M.d. Anderson Cancer Center

This study tests a combination of seven drugs (including asciminib and venetoclax) in 30 adults with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute myeloid leukemia. The first phase checks safety, and the second phase sees if the combo helps control t…

This phase 2 study tests the drug zanzalintinib in 16 adults with recurrent or metastatic olfactory neuroblastoma, a rare cancer of the nasal cavity. The goal is to see if the drug can help control the disease and to check its safety. Participants must not have had prior treatmen…

This phase 2 trial tests two experimental drugs, BGB-16673 and sonrotoclax, given together for a limited time in 40 people with untreated chronic lymphocytic leukemia (CLL). The goal is to see if the combination is safe and can control the disease. Participants take both drugs by…

This early-phase trial tests a new combination treatment for people with advanced breast cancer that has not responded to standard therapies. The treatment uses specially engineered immune cells (TRICK-NK) plus a targeted drug called T-Dxd. The study aims to find the safest dose …

This early-phase trial tests whether matching drug combinations to a patient's tumor characteristics can better control metastatic colorectal cancer. Researchers will use blood draws, biopsies, and imaging to track how tumors resist treatment. The study enrolls 100 adults with me…

This early-phase trial tests a new oral drug called REC-617 in 15 people with a rare type of sarcoma (leiomyosarcoma) that has spread and no longer responds to standard treatments. The drug targets a protein called CDK7, which may help control tumor growth. The main goal is to ch…

This early-phase trial tests a new treatment for stomach cancer that has spread to the lining of the abdomen. Ten adults will receive specially engineered natural killer (NK) cells directly into their belly, along with chemotherapy, to see if it is safe and what dose works best. …

This early-phase trial tests a new treatment for people with certain blood cancers (lymphomas and leukemias) that have not responded to standard therapies. The treatment uses specially engineered natural killer (NK) cells from donated cord blood, designed to better target cancer …

This study tests a virus called G207 combined with a small dose of radiation in children whose high-grade glioma has come back or is growing. The goal is to see if the treatment is safe and helps control the tumor. About 38 children will take part.

This study tests whether a combination of two drugs, zanzalintinib and cemiplimab, can help people with a rare and fast-growing thyroid cancer called anaplastic thyroid cancer live longer. The goal is to extend average survival by about 4 months. The trial will include 12 adults …

This study tests a drug called sacituzumab tirumotecan in 20 people with advanced anal or rectal cancer that has spread or cannot be removed and has not responded to other treatments. The goal is to see if the drug can shrink tumors and how safe it is. Participants will receive t…

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This early-phase trial tests whether specially engineered natural killer (NK) cells can be safely delivered to the brain in people with recurrent glioblastoma, an aggressive brain cancer. The NK cells are modified to better recognize and attack tumor cells while resisting the tum…

This phase 2 study tests the drug mosunetuzumab in 30 adults with chronic lymphocytic leukemia (CLL) who still have signs of the disease after at least 6 months of standard therapy. The drug is designed to help the immune system attack cancer cells. Researchers will monitor safet…

This Phase 2 trial tests the drug imetelstat in 30 adults with myelodysplastic/myeloproliferative neoplasms (MDS/MPN), a rare blood cancer. The goal is to see if imetelstat can help control the disease and to check for side effects. Participants receive the drug by IV, and the st…

This early-phase trial tests a virus called DNX-2401, designed to infect and destroy melanoma cells in the brain and body. About 50 adults with stage IV melanoma will receive injections to find the safest dose and number of treatments. The main goal is to check for side effects, …

This study tests a drug called sacituzumab tirumotecan in 20 people with a rare and aggressive kidney cancer (SMARCB1-deficient renal medullary carcinoma) that has worsened after at least one prior treatment. The goal is to see if the drug can shrink or control the cancer. Resear…

This study compares two types of voice prostheses (ActiValve vs standard) in 48 adults who have had their voice box removed due to cancer. The goal is to see if using ActiValve routinely reduces how often the device needs to be replaced each year. Participants must be at least 6 …

This early-phase study tests two drugs, blinatumomab and revumenib, given together to adults with a rare and aggressive form of acute lymphoblastic leukemia (ALL) that has a specific genetic change called KMT2A rearrangement. The main goal is to find a safe dose and understand si…

This study tests whether adding nivolumab to standard chemotherapy (AVD) can better control early-stage Hodgkin lymphoma in patients aged 2 to 21. The treatment is given to 15 participants to see if it is safe and effective. The goal is to improve outcomes while reducing long-ter…

This early-phase study tests two drugs together—navlimetostat and pumitamig—in people with advanced non-small cell lung cancer that has a specific genetic change (MTAP-deficient). The main goal is to find a safe dose and see if the combination helps shrink tumors. About 17 adults…

This early-phase study tests a new treatment called LNK001 for people with advanced or spreading clear cell kidney cancer. The therapy uses specially designed immune cells (CAR T cells) that target two markers on cancer cells to try to attack the tumor more safely. The study will…

This study tests whether combining dasatinib with ropeginterferon can better control chronic myeloid leukemia in its early phase. About 40 adults newly diagnosed with CML will receive the drug pair to see if it improves disease control and reduces side effects. The goal is to man…

This early-phase study tests a new treatment for people with widespread or multiple precancerous patches in the mouth. The treatment uses specially engineered immune cells (NK cells) from donated cord blood, designed to target and destroy abnormal cells. The main goal is to check…

This study tests a new treatment called CD70.CAR NK cells for people with diffuse large B-cell lymphoma or Hodgkin lymphoma that did not respond to or came back quickly after initial therapy. The treatment uses specially designed immune cells from a donor to find and attack cance…

This early-phase study tests a new treatment for a rare and serious condition where melanoma spreads to the lining of the brain or spinal cord. Up to 8 adults will receive their own specially trained immune cells injected directly into the spinal fluid. The main goal is to check …

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This early-phase study tests a combination of three drugs (avutometinib, defactinib, and everolimus) in people with recurrent endometrial cancer that has specific genetic changes in the RAS pathway. The main goal is to find a safe dose and understand side effects. About 31 partic…

This study tests whether a new combination of two drugs (blinatumomab given as a shot under the skin and olverembatinib taken by mouth) can help control a specific type of leukemia called Ph-positive ALL. The trial will enroll 60 adults with newly diagnosed or returning leukemia.…

This study tests a combination of three drugs (cemiplimab, fianlimab, and ipilimumab) given before surgery to people with advanced melanoma that can be removed. The goal is to see if the drugs are safe and help shrink tumors. About 20 adults with stage III or limited stage IV mel…

This study tests an oral chemotherapy drug, cladribine, combined with two other drugs (low-dose cytarabine and venetoclax) in people with acute myeloid leukemia (AML). The first part finds the safest dose; the second part checks if that dose helps control the disease. About 58 ad…

This study tests a new treatment for people with aggressive T-cell blood cancers, like certain leukemias and lymphomas. It uses specially engineered natural killer (NK) cells from donated cord blood, designed to target and destroy cancer cells. Participants will receive chemother…

This study tests whether combining three drugs (cladribine, ruxolitinib, and venetoclax) can control a rare, aggressive leukemia called T-PLL that has come back or not responded to prior treatment. The trial will enroll 36 adults and focus on safety and how well the drug combo wo…

This pilot study tests whether the drug infliximab can safely reverse insulin dependence in people who developed diabetes after taking checkpoint inhibitor cancer therapy. About 14 participants will receive the drug and be monitored for side effects and changes in their need for …

This early-phase study tests a combination of two drugs, izalontamab brengitecan and adagrasib, in 18 adults with advanced KRAS G12C-mutant non-small cell lung cancer that has not responded to other treatments. The main goal is to see if the combination is safe and works better t…

This early-phase study tests a combination of four drugs (pazopanib, trabectedin, ipilimumab, and nivolumab) in 18 children and young adults (ages 1-30) whose soft tissue sarcoma has come back. The main goal is to see if the treatment is safe and to find the best dose. This is no…

This study tests whether a drug called blinatumomab, given as a simple injection under the skin, can control small amounts of leftover leukemia cells (called measurable residual disease, or MRD) in adults with B-cell acute lymphoblastic leukemia. The goal is to prevent the cancer…

This study tests a combination of two drugs (AZA and APG1252) in 52 adults with high-risk acute myeloid leukemia (AML). The goal is to see if the combo is safe and can help control the disease. Participants include those whose cancer returned or didn't respond to prior treatment,…

This study tests a special microscope that takes very clear, detailed pictures of cervical tissue right where the patient is being seen. The goal is to see if it can give doctors the same quality images as a standard lab test, but much faster. About 400 women in Mozambique and Br…

This study aims to see if a contrast agent called gadopiclenol can improve MRI detection of leptomeningeal disease (LMD), a rare spread of cancer to the brain and spinal cord lining. About 40 adults with solid tumors who have unclear MRI results will receive the agent and be moni…

This study tests if drawing blood directly from veins inside the brain is a safe and effective way to diagnose high-grade glioma, a type of brain cancer. Twenty adults with suspected or confirmed glioma will participate. The goal is to see if this method can provide the same deta…

This Phase 2 trial tests whether psilocybin, the active ingredient in magic mushrooms, can prevent or reduce chemotherapy-induced peripheral neuropathy (nerve damage causing pain and numbness). About 83 adults with breast, colorectal, or head and neck cancer receiving platinum-ba…

This study looks at whether inhaling isopropyl alcohol (rubbing alcohol) can help reduce nausea in cancer patients. About 112 adults with cancer who rate their nausea as at least 4 out of 10 will be asked to inhale the alcohol and report any changes. The goal is to find a quick, …

This study tests if a program that delivers healthy food and teaches cooking skills is helpful for parents of children who have finished cancer treatment. The study will include 21 parents of children aged 5-12 who completed cancer therapy within the last five years. Researchers …

This study tests a virtual group lifestyle program for women with stable HR+/HER2- metastatic breast cancer. The goal is to see how much support helps them stick with healthy habits like diet and exercise. About 100 women will take part, and researchers will track safety and any …

This study tests a program called COPE (Creating Opportunities for Personal Empowerment) to see if it helps women with breast cancer feel more in control and supported during their first round of treatment. About 40 women will either receive the COPE program or standard care. The…

This study will interview 120 cancer patients in Texas to learn what makes it easier or harder to get timely cancer treatment. Researchers will talk with patients by phone or video to understand their experiences across different cancer types and insurance plans. The goal is to i…

This study tests a program to help people with inherited genetic mutations that raise their cancer risk stick to recommended screening schedules. Researchers will interview 80 women with BRCA or Lynch syndrome mutations and track how well they follow cancer surveillance guideline…

This study interviews 20 pancreatic cancer patients to learn why certain groups—like racial minorities, low-income individuals, or rural residents—are less likely to join clinical trials. Researchers hope to find ways to make trials more accessible and fair for everyone. The stud…

This study looks at whether audio recording a cancer clinic visit helps patients remember what the doctor said and share it with family who couldn't attend. About 200 adults with advanced cancer will be asked to record part of their visit. Researchers will then survey them to see…

This study tests a program to help people with certain genetic mutations share their results with at-risk relatives and make informed decisions about genetic testing and care. About 2100 adults in the U.S. who speak English or Spanish will take part. The program provides free gen…

This early-phase study aims to understand how the drug cabozantinib changes the immune environment inside bone for people with kidney cancer that has spread to bone. Researchers will monitor side effects and look for clues to prevent bone complications. About 16 participants will…

This study will give 50 women a Fitbit to wear before and after DIEP flap breast reconstruction surgery. The device tracks steps, heart rate, and sleep, and patients fill out short questionnaires. The goal is to learn more about recovery patterns to help doctors better prepare fu…

This study will collect medical information and samples from 300 cancer patients who have a rare fungal infection called mucormycosis, or are at risk for it. The goal is to learn more about the disease and find better ways to diagnose and treat it. Participants will undergo stand…

This study looks at what helps or hinders prostate cancer patients from completing genetic testing. Researchers will develop and test a decision support tool to educate patients and help them decide about testing. The goal is to increase testing rates, which can guide treatment a…

This study looks at whether a special catheter called TriNav can improve CT scans of liver tumors compared to a standard catheter. The goal is to see if it helps doctors better plan a treatment called Y90-radioembolization. About 20 adults with liver tumors that cannot be removed…

This study looks at how cancer patients view their doctor's compassion, communication, and professionalism when the doctor uses an electronic health record (EHR) during the visit. About 88 adults with cancer will watch videos or fill out questionnaires. The goal is to understand …

This study focuses on increasing the number of minority patients in prostate cancer clinical trials. Researchers will test ways to remove barriers for patients, doctors, and the hospital system. About 60 prostate cancer patients at Lyndon B. Johnson Hospital will take part. The g…

This study looks at whether intermittent fasting (a pattern of eating only during certain hours) is safe and doable for 20 people at high risk for pancreatic cancer. Researchers will also check if fasting changes certain body markers linked to metabolism, inflammation, and gut he…

This study aims to understand how migration history and social factors affect the quality of life of Black immigrant men from Sub-Saharan Africa and the Caribbean who have been diagnosed with prostate cancer. Researchers will interview 40 men to learn about their experiences and …

This study looks at whether blood tests and imaging scans can show if early-stage triple-negative breast cancer has fully responded to chemotherapy before surgery. About 200 people will receive standard chemo plus immunotherapy, and researchers will check if these tests can accur…

This study looks at how cancer care is provided in oncology and supportive care clinics. Researchers will collect feedback from 200 adults with advanced solid tumors to better understand and improve care delivery. The goal is to help doctors learn from patient experiences, not to…

This early-stage study tests whether a magnetic tracer and a fluorescent dye can safely help doctors find lymph nodes where stomach cancer may have spread. About 20 adults with early stomach cancer will receive the injection before surgery. The goal is to see if this method is sa…

This study looks at why some people have ongoing loose stools after surgery for colon cancer. Researchers will use a new device to check for bile acid problems and bacterial overgrowth in the small intestine. The goal is to better understand these symptoms and how they affect qua…

This study looks at the stress and unmet needs of people caring for someone with gynecologic cancer. It will follow 250 patients and their caregivers for 6 months to see how caregiver distress affects both the caregiver and the patient. The goal is to find better ways to support …