate cancer has spread but who have not yet received hormone therapy. The goal is to see how long patients can stay on treatment and to measure cancer progression and side…

This study looked at whether adding the drug cidofovir to usual care helps people who develop painful bladder bleeding from the BK virus after a stem cell transplant. About 27 participants received either cidofovir or standard supportive care. The goal was to see if symptoms impr…

This study tests a drug called brentuximab vedotin in 79 people with rare skin lymphomas (ALCL, mycosis fungoides, or lymphomatoid papulosis) that have a marker called CD30. The goal is to see if the drug can shrink or control the cancer. Participants receive the drug every 3 wee…

This study tests a radioactive drug (177Lu rhPSMA-10.1) alone or with hormone therapy in men with high-risk prostate cancer before they have surgery. The goal is to see if the drug is safe and can shrink the tumor. Only 6 men are taking part in this early-phase trial.

This study tests whether taking apalutamide for 6 months before prostate removal surgery can reduce signs of aggressive cancer that often lead to radiation therapy afterward. It involves 45 men with intermediate-risk prostate cancer. The goal is to see if this approach can make s…

This study aimed to test an abbreviated MRI method (using restriction spectrum imaging plus T2-weighted images) for detecting prostate cancer, comparing it to the standard multiparametric MRI. The goal was to see if the faster, cheaper scan could find cancer just as well, while a…

This study compares MRI scans to standard CT scans for imaging thymoma, a rare chest tumor, in 40 adults scheduled for surgery. The goal is to see if MRI can more accurately detect how far the tumor has spread, potentially offering a radiation-free alternative. Researchers will a…

This study tests a new 3D MRI technique to see if it can detect prostate cancer as well as or better than standard MRI, without needing an endorectal coil. It involves 33 men with untreated prostate cancer who are scheduled for surgery. The goal is to improve imaging comfort and …

This study compares two types of scans—PET/MR and CECT—to see which one better finds ovarian cancer tumors in the abdomen. About 21 adults with known or suspected ovarian cancer will get both scans before surgery. The goal is to improve how doctors decide if tumors can be fully r…

This study tests whether a low-radiation CT scan, enhanced with artificial intelligence software, can detect liver tumors as accurately as a standard CT scan. About 146 adults with colorectal cancer and known liver metastases will receive both scans. The goal is to see if the low…

This study is testing a new imaging agent called 18F-FSPG to see if it can better detect liver cancer (hepatocellular carcinoma) and other liver tumors compared to standard PET scans. About 110 adults with liver cancer or benign liver tumors will receive the tracer before their s…

This study looks at whether a special whole-body MRI can better find prostate cancer that has spread to bones or lymph nodes. About 98 men with high-risk prostate cancer will get this MRI plus standard bone and CT scans. The goal is to see if the MRI is more accurate, which could…

This study tests whether using two contrast dyes during MRI can better tell apart benign and malignant liver lesions. About 100 patients with known or suspected liver growths will receive both gadoxetate disodium and gadobutrol before imaging. The goal is to see if the combinatio…

This study tests whether a combined PET/MRI scan can more accurately show how deep cervical cancer has grown and whether it has spread to lymph nodes. About 25 people with early-stage cervical cancer that can be removed by surgery will get the scan before their operation. The goa…

This study looks at whether a special type of mammogram called contrast-enhanced mammography (CEM) can more accurately predict breast cancer in women with suspicious calcium spots in the breast. About 59 women with large areas of these spots will get both a standard mammogram and…

This study tests a new radioactive tracer called [18F]FluorThanatrace (FTT) to improve PET/CT scans for breast cancer. About 36 adults with known breast cancer will receive the tracer before standard surgery or biopsy. The goal is to see if FTT can help detect an enzyme linked to…

This study looks at whether combining a special scan (PET/CT) with a dye that highlights lymph nodes can better detect cancer spread in women with high-risk endometrial cancer. About 100 women scheduled for surgery will get both tests before their operation. The goal is to see if…

This study tests contrast-enhanced mammography (CEM), a special X-ray that uses an injected dye to make breast tissue and blood vessels clearer. It aims to see if CEM can find breast cancer more accurately than standard mammograms and help doctors choose the best spots for biopsy…

This study tests whether special imaging devices can better detect pre-cancerous or cancerous spots in the mouth compared to a standard visual exam. About 63 adults with suspicious mouth lesions or a history of oral cancer will be followed over time. The goal is to see if these a…

This study compares two imaging techniques—CT urography and intravenous urography—to see which works better for detecting urothelial tumors in people at risk of bladder cancer. About 133 participants will receive both scans as part of their routine care. The goal is to determine …

This study tests a special contrast agent called hyperpolarized 13-C pyruvate during MRI scans to see if it can show prostate tumors more clearly than standard imaging. About 130 men with prostate cancer will be scanned at two hospitals. The goal is to improve how doctors find an…

This small pilot study tests whether a special PET scan called Axumin can help doctors tell the difference between real tumor growth and treatment-related inflammation (pseudo-progression) in people with brain metastases who are on immunotherapy. The study enrolled 3 adults with …

This study looks at whether a special type of CT scan, called dual energy CT, can better detect carcinoid tumors in the digestive system. About 71 people with signs or confirmed carcinoid tumors will get this scan during a routine check-up. The goal is to see if this imaging meth…

This early-phase study tests how well a special PET-CT scan called FAZA can measure oxygen levels in solid tumors like breast, colorectal, and pancreatic cancers. About 25 participants will receive the FAZA tracer and undergo imaging to see if the results are consistent over time…

This study tests whether special lights and cameras can help find early signs of mouth cancer in people at high risk. About 338 participants with precancerous spots or conditions like Fanconi anemia will have their mouths examined with fluorescence imaging, which makes abnormal c…

This study tests whether a modified MRI scan (called Dixon sequencing) can produce clearer images of prostate cancer than the standard MRI. Researchers will compare the two methods in 65 men who have prostate cancer and are scheduled for prostate removal. The goal is to see if th…

This study tests whether adding canned navy beans to your daily diet can improve gut bacteria and lower obesity-related cancer risk. About 71 adults who are overweight and have a history of colorectal polyps or cancer will eat beans for 8 weeks. Researchers will check changes in …

This study tests whether moving lymph nodes from one part of the body to the armpit during breast reconstruction can lower the risk of lymphedema, a painful arm swelling. Thirty breast cancer patients who had mastectomy and lymph node removal will receive the extra procedure. Res…

This study tests whether injecting bone cement into the spine can prevent fractures in cancer patients whose tumors have spread to the spine and who are receiving high-dose radiation. About 87 adults with solid tumors and spine metastases will either get standard radiation alone …

This study tests a program called Tu Salud Si Cuenta! to see if it helps Latino families eat more fruits and vegetables and get more physical activity. About 600 adults will take part. The goal is to prevent future health problems by encouraging healthier lifestyles at home.

This study looks at whether eating a diet high in magnesium can help prevent low blood magnesium levels in women with ovarian cancer who are receiving carboplatin chemotherapy. Low magnesium is a common side effect of this treatment. The study enrolled 26 participants and will me…

This study tests whether giving whole brain radiation to patients with small cell carcinoma of the urinary tract (including the bladder) can lower their risk of developing brain tumors. The 31 participants have already responded well to chemotherapy. They receive radiation for 3 …

This Phase 3 trial tests whether acupuncture can prevent dry mouth in 435 head and neck cancer patients receiving radiation. Participants get one of two acupuncture approaches or standard oral care. The goal is to see if acupuncture reduces dry mouth symptoms and improves quality…

This study tests a program to help people with BRCA or Lynch syndrome mutations—and their families—lose weight and adopt healthier habits like better diet and more exercise. The goal is to see if these lifestyle changes can lower their risk of developing cancer. About 384 partici…

This study looks at how to increase HPV vaccination rates among young adults aged 18-26 in Texas. Researchers will test different ways to encourage college students who haven't had the vaccine to start and complete the series. The goal is to prevent HPV infections and related can…

This study looks at whether a lifestyle program focusing on diet and exercise can reduce breast cancer risk in normal-weight postmenopausal women who have excess body fat. The goal is to change body composition and lower inflammation. About 40 women will take part to see if the p…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize true hunger. T…

This study tests whether a program that includes diet advice, physical activity, stress management, mindfulness, sleep tips, and counseling can help prevent breast cancer in premenopausal women at higher risk. About 60 women will take part to see if the program is practical and w…

This study looks at two types of surgery to prevent ovarian cancer in women aged 30-50 who have gene mutations that raise their risk. One surgery removes both the fallopian tubes and ovaries, while the other removes only the tubes first and delays removing the ovaries. The goal i…

This study tests different programs to help people at high risk for cancer (such as those with BRCA or Lynch syndrome) or cancer survivors increase their physical activity and eat healthier. The goal is to see which programs work best to reduce cancer risk. About 337 participants…

This study tests whether using home sensors to monitor dehydration risk can reduce hospitalizations and emergency room visits in head and neck cancer patients. About 427 participants will either use the CYCORE sensor system plus standard care, or standard care alone. The goal is …

This study looks at three approaches to prevent ovarian cancer in women with BRCA1 or BRCA2 gene mutations: regular screening, removing both fallopian tubes and ovaries at once, or removing only the fallopian tubes first and the ovaries later. The two-step surgery aims to delay m…

This study looks at whether weekly phone counseling can help identify and treat depression in women with ovarian, peritoneal, or fallopian tube cancer. About 409 participants will either receive phone counseling or standard care with resource lists. The goal is to see which appro…

This study tests an online mind-body program designed for people with brain tumors (glioma) and their partners. The program aims to improve spiritual well-being, sleep, mood, and overall quality of life for both. Researchers are enrolling 74 couples to see if the program is pract…

This study tests whether a technology-enhanced symptom monitoring program, used alongside standard in-person and remote palliative care, can improve quality of life for 119 adults with advanced solid tumors who are also in phase I immunotherapy trials. Participants use the progra…

This pilot study tests whether two smartphone apps can help current smokers quit. 24 participants will use either the KickAsh app (to track mood and activity) or the Breathe2Relax app (for relaxation). Researchers will check if the apps improve mood, increase activity, and lead t…

This study looks at whether exercise training and dietary counseling can help cancer survivors who have heart failure. About 85 participants will either receive usual care or join a program with exercise three times a week and low-salt diet guidance. The goal is to see if these l…

This study tests whether adding the steroid dexamethasone to a physical activity program helps reduce severe fatigue in people with advanced cancer. About 99 participants will take the drug or a placebo while doing strength and walking exercises. The goal is to see if the combina…

This study tests whether yoga therapy can improve physical and emotional well-being in people with cervical cancer undergoing chemotherapy and radiation. About 40 participants with stage IB2 to IIIB cervical cancer will attend yoga classes or receive a DVD. The main goal is to se…

This study looks at whether mirtazapine, a drug often used for depression, can improve appetite in people with advanced cancer who have lost weight and have little desire to eat. About 98 patients will receive either mirtazapine or a placebo for 29 days. Researchers will track ch…

This study tests whether coaching people with breast cancer on diaphragmatic breathing helps them take larger, more consistent breaths during radiation therapy. Researchers will also see if it reduces treatment anxiety. The study involves 40 adults with left-sided breast cancer w…

This pilot study tests a vibrating device strapped to the leg to see if it can improve walking in young people (ages 6-39) who have nerve damage from chemotherapy. The device is applied to specific leg muscles while step times are measured. Only 15 participants are enrolled, maki…

This study tests whether dexamethasone, a steroid, can improve fatigue, pain, nausea, and other symptoms in people with advanced solid tumors. Participants take the drug or a placebo by mouth twice daily for 14 days. The goal is to see if symptoms get better, which could improve …

This pilot study tests whether neurofeedback training can reduce pain caused by radiotherapy in head and neck cancer patients. Participants learn to modify their own brain waves using EEG and computer software, with the goal of lowering pain perception and improving quality of li…

This study tests an online program called BREATHE for women with non-small cell lung cancer. The program uses mindfulness, compassion, and emotional processing to help improve social well-being and reduce distress. About 70 women will participate, and the main goal is to see if t…

This study tests whether giving breast cancer patients a 3D printed model of their breast helps them make better surgery decisions. Twenty women who need surgery for breast cancer will be randomly assigned to get either a 3D model or standard scans. Researchers will measure how c…

This study is testing a culturally adapted mindfulness program for Latino cancer patients and their family caregivers. The goal is to see if the program is practical and helpful for reducing stress and anxiety. About 68 patient-caregiver pairs will take part, with some starting t…

This phase III trial tests whether a combination of methylphenidate (a stimulant drug) and physical activity can reduce cancer-related fatigue in 212 patients with metastatic cancer who are receiving anti-PD1 immunotherapy. Participants will be randomly assigned to receive either…

This phase 2 trial tests whether electroacupuncture can reduce chronic pain in women who have completed treatment for stage I-III breast cancer. 111 participants will receive either real acupuncture, sham acupuncture, or no treatment. The goal is to see if this gentle needle ther…

This study tests a procedure called cordotomy for people with advanced cancer who have severe pain that is not controlled by standard treatments. Doctors use a needle guided by CT scans to target pain pathways in the spinal cord. The goal is to see if this can safely reduce pain …

This study looks at whether a drug called anamorelin can help improve appetite and stop weight loss in people with advanced lung cancer who have lost their appetite and are losing weight. About 25 participants will take either the drug or a placebo and share their experiences thr…

This study looks at whether regular exercise and behavioral skills training can improve physical fitness and quality of life in people with pancreatic cancer who are getting chemotherapy or radiation before surgery. About 128 participants will take part at MD Anderson. The main g…

This study looks at whether weighted blankets can improve sleep for people with blood cancers. Researchers will check if the blankets are safe and if they help with sleep quality. The study involves 20 adult outpatients at MD Anderson Cancer Center.

This study looks at whether a yoga program designed for both head and neck cancer patients undergoing radiation and their family caregivers is practical and helpful. About 236 patient-caregiver pairs will take part. The goal is to see if yoga can improve quality of life, reduce f…

This study is testing a smartphone app designed to help people reduce or quit smoking. Participants use the app along with nicotine patches to see if this combination makes quitting easier. The study involves 56 adults who smoke at least 10 cigarettes a day and are willing to try…

This study tests whether a highly targeted form of radiation, called stereotactic spine radiotherapy, can safely and effectively relieve pain from cancer that has spread to the spine. About 150 adults with up to two spine metastases will receive this treatment. Researchers will t…

This study looks at whether a culturally tailored writing program can improve the well-being of Chinese immigrant women who had breast cancer (stages 0 to III). About 256 women who finished their main cancer treatment in the last 5 years will write about their experiences. The go…

This study tests whether a non-invasive therapy called neurofeedback can help people with chemotherapy-induced nerve pain learn to change their own brain waves to feel less pain. About 80 participants will be assigned to either receive neurofeedback training or a control conditio…

This study compares a 3-week course of radiation to the standard 5-week course for breast cancer patients who need radiation to the lymph nodes. The goal is to see if the shorter schedule is just as effective at preventing cancer from coming back, while causing less arm swelling …

This study tests an exercise program designed for Hispanic women who have had breast cancer. The goal is to find the best ways to help them become more physically active. Researchers will measure changes in exercise habits and look at certain health markers in the blood. The stud…

This study looks at whether a partner-based (dyadic) yoga program can improve quality of life and reduce hospital visits for head and neck cancer patients undergoing chemoradiation, as well as their family caregivers. About 415 patient-caregiver pairs are taking part. The yoga se…

This pilot study tests a behavioral coaching program for 33 adults with nerve pain caused by chemotherapy. The program helps patients identify their most important health goals and turn them into specific, measurable steps. The goal is to see if this approach is safe and feasible…

This pilot study tests a lifestyle intervention called Watchful Living for Black and Hispanic prostate cancer patients on active surveillance and their partners. The program includes nutrition counseling, an exercise plan, and telephone coaching to improve quality of life, physic…

This study compares two pain management approaches—neurofeedback (brain wave training) and a supportive care team—against standard care in 28 head and neck cancer patients at risk of misusing opioids. The goal is to see if these methods can lower pain and reduce the need for stro…

This study tests whether a supervised, video-based exercise program done at home during chemotherapy can help people with pancreatic cancer get stronger before surgery. About 58 patients will take part. The goal is to see if the program is safe and helps improve recovery.

This study tested whether the steroid dexamethasone can reduce shortness of breath (dyspnea) in people with cancer. About 135 cancer patients with moderate to severe breathing difficulty took part. Researchers measured changes in their breathlessness over one to two weeks to see …

This study looks at how cancer patients feel about using marijuana products (THC or CBD) compared to opioids for pain relief. Researchers will survey 200 adults with cancer-related pain who are already taking strong opioids. The goal is to understand patient preferences and perce…

This small pilot study tests whether a closed loop spinal cord stimulator can reduce pain and improve quality of life for people with nerve damage from chemotherapy. Ten adults with chemotherapy-induced peripheral neuropathy in their legs will receive the device and be monitored …

This study looks at whether draining fluid from the chest every day helps it resolve faster than draining it three times a week in people with advanced cancer. About 257 adults with cancer-related pleural effusion (fluid around the lung) will have a catheter placed and be randoml…

This study compares two relaxation programs (including stretching and relaxation techniques) to see if they improve physical and emotional well-being in women with breast cancer undergoing radiation therapy. About 700 women with early-stage breast cancer will participate, with so…

This study looks at whether hypnosis can help women with early-stage breast cancer relax during surgery, possibly reducing the need for general anesthesia. About 50 women will try hypnosedation, a technique that uses words and images to keep them calm and awake while numb. The go…

This study looks at whether adding acupuncture to standard care can reduce pain and the need for opioid painkillers after open abdominal surgery for colorectal or pancreatic cancer. About 70 patients will receive daily acupuncture sessions, and researchers will track how well the…

This study compares two different methods for prescribing opioid pain medication to people with abdominal cancer after surgery. The goal is to find which method provides better pain control while keeping side effects low. About 170 adults having certain types of abdominal surgery…

This study looks at the side effects and best dose of a second round of radiation for people whose brain tumors returned after previous radiation. About 40 adults will receive carefully planned reirradiation to see if it can control the tumor while limiting brain damage. The goal…

This study tests a skills training program for family members caring for someone with a high-grade glioma. The goal is to see if the training can reduce caregiver stress, improve their confidence, and help patients feel better. About 124 caregivers and patients will take part at …

This study looks at whether a yoga program can improve physical performance, quality of life, and reduce symptoms for cancer patients undergoing radiation therapy and their partners. About 600 patients with lung, head and neck, or esophageal cancer, along with their partners, wil…

This study looks at whether giving a single large dose of radiation to spine tumors that have returned after earlier treatment works better than giving three smaller doses. About 80 adults with solid tumors that spread to the spine will take part. The goal is to see which approac…

This study tested whether panax ginseng can reduce fatigue and improve mood in people with advanced cancer. 165 participants rated their fatigue levels before and after taking ginseng or a placebo for 29 days. The goal was to see if ginseng leads to greater improvement in fatigue…

This study looks at whether a regular exercise program is practical for women aged 65 and older who are receiving chemotherapy for early-stage breast cancer. Participants will be asked to walk and do arm exercises several times a week. The goal is to see if exercise can reduce th…

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…

This study tests whether an 8-week program of text messages can help people who sit a lot (over 6 hours a day) reduce their sedentary time. About 228 adults with smartphones will receive texts encouraging them to be more active, and their daily sitting minutes will be tracked wit…

This study tests a yoga-based program designed for Black adults to help them sit less, move more, and improve their mental and emotional wellbeing. About 251 participants in Houston will either join the program or a control group. The goal is to see if this culturally tailored ap…

This study tests whether manual therapy—gentle massage and stretching of the neck, throat, jaw, and mouth—can improve swallowing and movement in head and neck cancer survivors who have long-term swallowing problems due to tissue scarring (fibrosis). About 24 survivors who finishe…

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises during chemotherapy or after surgery. The goal…

This study tests whether a meditation-based mind-body program can improve quality of life for adolescents and young adults (ages 18-39) recently diagnosed with lymphoma. Participants practice guided meditation and mindfulness techniques to help lower distress, anxiety, and depres…

This study looks at whether combining exercise, supportive counseling, and a stimulant drug (methylphenidate) can help reduce severe fatigue in prostate cancer patients who are receiving radiation and hormone therapy. About 175 adults with prostate cancer and daily fatigue will b…

This study looks at whether a supervised exercise program can improve physical fitness in people with bone cancer before they have surgery. About 45 patients will take part, and the main goal is to see if the program is practical and safe. The researchers will also check if exerc…

This study looks at whether Scrambler therapy can safely reduce painful nerve damage caused by chemotherapy in adolescents and young adults (ages 15-39) who have finished active cancer treatment. Participants are randomly assigned to receive the therapy right away or after a wait…

This study looks at how well two drugs, haloperidol and lorazepam, can control severe agitation and confusion (delirium) in people with advanced cancer who are in palliative care. About 110 patients will be enrolled to compare different drug approaches. The goal is to improve com…

This study looks at whether exercising the muscles used for coughing and swallowing can reduce the risk of pneumonia in people who had radiation for head and neck cancer. About 175 survivors are involved. The main goal is to see if stronger cough muscles help prevent food or sali…

This study tests a mobile lifestyle program for women with breast cancer who have unhealthy habits. The program offers coaching on diet, exercise, stress management, mindfulness, and sleep. Researchers want to see if it's practical and helps improve quality of life. About 30 wome…

This study tests if a program combining gentle yoga and Christian spirituality is practical and well-liked by inactive Black adults in Northeast Texas. About 50 participants will take part to see if the program helps improve their mood and overall wellbeing. The goal is to find a…

This study tested whether simple breathing exercises and meditation could help healthcare workers at MD Anderson Cancer Center manage stress and improve lung health during the COVID-19 pandemic. About 100 workers participated. The main goals were to see if people would join the s…

This study tests a program that combines mood management with health and wellness coaching to help pregnant smokers who are depressed quit smoking and stay smoke-free after their baby is born. About 26 participants will take part during pregnancy and after birth. The goal is to s…

This study tests whether a non-invasive technique called navigated repetitive transcranial magnetic stimulation (nrTMS) can help people with brain tumors recover movement after surgery. About 32 patients who recently had surgery for a brain tumor near the movement-control area of…

This study compares a new counseling approach called Acceptance and Commitment Therapy (ACT) with standard counseling to help people with head and neck, lung, breast, gastrointestinal, or genitourinary cancer stop smoking. About 51 adults who smoke at least one cigarette per day …

This study looks at whether adding lorazepam to haloperidol can better reduce delirium (sudden confusion and agitation) in people with advanced cancer who are in a palliative care unit. About 93 participants will receive either haloperidol alone or with lorazepam, and their level…

This study tests whether a drug called anamorelin, combined with physical activity and nutritional counseling, can reduce severe fatigue in people with advanced solid tumors that have spread or returned. About 129 participants with incurable cancers and high fatigue levels will r…

This study tests whether adding a short course of the steroid dexamethasone to a physical activity program can better reduce severe fatigue in people with advanced cancer. About 90 participants will be randomly assigned to receive either a high or low dose of dexamethasone along …

This study tests a special check-up and support program for adults 65 and older who have finished treatment for early-stage breast cancer. The goal is to improve their overall health and quality of life by addressing physical, mental, and emotional needs. Participants will comple…

This study tests whether giving a second numbing injection (quadratus lumborum block) after surgery for retroperitoneal sarcoma can reduce the need for opioid painkillers. About 113 patients will receive either one or two injections of liposomal bupivacaine. The goal is to see if…

This study tests whether combining cognitive behavioral therapy with medications (methylphenidate, melatonin) and light therapy can improve sleep in cancer patients. About 68 adults with cancer and poor sleep (PSQI score 5 or higher) are participating. The goal is to reduce sleep…

This study compares two ways to manage pain after liver cancer surgery: thoracic epidural analgesia and a four-quadrant nerve block. About 100 adults having open liver surgery at MD Anderson Cancer Center will be randomly assigned to one method. The goal is to see which approach …

This study looks at whether listening to a self-hypnosis audio before surgery can help women with gynecologic cancer feel less pain and recover faster. About 152 patients having surgery for cancers of the female reproductive system will be randomly assigned to either usual care o…

This study tests high-dose steroids (prednisone or methylprednisolone) to see if they can improve symptoms of nerve damage caused by past radiation treatment in head and neck cancer survivors. The trial involves 35 adults who are at least two years past radiation and have specifi…

This study looks at whether haloperidol, given alone or with chlorpromazine, can safely reduce severe agitation and confusion (delirium) in 70 adults with advanced cancer who are in a palliative care unit. The goal is to find the best way to calm patients without oversedating the…

This study looks at whether people with throat cancer on one side of the neck can safely receive radiation to only that side, instead of both sides. The goal is to reduce side effects from unnecessary radiation. About 8 participants with early-stage HPV-related tonsil or tongue b…

This study tests whether a long-acting numbing medicine called EXPAREL can reduce pain better than the standard lidocaine in people with lung cancer who need a procedure to drain fluid from around the lungs. About 80 adults will be randomly assigned to receive one of the two medi…

This study tested whether a shorter course of higher-dose radiation (hypofractionated) works as well as standard radiation for early-stage breast cancer. About 300 women with ductal carcinoma in situ or early invasive breast cancer took part. The goal was to see if the shorter tr…

This study looks at whether an integrative oncology program—including diet advice, physical activity, stress management, social support, and reducing exposure to environmental toxins—can improve outcomes for women with stage II or III breast cancer who are receiving radiation the…

This study tests whether the drug ruxolitinib (Jakafi) can reduce severe fatigue in people with chronic lymphocytic leukemia (CLL) who do not yet need standard treatment. About 10 participants will take the drug and report their fatigue levels using a simple questionnaire. The go…

This study looks at whether a couple-based yoga program can help improve quality of life for people with high-grade glioma (a type of brain tumor) and their partners. About 216 couples will take part in Hatha yoga sessions while the patient undergoes radiation therapy. The goal i…

This study is testing a supportive care program designed specifically for Black patients with advanced cancer. The program uses meditation and mind-body techniques adapted to be culturally relevant. Researchers will work with 170 patients and their caregivers to see if this appro…

This study tests whether an open labeled placebo—a pill with no active medicine that patients know is a placebo—can reduce fatigue in people with advanced cancer. About 100 participants will either receive the placebo or be placed on a waitlist. The goal is to see if simply takin…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study compares two radiation treatments for people whose non-melanoma cancer has spread to the brain with 4 to 15 tumors. One method, stereotactic radiosurgery, delivers a high dose only to the tumors, while the other treats the whole brain. The goal is to see which better c…

This study tests if a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by oxaliplatin chemotherapy in people with stage I-IV cancer. rTMS uses magnetic pulses on the scalp to change brain activity. The trial includes 5…

This study looks at whether giving the painkiller hydromorphone slowly or quickly through an IV affects how well it controls cancer pain and how likely it is to be misused. About 84 hospitalized cancer patients with moderate to severe pain will receive both a slow and a fast infu…

This study looks at whether cognitive behavioral therapy (CBT) can help adults with acute myeloid leukemia or lymphoma who feel very tired from their cancer or treatment. Participants will attend up to 7 counseling sessions to learn skills to cope with fatigue, anxiety, and depre…

This small pilot study tests whether using a mobile app can help adults quit smoking. About 24 smokers from MD Anderson's Tobacco Treatment Program will use either a positive psychology app or a relaxation app alongside their usual care. The main goal is to see how well people st…

This study tests whether combining a stimulant drug (methylphenidate) with an exercise program can reduce severe fatigue in prostate cancer patients undergoing radiation and hormone therapy. About 200 participants will be assigned to drug plus exercise, drug alone, exercise alone…

This study looks at whether exercise and weight management can help reduce fatigue in people who have had chronic lymphocytic leukemia (CLL). About 30 adults aged 18-85 with CLL will take part. Participants will be randomly assigned to start the program right away or after a wait…

This study looks at whether massage therapy can reduce nerve problems like pain, numbness, and tingling caused by chemotherapy in people with breast or digestive system cancers. About 90 participants will receive massage sessions to see if it improves symptoms and quality of life…

This study tests a treatment called neuromodulation to see if it can reduce nerve pain caused by chemotherapy. About 24 adults with nerve pain in their legs from certain chemo drugs will take part. Researchers will check for side effects and measure changes in pain and nerve func…

This study looks at whether starting a stress-reduction program before chemotherapy can improve mood, stress, and physical symptoms in women newly diagnosed with breast cancer. About 62 women with stage I-III breast cancer will take part. Researchers will track changes in symptom…

This study tests whether neurofeedback training—a non-invasive therapy that uses brain wave monitoring—can help people with chemotherapy-induced peripheral neuropathy (nerve pain, numbness, or tingling) learn to change their own brain activity to feel less pain and improve qualit…

This study compares a single session of palliative radiation therapy to the standard multiple sessions for people with gynecologic cancers that have spread. The goal is to see if one treatment can improve symptoms like pain and bleeding and boost quality of life just as well. Abo…

This early-phase study tests whether a liver cancer treatment called Y90 radioembolization can be safely done in a single session instead of the usual two-day process. The treatment uses tiny radioactive beads injected into the liver's blood supply to block tumor growth. Research…

This study tests if fast-acting opioids (fentanyl or morphine) can reduce shortness of breath during or after walking in 150 cancer patients who already take strong painkillers. Participants will take the drug or a placebo before a short walk test, and researchers will measure ch…

This study is screening 1,000 patients at the HOPE clinic in Houston for liver fibrosis and cirrhosis using surveys, blood tests, and a non-invasive liver scan called FibroScan. The goal is to find early signs of liver damage that could lead to cancer, so that prevention or early…

This study follows 116 people with recurrent rectal cancer to understand how their treatment affects their quality of life and well-being. Participants fill out questionnaires every 3 months about their symptoms, daily activities, and overall health. The goal is to learn what mat…

This large study in Mozambique is testing whether offering HPV self-testing alongside voluntary family planning services increases the number of women who get screened for cervical cancer. Over 9,000 women aged 30–49 or living with HIV are taking part. The goal is to see if integ…

This study tracks how often cancer patients experience cachexia (unexplained weight loss and appetite loss) and measures the emotional burden on both patients and their primary caregivers. About 192 patients and their caregivers will fill out questionnaires at a supportive care c…

This study looks at how people with advanced cancer decide what should happen to their social media accounts after they pass away. Researchers at MD Anderson Cancer Center are surveying 117 patients to understand if they've talked to family or friends about managing accounts like…

This study looks at whether the bacteria in your gut and what you eat can influence how well the flu vaccine works. Researchers will collect blood and stool samples from 74 adults before and after they get their flu shot. The goal is to find links between gut microbiome diversity…

This study aimed to track sleep disturbances in adults with gastrointestinal cancers before and after surgery using a sleep questionnaire. It planned to enroll patients staying at least 72 hours in the hospital. However, the study was withdrawn before any participants were enroll…

This study looks at how Hispanic patients with non-alcoholic fatty liver disease (NAFLD) and their primary care doctors understand and manage the condition. Researchers will use questionnaires and interviews to learn about cultural factors, diagnosis practices, and treatment appr…

This study compares two different information sheets given to advanced cancer patients and their caregivers before a doctor visit. One sheet has sample questions to ask, the other has general information. The goal is to see which one helps patients and caregivers communicate bett…

This study looks at how smokers with different reading skills respond to various health messages about smoking risks. About 494 smokers will listen to and read messages that are either factual or emotional, and either highlight benefits of quitting or costs of not quitting. The g…

This study follows women who have had pelvic exenteration—a surgery removing the lower colon, rectum, and bladder—for gynecologic cancers like cervical or endometrial cancer. Researchers want to see if factors like tumor size or surgery type affect complications, quality of life,…

This study looks at whether cancer patients and their doctors have similar expectations about how well patients will perform daily activities after short-term inpatient rehabilitation. About 133 adults with cancer who can tolerate 3 hours of rehab per day will fill out surveys be…

This study looks at whether teaching African American women how to support a partner's exercise habits can help them become more active. Researchers will recruit 80 sedentary women aged 18-65 and provide training, a workbook, and a pedometer. Participants will also complete quest…

This study looks at why adults with cancer may fear taking opioid pain medication after surgery. Researchers will use questionnaires to measure barriers, fears, and medication adherence in 50 patients. The goal is to learn more about these concerns to improve pain management afte…

This study was designed to look at cancer patients with neutropenic fever (a serious side effect of chemotherapy) who might be eligible for a 'hospital at home' program, where they receive acute care at home instead of in the hospital. Researchers planned to review medical charts…

This study aims to develop an educational aid to help people make informed decisions about multi-cancer early detection (MCED) blood tests. Researchers will hold focus groups with 150 participants to discuss knowledge, preferences, and concerns about these tests. The goal is to c…

This study asks cancer patients and their caregivers whether they would rather wait in an exam room or a waiting room when they arrive at the clinic. The goal is to understand their preferences to improve the clinic experience. About 406 people with advanced cancer and their care…

This study was designed to test new drug combinations for people with pancreatic cancer that hasn't spread. It planned to compare new treatments against standard chemotherapy in three groups based on how far the cancer had grown. However, the study was withdrawn before enrolling …

This study looks at how seizures change over time in people with low grade glioma (a slow-growing brain tumor) who are on treatment. By tracking seizure frequency and comparing it to MRI scans, researchers hope to find early signs of tumor changes. The goal is to help doctors det…

This study surveys women aged 18-45 who have had gynecological or breast cancer to learn how they think about having a baby after cancer. Researchers will use the results to help future patients make informed decisions about treatment and family planning. About 1,410 participants…

This study looks at small molecules called microRNAs in the blood of people with sepsis, a severe bloodstream infection. Researchers want to see if changes in these molecules can help predict who will survive. About 150 participants will provide blood samples, and their microRNA …

This study looks at how severe financial distress is among people with advanced cancer. Researchers want to understand how money worries affect symptoms and quality of life. About 141 patients will fill out a short survey about their financial well-being. The goal is to learn mor…

This study looks at tiny pieces of cancer cells or DNA floating in the blood of people with rectal cancer. Researchers want to see if these markers can help predict how the tumor responds to standard treatment. About 341 participants, including healthy volunteers, will provide bl…

This study gathers health questionnaires from up to 1,500 people with multiple endocrine neoplasia (MEN1 or MEN2) and their close relatives. The goal is to build a database that helps researchers better understand these rare inherited conditions. No new treatments or procedures a…

This study tests whether a less invasive ultrasound-guided biopsy can accurately tell if breast cancer has been completely wiped out by chemotherapy, compared to the standard method of checking during surgery. About 43 women with aggressive breast cancer types (triple negative or…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study looks at whether molecular testing and lymph node mapping can help predict if low-risk endometrial cancer will return after surgery. About 518 patients with early-stage, low-grade cancer will be followed for two years. The goal is to improve follow-up care by identifyi…

This study looks at whether doing MRI scans in the same position used for radiation treatment helps doctors plan more accurate therapy for spinal tumors. About 21 adults with cancer that has spread to the spine will have two MRI scans—one with a special immobilization device and …

This study looks at why some adults with advanced cancer are afraid to take opioids for pain, even when prescribed. Researchers will survey 50 patients to understand how fear, anxiety, and depression affect pain relief and medication use. The goal is to identify barriers so docto…

This study aims to learn more about how oxygen, metabolism, and blood supply work in high-grade brain tumors and cervical cancers. About 20 adults with these cancers will receive special PET and MRI scans. No treatment is given; the goal is to better understand tumor biology.

This study tests a new program designed to help head and neck cancer patients who feel depressed. The goal is to see if the program is practical and liked by patients, and if it can improve their mood and help them follow through with swallowing exercises and dental care. About 1…

This study aims to understand the experiences of cancer patients who receive care at home through MD Anderson's Care and Monitoring at Home program. Researchers will use surveys to measure quality of life and gather feedback from up to 40 participants. The goal is to learn whethe…

This early-phase trial is testing a drug called adavosertib in 38 people with advanced ovarian, fallopian tube, or peritoneal cancer. Participants take the drug for up to 28 days before their scheduled surgery. Researchers will compare tumor DNA before and after treatment to see …

This early-phase trial is testing whether two advanced imaging techniques—DCE-MRI and molecular breast imaging (MBI)—can accurately assess how triple-negative breast cancer tumors respond to chemotherapy. About 96 patients will undergo these scans before, during, and after treatm…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This phase 2 trial tests whether a software-aided imaging system (Morfeus) can help doctors confirm that liver tumors are fully covered during ablation. About 107 patients with up to 3 liver tumors will be treated with standard ablation, and the software will be used to assess th…

This study looks at how the COVID-19 pandemic impacted the quality of life of 274 cancer patients who also have neuropathy (nerve pain). All participants had taken part in earlier clinical trials. Researchers want to see if there are differences between those who received a brain…

This study follows 125 head and neck cancer patients after surgery to see how many develop long-term opioid use. Researchers will also look at factors like symptom burden and risk of opioid misuse. The goal is to better understand who is at risk and why, which could help improve …

This pilot study at MD Anderson Cancer Center surveys 100 cancer patients about their use of cannabis and CBD for pain. Researchers want to learn how often patients use these products, why they use them, and where they get their information. The goal is to improve patient educati…

This study tests whether group education sessions can help medically underserved women and racial/ethnic minorities with BRCA 1 or 2 mutations follow recommended cancer surveillance and risk-reducing procedures. Thirty participants will attend 90-minute group classes via Zoom. Th…

This study tracks 130 adults who have had their voice box removed (laryngectomy) to see how often they use a special breathing filter called a heat-moisture exchanger (HME). Researchers at MD Anderson Cancer Center want to learn what factors—like patient habits or clinical follow…

This small study tests whether men with intermediate-risk prostate cancer can follow a Mediterranean diet for a few weeks before their scheduled prostate removal surgery. The main goal is to see if this approach is practical and well-tolerated, not to cure the cancer. Researchers…

This trial looks at a program called Tu Salud Si Cuenta (Your Health Matters!) to see if it helps Latino families eat healthier and be more active. About 80 adults will get home visits from a community health worker who teaches skills like goal-setting and problem-solving. The go…

This study looks at how women aged 65 and older with early-stage breast cancer decide whether to have chemotherapy before or after surgery. Researchers will use surveys to understand their needs and then create a tool to help patients and doctors make better, shared decisions. Th…

This study gathers information from 240 women who have lived with ovarian cancer for at least seven years. Researchers want to understand how diet, exercise, emotions, and social support affect their health and survival. No new treatments are tested; the goal is to learn what fac…

This study tests whether a non-invasive brain-mapping tool called nTMS can help doctors plan radiation treatment for brain tumors near the motor cortex—the area that controls movement. About 22 adults who already had radiation for brain tumors will undergo nTMS to see if it provi…

This study asks breast cancer patients about their opinions on screening for lymphedema, a side effect that can cause arm pain and swelling. Researchers want to see if using a perometer (a device that measures arm size) for regular checks after surgery is effective and satisfying…

This study planned to monitor tiny bits of tumor DNA in the blood of people with early breast cancer. Researchers wanted to see how these DNA levels change during treatment and follow-up. The study was withdrawn before any participants were enrolled, so no results are available.

This study looks at whether eating more fiber can change the bacteria in your gut and improve how well the flu vaccine works. Researchers are asking 31 healthy adults to follow a special diet before getting their flu shot. The goal is to see if this simple change can make the vac…

This study tests a decision aid website designed to help women with cancer make informed choices about preserving their fertility before treatment. About 130 women with newly diagnosed breast, colorectal, or reproductive system cancers, or lymphoma/myeloma, will use the website o…

This study looks at whether certain gene mutations (ARID1A and KDM6A) and a protein called CXCL13 in tumors can help predict if the immunotherapy drug nivolumab will work for people with advanced bladder cancer that has spread. Only 6 participants with these specific gene changes…

This study looks at whether extra MRIs and blood tests can help doctors predict how head and neck tumors change during radiation therapy. Up to 100 people (80 patients and 20 healthy volunteers) will take part. The goal is to learn more about tumor growth and response, not to tes…

This study aims to understand why some people are more likely to develop bladder cancer. Researchers will compare people with and without bladder cancer to see how genes and lifestyle choices, like smoking, affect risk. Over 6,000 participants will provide samples and answer ques…

This study looks at whether it's possible for people with a new brain tumor (glioma) to wear a step counter like a Fitbit or pedometer during radiation therapy. About 50 participants will track their steps for 6 weeks to see if it helps improve their quality of life and symptoms.…

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study surveys over 1,200 cancer patients who previously took part in behavioral trials to learn how the COVID-19 pandemic impacted their quality of life, mental health, and daily routines. Participants fill out questionnaires about stress, sleep, diet, exercise, and social s…

This study looks at whether a special health check-up for older adults (called a geriatric assessment) can help them and their caregivers talk more effectively with their doctors about age-related concerns. About 479 older cancer patients and their caregivers are taking part. The…

This study looks at how different breast cancer treatment decisions, like choosing between a lumpectomy or mastectomy, affect women's quality of life and emotional distress. Researchers followed 345 women with early-stage breast cancer and their partners to measure cancer-related…

This study aims to learn how patients feel about their decision to have groin lymph node surgery for penile cancer. Researchers will ask 20 adults who had the surgery at least 6 months ago to fill out questionnaires about regret and needs. The goal is to improve care and support …

This study uses a brain wave test (EEG) to check if cancer patients who seem unresponsive in their last days can still hear or feel. Researchers will measure brain activity when sounds or words are played. The goal is to help families and doctors understand what patients may expe…

This study looks at what happens when older smokers (ages 50-80) who are at high risk for lung cancer switch from regular cigarettes to e-cigarettes. Researchers will track how many cigarettes they smoke and measure health markers like inflammation in their blood. The goal is to …

This study uses surveys to understand how patients and doctors feel about using telemedicine (video visits) for radiation oncology care. About 200 adults who have had at least one telemedicine visit will share their satisfaction. The goal is to learn what works and what can be im…

This study looks at whether a genetic test on tumor samples can predict how well HER2-negative breast cancer will respond to standard treatments like chemotherapy or hormone therapy. About 1,100 people with stage I-III breast cancer are taking part. The goal is to see if this tes…

This study looks at genetic markers that may increase the risk of developing colorectal cancer at a young age (18-50). Researchers will compare data from 818 patients and their family members to find patterns in genes, treatments, and outcomes. The goal is to better identify who …

This study tests whether a special type of CT scan (DCE-CT) can help doctors see if targeted therapy drugs for advanced kidney cancer are working. About 120 adults with metastatic renal cell carcinoma will get these scans before and shortly after starting treatment. The goal is t…

This study looks at whether a special video mentoring program (called ECHO) can help diagnostic imaging doctors feel more connected and work more efficiently. About 36 doctors from MD Anderson will take part in regular online team meetings. The goal is to see if this approach imp…

This study is creating a web-based program to help people with hereditary cancer mutations share their genetic test results with family members. The goal is to increase awareness among at-risk relatives so they can take steps to prevent cancer. The program is designed for patient…

This study looks at how well a symptom questionnaire works for teenagers aged 13-17 who have cancer. Researchers will interview teens to see if the survey is easy to use and accurately captures their symptoms. The goal is to improve the questionnaire so doctors can better underst…

This study looks at whether a special type of breast scan, called molecular breast imaging, can help doctors predict how well chemotherapy is working in women with invasive breast cancer. About 96 women will get the scan before, during, and after treatment. The goal is to see if …

This early-phase study looks at how the immune system responds to leukemia tumors after low-dose radiation given as part of standard care. Ten adults with new or recurrent myeloid leukemia will have their immune responses measured. The goal is to learn whether adding immunotherap…

This study looks at whether watching an online genetics video, with or without phone counseling from a genetic counselor, can reduce the stress women feel about their cancer risk. It involves 5,200 women aged 30 or older who have had triple-negative breast cancer and still have a…

This study offers lung cancer screenings to smokers who want to quit. All participants receive smoking cessation counseling, and some may also get FDA-approved quit-smoking drugs. The goal is to see which type of counseling works best to help people stop smoking. About 630 to 126…

This study looks at how quickly a commercial genomic test (MF Portrait) can provide results for people with diffuse large B-cell lymphoma. Researchers want to see if test results are available within 7 days to help guide treatment decisions. The study involves 111 adults and is l…

This study surveys parents of children with cancer to learn about their attitudes and beliefs regarding the risks of using opioids for pain. Pain is common in pediatric cancer, and opioids are a key treatment, but parents often hesitate or underuse them. The goal is to fill a kno…

This study tests a computer app that shows personalized images of what breast reconstruction might look like after surgery. The goal is to help patients make more informed decisions and reduce confusion. About 35 adults planning mastectomy and immediate reconstruction at MD Ander…

This study looks at whether chemotherapy slows tumor growth in people with a rare type of appendiceal cancer that has spread. About 30 participants will be observed with and without chemotherapy to compare tumor growth rates. The goal is to give doctors clearer guidance on whethe…

This study tests whether a special catheter (TriNav) helps deliver radiation more accurately to liver tumors. About 19 adults with liver cancer that cannot be removed by surgery will receive a test dose followed by the actual treatment. The goal is to see if the two doses match b…

This study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program can improve quality of life, diet, physical activity, and partner support. Only 6 participants were enrolled,…

This study looks at how day-to-day stress, social support, and healthy habits like exercise and diet affect Black prostate cancer survivors and their partners. About 200 couples will use a smartphone app to report their activities and feelings throughout the day. The goal is to u…

This early-phase pilot study tested whether adding zoledronic acid to standard chemotherapy (paclitaxel and bevacizumab) could change immune cells called macrophages in women with platinum-resistant ovarian, fallopian tube, or primary peritoneal cancer. Only 14 women who had alre…

This study looks at symptoms reported by patients with oropharyngeal (throat) cancer after they finish radiation or chemoradiation therapy. Researchers want to learn which symptoms matter most to patients, so they can improve follow-up care. About 77 adults are taking part, all t…

This study looks at whether short educational videos can help people with inherited cancer gene mutations learn more about their condition. About 43 adults who carry mutations in genes like BRCA1 or BRCA2 will watch the videos and then take a quiz. The goal is to see if this simp…

This study looks at how financial stress (called financial toxicity) affects people recently diagnosed with cancer. Researchers will survey 625 English- or Spanish-speaking adults to understand what social, behavioral, and knowledge factors contribute to financial hardship. The g…

This study tests whether reminder messages can encourage adults aged 40 to 80 who smoke or used to smoke to get screened for lung cancer. Researchers will ask participants how acceptable they find these reminders. The goal is to learn if this approach can help more people get scr…

This study looks at pelvic floor problems and quality of life in people who survived uterine cancer. Researchers will use questionnaires to gather information from about 310 survivors treated with surgery at MD Anderson between 2006 and 2017. The goal is to better understand how …

This study is testing whether a special MRI contrast agent, called hyperpolarized 13-C pyruvate, can help doctors see how aggressive ovarian cancer is. About 30 women at high risk for ovarian cancer will be scanned. The goal is to improve early detection, not to treat the disease…

This study tests a program called Harmony & Health that combines yoga with Christian spirituality. The goal is to see if it helps Black adults who are not very active get more exercise. About 100 participants will take part across multiple sites. The study focuses on whether the …

This study looks at whether eating a high-fiber diet can change the gut bacteria of people with advanced melanoma who are receiving standard immunotherapy. About 50 participants will be randomly assigned to either a high-fiber or a healthy control diet for a set period. The main …

This study looks at why some children with cancer may not get the occupational or physical therapy they need. Researchers will interview doctors, therapists, and hospital administrators to find out what helps or hinders access. The goal is to reduce unfair differences in care and…

This study surveys 182 high-risk patients and their caregivers to understand their attitudes and beliefs about being prescribed intranasal naloxone spray, a medication that reverses opioid overdoses. The goal is to find out what barriers exist to prescribing this life-saving spra…

This study was designed to test new nano-sized painkillers on nerve cells from the spinal cord of people undergoing spinal tumor surgery. The goal was to see how well these cells respond to pain signals and treatments. However, the study was withdrawn before any participants were…

This study looks at whether a website and a genetic family navigator can help more relatives of people with hereditary cancer get genetic testing. About 205 participants will use the online hub and work with a navigator to learn about their cancer risk. The goal is to see if this…

This study tests whether wearable devices like Fitbits and continuous glucose monitors can reliably track daily exercise in people with cancer or diabetes. About 35 adults who are not very active will wear these devices for a period of time. The goal is to see if people find them…

This study looks at whether electronic tools can effectively screen mental function in 100 patients scheduled for liver surgery. Participants will complete both a digital brain test (BrainCheck) and a traditional paper test. Researchers will compare completion rates, time, and ac…

This study looks at whether analyzing the genetic changes in a patient's tumor can help doctors pick a more effective treatment for cancer that has spread. Over 1,300 participants with metastatic cancer are randomly assigned to receive either a targeted therapy based on their tum…

This study explores whether adults at low risk for heart disease can reliably measure their own physical activity, fitness, and body size at home using simple tools like pedometers and tape measures. Researchers will compare home-collected data to standard clinic measurements. Th…

This study checks if a special scale can accurately measure muscle and fat in 50 head and neck cancer patients getting radiation therapy. The goal is to see if the scale can spot muscle loss early, helping doctors decide when to add nutrition support or a feeding tube. Participan…

This study looks at why women might want to get their screening mammogram results during the same visit, instead of waiting. Researchers will survey female patients aged 30 and older at three breast imaging centers. The goal is to understand patient preferences and improve the ov…

This study looks at whether detailed nutritional assessments can help identify malnutrition in older adults with cancer. Researchers will follow 180 patients to see how nutrition status relates to survival over 6 months and 1 year. The goal is to improve screening and care for th…

This study looks at how patients at MD Anderson Cancer Center perceive their doctor's empathy during the COVID-19 pandemic. It compares in-person visits where doctors wear protective gear (PPE) to video calls where doctors do not wear PPE. About 107 English-speaking adults will s…

This study gathers medical information from 450 head and neck cancer patients who received or will receive proton therapy. Researchers will analyze outcomes and side effects to help doctors improve treatment for future patients. The study does not test a new treatment but collect…

This study tests whether a special PET scan called 18F-FSPG can help doctors see how well chemotherapy and radiation are working in patients with esophageal cancer. Nine adults with untreated, locally advanced esophageal cancer will receive the scan before and during treatment. T…

This study looks at how a single dose of antibiotics given before melanoma surgery changes the bacteria in your gut. Researchers want to see if these changes affect how well the body responds to surgery and cancer treatment. The study involves 20 adults with early-stage melanoma …

This study looks at side effects and overall well-being in people who have had melanoma and are now getting immunotherapy to prevent the cancer from coming back. Researchers will track side effects and ask participants about their quality of life, depression, and fatigue for up t…

This study looks at how the COVID-19 pandemic impacted the well-being and quality of life of over 13,000 cancer patients and survivors. Researchers used questionnaires to gather information on experiences like exposure, isolation, and financial disruptions. The goal is to underst…

This study looks at skin and soft tissue removed during breast implant surgery after mastectomy. Researchers want to see if the physical properties of the tissue can help predict complications like implant loss. The goal is to better understand risks and improve surgical outcomes…