M.d. Anderson Cancer Center

This early-phase trial tested a personalized vaccine made from each patient's own blood and bone marrow. The goal was to help the immune system recognize and attack cancer cells in people with smoldering multiple myeloma, a high-risk condition. The study involved 30 adults and fo…

This study tested a mix of two immunotherapy drugs (durvalumab and tremelimumab) plus a targeted therapy (selumetinib) in 40 people with advanced non-small cell lung cancer that had returned. The goal was to find the safest dose and see if the combination could shrink tumors or s…

This study looked at adding a drug called axitinib to standard hormone therapy before surgery for prostate cancer that had spread to lymph nodes. The goal was to see if the combination could delay cancer return after surgery. 73 men participated, and the study compared how long t…

This early-stage trial tested a combination of two targeted drugs, vandetanib and everolimus, in 151 people with advanced cancers that had stopped responding to standard treatments. The main goals were to find the safest dose and see how well the drugs worked together to shrink t…

This early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy and radiation is safe for people with small cell lung cancer. 83 participants received the combination to find the best dose and check for side effects. Researchers also tra…

This study tested a combination of two immunotherapy drugs (low-dose ipilimumab and pembrolizumab) in 24 people with advanced melanoma that had spread to the brain. The goal was to see if the treatment could shrink or control brain tumors and improve survival. Participants receiv…

This study looked at whether taking vitamin D and aspirin daily, along with exercise and a low-fat diet, could lower the chance of colorectal cancer returning in people who had already been treated. It involved 16 adults with no visible cancer but with tiny bits of cancer DNA in …

This early-phase trial tested a combination of two antibody drugs (utomilumab and cetuximab) plus chemotherapy (irinotecan) in 34 people with advanced colorectal cancer that had spread. The main goals were to find the safest dose and see if the tumors shrank. The study is complet…

This study tested whether giving the drug ibrutinib early to people with chronic lymphocytic leukemia (CLL) who have high-risk features but no symptoms yet is better than waiting until symptoms appear. Twenty-three participants took ibrutinib for up to 24 months. The goal was to …

This study tested a combination of three drugs (panitumumab, carboplatin, and paclitaxel) given before surgery to women with triple-negative breast cancer that did not respond to standard chemotherapy. The goal was to shrink tumors enough to allow less extensive surgery. The tria…

This study tested the drug dasatinib in 68 adults with various blood cancers and disorders, including certain leukemias, myelofibrosis, and mastocytosis. The main goal was to see if dasatinib could help control the disease and to check its safety. Researchers measured how many pa…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 29 people whose acute myeloid leukemia or myelodysplastic syndrome returned or did not respond after a donor stem cell transplant. The goal was to find the safest dose and see if the drugs could help the immu…

This study tested a combination of two drugs, ruxolitinib and azacytidine, in 121 people with myelofibrosis or related blood cancers. The goal was to see if the combo could shrink tumors and improve blood cell counts. While the treatment aims to control the disease, it is not a c…

This early-phase study tested the safety and best dose of olaparib when added to high-dose chemotherapy for people with lymphomas that returned or didn't respond to treatment. All participants were scheduled for a stem cell transplant. The goal was to see if the combination could…

This study tested whether the immunotherapy drug pembrolizumab (Keytruda) can help prevent oral cancer in 15 people with high-risk precancerous mouth lesions. Participants were randomly assigned to receive the drug or be observed. The goal was to see if the drug could keep the le…

This study tested a drug called blinatumomab in 36 adults with B-cell acute lymphoblastic leukemia who were in remission but still had tiny amounts of cancer cells (minimal residual disease). The goal was to see if the drug could clear those leftover cells and help patients stay …

This early-stage trial tested a combination of three drugs—vemurafenib, cetuximab, and irinotecan—in 47 people with advanced solid tumors that have a specific BRAF V600 mutation and cannot be removed by surgery. The main goal was to find the safest dose and understand side effect…

This study tested a drug called guadecitabine combined with donor white blood cell infusions in 55 adults whose leukemia or MDS came back after a stem cell transplant. The goal was to see if this combination could safely help patients achieve remission. The approach aims to stop …

This study tested a combination of the immunotherapy drug pembrolizumab and targeted radiation in 17 patients with non-Hodgkin lymphoma that had returned or stopped responding to treatment. The goal was to see if adding radiation could help the immune system fight the cancer bett…

This study tested the drug dasatinib in 17 people with chronic lymphocytic leukemia (CLL) who had already received other treatments. The goal was to see if the drug could shrink or control the cancer. Researchers measured how many patients had a complete or partial response to th…

This study tested a new treatment for people with certain types of lymphoma (Hodgkin or non-Hodgkin) that returned or didn't respond to standard therapy. The treatment combines a special antibody (AFM13) with immune cells called natural killer (NK) cells from donated umbilical co…

This early-phase trial tested a combination of two drugs—binimetinib and hydroxychloroquine—in 34 people with advanced pancreatic cancer that has a specific gene change (KRAS mutation) and has spread to other parts of the body. The goal was to find the safest dose of hydroxychlor…

This study looked at whether adding the targeted drug erlotinib to standard chemotherapy (docetaxel plus cisplatin or carboplatin) helps shrink head and neck tumors more than chemo alone before surgery. About 55 adults with advanced but operable head and neck cancer took part. Th…

This study tested a drug called sintilimab in 10 people with advanced cancer of unknown primary (CUP) that had not responded to standard chemotherapy. Sintilimab is an immunotherapy that helps the immune system attack cancer cells. The goal was to see if the drug could shrink tum…

This study looked at whether adding a special scope test (EBUS-TBNA) after a standard PET/CT scan can more accurately stage early-stage non-small cell lung cancer. About 150 patients with stage I-IIA cancer who were being considered for radiation therapy took part. The goal was t…

This study tested whether contrast-enhanced mammography (CEM) can find breast cancers that standard mammograms miss. 89 women already diagnosed or highly suspected of having breast cancer received CEM, which uses an iodine dye to make tumors stand out. The goal was to see if CEM …

This study tested whether the immunotherapy drug pembrolizumab can prevent lung cancer from coming back in 45 people with early-stage (stage I-II) non-small cell lung cancer or high-risk lung nodules. Participants received pembrolizumab to help their immune system attack any rema…

This study tested a single, high-dose radiation treatment (stereotactic body radiotherapy) for people with cancer that has spread to the spine. The goal was to see if it safely relieves pain and controls tumor growth. 71 adults with up to two spine tumors received one session of …

This study tested whether playing an augmented reality game called SpellBound can help children aged 5-15 with cancer feel less pain and need fewer opioids after surgery. The game was used alongside standard care to distract and engage patients. The goal was to improve quality of…

This study looked at why Black men in faith-based communities may not get screened for prostate cancer. Researchers worked with 24 participants to gather information. The goal is to create a prostate cancer education program that fits the needs of Black men in church settings and…

This study tested two devices—a flexible scope alone or combined with a video laryngoscope—to help doctors place breathing tubes in 143 head and neck cancer patients before surgery. Both devices use a small camera to see the airway on a screen, aiming to reduce complications like…

This early-phase study looked at whether giving the drug erlotinib before surgery could help treat head and neck cancer. 48 patients received either a standard or high dose of the drug, which works by blocking enzymes that help cancer cells grow. The main goal was to measure chan…

This study tested whether a tool called an oncology dashboard could help people with sarcoma and their doctors better understand and manage their cancer treatment. The dashboard collects and shows key information about a patient's disease and care. The goal was to see if it could…

This study tested what happens when smokers use cigarettes with very low nicotine while also having e-cigarettes with different nicotine levels. Researchers wanted to see how this affects how many cigarettes people smoke, their cravings, and withdrawal symptoms. The study include…

This study looked at 169 adult smokers to see if men and women have different experiences when switching from regular cigarettes to a standard research e-cigarette. Researchers measured how many cigarettes people smoked, how often they used the e-cigarette, and their nicotine lev…