M.d. Anderson Cancer Center

This early-phase trial tested a personalized vaccine made from each patient's own blood and bone marrow. The goal was to help the immune system recognize and kill cancer cells in people with smoldering multiple myeloma, a pre-cancer condition. The study involved 30 adults at high…

This phase 2 study tested a combination of oral azacitidine (a chemotherapy-like drug) and pembrolizumab (an immunotherapy) in 24 people with advanced melanoma that had spread. The goal was to see if the combo could shrink tumors or slow the disease, both in patients who had neve…

This early-phase trial tested whether giving the immunotherapy drug pembrolizumab (Keytruda) after radiation therapy is safe for people with malignant pleural mesothelioma, a rare cancer of the lung lining. Twenty-five participants received radiation followed by pembrolizumab. Th…

This phase II trial tested a combination of panitumumab (a targeted therapy) plus two chemotherapy drugs (carboplatin and paclitaxel) given before surgery to women with triple-negative breast cancer that didn't respond to standard chemo. The goal was to shrink tumors and reduce t…

This phase II trial tested blinatumomab in 36 adults with B-cell acute lymphoblastic leukemia who were in remission but still had tiny amounts of leukemia cells (minimal residual disease). The drug is an immunotherapy that helps the body's immune system find and destroy these hid…

This study tested a combination of three drugs (decitabine, venetoclax, and ponatinib) in 20 adults with a rare, aggressive leukemia called Philadelphia chromosome-positive acute myeloid leukemia or chronic myelogenous leukemia in blast phase. The goal was to see if the drugs cou…

This early-phase study tested a combination of two immunotherapy drugs (nivolumab and ipilimumab) in 29 adults whose acute myeloid leukemia or myelodysplastic syndrome came back or did not respond after a donor stem cell transplant. The main goal was to find the safest dose and c…

This study tested a drug called guadecitabine combined with donor lymphocyte infusions in 55 patients whose acute myeloid leukemia or myelodysplastic syndrome came back after a stem cell transplant. The goal was to see if the drug could help the donor immune cells fight the cance…

This phase 2 trial tested whether adding the drug axitinib to standard hormone therapy before surgery helps control prostate cancer that has spread to nearby lymph nodes. 73 men with previously untreated prostate cancer received either hormone therapy alone or hormone therapy plu…

This study tested whether the drug varenicline helps smokers quit better than nicotine patches and lozenges. Over 600 smokers were randomly assigned to one of the treatments, and all received counseling. The main goal was to see who could stop smoking for at least a week, confirm…

This study tested a drug called RAD001 (everolimus) in 29 people with blood cancers like leukemia, lymphoma, or myelofibrosis that had come back or not responded to treatment. The goal was to find the safest dose and see if it could shrink or control the cancer. The trial combine…

This early-phase trial tested a new approach for people with CD30-positive Hodgkin or non-Hodgkin lymphomas that returned or didn't respond to standard treatments. Participants received a combination of AFM13 (an antibody that helps immune cells target cancer) and natural killer …

This early-phase trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and could not be removed by surgery or had spread. The main goal was to find the safest dose and under…

This early-phase study tested the safety and best dose of the drug olaparib when combined with high-dose chemotherapy for people with lymphomas that returned or didn't respond to treatment. The 50 participants were adults aged 18-65 with certain types of lymphoma who were also sc…

This early-phase trial tested a combination of two drugs, vandetanib and everolimus, in 151 people with advanced or metastatic cancer that had stopped responding to standard treatments. The goal was to find the safest dose and see if the combination could slow or stop cancer grow…

This study tested a combination of two drugs, ruxolitinib and azacytidine, in 121 people with myelofibrosis or related blood cancers. The goal was to see if the combo could shrink tumors or improve blood counts. While the treatment aims to control the disease, it is not a cure, a…

This study tested a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus a targeted therapy (selumetinib) in 40 people with advanced non-small cell lung cancer that had returned or spread. The goal was to find the safest dose and see if the combo could shrink…

This study tested the drug dasatinib in 17 people with chronic lymphocytic leukemia (CLL) who had already tried other treatments. The goal was to see if dasatinib could shrink or control the cancer. Researchers also checked for side effects. The study was completed and measured h…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation helps people with newly diagnosed glioblastoma, an aggressive brain cancer. About 60 participants received the combination to see if it improves survival and controls the d…

This study tested whether adding the targeted drug erlotinib to standard chemotherapy helps control head and neck cancer before surgery. About 55 adults with advanced but operable head and neck cancer took part. The main goal was to see if the combination led to fewer remaining c…

This early-stage study tested two drugs, cabozantinib and pamiparib, together in 44 people with advanced solid tumors that had stopped responding to standard treatments. The goal was to find the safest dose and understand side effects. The drugs work by blocking certain enzymes t…

This study tested whether adding ready-made natural killer (NK) cells from a donor to a standard stem cell transplant could safely reduce the chance of cancer returning in people with high-risk myeloid cancers like acute myeloid leukemia, myelodysplastic syndrome, and chronic mye…

This study tested a new antibiotic combination (imipenem-relebactam) against standard antibiotics for treating fever caused by low white blood cells in 100 cancer patients. The goal was to see if the new drug works better at controlling infections. Results may help improve care f…

This study looked at whether taking daily aspirin and vitamin D, along with exercise and a low-fat diet, could help prevent colorectal cancer from returning in 16 patients who had no visible cancer but still had signs of cancer DNA in their blood. The goal was to see if these lif…

This study tested the drug pembrolizumab (Keytruda) in 15 people with high-risk precancerous mouth lesions. The goal was to see if the drug could prevent these lesions from turning into oral cancer. Participants were randomly assigned to receive the drug or just be watched. The s…

This early-phase trial tested a new drug called ALRN-6924 combined with the chemotherapy paclitaxel in 28 adults with advanced solid tumors that had spread or couldn't be removed by surgery, including a type of breast cancer. The main goal was to find the safest dose and check fo…

This study tested giving immunotherapy drugs (nivolumab alone or with ipilimumab) or immunotherapy plus chemotherapy before surgery for people with early-stage non-small cell lung cancer (stages I to IIIA). The goal was to see if these treatments could shrink or eliminate the tum…

This study tested a new drug called uproleselan added to standard chemotherapy for people with a specific type of leukemia (secondary AML that has been treated before). The goal was to find the best dose and see how well the combination works. 37 adults took part, and the study l…

This study tested whether adding a type of immunotherapy (pembrolizumab) to targeted radiation therapy could help control advanced non-small cell lung cancer. 124 patients with stage IV disease received the combination. The goal was to shrink tumors and delay cancer growth, not t…

This study tested whether adding radiation to an immunotherapy drug (pembrolizumab) could help people with non-Hodgkin lymphoma that returned or didn't respond to prior treatments. Seventeen adults with aggressive types of lymphoma received both treatments. The goal was to see if…

This study tested a combination of two immunotherapy drugs, low-dose ipilimumab and pembrolizumab, in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This early-phase trial tested two drugs—binimetinib and hydroxychloroquine—in 34 people with a specific type of advanced pancreatic cancer (KRAS-mutant) that had spread. The goal was to find the safest dose of hydroxychloroquine when used with binimetinib, and to see if the combi…

This study tested the drug dasatinib in 68 adults with several types of blood and bone marrow disorders, including certain leukemias, myelofibrosis, and mastocytosis. The goal was to see if dasatinib could help control the disease and to check its safety. Participants took dasati…

This early-phase trial tested a combination of two antibody drugs (utomilumab and cetuximab) plus chemotherapy (irinotecan) in 34 people with advanced colorectal cancer that had spread. The main goals were to find the safest dose and check if the treatment shrinks tumors. The stu…

This study tested a combination of chemotherapy (nab-paclitaxel) and immunotherapy (atezolizumab) given before surgery to women with triple-negative breast cancer. The goal was to shrink tumors and reduce the amount of breast tissue that needs to be removed. The trial involved 37…

This early-phase trial tested two experimental drug combinations in 37 people with advanced EGFR-mutant lung cancer that no longer responded to the targeted therapy osimertinib. The goal was to find safe, tolerable doses of alisertib or sapanisertib when given together with osime…

This study looked at whether giving the drug ibrutinib early to people with chronic lymphocytic leukemia (CLL) who have high-risk features but no symptoms is better than waiting until symptoms develop. 23 participants took ibrutinib for up to 24 months. The goal was to see how ma…

This study tested a combination of enzalutamide (a hormone blocker) and paclitaxel (chemotherapy) given before surgery to 24 people with a specific type of triple-negative breast cancer that has androgen receptors. The goal was to see if this treatment could shrink tumors enough …

This study tested a combination of three immunotherapy drugs (BMS-986156, ipilimumab, and nivolumab) with or without precise radiation therapy in 51 people with advanced lung, chest, or liver cancer that had spread. The goal was to find the safest doses and see if the treatment h…

This study tested two immunotherapy drugs, durvalumab and tremelimumab, in 100 people with ovarian, fallopian tube, or peritoneal cancer that came back or stopped responding to platinum chemotherapy. The goal was to see if giving both drugs together or one after the other works b…

This study tested the drug pegloticase in 10 cancer patients with high uric acid levels caused by tumor lysis syndrome, a complication where cancer cells break down quickly. The goal was to see if the drug could safely lower uric acid and protect kidney function. Results are not …

This study tested whether the drug dasatinib can control chronic myeloid leukemia (CML) in its early chronic phase. 150 adults with newly diagnosed CML took dasatinib, and researchers measured how many achieved a major molecular response (very low levels of cancer genes) after 12…

This early-phase study tested a combination of three chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in children whose acute myeloid leukemia (AML) had come back or didn't respond to standard treatment. The main goals were to find the best dose and check for side effects. …

This study tested a drug called sintilimab in people with a rare cancer where doctors cannot find where the cancer started (cancer of unknown primary). The goal was to see if the drug could shrink tumors or stop them from growing. Ten patients who had already tried other treatmen…

This study tested a new formulation of two chemotherapy drugs (CPX-351) in 56 adults with newly diagnosed acute myeloid leukemia (AML) who were at high risk of not responding to standard treatment. The goal was to find the best dose and see how well it worked to stop cancer cells…

This early-phase study tested a combination therapy in 15 people with colon cancer who had completed standard treatment but still had tiny amounts of cancer DNA in their blood (called minimal residual disease). The treatment used specially activated immune cells from donated umbi…

This early-phase trial tested the safety and best dose of the immunotherapy drug pembrolizumab when combined with chemotherapy and radiation for people with small cell lung cancer. The goal was to see if adding pembrolizumab helps the immune system fight the cancer more effective…

This study looked at whether adding a special scope test (EBUS-TBNA) after a standard PET/CT scan can more accurately stage early-stage non-small cell lung cancer. About 150 patients who were being considered for precise radiation therapy (SBRT) took part. The goal was to see if …

This study looked at whether contrast-enhanced mammography (CEM) can find breast cancers that standard imaging might miss. 89 women with known or suspected breast cancer received CEM, which uses an iodine dye to make tumors and blood vessels stand out. The goal was to see if CEM …

This phase II trial tested whether the immunotherapy drug pembrolizumab (Keytruda) can prevent lung cancer in 45 people with high-risk lung nodules or early-stage non-small cell lung cancer. Participants received pembrolizumab intravenously, and researchers tracked tumor response…

This study looked at whether giving an additional anesthetic nerve block after pancreatic surgery helps patients use fewer opioid painkillers. 136 adults having open pancreatic surgery for cancer were randomly assigned to receive either one nerve block or a repeat block. The main…

This study looked at whether giving a light electrical pulse to a specific spot on the wrist (called P6) during breast cancer surgery could help prevent nausea and vomiting after the operation. 188 women at high risk for post-operative nausea took part. The goal was to see if add…

This study tested whether a single, precise session of high-dose radiation (stereotactic body radiotherapy) can safely relieve pain and control tumor growth in people with cancer that has spread to the spine. 71 adults with up to two spine tumors participated. Researchers measure…

This study tested if playing an augmented reality game called SpellBound can help children with cancer feel less pain and need fewer opioids after surgery. 29 kids aged 5-15 who had never taken opioids before took part. The game was used alongside standard care to see if it impro…

This study tested whether doing simple positive activities, like helping with household chores or writing a thank-you letter, could improve quality of life for cancer patients from collectivist cultures (e.g., Latino, Asian American, African American). 75 patients and their careg…

This study looked at 232 adult cancer patients with sepsis and low blood pressure to see if adding a type of antibiotic called aminoglycosides helps them recover faster. The main goal was to see how quickly their blood pressure returned to normal without needing strong blood pres…

This early-phase study tested a drug called erlotinib in 48 people with head and neck cancer who were scheduled for surgery. The goal was to see how the drug affects certain markers in tumor tissue, not to cure the disease. Participants received either a standard or high dose of …

This study looked at how men and women react differently when they switch from regular cigarettes to a standard research e-cigarette. About 169 adult smokers took part. The goal was to understand if gender affects how much people use e-cigarettes and how dependent they become on …

This study tested a mobile app called JEEVA designed to help breast surgery patients before and after their operation. 60 patients used the app to see if it was easy to use and helpful. The goal was to learn how accessible the app is, not to measure health outcomes.

This study tested whether implanting tiny gold markers near spinal tumors helps deliver radiation more accurately. Researchers also checked if giving slightly more radiation to the nearby esophagus is safe, which might improve tumor control. The study involved 41 adults with vari…

This study tested what happens when smokers use cigarettes with very low nicotine while also having e-cigarettes with different nicotine levels. Researchers wanted to see how this affects how many cigarettes people smoke, their cravings, and withdrawal symptoms. The study include…

This study tested two new methods to measure pressure and stiffness inside solid tumors in 27 patients. One method uses a thin catheter to measure pressure directly, and the other uses sound waves like an ultrasound to check stiffness. The goal was to see if these measurements co…

This study looked at what stops Black men in faith-based communities from getting screened for prostate cancer. Researchers worked with 24 participants to gather information that will help create a prostate cancer education program designed for Black men in church settings. The g…

This study tested two devices that help doctors place a breathing tube before surgery in 143 head and neck cancer patients with difficult airways. One device is a flexible scope, and the other combines that scope with a video laryngoscope. The goal was to see which method reduces…

This study tested a tool called an oncology dashboard that shows a patient's cancer treatment information to them, their doctor, and their radiologist. The goal was to see if it helps patients understand their disease better and makes care more efficient. The study included 92 pe…